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Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies.

Watson A, Spalluto CM, McCrae C, Cellura D, Burke H, Cunoosamy D, Freeman A, Hicks A, Hühn M, Ostridge K, Staples KJ, Vaarala O, Wilkinson T.

Am J Respir Crit Care Med. 2020 Jan 1;201(1):83-94. doi: 10.1164/rccm.201901-0214OC.


Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs.

Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH.

Front Immunol. 2019 Jul 24;10:1698. doi: 10.3389/fimmu.2019.01698. eCollection 2019.


Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis.

Schneider-Thoma J, Efthimiou O, Bighelli I, Dörries C, Huhn M, Krause M, Reichelt L, Röder H, Furukawa TA, Davis JM, Leucht S.

Lancet Psychiatry. 2019 Sep;6(9):753-765. doi: 10.1016/S2215-0366(19)30223-8. Epub 2019 Jul 15.


Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma.

Gottlow M, Svensson DJ, Lipkovich I, Huhn M, Bowen K, Wessman P, Colice G.

BMC Pulm Med. 2019 Jul 17;19(1):129. doi: 10.1186/s12890-019-0889-4.


Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis.

Huhn M, Nikolakopoulou A, Schneider-Thoma J, Krause M, Samara M, Peter N, Arndt T, Bäckers L, Rothe P, Cipriani A, Davis J, Salanti G, Leucht S.

Lancet. 2019 Sep 14;394(10202):939-951. doi: 10.1016/S0140-6736(19)31135-3. Epub 2019 Jul 11. Erratum in: Lancet. 2019 Sep 14;394(10202):918.


Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis.

Leucht S, Chaimani A, Mavridis D, Leucht C, Huhn M, Helfer B, Samara M, Cipriani A, Geddes JR, Davis JM.

Neuropsychopharmacology. 2019 Oct;44(11):1955-1966. doi: 10.1038/s41386-019-0440-6. Epub 2019 Jun 18.


Defective exocytosis and processing of insulin in a cystic fibrosis mouse model.

Edlund A, Barghouth M, Huhn M, Abels M, Esguerra J, Mollet I, Svedin E, Wendt A, Renstrom E, Zhang E, Wierup N, Scholte BJ, Flodström-Tullberg M, Eliasson L.

J Endocrinol. 2019 Feb 1. pii: JOE-18-0570.R1. doi: 10.1530/JOE-18-0570. [Epub ahead of print]


Response rates in patients with schizophrenia and positive symptoms receiving cognitive behavioural therapy: a systematic review and single-group meta-analysis.

Bighelli I, Huhn M, Schneider-Thoma J, Krause M, Reitmeir C, Wallis S, Schwermann F, Pitschel-Walz G, Barbui C, Furukawa TA, Leucht S.

BMC Psychiatry. 2018 Dec 4;18(1):380. doi: 10.1186/s12888-018-1964-8.


Efficacy, acceptability and tolerability of antipsychotics in patients with schizophrenia and comorbid substance use. A systematic review and meta-analysis.

Krause M, Huhn M, Schneider-Thoma J, Bighelli I, Gutsmiedl K, Leucht S.

Eur Neuropsychopharmacol. 2019 Jan;29(1):32-45. doi: 10.1016/j.euroneuro.2018.11.1105. Epub 2018 Nov 22.


Antipsychotic drugs for elderly patients with schizophrenia: A systematic review and meta-analysis.

Krause M, Huhn M, Schneider-Thoma J, Rothe P, Smith RC, Leucht S.

Eur Neuropsychopharmacol. 2018 Dec;28(12):1360-1370. doi: 10.1016/j.euroneuro.2018.09.007. Epub 2018 Sep 20.


Psychological interventions to reduce positive symptoms in schizophrenia: systematic review and network meta-analysis.

Bighelli I, Salanti G, Huhn M, Schneider-Thoma J, Krause M, Reitmeir C, Wallis S, Schwermann F, Pitschel-Walz G, Barbui C, Furukawa TA, Leucht S.

World Psychiatry. 2018 Oct;17(3):316-329. doi: 10.1002/wps.20577.


Second-generation antipsychotic drugs and short-term mortality: a systematic review and meta-analysis of placebo-controlled randomised controlled trials.

Schneider-Thoma J, Efthimiou O, Huhn M, Krause M, Reichelt L, Röder H, Davis JM, Salanti G, Leucht S.

Lancet Psychiatry. 2018 Aug;5(8):653-663. doi: 10.1016/S2215-0366(18)30177-9. Epub 2018 Jul 2.


