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Items: 1 to 50 of 71

1.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
2.

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.

Wong M, Sun Y, Xi Z, Milazzo G, Poulos RC, Bartenhagen C, Bell JL, Mayoh C, Ho N, Tee AE, Chen X, Li Y, Ciaccio R, Liu PY, Jiang CC, Lan Q, Jayatilleke N, Cheung BB, Haber M, Norris MD, Zhang XD, Marshall GM, Wang JY, Hüttelmaier S, Fischer M, Wong JWH, Xu H, Perini G, Dong Q, George RE, Liu T.

Nat Commun. 2019 Jul 25;10(1):3319. doi: 10.1038/s41467-019-11132-w.

3.

POLIII-derived non-coding RNAs acting as scaffolds and decoys.

Täuber H, Hüttelmaier S, Köhn M.

J Mol Cell Biol. 2019 Jun 1. pii: mjz049. doi: 10.1093/jmcb/mjz049. [Epub ahead of print]

PMID:
31152666
4.

Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.

Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A.

Nat Commun. 2019 May 22;10(1):2266. doi: 10.1038/s41467-019-09769-8.

5.

The Critical Role of RNA m6A Methylation in Cancer.

Lan Q, Liu PY, Haase J, Bell JL, Hüttelmaier S, Liu T.

Cancer Res. 2019 Apr 1;79(7):1285-1292. doi: 10.1158/0008-5472.CAN-18-2965. Epub 2019 Mar 20. Review.

PMID:
30894375
6.

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner.

Müller S, Glaß M, Singh AK, Haase J, Bley N, Fuchs T, Lederer M, Dahl A, Huang H, Chen J, Posern G, Hüttelmaier S.

Nucleic Acids Res. 2019 Jan 10;47(1):375-390. doi: 10.1093/nar/gky1012.

7.

Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases.

Bertoldo JB, Terenzi H, Hüttelmaier S, Bernardes GJL.

Biochemistry. 2018 Oct 30;57(43):6144-6152. doi: 10.1021/acs.biochem.8b00639. Epub 2018 Oct 16.

PMID:
30280890
8.

Large-scale identification of functional microRNA targeting reveals cooperative regulation of the hemostatic system.

Nourse J, Braun J, Lackner K, Hüttelmaier S, Danckwardt S.

J Thromb Haemost. 2018 Nov;16(11):2233-2245. doi: 10.1111/jth.14290. Epub 2018 Oct 15.

PMID:
30207063
9.

Corrigendum: Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.

Minocha R, Popova V, Kopytova D, Misiak D, Hüttelmaier S, Georgieva S, Sträßer K.

Nucleic Acids Res. 2018 Oct 12;46(18):9890. doi: 10.1093/nar/gky782. No abstract available.

10.

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.

Minocha R, Popova V, Kopytova D, Misiak D, Hüttelmaier S, Georgieva S, Sträßer K.

Nucleic Acids Res. 2018 Oct 12;46(18):9749-9763. doi: 10.1093/nar/gky640. Erratum in: Nucleic Acids Res. 2018 Oct 12;46(18):9890.

11.

HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA.

Tebaldi T, Zuccotti P, Peroni D, Köhn M, Gasperini L, Potrich V, Bonazza V, Dudnakova T, Rossi A, Sanguinetti G, Conti L, Macchi P, D'Agostino V, Viero G, Tollervey D, Hüttelmaier S, Quattrone A.

Mol Cell. 2018 Jul 19;71(2):256-270.e10. doi: 10.1016/j.molcel.2018.06.032.

12.

Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J.

Nat Cell Biol. 2018 Sep;20(9):1098. doi: 10.1038/s41556-018-0102-7.

PMID:
29880862
13.

The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy.

Mensch A, Meinhardt B, Bley N, Hüttelmaier S, Schneider I, Stoltenburg-Didinger G, Kraya T, Müller T, Zierz S.

Exp Neurol. 2018 Aug;306:222-231. doi: 10.1016/j.expneurol.2018.05.012. Epub 2018 May 12. No abstract available.

PMID:
29763601
14.

Therapeutic targeting of tumor-associated macrophages in pancreatic neuroendocrine tumors.

Krug S, Abbassi R, Griesmann H, Sipos B, Wiese D, Rexin P, Blank A, Perren A, Haybaeck J, Hüttelmaier S, Rinke A, Gress TM, Michl P.

Int J Cancer. 2018 Oct 1;143(7):1806-1816. doi: 10.1002/ijc.31562.

