Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 193

1.

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity.

Medler J, Nelke J, Weisenberger D, Steinfatt T, Rothaug M, Berr S, Hünig T, Beilhack A, Wajant H.

Cell Death Dis. 2019 Mar 4;10(3):224. doi: 10.1038/s41419-019-1456-x.

2.

TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen.

Sánchez-Ruiz M, Polakos NK, Blau T, Utermöhlen O, Brunn A, Montesinos-Rongen M, Hünig T, Deckert M.

Eur J Immunol. 2019 Mar;49(3):413-427. doi: 10.1002/eji.201847834. Epub 2019 Feb 11.

PMID:
30666625
3.

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.

Langenhorst D, Haack S, Göb S, Uri A, Lühder F, Vanhove B, Hünig T, Beyersdorf N.

Front Immunol. 2018 May 16;9:1060. doi: 10.3389/fimmu.2018.01060. eCollection 2018.

4.

Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.

Langenhorst D, Tabares P, Gulde T, Becklund BR, Berr S, Surh CD, Beyersdorf N, Hünig T.

Front Immunol. 2018 Jan 30;8:1985. doi: 10.3389/fimmu.2017.01985. eCollection 2017.

5.

Clinical validation of a novel enzyme-linked immunosorbent spot assay-based in vitro diagnostic assay to monitor cytomegalovirus-specific cell-mediated immunity in kidney transplant recipients: a multicenter, longitudinal, prospective, observational study.

Banas B, Steubl D, Renders L, Chittka D, Banas MC, Wekerle T, Koch M, Witzke O, Mühlfeld A, Sommerer C, Habicht A, Hugo C, Hünig T, Lindemann M, Schmidt T, Rascle A, Barabas S, Deml L, Wagner R, Krämer BK, Krüger B.

Transpl Int. 2018 Apr;31(4):436-450. doi: 10.1111/tri.13110. Epub 2018 Jan 16.

6.

Short-term cytokine stimulation reveals regulatory T cells with down-regulated Foxp3 expression in human peripheral blood.

Tabares P, Berr S, Langenhorst D, Sawitzki B, Ten Berge I, Tony HP, Hünig T.

Eur J Immunol. 2018 Feb;48(2):366-379. doi: 10.1002/eji.201747244. Epub 2017 Nov 2.

7.

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF.

Mol Immunol. 2018 Jan;93:266-277. doi: 10.1016/j.molimm.2017.07.010. Epub 2017 Aug 30.

PMID:
28860090
8.

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells.

Uri A, Werner S, Lühder F, Hünig T, Kerkau T, Beyersdorf N.

Front Immunol. 2017 Jun 23;8:721. doi: 10.3389/fimmu.2017.00721. eCollection 2017.

9.

Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy.

Ibrahim T, Przybyl L, Harmon AC, Amaral LM, Faulkner JL, Cornelius DC, Cunningham MW, Hünig T, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Reprod Immunol. 2017 Nov;78(5). doi: 10.1111/aji.12724. Epub 2017 Jul 6.

10.

Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4+ T Cells.

Bergfeld A, Dasari P, Werner S, Hughes TR, Song WC, Hortschansky P, Brakhage AA, Hünig T, Zipfel PF, Beyersdorf N.

Front Microbiol. 2017 May 11;8:844. doi: 10.3389/fmicb.2017.00844. eCollection 2017.

11.

Hsp90 inhibition ameliorates CD4+ T cell-mediated acute Graft versus Host disease in mice.

Berges C, Kerkau T, Werner S, Wolf N, Winter N, Hünig T, Einsele H, Topp MS, Beyersdorf N.

Immun Inflamm Dis. 2016 Oct 10;4(4):463-473. eCollection 2016 Dec.

12.

Targeting of the WT191-138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination.