60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response.

Leucht S, Chaimani A, Leucht C, Huhn M, Mavridis D, Helfer B, Samara M, Cipriani A, Geddes JR, Salanti G, Davis JM.

Schizophr Res. 2018 Nov;201:315-323. doi: 10.1016/j.schres.2018.05.009. Epub 2018 May 24.


Efficacy, acceptability, and tolerability of antipsychotics in children and adolescents with schizophrenia: A network meta-analysis.

Krause M, Zhu Y, Huhn M, Schneider-Thoma J, Bighelli I, Chaimani A, Leucht S.

Eur Neuropsychopharmacol. 2018 Jun;28(6):659-674. doi: 10.1016/j.euroneuro.2018.03.008. Epub 2018 May 24. Review.


Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis.

Krause M, Zhu Y, Huhn M, Schneider-Thoma J, Bighelli I, Nikolakopoulou A, Leucht S.

Eur Arch Psychiatry Clin Neurosci. 2018 Oct;268(7):625-639. doi: 10.1007/s00406-018-0869-3. Epub 2018 Jan 24. Review.


A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, Lind K, Hägglöf T, Pincikova T, Laitinen OH, McInerney GM, Scholte B, Hjelte L, Karlsson MCI, Flodström-Tullberg M.

J Infect Dis. 2017 Dec 5;216(10):1308-1317. doi: 10.1093/infdis/jix474.


Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.

Hinrichsen I, Weßbecher IM, Huhn M, Passmann S, Zeuzem S, Plotz G, Biondi RM, Brieger A.

Mol Carcinog. 2017 Dec;56(12):2663-2668. doi: 10.1002/mc.22709. Epub 2017 Sep 7.


Antipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia: a systematic review with pairwise and network meta-analyses.

Zhu Y, Krause M, Huhn M, Rothe P, Schneider-Thoma J, Chaimani A, Li C, Davis JM, Leucht S.

Lancet Psychiatry. 2017 Sep;4(9):694-705. doi: 10.1016/S2215-0366(17)30270-5. Epub 2017 Jul 20.


How well do patients with a first episode of schizophrenia respond to antipsychotics: A systematic review and meta-analysis.

Zhu Y, Li C, Huhn M, Rothe P, Krause M, Bighelli I, Schneider-Thoma J, Leucht S.

Eur Neuropsychopharmacol. 2017 Sep;27(9):835-844. doi: 10.1016/j.euroneuro.2017.06.011. Epub 2017 Jun 29. Review.


Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors.

Leucht S, Leucht C, Huhn M, Chaimani A, Mavridis D, Helfer B, Samara M, Rabaioli M, Bächer S, Cipriani A, Geddes JR, Salanti G, Davis JM.

Am J Psychiatry. 2017 Oct 1;174(10):927-942. doi: 10.1176/appi.ajp.2017.16121358. Epub 2017 May 25. Review.


An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, Flodström-Tullberg M.

Sci Rep. 2016 Dec 21;6:39378. doi: 10.1038/srep39378.


Suspended micro-sized PVC particles impair the performance and decrease survival in the Asian green mussel Perna viridis.

Rist SE, Assidqi K, Zamani NP, Appel D, Perschke M, Huhn M, Lenz M.

Mar Pollut Bull. 2016 Oct 15;111(1-2):213-220. doi: 10.1016/j.marpolbul.2016.07.006. Epub 2016 Aug 1.


Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

Chen HH, Händel N, Ngeow J, Muller J, Hühn M, Yang HT, Heindl M, Berbers RM, Hegazy AN, Kionke J, Yehia L, Sack U, Bläser F, Rensing-Ehl A, Reifenberger J, Keith J, Travis S, Merkenschlager A, Kiess W, Wittekind C, Walker L, Ehl S, Aretz S, Dustin ML, Eng C, Powrie F, Uhlig HH.

J Allergy Clin Immunol. 2017 Feb;139(2):607-620.e15. doi: 10.1016/j.jaci.2016.03.059. Epub 2016 Jun 18.


Efficacy and Safety of Antidepressants Added to Antipsychotics for Schizophrenia: A Systematic Review and Meta-Analysis.

Helfer B, Samara MT, Huhn M, Klupp E, Leucht C, Zhu Y, Engel RR, Leucht S.

Am J Psychiatry. 2016 Sep 1;173(9):876-86. doi: 10.1176/appi.ajp.2016.15081035. Epub 2016 Jun 10. Review.


Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.

Wendt E, White GE, Ferry H, Huhn M, Greaves DR, Keshav S.

J Immunol. 2016 May 1;196(9):3910-9. doi: 10.4049/jimmunol.1500619. Epub 2016 Mar 25.


Tolerance to stress differs between Asian green mussels Perna viridis from the impacted Jakarta Bay and from natural habitats along the coast of West Java.

Huhn M, Hattich GS, Zamani NP, von Juterzenka K, Lenz M.

Mar Pollut Bull. 2016 Sep 30;110(2):757-66. doi: 10.1016/j.marpolbul.2016.02.020. Epub 2016 Feb 18.


RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

de Wit J, Al-Mossawi MH, Hühn MH, Arancibia-Cárcamo CV, Doig K, Kendrick B, Gundle R, Taylor P, Mcclanahan T, Murphy E, Zhang H, Barr K, Miller JR, Hu X, Aicher TD, Morgan RW, Glick GD, Zaller D, Correll C, Powrie F, Bowness P.

J Allergy Clin Immunol. 2016 Mar;137(3):960-3. doi: 10.1016/j.jaci.2015.09.048. Epub 2015 Nov 21. No abstract available.


CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

Fergusson JR, Hühn MH, Swadling L, Walker LJ, Kurioka A, Llibre A, Bertoletti A, Holländer G, Newell EW, Davis MM, Sverremark-Ekström E, Powrie F, Capone S, Folgori A, Barnes E, Willberg CB, Ussher JE, Klenerman P.

Mucosal Immunol. 2016 Mar;9(2):401-13. doi: 10.1038/mi.2015.69. Epub 2015 Jul 29.


Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies.

Hristodorov D, Mladenov R, von Felbert V, Huhn M, Fischer R, Barth S, Thepen T.

MAbs. 2015;7(5):853-62. doi: 10.1080/19420862.2015.1066950.


Study on risk factors and phenotypes of acute exacerbations of chronic obstructive pulmonary disease in Guangzhou, China-design and baseline characteristics.

Zhou Y, Bruijnzeel PL, McCrae C, Zheng J, Nihlen U, Zhou R, Van Geest M, Nilsson A, Hadzovic S, Huhn M, Taib Z, Gu Y, Xie J, Ran P, Chen R, Zhong N.

J Thorac Dis. 2015 Apr;7(4):720-33. doi: 10.3978/j.issn.2072-1439.2015.04.14. Erratum in: J Thorac Dis. 2015 Jul;7(7):E206.


Perphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia.

Tardy M, Huhn M, Engel RR, Leucht S.

Cochrane Database Syst Rev. 2014 Oct 7;(10):CD009369. doi: 10.1002/14651858.CD009369.pub2. Review.


Fluphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia.

Tardy M, Huhn M, Engel RR, Leucht S.

Cochrane Database Syst Rev. 2014 Aug 3;(8):CD009230. doi: 10.1002/14651858.CD009230.pub2. Review.


Haloperidol versus low-potency first-generation antipsychotic drugs for schizophrenia.

Tardy M, Huhn M, Kissling W, Engel RR, Leucht S.

Cochrane Database Syst Rev. 2014 Jul 9;(7):CD009268. doi: 10.1002/14651858.CD009268.pub2. Review.


EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein.

Hristodorov D, Amoury M, Mladenov R, Niesen J, Arens K, Berges N, Hein L, Di Fiore S, Pham AT, Huhn M, Helfrich W, Fischer R, Thepen T, Barth S.

Mol Cancer Ther. 2014 Sep;13(9):2194-202. doi: 10.1158/1535-7163.MCT-13-0781. Epub 2014 Jun 30.


The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism.

Pickhard A, Siegl M, Baumann A, Huhn M, Wirth M, Reiter R, Rudelius M, Piontek G, Brockhoff G.

Oncotarget. 2014 Jul 30;5(14):5428-38.


Efficacy of pharmacotherapy and psychotherapy for adult psychiatric disorders: a systematic overview of meta-analyses.

Huhn M, Tardy M, Spineli LM, Kissling W, Förstl H, Pitschel-Walz G, Leucht C, Samara M, Dold M, Davis JM, Leucht S.

JAMA Psychiatry. 2014 Jun;71(6):706-15. doi: 10.1001/jamapsychiatry.2014.112.


Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins.

Schiffer S, Rosinke R, Jost E, Hehmann-Titt G, Huhn M, Melmer G, Barth S, Thepen T.