15.

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors.

Müller S, Bley N, Glaß M, Busch B, Rousseau V, Misiak D, Fuchs T, Lederer M, Hüttelmaier S.

Nucleic Acids Res. 2018 Jul 6;46(12):6285-6303. doi: 10.1093/nar/gky229.

16.

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J.

Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23. Erratum in: Nat Cell Biol. 2018 Sep;20(9):1098.

17.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.

PMID:
28650479
18.

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.

Wong M, Tee AEL, Milazzo G, Bell JL, Poulos RC, Atmadibrata B, Sun Y, Jing D, Ho N, Ling D, Liu PY, Zhang XD, Hüttelmaier S, Wong JWH, Wang J, Polly P, Perini G, Scarlett CJ, Liu T.

Cancer Res. 2017 May 1;77(9):2522-2533. doi: 10.1158/0008-5472.CAN-16-1663. Epub 2017 Feb 16.

19.

UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis.

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S, Cerezo-Wallis D, Martinez-Useros J, García-Fernández M, Hüttelmaier S, Soengas MS, Gebauer F.

Cancer Cell. 2016 Nov 14;30(5):694-707. doi: 10.1016/j.ccell.2016.10.004. Epub 2016 Oct 27.

20.

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family.

Busch B, Bley N, Müller S, Glaß M, Misiak D, Lederer M, Vetter M, Strauß HG, Thomssen C, Hüttelmaier S.

Nucleic Acids Res. 2016 May 5;44(8):3845-64. doi: 10.1093/nar/gkw099. Epub 2016 Feb 24.

21.

Non-coding RNAs, the cutting edge of histone messages.

Köhn M, Hüttelmaier S.

RNA Biol. 2016;13(4):367-72. doi: 10.1080/15476286.2016.1152439. Epub 2016 Feb 24.

22.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.

Cancer Res. 2015 Dec 1;75(23):5143-54. doi: 10.1158/0008-5472.CAN-15-0423. Epub 2015 Oct 15.

23.

The Y3** ncRNA promotes the 3' end processing of histone mRNAs.

Köhn M, Ihling C, Sinz A, Krohn K, Hüttelmaier S.

Genes Dev. 2015 Oct 1;29(19):1998-2003. doi: 10.1101/gad.266486.115.

24.

Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma.

Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B.

Oncoimmunology. 2015 Mar 2;4(6):e1008805. eCollection 2015 Jun.

25.

IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma.

Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S.

J Clin Oncol. 2015 Apr 10;33(11):1285-93. doi: 10.1200/JCO.2014.55.9880. Epub 2015 Mar 9.

PMID:
25753434
26.

Stress granules are dispensable for mRNA stabilization during cellular stress.

Bley N, Lederer M, Pfalz B, Reinke C, Fuchs T, Glaß M, Möller B, Hüttelmaier S.

Nucleic Acids Res. 2015 Feb 27;43(4):e26. doi: 10.1093/nar/gku1275. Epub 2014 Dec 8.

27.

The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer.

Lederer M, Bley N, Schleifer C, Hüttelmaier S.

Semin Cancer Biol. 2014 Dec;29:3-12. doi: 10.1016/j.semcancer.2014.07.006. Epub 2014 Jul 25. Review.

28.

Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.

Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, Wong M, Liu B, Bell JL, Zhang XD, Milazzo G, Cheung BB, Fox A, Swarbrick A, Hüttelmaier S, Kavallaris M, Perini G, Mattick JS, Dinger ME, Liu T.

J Natl Cancer Inst. 2014 Jun 6;106(7). pii: dju113. doi: 10.1093/jnci/dju113. Print 2014 Jul. Erratum in: J Natl Cancer Inst. 2015 Jan;107(1):doi/10.1093/jnci/dju359.

29.

Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification).

Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S.

Nucleic Acids Res. 2014 Apr;42(8):e66. doi: 10.1093/nar/gku127. Epub 2014 Feb 7.

30.

Extraction of protein profiles from primary neurons using active contour models and wavelets.

Misiak D, Posch S, Lederer M, Reinke C, Hüttelmaier S, Möller B.

J Neurosci Methods. 2014 Mar 30;225:1-12. doi: 10.1016/j.jneumeth.2013.12.009. Epub 2014 Jan 20.

31.

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S.

Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1.

PMID:
24395596
32.

FMRP regulates actin filament organization via the armadillo protein p0071.

