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Items: 47

1.

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.

Oncogene. 2016 Apr 7;35(14):1832-46. doi: 10.1038/onc.2015.248. Epub 2015 Jul 13.

PMID:
26165838
2.

Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.

Hewitson KS, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran CT.

J Med Chem. 2012 Apr 12;55(7):3513-20. doi: 10.1021/jm300203r. Epub 2012 Mar 28.

PMID:
22424239
3.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. doi: 10.1016/j.bmcl.2010.08.032. Epub 2010 Aug 10.

PMID:
20822901
4.

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.

Iqbal A, Arunlanantham H, Brown T Jr, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ.

Proteins. 2010 May 1;78(6):1398-407. doi: 10.1002/prot.22653.

PMID:
20014241
5.

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ.

Structure. 2009 Jul 15;17(7):981-9. doi: 10.1016/j.str.2009.06.002.

6.

Direct analysis of enzyme-catalyzed DNA demethylation.

Karkhanina AA, Mecinović J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN.

Anal Chem. 2009 Jul 15;81(14):5871-5. doi: 10.1021/ac9010556.

PMID:
19518090
7.

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA.

J Biol Chem. 2008 Sep 19;283(38):25971-8. doi: 10.1074/jbc.M804999200. Epub 2008 Jul 8.

8.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ.

J Biol Chem. 2008 Feb 15;283(7):3808-15. Epub 2007 Dec 5.

9.

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Hewitson KS, Schofield CJ, Ratcliffe PJ.

Methods Enzymol. 2007;435:25-42.

PMID:
17998047
10.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

11.

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2007 Aug 17;282(33):24027-38. Epub 2007 Jun 15.

12.

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ.

J Biol Chem. 2007 Feb 2;282(5):3293-301. Epub 2006 Nov 29.

13.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26.

14.

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.

Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ.

Biochem J. 2007 Jan 1;401(1):227-34.

15.

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ.

Mol Biosyst. 2005 Oct;1(4):321-4. Epub 2005 Aug 22.

PMID:
16880998
16.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16.

17.

Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro.

Murray-Rust TA, Oldham NJ, Hewitson KS, Schofield CJ.

FEBS Lett. 2006 Apr 3;580(8):1911-8. Epub 2006 Feb 17.

18.

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.

Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ.

Chem Commun (Camb). 2005 Nov 21;(43):5438-40. Epub 2005 Oct 4.

PMID:
16261239
19.

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.

Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ.

J Biol Chem. 2006 Jan 6;281(1):279-87. Epub 2005 Oct 26.

20.

Selective inhibition of factor inhibiting hypoxia-inducible factor.

McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ.

J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

PMID:
15913349
21.

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Hewitson KS, Granatino N, Welford RW, McDonough MA, Schofield CJ.

Philos Trans A Math Phys Eng Sci. 2005 Apr 15;363(1829):807-28; discussion 1035-40. Review.

PMID:
15901537
22.

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases.

McNeill LA, Bethge L, Hewitson KS, Schofield CJ.

Anal Biochem. 2005 Jan 1;336(1):125-31.

PMID:
15582567
23.

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.

Tuckerman JR, Zhao Y, Hewitson KS, Tian YM, Pugh CW, Ratcliffe PJ, Mole DR.

FEBS Lett. 2004 Oct 8;576(1-2):145-50.

24.

The HIF pathway as a therapeutic target.

Hewitson KS, Schofield CJ.

Drug Discov Today. 2004 Aug 15;9(16):704-11. Review.

PMID:
15341784
25.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ.

Biochem J. 2004 Nov 1;383(Pt. 3):429-37.

26.

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.

Hewitson KS, McNeill LA, Schofield CJ.

Curr Pharm Des. 2004;10(8):821-33. Review.

PMID:
15032687
27.

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.

Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CM, Baldwin JE, Schofield CJ.

J Biol Chem. 2004 Apr 9;279(15):15420-6. Epub 2004 Jan 20.

28.

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.

Caines ME, Elkins JM, Hewitson KS, Schofield CJ.

J Biol Chem. 2004 Feb 13;279(7):5685-92. Epub 2003 Nov 17.

29.

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.

Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80.

PMID:
12873492
30.

The role of iron and 2-oxoglutarate oxygenases in signalling.

Hewitson KS, McNeill LA, Elkins JM, Schofield CJ.

Biochem Soc Trans. 2003 Jun;31(Pt 3):510-5. Review.

PMID:
12773146
31.

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.

Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ.

Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4.

PMID:
12668010
32.

The selectivity and inhibition of AlkB.

Welford RW, Schlemminger I, McNeill LA, Hewitson KS, Schofield CJ.

J Biol Chem. 2003 Mar 21;278(12):10157-61. Epub 2003 Jan 6.

33.

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.

Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2003 Jan 17;278(3):1802-6. Epub 2002 Nov 21.

34.

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ.

Biochem J. 2002 Nov 1;367(Pt 3):571-5.

35.

Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase.

Ollagnier-De-Choudens S, Mulliez E, Hewitson KS, Fontecave M.

Biochemistry. 2002 Jul 23;41(29):9145-52.

PMID:
12119030
36.

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ.

J Biol Chem. 2002 Jul 19;277(29):26351-5. Epub 2002 May 31.

37.

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ.

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50.

PMID:
12039559
38.

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

Elkins JM, Clifton IJ, Hernández H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS.

Biochem J. 2002 Sep 1;366(Pt 2):423-34.

39.

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.

Kershaw NJ, McNaughton HJ, Hewitson KS, Hernández H, Griffin J, Hughes C, Greaves P, Barton B, Robinson CV, Schofield CJ.

Eur J Biochem. 2002 Apr;269(8):2052-9.

40.

The iron-sulfur center of biotin synthase: site-directed mutants.

Hewitson KS, Ollagnier-de Choudens S, Sanakis Y, Shaw NM, Baldwin JE, Münck E, Roach PL, Fontecave M.

J Biol Inorg Chem. 2002 Jan;7(1-2):83-93. Epub 2001 Jul 11.

PMID:
11862544
41.

Enzymatic synthesis of monocyclic beta-lactams.

Sleeman MC, MacKinnon CH, Hewitson KS, Schofield CJ.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):597-9.

PMID:
11844680
42.

Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli.

Ollagnier-de Choudens S, Sanakis Y, Hewitson KS, Roach P, Münck E, Fontecave M.

J Biol Chem. 2002 Apr 19;277(16):13449-54. Epub 2002 Feb 7.

43.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ.

Cell. 2001 Oct 5;107(1):43-54.

44.

Observation of the iron-sulfur cluster in Escherichia coli biotin synthase by nanoflow electrospray mass spectrometry.

Hernández H, Hewitson KS, Roach P, Shaw NM, Baldwin JE, Robinson CV.

Anal Chem. 2001 Sep 1;73(17):4154-61.

PMID:
11569804
45.

MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro.

Birch OM, Hewitson KS, Fuhrmann M, Burgdorf K, Baldwin JE, Roach PL, Shaw NM.

J Biol Chem. 2000 Oct 13;275(41):32277-80.

46.

Iron-sulfur center of biotin synthase and lipoate synthase.

Ollagnier-De Choudens S, Sanakis Y, Hewitson KS, Roach P, Baldwin JE, Münck E, Fontecave M.

Biochemistry. 2000 Apr 11;39(14):4165-73.

PMID:
10747808
47.

Mutagenesis of the proposed iron-sulfur cluster binding ligands in Escherichia coli biotin synthase.

Hewitson KS, Baldwin JE, Shaw NM, Roach PL.

FEBS Lett. 2000 Jan 28;466(2-3):372-6.

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