Int J Cancer. 2014 Sep 15;135(6):1497-508. doi: 10.1002/ijc.28786. Epub 2014 Mar 18.


Human microtubule-associated protein tau mediates targeted killing of CD30(+) lymphoma cells in vitro and inhibits tumour growth in vivo.

Hristodorov D, Nordlohne J, Mladenov R, Huhn M, Fischer R, Thepen T, Barth S.

Br J Haematol. 2014 Jan;164(2):251-7. doi: 10.1111/bjh.12626. Epub 2013 Oct 25.


Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells.

Schiffer S, Letzian S, Jost E, Mladenov R, Hristodorov D, Huhn M, Fischer R, Barth S, Thepen T.

Cancer Lett. 2013 Dec 1;341(2):178-85. doi: 10.1016/j.canlet.2013.08.005. Epub 2013 Aug 22.


Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo.

Hristodorov D, Mladenov R, Pardo A, Pham AT, Huhn M, Fischer R, Thepen T, Barth S.

Br J Cancer. 2013 Sep 17;109(6):1570-8. doi: 10.1038/bjc.2013.457. Epub 2013 Aug 13.


Habitat degradation correlates with tolerance to climate-change related stressors in the green mussel Perna viridis from West Java, Indonesia.

Wendling CC, Huhn M, Ayu N, Bachtiar R, von Juterzenka K, Lenz M.

Mar Pollut Bull. 2013 Jun 15;71(1-2):222-9. doi: 10.1016/j.marpolbul.2013.03.004. Epub 2013 May 6.


Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model.

Schiffer S, Hansen HP, Hehmann-Titt G, Huhn M, Fischer R, Barth S, Thepen T.

Blood Cancer J. 2013 Mar 22;3:e106. doi: 10.1038/bcj.2013.4.


Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

Cosgrove C, Ussher JE, Rauch A, Gärtner K, Kurioka A, Hühn MH, Adelmann K, Kang YH, Fergusson JR, Simmonds P, Goulder P, Hansen TH, Fox J, Günthard HF, Khanna N, Powrie F, Steel A, Gazzard B, Phillips RE, Frater J, Uhlig H, Klenerman P.

Blood. 2013 Feb 7;121(6):951-61. doi: 10.1182/blood-2012-06-436436. Epub 2012 Dec 18.


Amitriptyline versus placebo for major depressive disorder.

Leucht C, Huhn M, Leucht S.

Cochrane Database Syst Rev. 2012 Dec 12;12:CD009138. doi: 10.1002/14651858.CD009138.pub2. Review.


Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases.

Hristodorov D, Mladenov R, Huhn M, Barth S, Thepen T.

Toxins (Basel). 2012 Sep;4(9):676-94. doi: 10.3390/toxins4090676. Epub 2012 Sep 14. Review.


Labeling of anti-MUC-1 binding single chain Fv fragments to surface modified upconversion nanoparticles for an initial in vivo molecular imaging proof of principle approach.

Hischemöller A, Walter C, Weiler V, Hummel H, Thepen T, Huhn M, Barth S, Hoheisel W, Köhler K, Dimova-Landen D, Bremer C, Haase M, Waldeck J.

Int J Mol Sci. 2012;13(4):4153-67. doi: 10.3390/ijms13044153. Epub 2012 Mar 29.


Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.

Lind K, Hühn MH, Flodström-Tullberg M.

Clin Exp Immunol. 2012 Apr;168(1):30-8. doi: 10.1111/j.1365-2249.2011.04557.x. Review.


In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA' in a human acute myeloid leukemia xenograft tumor model.

Tur MK, Huhn M, Jost E, Thepen T, Brümmendorf TH, Barth S.

Int J Cancer. 2011 Sep 1;129(5):1277-82. doi: 10.1002/ijc.25766. Epub 2011 Feb 26.


Recombinant, ETA'-based CD64 immunotoxins: improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice.

Ribbert T, Thepen T, Tur MK, Fischer R, Huhn M, Barth S.

Br J Dermatol. 2010 Aug;163(2):279-86. doi: 10.1111/j.1365-2133.2010.09824.x. Epub 2010 Apr 26.


Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.

Hühn MH, McCartney SA, Lind K, Svedin E, Colonna M, Flodström-Tullberg M.

Virology. 2010 May 25;401(1):42-8. doi: 10.1016/j.virol.2010.02.010. Epub 2010 Mar 5.

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