Dagvadorj N, Deuretzbacher A, Weisenberger D, Baumeister E, Trebing J, Lang I, Köchel C, Kapp M, Kapp K, Beilhack A, Hünig T, Einsele H, Wajant H, Grigoleit GU.

Cancer Immunol Immunother. 2017 Mar;66(3):319-332. doi: 10.1007/s00262-016-1938-y. Epub 2016 Nov 28.

PMID:
27896368
13.

From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis.

Tyrsin D, Chuvpilo S, Matskevich A, Nemenov D, Römer PS, Tabares P, Hünig T.

Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):45-8. Epub 2016 Jul 20. Review.

14.

The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.

Hünig T.

FEBS J. 2016 Sep;283(18):3325-34. doi: 10.1111/febs.13754. Epub 2016 Jun 6.

15.

Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.

Fröhlich M, Gogishvili T, Langenhorst D, Lühder F, Hünig T.

Eur J Immunol. 2016 Jul;46(7):1644-55. doi: 10.1002/eji.201546232. Epub 2016 May 17.

16.

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.

Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T.

Eur J Immunol. 2016 May;46(5):1193-202. doi: 10.1002/eji.201546104. Epub 2016 Jan 20.

17.

Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.

Schmidt T, Willenborg S, Hünig T, Deeg CA, Sonderstrup G, Hertl M, Eming R.

Exp Dermatol. 2016 Apr;25(4):293-8. doi: 10.1111/exd.12919. Epub 2016 Feb 15.

PMID:
26661498
18.

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.

Wegner J, Hackenberg S, Scholz CJ, Chuvpilo S, Tyrsin D, Matskevich AA, Grigoleit GU, Stevanović S, Hünig T.

Blood. 2015 Jul 9;126(2):185-94. doi: 10.1182/blood-2015-01-622704. Epub 2015 May 29.

PMID:
26024876
19.

A novel multicolor immunostaining method using ethynyl deoxyuridine for analysis of in situ immunoproliferative response.

Kitazawa Y, Ueta H, Hünig T, Sawanobori Y, Matsuno K.

Histochem Cell Biol. 2015 Sep;144(3):195-208. doi: 10.1007/s00418-015-1329-z. Epub 2015 May 15.

20.

In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease.

Beyersdorf N, Werner S, Wolf N, Hünig T, Kerkau T.

Eur J Immunol. 2015 Jul;45(7):1997-2007. doi: 10.1002/eji.201445317. Epub 2015 May 12.

21.

The T cell-selective IL-2 mutant AIC284 mediates protection in a rat model of Multiple Sclerosis.

Weishaupt A, Paulsen D, Werner S, Wolf N, Köllner G, Rübsamen-Schaeff H, Hünig T, Kerkau T, Beyersdorf N.

J Neuroimmunol. 2015 May 15;282:63-72. doi: 10.1016/j.jneuroim.2015.03.020. Epub 2015 Mar 27.

PMID:
25903730
22.

Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia.

Przybyl L, Ibrahim T, Haase N, Golic M, Rugor J, Luft FC, Bendix I, Serdar M, Wallukat G, Staff AC, Müller DN, Hünig T, Felderhoff-Müser U, Herse F, LaMarca B, Dechend R.

Hypertension. 2015 Jun;65(6):1298-306. doi: 10.1161/HYPERTENSIONAHA.114.04892. Epub 2015 Apr 6.

23.

Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Müller J, Schmidt D, Kocoski V, Kerkau T, Hünig T, Ertl G, Lohse MJ, Jahns R.

PLoS One. 2015 Feb 20;10(2):e0117589. doi: 10.1371/journal.pone.0117589. eCollection 2015.

24.

CD28 co-stimulation in T-cell homeostasis: a recent perspective.

Beyersdorf N, Kerkau T, Hünig T.

Immunotargets Ther. 2015 May 28;4:111-22. doi: 10.2147/ITT.S61647. eCollection 2015. Review.

25.

