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Items: 1 to 50 of 55

1.

Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women.

Rad M, Hümpel M, Schaefer O, Schoemaker RC, Schleuning WD, Cohen AF, Burggraaf J.

Br J Clin Pharmacol. 2006 Sep;62(3):288-96.

2.

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Hümpel M, Isaksson P, Schaefer O, Kaufmann U, Ciana P, Maggi A, Schleuning WD.

J Steroid Biochem Mol Biol. 2005 Nov;97(3):299-305. Epub 2005 Sep 8.

PMID:
16153822
3.

Development of a radioimmunoassay for the quantitative determination of 8-prenylnaringenin in biological matrices.

Schaefer O, Bohlmann R, Schleuning WD, Schulze-Forster K, Hümpel M.

J Agric Food Chem. 2005 Apr 20;53(8):2881-9.

PMID:
15826034
4.

8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo.

Pepper MS, Hazel SJ, Hümpel M, Schleuning WD.

J Cell Physiol. 2004 Apr;199(1):98-107.

PMID:
14978739
5.

8-Prenyl naringenin is a potent ERalpha selective phytoestrogen present in hops and beer.

Schaefer O, Hümpel M, Fritzemeier KH, Bohlmann R, Schleuning WD.

J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):359-60. No abstract available.

PMID:
12711023
6.

In vivo conversion of norethisterone and norethisterone acetate to ethinyl etradiol in postmenopausal women.

Kuhnz W, Heuner A, Hümpel M, Seifert W, Michaelis K.

Contraception. 1997 Dec;56(6):379-85.

PMID:
9494772
7.
8.

A single-dose and 3-month clinical-pharmacokinetic study with a new combination oral contraceptive.

Heuner A, Kuhnz W, Heger-Mahn D, Richert K, Hümpel M.

Adv Contracept. 1995 Sep;11(3):207-25.

PMID:
8533624
9.
10.

Absence of an effect of high vitamin C dosage on the systemic availability of ethinyl estradiol in women using a combination oral contraceptive.

Zamah NM, Hümpel M, Kuhnz W, Louton T, Rafferty J, Back DJ.

Contraception. 1993 Oct;48(4):377-91.

PMID:
8222665
11.

Pharmacokinetics, hydrolysis and aromatisation of norethisterone-3-oxime in female cynomolgus monkey.

Li QG, Hümpel M.

Eur J Drug Metab Pharmacokinet. 1992 Oct-Dec;17(4):281-91.

PMID:
1301358
12.
13.
14.

ZK 90 695: a new antiarthritic drug with tissue targeting properties.

Hümpel M, Günzel P, Biere H, Junginger B.

Agents Actions. 1991 Jan;32(1-2):22-3. No abstract available.

PMID:
2058464
15.

Investigations on the percutaneous absorption of the antidepressant rolipram in vitro and in vivo.

Hadgraft J, Hill S, Hümpel M, Johnston LR, Lever LR, Marks R, Murphy TM, Rapier C.

Pharm Res. 1990 Dec;7(12):1307-12.

PMID:
2095571
16.

Pharmacokinetics of gestodene and ethinyl estradiol after oral administration of a monophasic contraceptive.

Täuber U, Kuhnz W, Hümpel M.

Am J Obstet Gynecol. 1990 Oct;163(4 Pt 2):1414-20. Review.

PMID:
2220966
18.

Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique.

Hellstern A, Hildebrand M, Hümpel M, Hellenbrecht D, Saller R, Madetzki C.

Int J Clin Pharmacol Ther Toxicol. 1990 Jun;28(6):256-61.

PMID:
1973917
21.

Comparison of serum ethinyl estradiol, sex-hormone-binding globulin, corticoid-binding globulin and cortisol levels in women using two low-dose combined oral contraceptives.

Hümpel M, Tüber U, Kuhnz W, Pfeffer M, Brill K, Heithecker R, Louton T, Steinberg B.

Horm Res. 1990;33(1):35-9.

PMID:
2142929
22.

Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers.

Hildebrand M, Hellstern A, Hümpel M, Hellenbrecht D, Saller R.

Eur J Drug Metab Pharmacokinet. 1990 Jan-Mar;15(1):19-26.

PMID:
1974495
23.

Development and application of a radioimmunoassay of the new progestagen gestodene.

Nieuweboer B, Tack J, Täuber U, Hümpel M, Wendt H.

Contraception. 1989 Sep;40(3):313-23.

PMID:
2766723
24.

Studies on the biotransformation of lonazolac, bromerguride, lisuride and terguride in laboratory animals and their hepatocytes.

Hümpel M, Sostarek D, Gieschen H, Labitzky C.

Xenobiotica. 1989 Apr;19(4):361-77.

