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Items: 1 to 50 of 199

1.

The role of succinate and ROS in reperfusion injury - A critical appraisal.

Andrienko TN, Pasdois P, Pereira GC, Ovens MJ, Halestrap AP.

J Mol Cell Cardiol. 2017 Sep;110:1-14. doi: 10.1016/j.yjmcc.2017.06.016. Epub 2017 Jul 5. Review.

2.
3.

Mechanism of antineoplastic activity of lonidamine.

Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD.

Biochim Biophys Acta. 2016 Dec;1866(2):151-162. doi: 10.1016/j.bbcan.2016.08.001. Epub 2016 Aug 4. Review.

4.

Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity.

Richardson AP, Halestrap AP.

Biochem J. 2016 May 1;473(9):1129-40. doi: 10.1042/BCJ20160070. Epub 2016 Feb 26.

5.

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP.

Biochem J. 2016 Apr 1;473(7):929-36. doi: 10.1042/BJ20151120. Epub 2016 Feb 1.

6.

Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury.

Hansson MJ, Llwyd O, Morin D, de Paulis D, Arnoux T, Gouarné C, Koul S, Engblom H, Bordet T, Tissier R, Arheden H, Erlinge D, Halestrap AP, Berdeaux A, Pruss RM, Schaller S.

Eur J Pharmacol. 2015 Aug 5;760:7-19. doi: 10.1016/j.ejphar.2015.04.009. Epub 2015 Apr 17.

PMID:
25895640
7.

Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.

Nancolas B, Sessions RB, Halestrap AP.

Biochem J. 2015 Apr 1;467(1):192. No abstract available.

PMID:
25793420
8.

Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.

Nancolas B, Sessions RB, Halestrap AP.

Biochem J. 2015 Feb 15;466(1):177-88. doi: 10.1042/BJ20141223. Erratum in: Biochem J. 2015 Apr 1;467(1):192.

9.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

10.

Switching back to normal diet following high-fat diet feeding reduces cardiac vulnerability to ischaemia and reperfusion injury.

Littlejohns B, Lin H, Angelini GD, Halestrap AP, Suleiman MS.

Cell Physiol Biochem. 2014;34(4):1090-100. doi: 10.1159/000366323. Epub 2014 Sep 16.

11.

The role of hexokinase in cardioprotection - mechanism and potential for translation.

Halestrap AP, Pereira GC, Pasdois P.

Br J Pharmacol. 2015 Apr;172(8):2085-100. doi: 10.1111/bph.12899. Epub 2014 Nov 24. Review.

12.

The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal.

Halestrap AP.

Front Oncol. 2014 Aug 25;4:234. doi: 10.3389/fonc.2014.00234. eCollection 2014. No abstract available.

13.

The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury.

Halestrap AP, Richardson AP.

J Mol Cell Cardiol. 2015 Jan;78:129-41. doi: 10.1016/j.yjmcc.2014.08.018. Epub 2014 Aug 30. Review.

PMID:
25179911
14.

Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury.

Littlejohns B, Pasdois P, Duggan S, Bond AR, Heesom K, Jackson CL, Angelini GD, Halestrap AP, Suleiman MS.

PLoS One. 2014 Jun 20;9(6):e100579. doi: 10.1371/journal.pone.0100579. eCollection 2014.

15.

Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion.

Khaliulin I, Halestrap AP, Bryant SM, Dudley DJ, James AF, Suleiman MS.

J Transl Med. 2014 May 21;12:139. doi: 10.1186/1479-5876-12-139.

16.

Monocarboxylic acid transport.

Halestrap AP.

Compr Physiol. 2013 Oct;3(4):1611-43. doi: 10.1002/cphy.c130008. Review.

PMID:
24265240
17.

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.

Wilson MC, Kraus M, Marzban H, Sarna JR, Wang Y, Hawkes R, Halestrap AP, Beesley PW.

PLoS One. 2013 Nov 18;8(11):e78654. doi: 10.1371/journal.pone.0078654. eCollection 2013.