Nolze A, Schneider J, Keil R, Lederer M, Hüttelmaier S, Kessels MM, Qualmann B, Hatzfeld M.

RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23.

33.

IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG).

Zirkel A, Lederer M, Stöhr N, Pazaitis N, Hüttelmaier S.

Nucleic Acids Res. 2013 Jul;41(13):6618-36. doi: 10.1093/nar/gkt410. Epub 2013 May 15.

34.

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

Wächter K, Köhn M, Stöhr N, Hüttelmaier S.

Biol Chem. 2013 Aug;394(8):1077-90. doi: 10.1515/hsz-2013-0111.

PMID:
23640942
35.

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M.

J Cell Sci. 2013 Apr 15;126(Pt 8):1832-44. doi: 10.1242/jcs.118992. Epub 2013 Feb 26.

36.

Why YRNAs? About Versatile RNAs and Their Functions.

Köhn M, Pazaitis N, Hüttelmaier S.

Biomolecules. 2013 Feb 8;3(1):143-56. doi: 10.3390/biom3010143.

37.

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S.

Cell Mol Life Sci. 2013 Aug;70(15):2657-75. doi: 10.1007/s00018-012-1186-z. Epub 2012 Oct 16. Review.

38.

IGF2BP1: a post-transcriptional "driver" of tumor cell migration.

Stöhr N, Hüttelmaier S.

Cell Adh Migr. 2012 Jul-Aug;6(4):312-8. doi: 10.4161/cam.20628. Epub 2012 Jul 1.

39.

Keratins mediate localization of hemidesmosomes and repress cell motility.

Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM.

J Invest Dermatol. 2013 Jan;133(1):181-90. doi: 10.1038/jid.2012.256. Epub 2012 Aug 16.

40.

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming.

Berndt H, Harnisch C, Rammelt C, Stöhr N, Zirkel A, Dohm JC, Himmelbauer H, Tavanez JP, Hüttelmaier S, Wahle E.

RNA. 2012 May;18(5):958-72. doi: 10.1261/rna.032292.112. Epub 2012 Mar 22. Erratum in: RNA. 2014 Aug;20(8):1349.

41.

IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.

Stöhr N, Köhn M, Lederer M, Glass M, Reinke C, Singer RH, Hüttelmaier S.

Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111.

42.

Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin.

Braun J, Hüttelmaier S.

Thyroid Res. 2011 Aug 3;4 Suppl 1:S1. doi: 10.1186/1756-6614-4-S1-S1.

43.

Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas.

Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S.

Oncogene. 2010 Jul 22;29(29):4237-44. doi: 10.1038/onc.2010.169. Epub 2010 May 24.

PMID:
20498632
44.

Near-infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the noncoding Y3-RNA.

Köhn M, Lederer M, Wächter K, Hüttelmaier S.

RNA. 2010 Jul;16(7):1420-8. doi: 10.1261/rna.2152710. Epub 2010 May 21.

45.

Plakophilin 1 stimulates translation by promoting eIF4A1 activity.

Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck-Lederer A, Hüttelmaier S, Hatzfeld M.

J Cell Biol. 2010 Feb 22;188(4):463-71. doi: 10.1083/jcb.200908135. Epub 2010 Feb 15.

46.

IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR.

Weinlich S, Hüttelmaier S, Schierhorn A, Behrens SE, Ostareck-Lederer A, Ostareck DH.

RNA. 2009 Aug;15(8):1528-42. doi: 10.1261/rna.1578409. Epub 2009 Jun 18.

47.

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S.

RNA. 2009 Jan;15(1):104-15. doi: 10.1261/rna.1175909. Epub 2008 Nov 24.

48.

Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules.

White R, Gonsior C, Krämer-Albers EM, Stöhr N, Hüttelmaier S, Trotter J.

J Cell Biol. 2008 May 19;181(4):579-86. doi: 10.1083/jcb.200706164.

49.

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription.

Pan F, Hüttelmaier S, Singer RH, Gu W.

Mol Cell Biol. 2007 Dec;27(23):8340-51. Epub 2007 Sep 24. Erratum in: Mol Cell Biol. 2009 May;29(9):2481.

50.

Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma.

Köbel M, Weidensdorfer D, Reinke C, Lederer M, Schmitt WD, Zeng K, Thomssen C, Hauptmann S, Hüttelmaier S.

Oncogene. 2007 Nov 29;26(54):7584-9. Epub 2007 Jun 4.

PMID:
17546046

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