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Items: 1 to 50 of 369

1.

Exploring the limits of modelling thrombus formation: Comment on "Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones" by A.V. Belyaev et al.

Hemker HC, Bloemen S, Hemker PW.

Phys Life Rev. 2018 Nov;26-27:100-105. doi: 10.1016/j.plrev.2018.06.010. Epub 2018 Jun 28. No abstract available.

PMID:
30007847
2.

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.

Kremers RMW, Zuily S, Kelchtermans H, Peters TC, Bloemen S, Regnault V, Hemker HC, de Groot PG, Wahl D, de Laat B.

Blood Adv. 2018 Jun 12;2(11):1315-1324. doi: 10.1182/bloodadvances.2018018036.

3.

Thrombin generation in low plasma volumes.

Bloemen S, Kelchtermans H, Hemker HC.

Thromb J. 2018 May 15;16:10. doi: 10.1186/s12959-018-0164-6. eCollection 2018.

4.

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.

Dargaud Y, Wolberg AS, Gray E, Negrier C, Hemker HC; Subcommittee on Factor VIII, Factor IX, and Rare Coagulation Disorders.

J Thromb Haemost. 2017 Aug;15(8):1704-1707. doi: 10.1111/jth.13743. Epub 2017 Jun 28. No abstract available.

5.

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis.

Kremers RMW, Kleinegris MC, Ninivaggi M, de Laat B, Ten Cate H, Koek GH, Wagenvoord RJ, Hemker HC.

PLoS One. 2017 May 4;12(5):e0177020. doi: 10.1371/journal.pone.0177020. eCollection 2017.

6.

Computational modelling of clot development in patient-specific cerebral aneurysm cases: rebuttal.

Kremers RM, de Laat B, Wagenvoord RJ, Hemker HC.

J Thromb Haemost. 2017 Feb;15(2):399. doi: 10.1111/jth.13593. Epub 2017 Feb 3. No abstract available.

7.

Computational modelling of clot development in patient-specific cerebral aneurysm cases: comment.

Kremers RM, de Laat B, Wagenvoord RJ, Hemker HC.

J Thromb Haemost. 2017 Feb;15(2):395-396. doi: 10.1111/jth.13591. Epub 2017 Feb 3. No abstract available.

8.

A century of heparin: past, present and future.

Hemker HC.

J Thromb Haemost. 2016 Dec;14(12):2329-2338. doi: 10.1111/jth.13555. Epub 2016 Dec 16.

9.

[Measuring thrombin formation].

Hemker HC.

Ned Tijdschr Geneeskd. 2016;160:D318. Dutch.

PMID:
27650017
10.

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

Ten Cate H, Hemker HC.

J Am Heart Assoc. 2016 Aug 8;5(8). pii: e003553. doi: 10.1161/JAHA.116.003553. No abstract available.

11.

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception.

Hugon-Rodin J, Alhenc-Gelas M, Hemker HC, Brailly-Tabard S, Guiochon-Mantel A, Plu-Bureau G, Scarabin PY.

Biomarkers. 2017 Feb;22(1):81-85. doi: 10.1080/1354750X.2016.1204010. Epub 2016 Jul 6.

PMID:
27323874
12.

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.

Kremers RM, Bosch YP, Bloemen S, de Laat B, Weerwind PW, Mochtar B, Maessen JG, Wagenvoord RJ, Al Dieri R, Hemker HC.

Thromb Haemost. 2016 Aug 30;116(3):442-51. doi: 10.1160/TH16-02-0094. Epub 2016 Apr 28.

PMID:
27121983
13.

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions.

Kelchtermans H, Pelkmans L, Bouwhuis A, Schurgers E, Lindhout T, Huskens D, Miszta A, Hemker HC, Lancé MD, de Laat B.

Thromb Haemost. 2016 Jul 4;116(1):134-45. doi: 10.1160/TH15-10-0801. Epub 2016 Apr 14.

PMID:
27074907
14.

Can global assays make anticoagulation safer and more effective?

Hemker HC.

Clin Adv Hematol Oncol. 2016 Jan;14(1):35-7. No abstract available.

PMID:
27057665
15.

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion.

Kremers RM, Wagenvoord RJ, de Laat HB, Monagle P, Hemker HC, Ignjatovic V.

Thromb Haemost. 2016 Jun 2;115(6):1090-100. doi: 10.1160/TH15-09-0716. Epub 2016 Jan 28.

PMID:
26819003
16.

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups.

