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Items: 1 to 50 of 79

1.

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.

Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK.

Cell Syst. 2019 May 22;8(5):412-426.e7. doi: 10.1016/j.cels.2019.03.009. Epub 2019 May 8.

2.

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr.

Science. 2019 Mar 15;363(6432):1217-1222. doi: 10.1126/science.aaw1026. Epub 2019 Mar 14.

PMID:
30872525
3.

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13347-13352. doi: 10.1073/pnas.1804149115. Epub 2018 Dec 10.

4.

Chemical and Physiological Features of Mitochondrial Acylation.

Ringel AE, Tucker SA, Haigis MC.

Mol Cell. 2018 Nov 15;72(4):610-624. doi: 10.1016/j.molcel.2018.10.023. Review.

PMID:
30444998
5.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.

Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13.

PMID:
30220459
6.

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.

Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME.

Mol Metab. 2018 Nov;17:61-70. doi: 10.1016/j.molmet.2018.08.002. Epub 2018 Aug 11.

7.

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.

Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18.

PMID:
30022159
8.

The multifaceted contributions of mitochondria to cellular metabolism.

Spinelli JB, Haigis MC.

Nat Cell Biol. 2018 Jul;20(7):745-754. doi: 10.1038/s41556-018-0124-1. Epub 2018 Jun 27. Review.

9.

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.

Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7057-7062. doi: 10.1073/pnas.1800440115. Epub 2018 Jun 18.

10.

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.

Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD.

Mol Cell. 2018 Mar 1;69(5):729-743.e7. doi: 10.1016/j.molcel.2018.02.005.

11.

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.

Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC.

Cell Rep. 2018 Feb 20;22(8):1945-1955. doi: 10.1016/j.celrep.2018.01.076.

12.

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC.

Science. 2017 Nov 17;358(6365):941-946. doi: 10.1126/science.aam9305. Epub 2017 Oct 12.

13.

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.

Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K.

Cancer Discov. 2017 Dec;7(12):1450-1463. doi: 10.1158/2159-8290.CD-17-0177. Epub 2017 Sep 29.

14.

An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues.

Spinelli JB, Kelley LP, Haigis MC.

Sci Rep. 2017 Sep 4;7(1):10304. doi: 10.1038/s41598-017-09993-6.

15.

Strength in numbers: Phosphofructokinase polymerization prevails in the liver.

Zaganjor E, Spinelli JB, Haigis MC.

J Cell Biol. 2017 Aug 7;216(8):2239-2241. doi: 10.1083/jcb.201706005. Epub 2017 Jul 17.

16.

SIRT4 Is a Regulator of Insulin Secretion.

Zaganjor E, Vyas S, Haigis MC.

Cell Chem Biol. 2017 Jun 22;24(6):656-658. doi: 10.1016/j.chembiol.2017.06.002.

17.

Mitochondrial Sirtuins and Molecular Mechanisms of Aging.

van de Ven RAH, Santos D, Haigis MC.

Trends Mol Med. 2017 Apr;23(4):320-331. doi: 10.1016/j.molmed.2017.02.005. Epub 2017 Mar 10. Review.

18.

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC.

Cell. 2016 Nov 3;167(4):985-1000.e21. doi: 10.1016/j.cell.2016.10.016. Epub 2016 Oct 27.

19.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.

Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3.

20.

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC.

Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014.

21.

Mitochondria and Cancer.

Vyas S, Zaganjor E, Haigis MC.

Cell. 2016 Jul 28;166(3):555-566. doi: 10.1016/j.cell.2016.07.002. Review.

22.

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC.

Cell Metab. 2016 Jul 12;24(1):104-17. doi: 10.1016/j.cmet.2016.06.007.

23.

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.

Jeong SM, Haigis MC.

Mol Cells. 2015 Sep;38(9):750-8. doi: 10.14348/molcells.2015.0167. Epub 2015 Sep 18. Review.

24.

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.

Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH.

Cell Rep. 2015 Jul 14;12(2):163-71. doi: 10.1016/j.celrep.2015.06.015. Epub 2015 Jul 2.

25.

Sirtuins and the Metabolic Hurdles in Cancer.

German NJ, Haigis MC.

Curr Biol. 2015 Jun 29;25(13):R569-83. doi: 10.1016/j.cub.2015.05.012. Review.

26.

Nuclear respiratory factor 2 induces SIRT3 expression.

Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC.

