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Items: 1 to 50 of 62

1.

Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.

Froude JW, Herbert AS, Pelat T, Miethe S, Zak SE, Brannan JM, Bakken RR, Steiner AR, Yin G, Hallam TJ, Sato AK, Hust M, Thullier P, Dye JM.

Viruses. 2018 May 26;10(6). pii: E286. doi: 10.3390/v10060286.

2.

RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates.

Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CD, McEvoy LM, Sato AK, Hallam TJ.

Sci Rep. 2017 Jun 8;7(1):3026. doi: 10.1038/s41598-017-03192-z.

3.

Antibody conjugates with unnatural amino acids.

Hallam TJ, Wold E, Wahl A, Smider VV.

Mol Pharm. 2015 Jun 1;12(6):1848-62. doi: 10.1021/acs.molpharmaceut.5b00082. Epub 2015 May 21. Review.

PMID:
25898256
4.

A simplified and robust protocol for immunoglobulin expression in Escherichia coli cell-free protein synthesis systems.

Cai Q, Hanson JA, Steiner AR, Tran C, Masikat MR, Chen R, Zawada JF, Sato AK, Hallam TJ, Yin G.

Biotechnol Prog. 2015 May-Jun;31(3):823-31. doi: 10.1002/btpr.2082. Epub 2015 Apr 18.

5.

Methods to Make Homogenous Antibody Drug Conjugates.

Kline T, Steiner AR, Penta K, Sato AK, Hallam TJ, Yin G.

Pharm Res. 2015 Nov;32(11):3480-93. doi: 10.1007/s11095-014-1596-8. Epub 2014 Dec 16. Review.

6.

Production of bispecific antibodies in "knobs-into-holes" using a cell-free expression system.

Xu Y, Lee J, Tran C, Heibeck TH, Wang WD, Yang J, Stafford RL, Steiner AR, Sato AK, Hallam TJ, Yin G.

MAbs. 2015;7(1):231-42. doi: 10.4161/19420862.2015.989013.

7.

A general sequence processing and analysis program for protein engineering.

Stafford RL, Zimmerman ES, Hallam TJ, Sato AK.

J Chem Inf Model. 2014 Oct 27;54(10):3020-32. doi: 10.1021/ci500362s. Epub 2014 Oct 3.

8.

Unnatural amino acids in novel antibody conjugates.

Hallam TJ, Smider VV.

Future Med Chem. 2014 Jul;6(11):1309-24. doi: 10.4155/fmc.14.79. Review.

PMID:
25163001
9.

In vitro Fab display: a cell-free system for IgG discovery.

Stafford RL, Matsumoto ML, Yin G, Cai Q, Fung JJ, Stephenson H, Gill A, You M, Lin SH, Wang WD, Masikat MR, Li X, Penta K, Steiner AR, Baliga R, Murray CJ, Thanos CD, Hallam TJ, Sato AK.

Protein Eng Des Sel. 2014 Apr;27(4):97-109. doi: 10.1093/protein/gzu002. Epub 2014 Feb 28.

10.

Engineering toward a bacterial "endoplasmic reticulum" for the rapid expression of immunoglobulin proteins.

Groff D, Armstrong S, Rivers PJ, Zhang J, Yang J, Green E, Rozzelle J, Liang S, Kittle JD Jr, Steiner AR, Baliga R, Thanos CD, Hallam TJ, Sato AK, Yam AY.

MAbs. 2014 May-Jun;6(3):671-8. doi: 10.4161/mabs.28172. Epub 2014 Feb 11.

11.

Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system.

Zimmerman ES, Heibeck TH, Gill A, Li X, Murray CJ, Madlansacay MR, Tran C, Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang W, Hallam TJ, Thanos CD, Sato AK.

Bioconjug Chem. 2014 Feb 19;25(2):351-61. doi: 10.1021/bc400490z. Epub 2014 Jan 29.

PMID:
24437342
12.

In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator.

Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW, Panettieri RA Jr.

Pulm Pharmacol Ther. 2013 Apr;26(2):229-38. doi: 10.1016/j.pupt.2012.11.001. Epub 2012 Nov 12.

13.

Developing treatments for female sexual dysfunction.

Jordan R, Hallam TJ, Molinoff P, Spana C.

Clin Pharmacol Ther. 2011 Jan;89(1):137-41. doi: 10.1038/clpt.2010.262. Epub 2010 Nov 17.

PMID:
21085115
14.

Melanocortins in the treatment of male and female sexual dysfunction.

Shadiack AM, Sharma SD, Earle DC, Spana C, Hallam TJ.

Curr Top Med Chem. 2007;7(11):1137-44. Review.

PMID:
17584134
15.

Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors.