Kremers RM, Mohamed AB, Pelkmans L, Hindawi S, Hemker HC, de Laat HB, Huskens D, Al Dieri R.

PLoS One. 2015 Oct 28;10(10):e0141491. doi: 10.1371/journal.pone.0141491. eCollection 2015.

17.

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation.

Kremers RM, Wagenvoord RJ, Hemker HC.

Thromb Haemost. 2016 Apr;115(4):869-70. doi: 10.1160/TH15-09-0699. Epub 2015 Oct 15. No abstract available.

PMID:
26467386
18.

Thrombin generation: biochemical possibilities and clinical reality.

Hemker HC.

Blood. 2015 Jul 16;126(3):288-9. doi: 10.1182/blood-2015-05-643403.

19.

The application of thrombin generation in real life clinical situations.

Hemker HC.

Thromb Res. 2015 Jul;136(1):3-4. doi: 10.1016/j.thromres.2015.04.010. Epub 2015 Apr 14. No abstract available.

PMID:
25957867
20.

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects.

Panteleev MA, Hemker HC.

Thromb J. 2015 Jan 28;13(1):5. doi: 10.1186/s12959-014-0032-y. eCollection 2015. No abstract available.

21.

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.

Dargaud Y, Scoazec JY, Wielders SJ, Trzeciak C, Hackeng TM, Négrier C, Hemker HC, Lindhout T, Castoldi E.

Blood. 2015 Feb 26;125(9):1497-501. doi: 10.1182/blood-2014-10-604553. Epub 2015 Jan 6.

22.

The balance of pro- and anticoagulant processes underlying thrombin generation.

Kremers RM, Peters TC, Wagenvoord RJ, Hemker HC.

J Thromb Haemost. 2015 Mar;13(3):437-47. doi: 10.1111/jth.12798. Epub 2015 Jan 7.

23.

The effect of fibrin(ogen) on thrombin generation and decay.

Kremers RM, Wagenvoord RJ, Hemker HC.

Thromb Haemost. 2014 Sep 2;112(3):486-94. doi: 10.1160/TH14-02-0172. Epub 2014 Jun 26.

PMID:
24964786
24.

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA.

Blood. 2014 Feb 13;123(7):1098-101. doi: 10.1182/blood-2013-07-514984. Epub 2013 Nov 21.

25.

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X.

Al Dieri R, Bloemen S, Kelchtermans H, Wagenvoord R, Hemker HC.

J Thromb Haemost. 2013 Mar;11(3):503-11. doi: 10.1111/jth.12126.

26.

Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: a rebuttal.

Hemker HC, Béguin S.

J Thromb Haemost. 2013 Mar;11(3):564. doi: 10.1111/jth.12116. No abstract available.

27.

Data management in thrombin generation.

Hemker HC, Kremers R.

Thromb Res. 2013 Jan;131(1):3-11. doi: 10.1016/j.thromres.2012.10.011. Epub 2012 Nov 13. Review.

28.

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation.

Bloemen S, Hemker HC, Al Dieri R.

Haematologica. 2013 Apr;98(4):549-54. doi: 10.3324/haematol.2012.073601. Epub 2012 Oct 25.

29.

Thrombin generation: what have we learned?

Al Dieri R, de Laat B, Hemker HC.

Blood Rev. 2012 Sep;26(5):197-203. doi: 10.1016/j.blre.2012.06.001. Epub 2012 Jul 2. Review.

PMID:
22762893
30.

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

Ninivaggi M, Apitz-Castro R, Dargaud Y, de Laat B, Hemker HC, Lindhout T.

Clin Chem. 2012 Aug;58(8):1252-9. doi: 10.1373/clinchem.2012.184077. Epub 2012 Jun 4.

31.

Is there value in kinetic modeling of thrombin generation? No (unless…).

Hemker HC, Kerdelo S, Kremers RM.

J Thromb Haemost. 2012 Aug;10(8):1470-7. doi: 10.1111/j.1538-7836.2012.04802.x. No abstract available.

32.

Fluorogenic peptide-based substrates for monitoring thrombin activity.

van Berkel SS, van der Lee B, van Delft FL, Wagenvoord R, Hemker HC, Rutjes FP.

ChemMedChem. 2012 Apr;7(4):606-17. doi: 10.1002/cmdc.201100560. Epub 2012 Jan 31.

PMID:
22294421
33.

No effect of ethanol intake on thrombin generation parameters.

Bloemen S, Pieters M, Hemker HC, Al Dieri R.