Immature dendritic cells convert anergic nonregulatory T cells into Foxp3- IL-10+ regulatory T cells by engaging CD28 and CTLA-4.

Pletinckx K, Vaeth M, Schneider T, Beyersdorf N, Hünig T, Berberich-Siebelt F, Lutz MB.

Eur J Immunol. 2015 Feb;45(2):480-91. doi: 10.1002/eji.201444991. Epub 2014 Dec 2.

26.

Amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice.

Na SY, Mracsko E, Liesz A, Hünig T, Veltkamp R.

Stroke. 2015 Jan;46(1):212-20. doi: 10.1161/STROKEAHA.114.007756. Epub 2014 Nov 6.

PMID:
25378432
27.

Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses.

Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F.

PLoS Pathog. 2014 Feb 6;10(2):e1003906. doi: 10.1371/journal.ppat.1003906. eCollection 2014 Feb.

28.

Cell contact-dependent priming and Fc interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response.

Bartholomaeus P, Semmler LY, Bukur T, Boisguerin V, Römer PS, Tabares P, Chuvpilo S, Tyrsin DY, Matskevich A, Hengel H, Castle J, Hünig T, Kalinke U.

J Immunol. 2014 Mar 1;192(5):2091-8. doi: 10.4049/jimmunol.1302461. Epub 2014 Jan 27.

29.

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.

Tabares P, Berr S, Römer PS, Chuvpilo S, Matskevich AA, Tyrsin D, Fedotov Y, Einsele H, Tony HP, Hünig T.

Eur J Immunol. 2014 Apr;44(4):1225-36. doi: 10.1002/eji.201343967. Epub 2014 Feb 1.

30.

Eberhard Wecker (1923-2013).

Hünig T.

Eur J Immunol. 2013 Aug;43(8):1986-7. doi: 10.1002/eji.201370086. No abstract available.

31.

Foxp3+ regulatory T cells are required for recovery from severe sepsis.

Kühlhorn F, Rath M, Schmoeckel K, Cziupka K, Nguyen HH, Hildebrandt P, Hünig T, Sparwasser T, Huehn J, Pötschke C, Bröker BM.

PLoS One. 2013 May 28;8(5):e65109. doi: 10.1371/journal.pone.0065109. Print 2013.

32.

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

Camara M, Beyersdorf N, Fischer HJ, Herold MJ, Ip CW, van den Brandt J, Toyka KV, Taurog JD, Hünig T, Herrmann T, Reichardt HM, Weishaupt A, Kerkau T.

J Neuroimmunol. 2013 Jul 15;260(1-2):17-27. doi: 10.1016/j.jneuroim.2013.04.014. Epub 2013 May 7.

PMID:
23664330
33.

Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.

Langenhorst D, Gogishvili T, Ribechini E, Kneitz S, McPherson K, Lutz MB, Hünig T.

PLoS One. 2012;7(11):e50080. doi: 10.1371/journal.pone.0050080. Epub 2012 Nov 30.

34.

Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.

Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T.

J Allergy Clin Immunol. 2012 Dec;130(6):1394-403.e4. doi: 10.1016/j.jaci.2012.08.049. Epub 2012 Oct 24.

PMID:
23102920
35.

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.

Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, Hünig T.

Eur J Immunol. 2013 Jan;43(1):188-93. doi: 10.1002/eji.201242824. Epub 2012 Nov 17.

36.

Oligodendrocytes enforce immune tolerance of the uninfected brain by purging the peripheral repertoire of autoreactive CD8+ T cells.

Na SY, Hermann A, Sanchez-Ruiz M, Storch A, Deckert M, Hünig T.

Immunity. 2012 Jul 27;37(1):134-46. doi: 10.1016/j.immuni.2012.04.009. Epub 2012 Jun 7.

37.

Cyclic AMP underpins suppression by regulatory T cells.

Bodor J, Bopp T, Vaeth M, Klein M, Serfling E, Hünig T, Becker C, Schild H, Schmitt E.