18.

The SLC16 gene family - structure, role and regulation in health and disease.

Halestrap AP.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):337-49. doi: 10.1016/j.mam.2012.05.003. Review.

PMID:
23506875
19.

Hexokinase II and reperfusion injury: TAT-HK2 peptide impairs vascular function in Langendorff-perfused rat hearts.

Pasdois P, Parker JE, Griffiths EJ, Halestrap AP.

Circ Res. 2013 Jan 18;112(2):e3-7. doi: 10.1161/CIRCRESAHA.112.274233.

PMID:
23329796
20.

Mitochondrial 'flashes': a radical concept repHined.

Schwarzländer M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Müller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ.

Trends Cell Biol. 2012 Oct;22(10):503-8. doi: 10.1016/j.tcb.2012.07.007. Epub 2012 Aug 20. Review.

PMID:
22917552
21.

The mitochondrial pyruvate carrier: has it been unearthed at last?

Halestrap AP.

Cell Metab. 2012 Aug 8;16(2):141-3. doi: 10.1016/j.cmet.2012.07.013.

22.

Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.

Pullen TJ, Sylow L, Sun G, Halestrap AP, Richter EA, Rutter GA.

Diabetes. 2012 Jul;61(7):1719-25. doi: 10.2337/db11-1531. Epub 2012 Apr 20.

23.

The mitochondrial K(ATP) channel--fact or fiction?

Garlid KD, Halestrap AP.

J Mol Cell Cardiol. 2012 Mar;52(3):578-83. doi: 10.1016/j.yjmcc.2011.12.011. Epub 2012 Jan 2.

24.
25.

The monocarboxylate transporter family--role and regulation.

Halestrap AP, Wilson MC.

IUBMB Life. 2012 Feb;64(2):109-19. doi: 10.1002/iub.572. Epub 2011 Dec 9. Review.

26.

The monocarboxylate transporter family--Structure and functional characterization.

Halestrap AP.

IUBMB Life. 2012 Jan;64(1):1-9. doi: 10.1002/iub.573. Epub 2011 Nov 30. Review.

27.

Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II.

Klier M, Schüler C, Halestrap AP, Sly WS, Deitmer JW, Becker HM.

J Biol Chem. 2011 Aug 5;286(31):27781-91. doi: 10.1074/jbc.M111.255331. Epub 2011 Jun 16.

28.

Temperature preconditioning is optimal at 26° C and confers additional protection to hypothermic cardioplegic ischemic arrest.

Khaliulin I, Halestrap AP, Suleiman MS.

Exp Biol Med (Maywood). 2011 Jun 1;236(6):736-45. doi: 10.1258/ebm.2011.010357. Epub 2011 May 23.

29.

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore.

Varanyuwatana P, Halestrap AP.

Mitochondrion. 2012 Jan;12(1):120-5. doi: 10.1016/j.mito.2011.04.006. Epub 2011 May 8.

30.

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

Chiche J, Le Fur Y, Vilmen C, Frassineti F, Daniel L, Halestrap AP, Cozzone PJ, Pouysségur J, Lutz NW.

Int J Cancer. 2012 Apr 1;130(7):1511-20. doi: 10.1002/ijc.26125. Epub 2011 May 30.

31.

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia.

Pasdois P, Parker JE, Griffiths EJ, Halestrap AP.

Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.

32.

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.

Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, Halestrap AP, Roussel D, Masse I, Dallière N, Ségalat L, Billaud M, Solari F.

Aging Cell. 2011 Feb;10(1):39-54. doi: 10.1111/j.1474-9726.2010.00640.x. Epub 2010 Nov 15.

33.

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.

Ovens MJ, Manoharan C, Wilson MC, Murray CM, Halestrap AP.

Biochem J. 2010 Oct 15;431(2):217-25. doi: 10.1042/BJ20100890.

34.

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection.

Halestrap AP.

Biochem Soc Trans. 2010 Aug;38(4):841-60. doi: 10.1042/BST0380841.

