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Methylation Status of the Adeno-Associated Virus Type 2 (AAV2).

Tóth R, Mészáros I, Hüser D, Forró B, Marton S, Olasz F, Bányai K, Heilbronn R, Zádori Z.

Viruses. 2019 Jan 9;11(1). pii: E38. doi: 10.3390/v11010038.


CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis.

Lau J, Farzi A, Qi Y, Heilbronn R, Mietzsch M, Shi YC, Herzog H.

Mol Metab. 2018 Jan;7:102-118. doi: 10.1016/j.molmet.2017.10.015. Epub 2017 Nov 8.


Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells.

Kondratov O, Marsic D, Crosson SM, Mendez-Gomez HR, Moskalenko O, Mietzsch M, Heilbronn R, Allison JR, Green KB, Agbandje-McKenna M, Zolotukhin S.

Mol Ther. 2017 Dec 6;25(12):2661-2675. doi: 10.1016/j.ymthe.2017.08.003. Epub 2017 Aug 10.


Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice.

Drexel M, Romanov RA, Wood J, Weger S, Heilbronn R, Wulff P, Tasan RO, Harkany T, Sperk G.

J Neurosci. 2017 Aug 23;37(34):8166-8179. doi: 10.1523/JNEUROSCI.3456-16.2017. Epub 2017 Jul 21.


OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA.

Mietzsch M, Hering H, Hammer EM, Agbandje-McKenna M, Zolotukhin S, Heilbronn R.

Hum Gene Ther Methods. 2017 Feb;28(1):15-22. doi: 10.1089/hgtb.2016.164.


High Prevalence of Infectious Adeno-associated Virus (AAV) in Human Peripheral Blood Mononuclear Cells Indicative of T Lymphocytes as Sites of AAV Persistence.

Hüser D, Khalid D, Lutter T, Hammer EM, Weger S, Heßler M, Kalus U, Tauchmann Y, Hensel-Wiegel K, Lassner D, Heilbronn R.

J Virol. 2017 Jan 31;91(4). pii: e02137-16. doi: 10.1128/JVI.02137-16. Print 2017 Feb 15.


Comprehensive Small RNA-Seq of Adeno-Associated Virus (AAV)-Infected Human Cells Detects Patterns of Novel, Non-Coding AAV RNAs in the Absence of Cellular miRNA Regulation.

Stutika C, Mietzsch M, Gogol-Döring A, Weger S, Sohn M, Chen W, Heilbronn R.

PLoS One. 2016 Sep 9;11(9):e0161454. doi: 10.1371/journal.pone.0161454. eCollection 2016.


Vasopressinergic control of stress-related behavior: studies in Brattleboro rats.

Csikota P, Fodor A, Balázsfi D, Pintér O, Mizukami H, Weger S, Heilbronn R, Engelmann M, Zelena D.

Stress. 2016 Jul;19(4):349-61. doi: 10.1080/10253890.2016.1183117. Epub 2016 May 17. Review.


A Regulatory Element Near the 3' End of the Adeno-Associated Virus rep Gene Inhibits Adenovirus Replication in cis by Means of p40 Promoter-Associated Short Transcripts.

Weger S, Hammer E, Gonsior M, Stutika C, Heilbronn R.

J Virol. 2016 Mar 28;90(8):3981-93. doi: 10.1128/JVI.03120-15. Print 2016 Apr.


A Comprehensive RNA Sequencing Analysis of the Adeno-Associated Virus (AAV) Type 2 Transcriptome Reveals Novel AAV Transcripts, Splice Variants, and Derived Proteins.

Stutika C, Gogol-Döring A, Botschen L, Mietzsch M, Weger S, Feldkamp M, Chen W, Heilbronn R.

J Virol. 2015 Nov 11;90(3):1278-89. doi: 10.1128/JVI.02750-15. Print 2016 Feb 1.


NPY Y2 receptors in the central amygdala reduce cued but not contextual fear.

Verma D, Wood J, Lach G, Mietzsch M, Weger S, Heilbronn R, Herzog H, Bonaventure P, Sperk G, Tasan RO.