Eur J Immunol. 2012 Jun;42(6):1375-84. doi: 10.1002/eji.201141578. Review.

38.

The storm has cleared: lessons from the CD28 superagonist TGN1412 trial.

Hünig T.

Nat Rev Immunol. 2012 Apr 10;12(5):317-8. doi: 10.1038/nri3192.

PMID:
22487653
39.

Foxp3+ regulatory T cells control persistence of viral CNS infection.

Reuter D, Sparwasser T, Hünig T, Schneider-Schaulies J.

PLoS One. 2012;7(3):e33989. doi: 10.1371/journal.pone.0033989. Epub 2012 Mar 20.

40.

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.

Römer PS, Berr S, Avota E, Na SY, Battaglia M, ten Berge I, Einsele H, Hünig T.

Blood. 2011 Dec 22;118(26):6772-82. doi: 10.1182/blood-2010-12-319780. Epub 2011 Sep 19.

PMID:
21931118
41.

A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats.

Takabatake Y, Li XK, Mizui M, Miyasato K, Matsui I, Kawada N, Imai E, Hünig T, Takahara S, Wada T, Furuichi K, Rakugi H, Isaka Y.

Mol Med. 2011;17(7-8):686-96. doi: 10.2119/molmed.2010.00229. Epub 2011 Apr 8.

42.

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).

Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108. Epub 2011 Jan 24.

43.

Anti-protease and immunomodulatory activities of bacteria associated with Caribbean sponges.

Tabares P, Pimentel-Elardo SM, Schirmeister T, Hünig T, Hentschel U.

Mar Biotechnol (NY). 2011 Oct;13(5):883-92. doi: 10.1007/s10126-010-9349-0. Epub 2011 Jan 11.

PMID:
21222136
44.

The effects of Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody in DSS-induced mice colitis.

Chen J, Xie L, Toyama S, Hünig T, Takahara S, Li XK, Zhong L.

Int Immunopharmacol. 2011 May;11(5):610-7. doi: 10.1016/j.intimp.2010.11.034. Epub 2010 Dec 14.

PMID:
21163250
45.

CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats.

Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li XK, Hünig T, Takahara S, Rakugi H, Isaka Y.

Clin Exp Nephrol. 2011 Feb;15(1):50-7. doi: 10.1007/s10157-010-0370-4. Epub 2010 Nov 16.

PMID:
21076989
46.

Primate testing of TGN1412: right target, wrong cell.

Pallardy M, Hünig T.

Br J Pharmacol. 2010 Oct;161(3):509-11. doi: 10.1111/j.1476-5381.2010.00925.x.

47.

Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire.

van den Brandt J, Fischer HJ, Walter L, Hünig T, Klöting I, Reichardt HM.

J Immunol. 2010 Aug 15;185(4):2285-94. doi: 10.4049/jimmunol.1000462. Epub 2010 Jul 19.

48.

Prevention of graft-versus-host diseases by in vivo supCD28mAb-expanded antigen-specific nTreg cells.

Kitazawa Y, Li XK, Liu Z, Kimura H, Isaka Y, Hünig T, Takahara S.

Cell Transplant. 2010;19(6):765-74. doi: 10.3727/096368910X508870. Epub 2010 Jun 23.

PMID:
20573297
49.

Regulatory T cells protect from local and systemic bone destruction in arthritis.

Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hünig T, Schett G, David JP.

J Immunol. 2010 Jun 15;184(12):7238-46. doi: 10.4049/jimmunol.0903841. Epub 2010 May 17.

50.

CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.

Hünig T, Lühder F, Elflein K, Gogishvili T, Fröhlich M, Guler R, Cutler A, Brombacher F.

Med Microbiol Immunol. 2010 Aug;199(3):239-46. doi: 10.1007/s00430-010-0156-z. Review.

Supplemental Content

Support Center