Bottomley KM, Borkakoti N, Bradshaw D, Brown PA, Broadhurst MJ, Budd JM, Elliott L, Eyers P, Hallam TJ, Handa BK, Hill CH, James M, Lahm HW, Lawton G, Merritt JE, Nixon JS, Röthlisberger U, Whittle A, Johnson WH.

Biochem J. 1997 Apr 15;323 ( Pt 2):483-8.

16.

Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.

Anderson G, Anderson KL, Conroy LA, Hallam TJ, Moore NC, Owen JJ, Jenkinson EJ.

J Immunol. 1995 Apr 15;154(8):3636-43.

PMID:
7706707
17.

Protein kinase C. Measurement of translocation, activation, and role in cellular responses.

Wilkinson SE, Hallam TJ.

Methods Mol Biol. 1995;41:261-70. No abstract available.

PMID:
7655562
18.
19.

Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils.

Sullivan JA, Merritt JE, Budd JM, Booth RF, Hallam TJ.

Eur J Immunol. 1994 Mar;24(3):621-6.

PMID:
8125132
20.

Protein kinase C: is its pivotal role in cellular activation over-stated?

Wilkinson SE, Hallam TJ.

Trends Pharmacol Sci. 1994 Feb;15(2):53-7. Review.

PMID:
8165725
21.

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

Birchall AM, Bishop J, Bradshaw D, Cline A, Coffey J, Elliott LH, Gibson VM, Greenham A, Hallam TJ, Harris W, et al.

J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.

PMID:
8114006
22.
23.

Definition of early Ca2+ signals induced by anti-CD3 antibody in a human Jurkat T-cell line using a selective protein kinase C inhibitor, Ro 31-8425.

Conroy LA, Merritt JE, Giafi CF, Lamont AG, Hallam TJ.

Biochem Soc Trans. 1993 Nov;21(4):384S. No abstract available.

PMID:
8131961
24.

The role of protein kinase C in TCR-induced interleukin-2 secretion in human Jurkat T cells.

Williams DH, Hallam TJ, Murray EJ.

Biochem Soc Trans. 1993 Nov;21(4):383S. No abstract available.

PMID:
8131960
25.

Functional significance of protein kinase C in human T-cell activation: a new therapeutic class?

Hallam TJ.

Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S131-4.

PMID:
8324939
26.

Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor.

Merritt JE, Brown AM, Bund S, Cooper DG, Egan JW, Hallam TJ, Heagerty AM, Hickey DM, Kaumann AJ, Keen M, et al.

Br J Pharmacol. 1991 Jan;102(1):260-6.

27.

The involvement of calcium and protein kinase C in modulating agonist-stimulated chemotaxis of human neutrophils.

Merritt JE, Greener M, Hallam TJ, Swayne GT.

Cell Signal. 1991;3(1):73-7.

PMID:
2036297
28.

Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor.

Merritt JE, Hallam TJ, Brown AM, Boyfield I, Cooper DG, Hickey DM, Jaxa-Chamiec AA, Kaumann AJ, Keen M, Kelly E, et al.

Br J Pharmacol. 1991 Jan;102(1):251-9.

29.

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.

Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, Jaxa-Chamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ.

Biochem J. 1990 Oct 15;271(2):515-22.

30.
31.

The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function.

Murray KJ, England PJ, Hallam TJ, Maguire J, Moores K, Reeves ML, Simpson AW, Rink TJ.

Br J Pharmacol. 1990 Mar;99(3):612-6.

34.

Calcium signalling in non-excitable cells: notes on oscillations and store refilling.

Rink TJ, Hallam TJ.

Cell Calcium. 1989 Jul;10(5):385-95. Review.

PMID:
2670242
35.
36.
37.
38.

Receptor-mediated Ca2+ entry: diversity of function and mechanism.

Hallam TJ, Rink TJ.

Trends Pharmacol Sci. 1989 Jan;10(1):8-10. Review. No abstract available.

PMID:
2556820
39.
40.

Evidence that agonists stimulate bivalent-cation influx into human endothelial cells.

Hallam TJ, Jacob R, Merritt JE.

Biochem J. 1988 Oct 1;255(1):179-84.

41.

Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells.

Jacob R, Merritt JE, Hallam TJ, Rink TJ.

Nature. 1988 Sep 1;335(6185):40-5.

PMID:
3412458
42.
43.
44.

Thyrotropin-releasing hormone activates Na+/H+ exchange in rat pituitary cells.

Hallam TJ, Tashjian AH Jr.

Biochem J. 1987 Mar 1;242(2):411-6.

45.

Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

Lansman JB, Hallam TJ, Rink TJ.

Nature. 1987 Feb 26-Mar 4;325(6107):811-3.

PMID:
2434860
47.
49.

Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets.

Hallam TJ, Daniel JL, Kendrick-Jones J, Rink TJ.

Biochem J. 1985 Dec 1;232(2):373-7.

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