Neuropharmacology. 2015 Dec;99:665-74. doi: 10.1016/j.neuropharm.2015.08.038. Epub 2015 Aug 24.


Interactions of cullin3/KCTD5 complexes with both cytoplasmic and nuclear proteins: Evidence for a role in protein stabilization.

Rutz N, Heilbronn R, Weger S.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):922-8. doi: 10.1016/j.bbrc.2015.07.069. Epub 2015 Jul 16.


OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA.

Mietzsch M, Casteleyn V, Weger S, Zolotukhin S, Heilbronn R.

Hum Gene Ther. 2015 Oct;26(10):688-97. doi: 10.1089/hum.2015.050. Epub 2015 Aug 6.


Definition of herpes simplex virus helper functions for the replication of adeno-associated virus type 5.

Stutika C, Hüser D, Weger S, Rutz N, Heßler M, Heilbronn R.

J Gen Virol. 2015 Apr;96(Pt 4):840-50. doi: 10.1099/vir.0.000034. Epub 2014 Dec 22.


Adeno-associated virus type 2 wild-type and vector-mediated genomic integration profiles of human diploid fibroblasts analyzed by third-generation PacBio DNA sequencing.

Hüser D, Gogol-Döring A, Chen W, Heilbronn R.

J Virol. 2014 Oct;88(19):11253-63. doi: 10.1128/JVI.01356-14. Epub 2014 Jul 16.


Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q.

von Kietzell K, Pozzuto T, Heilbronn R, Grössl T, Fechner H, Weger S.

J Virol. 2014 Jul;88(14):8102-15. doi: 10.1128/JVI.00649-14. Epub 2014 May 7.


A simplified purification protocol for recombinant adeno-associated virus vectors.

Potter M, Lins B, Mietzsch M, Heilbronn R, Van Vliet K, Chipman P, Agbandje-McKenna M, Cleaver BD, Clément N, Byrne BJ, Zolotukhin S.

Mol Ther Methods Clin Dev. 2014 Aug 13;1:14034. doi: 10.1038/mtm.2014.34. eCollection 2014.


Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans.

Mietzsch M, Broecker F, Reinhardt A, Seeberger PH, Heilbronn R.

J Virol. 2014 Mar;88(5):2991-3003. doi: 10.1128/JVI.03371-13. Epub 2013 Dec 26.


OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.

Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R.

Hum Gene Ther. 2014 Mar;25(3):212-22. doi: 10.1089/hum.2013.184. Epub 2014 Jan 23.


Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Baldock PA, Zhang L, Sainsbury A, Herzog H, Lin S.

Cell Metab. 2013 Feb 5;17(2):236-48. doi: 10.1016/j.cmet.2013.01.006.


The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.

Rahman SH, Bobis-Wozowicz S, Chatterjee D, Gellhaus K, Pars K, Heilbronn R, Jacobs R, Cathomen T.

Hum Gene Ther. 2013 Jan;24(1):67-77. doi: 10.1089/hum.2012.168. Epub 2012 Dec 10.


Roles of E4orf6 and VA I RNA in adenovirus-mediated stimulation of human parvovirus B19 DNA replication and structural gene expression.

Winter K, von Kietzell K, Heilbronn R, Pozzuto T, Fechner H, Weger S.

J Virol. 2012 May;86(9):5099-109. doi: 10.1128/JVI.06991-11. Epub 2012 Feb 22.


DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8.

Alex M, Weger S, Mietzsch M, Slanina H, Cathomen T, Heilbronn R.

J Virol. 2012 Mar;86(5):2859-63. doi: 10.1128/JVI.06364-11. Epub 2011 Dec 28.


Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lütge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T.

PLoS One. 2011;6(12):e28911. doi: 10.1371/journal.pone.0028911. Epub 2011 Dec 14.


Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

Händel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, Müller-Lerch F, Kotin RM, Heilbronn R, Cathomen T.

Hum Gene Ther. 2012 Mar;23(3):321-9. doi: 10.1089/hum.2011.140. Epub 2011 Dec 14.


Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, Cathomen T.

Nucleic Acids Res. 2010 Dec;38(22):8269-76. doi: 10.1093/nar/gkq720. Epub 2010 Aug 16.


Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.

Hüser D, Gogol-Döring A, Lutter T, Weger S, Winter K, Hammer EM, Cathomen T, Reinert K, Heilbronn R.

PLoS Pathog. 2010 Jul 8;6(7):e1000985. doi: 10.1371/journal.ppat.1000985.


The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.

Tasan RO, Nguyen NK, Weger S, Sartori SB, Singewald N, Heilbronn R, Herzog H, Sperk G.

J Neurosci. 2010 May 5;30(18):6282-90. doi: 10.1523/JNEUROSCI.0430-10.2010.


Viral vectors for gene transfer: current status of gene therapeutics.

Heilbronn R, Weger S.

Handb Exp Pharmacol. 2010;(197):143-70. doi: 10.1007/978-3-642-00477-3_5. Review.


Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells.

Gellhaus K, Cornu TI, Heilbronn R, Cathomen T.

Hum Gene Ther. 2010 May;21(5):543-53. doi: 10.1089/hum.2009.167.


The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.

Hammer E, Heilbronn R, Weger S.

FEBS Lett. 2007 Nov 27;581(28):5418-24. Epub 2007 Oct 30.


[Do you have a grip on influenza? (interview by Dr. Thomas Meissner)].

Heilbronn R.

MMW Fortschr Med. 2007 Mar 1;149(9):16. German. No abstract available.


Patients at high risk for CMV infection and disease show delayed CD8+ T-cell immune recovery after allogeneic stem cell transplantation.

Ganepola S, Gentilini C, Hilbers U, Lange T, Rieger K, Hofmann J, Maier M, Liebert UG, Niederwieser D, Engelmann E, Heilbronn R, Thiel E, Uharek L.

Bone Marrow Transplant. 2007 Mar;39(5):293-9. Epub 2007 Jan 29.


Identification of a cytoplasmic interaction partner of the large regulatory proteins Rep78/Rep68 of adeno-associated virus type 2 (AAV-2).

Weger S, Hammer E, Götz A, Heilbronn R.

Virology. 2007 May 25;362(1):192-206. Epub 2007 Jan 17.


Role of the herpes simplex virus helicase-primase complex during adeno-associated virus DNA replication.

Slanina H, Weger S, Stow ND, Kuhrs A, Heilbronn R.

J Virol. 2006 Jun;80(11):5241-50.


Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.

Weger S, Hammer E, Heilbronn R.

FEBS Lett. 2005 Sep 12;579(22):5007-12.


ssDNA-dependent colocalization of adeno-associated virus Rep and herpes simplex virus ICP8 in nuclear replication domains.

Heilbronn R, Engstler M, Weger S, Krahn A, Schetter C, Boshart M.

Nucleic Acids Res. 2003 Nov 1;31(21):6206-13.


What is the WMA for? The case of the Israeli Medical Association.

Bamber H, Gordon E, Heilbronn R, Forrest D.

Lancet. 2003 Jul 19;362(9379):251-2; author reply 252. No abstract available.


High variability between results of different in-house tests for cytomegalovirus (CMV) monitoring and a standardized quantitative plasma CMV PCR assay.

Von Müller L, Hampl W, Hinz J, Meisel H, Reip A, Engelmann E, Heilbronn R, Gärtner B, Krämer O, Einsele H, Hebart H, Ljubicic T, Löffler J, Mertens T.

J Clin Microbiol. 2002 Jun;40(6):2285-7.


Attitudes to torture.

Bamber H, Gordon E, Heilbronn R, Forrest D.

J R Soc Med. 2002 May;95(5):271-2. No abstract available.


Discrimination between different types of human adeno-associated viruses in clinical samples by PCR.

Tobiasch E, Burguete T, Klein-Bauernschmitt P, Heilbronn R, Schlehofer JR.

J Virol Methods. 1998 Mar;71(1):17-25.


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