Thromb Res. 2012 Apr;129(4):530-1. doi: 10.1016/j.thromres.2011.11.011. Epub 2011 Nov 30. No abstract available.

PMID:
22133275
34.

Procoagulant effect of vitamin K antagonists?

Al Dieri R, Ten Cate-Hoek A, Bloemen S, Ten Cate H, Hemker HC.

J Thromb Haemost. 2011 Dec;9(12):2511-2. doi: 10.1111/j.1538-7836.2011.04527.x. No abstract available.

35.

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A.

Ninivaggi M, Dargaud Y, van Oerle R, de Laat B, Hemker HC, Lindhout T.

J Thromb Haemost. 2011 Aug;9(8):1549-55. doi: 10.1111/j.1538-7836.2011.04358.x.

36.

Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens.

Scarabin PY, Hemker HC, Clément C, Soisson V, Alhenc-Gelas M.

Menopause. 2011 Aug;18(8):873-9. doi: 10.1097/gme.0b013e31820eee88.

PMID:
21487317
37.

[Thrombinoscopy: measuring thrombin generation].

Hemker HC.

Ned Tijdschr Geneeskd. 2011;155:A2572. Dutch.

PMID:
21291579
38.

Thrombin generation is extremely sensitive to preheating conditions.

De Smedt E, Hemker HC.

J Thromb Haemost. 2011 Jan;9(1):233-4. doi: 10.1111/j.1538-7836.2010.04136.x. No abstract available.

39.

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay.

Debaugnies F, Azerad MA, Noubouossié D, Rozen L, Hemker HC, Corazza F, Efira A, Demulder A.

Thromb Res. 2010 Dec;126(6):531-5. doi: 10.1016/j.thromres.2010.09.002. Epub 2010 Sep 25.

PMID:
20870277
40.

Monitoring new oral antithrombotics: what we should know before we can decide.

Al Dieri R, Hemker HC.

J Thromb Haemost. 2010 Dec;8(12):2833-5. doi: 10.1111/j.1538-7836.2010.04057.x. No abstract available.

41.

Monitoring platelet dependent thrombin generation in mice.

Dargaud Y, Spronk HM, Leenders P, Hemker HC, Ten Cate H.

Thromb Res. 2010 Nov;126(5):436-41. doi: 10.1016/j.thromres.2010.08.007. Epub 2010 Sep 16.

PMID:
20843543
42.

High subretinal fluid procoagulant activity in rhegmatogenous retinal detachment.

Ricker LJ, Dieri RA, Beckers GJ, Pels E, Liem AT, Hendrikse F, Kijlstra A, Hemker HC, La Heij EC.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5234-9. doi: 10.1167/iovs.10-5354. Epub 2010 Apr 30.

PMID:
20435588
43.

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin.

Wagenvoord RJ, Deinum J, Elg M, Hemker HC.

J Thromb Haemost. 2010 Jun;8(6):1281-9. doi: 10.1111/j.1538-7836.2010.03822.x. Epub 2010 Feb 24.

44.

Thrombin generation and plasma dilution.

Hemker HC, De Smedt E, Chandler WL, Roshal M.

Am J Clin Pathol. 2010 Jan;133(1):163; author reply 164. doi: 10.1309/AJCPX63EFKZSYOQI. No abstract available.

PMID:
20023273
45.

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration.

De Smedt E, Al Dieri R, Spronk HM, Hamulyak K, ten Cate H, Hemker HC.

Thromb Haemost. 2008 Aug;100(2):343-9.

PMID:
18690357
46.

Recollections on thrombin generation.

Hemker HC.

J Thromb Haemost. 2008 Feb;6(2):219-26. Epub 2007 Dec 10.

47.

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.

Wagenvoord R, Al Dieri R, van Dedem G, Béguin S, Hemker HC.

Thromb Res. 2008;122(2):237-45. Epub 2007 Nov 28.

PMID:
18045667
48.

The contribution of alpha(2)-macroglobulin thrombin to the endogenous thrombin potential.

Hemker HC, de Smedt E, Al Dieri R.

Br J Haematol. 2007 Nov;139(3):513. Epub 2007 Sep 14. No abstract available.

PMID:
17868043
49.

The initiation phase--a review of old (clotting-) times.

Hemker HC.

Thromb Haemost. 2007 Jul;98(1):20-3. No abstract available.

PMID:
17597985
50.

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system.

Eilertsen AL, Liestøl S, Mowinckel MC, Hemker HC, Sandset PM.

Thromb Haemost. 2007 Jun;97(6):938-43.

PMID:
17549295

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