PMID:
2750201
25.

Pharmacokinetics of the dopamine partial agonist, terguride, in the rat and rhesus monkey.

Krause W, Hümpel M.

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):185-94.

PMID:
3240764
26.

Pharmacokinetics of proterguride in rat and cynomolgus monkey.

Krause W, Hümpel M.

Xenobiotica. 1988 Jan;18(1):41-8.

PMID:
3354231
27.

Pharmacokinetics of bromerguride, a new dopamine-antagonistic ergot derivative in rat and dog.

Hilderbrand M, Hümpel M, Krause W, Täuber U.

Eur J Drug Metab Pharmacokinet. 1987 Jan-Mar;12(1):31-40.

PMID:
3609071
28.

Development of antibody-mediated extraction followed by GC/MS (antibody/GC/MS) and its application to iloprost determination in plasma.

Krause W, Jakobs U, Schulze PE, Nieuweboer B, Hümpel M.

Prostaglandins Leukot Med. 1985 Feb;17(2):167-82.

PMID:
3885265
29.

Pharmacokinetics and biotransformation of estradiol valerate in ovariectomized women.

Düsterberg B, Schmidt-Gollwitzer M, Hümpel M.

Horm Res. 1985;21(3):145-54.

PMID:
2987096
30.

The pharmacokinetics and biotransformation of 14C-lisuride hydrogen maleate in rhesus monkey and in man.

Hümpel M, Krause W, Hoyer GA, Wendt H, Pommerenke G.

Eur J Drug Metab Pharmacokinet. 1984 Oct-Dec;9(4):347-57.

PMID:
6532807
31.

Biotransformation of the stable prostacyclin analogue, iloprost, in the rat.

Krause W, Hümpel M, Hoyer GA.

Drug Metab Dispos. 1984 Sep-Oct;12(5):645-51.

PMID:
6209077
32.

Disposition of oral lisuride in Parkinson's disease.

Burns RS, Gopinathan G, Hümpel M, Dorow R, Calne DB.

Clin Pharmacol Ther. 1984 Apr;35(4):548-56.

PMID:
6705456
35.

Pharmacokinetics and biotransformation of norethisterone in animals. A review.

Hümpel M.

Contraception. 1982 Jul;26(1):83-95. No abstract available.

PMID:
7128138
36.

S-adenosyl-L-methionine antagonizes ethynylestradiol-induced bile cholesterol supersaturation in humans without modifying the estrogen plasma kinetics.

Di Padova C, Tritapepe R, Cammareri G, Humpel M, Stramentinoli G.

Gastroenterology. 1982 Feb;82(2):223-7.

PMID:
7054023
37.
39.
40.

The pharmacokinetics of lisuride hydrogen maleate in rat, rabbit and rhesus monkey.

Humpel M, Toda T, Oshino N, Pommerenke G.

Eur J Drug Metab Pharmacokinet. 1981;6(3):207-19.

PMID:
7308240
41.

Transfer of cyproterone acetate to the milk of lactating women.

Stoppelli I, Rainer E, Hümpel M.

Contraception. 1980 Nov;22(5):485-93.

PMID:
7193550
42.
43.

The biotransformation of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys.

Mayo BC, Hawkins DR, Hümpel M, Chasseaud LF, Girkin R.

Xenobiotica. 1980 Jun;10(6):413-20. No abstract available.

PMID:
6106320
44.

The absorption, distribution and excretion of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys.

Girkin R, Baldock GA, Chasseaud LF, Hümpel M, Hawkins DR, Mayo BC.

Xenobiotica. 1980 Jun;10(6):401-11. No abstract available.

PMID:
6106319
45.

Investigations of pharmacokinetics of ethinyloestradiol to specific consideration of a possible first-pass effect in women.

Hümpel M, Nieuweboer B, Wendt H, Speck U.

Contraception. 1979 Apr;19(4):421-32.

PMID:
455989
46.

A new principle of injectable depot contraceptives. I Drug selection and studies in monkeys.

Hümpel M, Schulze PE, Speck U.

Contraception. 1979 Apr;19(4):411-9.

PMID:
110513
48.
49.

Investigations of pharmacokinetics of levonorgestrel to specific consideration of a possible first-pass effect in women.

Hümpel M, Wendt H, Pommerenke G, Weiss C, Speck U.

Contraception. 1978 Mar;17(3):207-20.

PMID:
648145
50.

[Plasma levels and pharamacokinetics of cyproterone acetate after application of 50 mg tablets to 5 men (author's transl)].

Hümpel M, Dogs G, Wendt H, Speck U.

Arzneimittelforschung. 1978;28(2):319-22. German. No abstract available.

PMID:
580402

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