Aging Cell. 2015 Oct;14(5):818-25. doi: 10.1111/acel.12360. Epub 2015 Jun 24.

27.

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.

Gonzalez Herrera KN, Lee J, Haigis MC.

Crit Rev Biochem Mol Biol. 2015;50(3):242-55. doi: 10.3109/10409238.2015.1031879. Epub 2015 Apr 21. Review.

28.

Mitochondrial metabolism in T cell activation and senescence: a mini-review.

Ron-Harel N, Sharpe AH, Haigis MC.

Gerontology. 2015;61(2):131-8. doi: 10.1159/000362502. Epub 2014 Nov 13. Review.

29.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R.

Nat Cell Biol. 2014 Oct;16(10):992-1003, 1-15. doi: 10.1038/ncb3039. Epub 2014 Sep 21. Erratum in: Nat Cell Biol. 2014 Nov;16(11):1125.

30.

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.

Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10574-9. doi: 10.1073/pnas.1409844111. Epub 2014 Jul 7.

31.

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10299-304. doi: 10.1073/pnas.1404399111. Epub 2014 Jun 30.

32.

Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter.

Satterstrom FK, Haigis MC.

Methods Enzymol. 2014;543:141-63. doi: 10.1016/B978-0-12-801329-8.00007-6.

33.

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.

Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC.

Oncogene. 2015 Apr 16;34(16):2115-24. doi: 10.1038/onc.2014.124. Epub 2014 Jun 9.

34.

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.

Jeong SM, Lee A, Lee J, Haigis MC.

J Biol Chem. 2014 Feb 14;289(7):4135-44. doi: 10.1074/jbc.M113.525949. Epub 2013 Dec 24.

35.

The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.

Bause AS, Matsui MS, Haigis MC.

J Biol Chem. 2013 Dec 20;288(51):36484-91. doi: 10.1074/jbc.M113.472324. Epub 2013 Nov 5.

36.

SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation.

Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC.

Mol Cell Biol. 2013 Nov;33(22):4552-61. doi: 10.1128/MCB.00087-13. Epub 2013 Sep 16.

37.

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC.

Mol Cell. 2013 Jun 6;50(5):686-98. doi: 10.1016/j.molcel.2013.05.012.

38.

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.

Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM.

Mol Cancer Res. 2013 Sep;11(9):1072-7. doi: 10.1158/1541-7786.MCR-13-0040-T. Epub 2013 May 30.

39.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.

Cell. 2013 May 9;153(4):840-54. doi: 10.1016/j.cell.2013.04.023.

40.

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC.

Cancer Cell. 2013 Apr 15;23(4):450-63. doi: 10.1016/j.ccr.2013.02.024. Epub 2013 Apr 4.

41.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC.

Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27. Erratum in: Nature. 2013 Jul 25;499(7459):504.

42.

Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.

Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW.

Mol Cell. 2013 Apr 25;50(2):172-84. doi: 10.1016/j.molcel.2013.02.014. Epub 2013 Mar 14.

43.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C.

Cell Mol Life Sci. 2013 Jun;70(11):2015-29. doi: 10.1007/s00018-012-1244-6. Epub 2013 Jan 3.

PMID:
23283301
44.

From sirtuin biology to human diseases: an update.

Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R.

J Biol Chem. 2012 Dec 14;287(51):42444-52. doi: 10.1074/jbc.R112.402768. Epub 2012 Oct 18. Review.

45.

SIRT3 regulation of mitochondrial oxidative stress.

Bause AS, Haigis MC.

Exp Gerontol. 2013 Jul;48(7):634-9. doi: 10.1016/j.exger.2012.08.007. Epub 2012 Aug 31. Review.

PMID:
22964489
46.

A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13.

47.

Acetylation-dependent regulation of Skp2 function.

Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.

Cell. 2012 Jul 6;150(1):179-93. doi: 10.1016/j.cell.2012.05.038.

48.

Metabolic regulation by SIRT3: implications for tumorigenesis.

Finley LW, Haigis MC.

Trends Mol Med. 2012 Sep;18(9):516-23. doi: 10.1016/j.molmed.2012.05.004. Epub 2012 Jun 27. Review.

49.

Regulation of RAS oncogenicity by acetylation.

Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18.

50.

SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.

Haigis MC, Deng CX, Finley LW, Kim HS, Gius D.

Cancer Res. 2012 May 15;72(10):2468-72. doi: 10.1158/0008-5472.CAN-11-3633.

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