PMID:
20658967
35.

Consecutive pharmacological activation of PKA and PKC mimics the potent cardioprotection of temperature preconditioning.

Khaliulin I, Parker JE, Halestrap AP.

Cardiovasc Res. 2010 Nov 1;88(2):324-33. doi: 10.1093/cvr/cvq190. Epub 2010 Jun 16.

36.

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.

Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP.

Biochem J. 2010 Jan 15;425(3):523-30. doi: 10.1042/BJ20091515.

37.

Mitochondrial calcium in health and disease.

Halestrap AP.

Biochim Biophys Acta. 2009 Nov;1787(11):1289-90. doi: 10.1016/j.bbabio.2009.07.011. No abstract available.

38.

Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.

Wilson MC, Meredith D, Bunnun C, Sessions RB, Halestrap AP.

J Biol Chem. 2009 Jul 24;284(30):20011-21. doi: 10.1074/jbc.M109.014217. Epub 2009 May 27.

39.

Mitochondria and reperfusion injury of the heart--a holey death but not beyond salvation.

Halestrap AP.

J Bioenerg Biomembr. 2009 Apr;41(2):113-21. doi: 10.1007/s10863-009-9206-x. Review.

PMID:
19357938
40.

What is the mitochondrial permeability transition pore?

Halestrap AP.

J Mol Cell Cardiol. 2009 Jun;46(6):821-31. doi: 10.1016/j.yjmcc.2009.02.021. Epub 2009 Mar 3. Review.

PMID:
19265700
41.

The role of the mitochondrial permeability transition pore in heart disease.

Halestrap AP, Pasdois P.

Biochim Biophys Acta. 2009 Nov;1787(11):1402-15. doi: 10.1016/j.bbabio.2008.12.017. Epub 2009 Jan 8. Review.

42.

UCPs--unlikely calcium porters.

Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD.

Nat Cell Biol. 2008 Nov;10(11):1235-7; author reply 1237-40. doi: 10.1038/ncb1108-1235. No abstract available.

43.

The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.

Leung AW, Varanyuwatana P, Halestrap AP.

J Biol Chem. 2008 Sep 26;283(39):26312-23. doi: 10.1074/jbc.M805235200. Epub 2008 Jul 30.

44.

Determination of the rate of K(+) movement through potassium channels in isolated rat heart and liver mitochondria.

Bednarczyk P, Barker GD, Halestrap AP.

Biochim Biophys Acta. 2008 Jun;1777(6):540-8. doi: 10.1016/j.bbabio.2008.04.018. Epub 2008 Apr 18.

45.

Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore.

Leung AW, Halestrap AP.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):946-52. doi: 10.1016/j.bbabio.2008.03.009. Epub 2008 Mar 25. Review.

46.

Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation.

Clarke SJ, Khaliulin I, Das M, Parker JE, Heesom KJ, Halestrap AP.

Circ Res. 2008 May 9;102(9):1082-90. doi: 10.1161/CIRCRESAHA.107.167072. Epub 2008 Mar 20.

47.

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.

Ptak RG, Gallay PA, Jochmans D, Halestrap AP, Ruegg UT, Pallansch LA, Bobardt MD, de Béthune MP, Neyts J, De Clercq E, Dumont JM, Scalfaro P, Besseghir K, Wenger RM, Rosenwirth B.

Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17. doi: 10.1128/AAC.01324-07. Epub 2008 Jan 22.

48.

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.

Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipilä I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J.

Am J Hum Genet. 2007 Sep;81(3):467-74. Epub 2007 Jul 26.

49.

The role of mitochondria in protection of the heart by preconditioning.

Halestrap AP, Clarke SJ, Khaliulin I.

Biochim Biophys Acta. 2007 Aug;1767(8):1007-31. Epub 2007 Jun 2. Review.

50.

Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.

Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L.

J Physiol. 2007 Sep 1;583(Pt 2):469-86. Epub 2007 Jun 28.

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