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Items: 1 to 50 of 56

1.

Impact of IL1RN variants on response to interleukin-1 blocking therapy in systemic juvenile idiopathic arthritis.

Hinze C, Fuehner S, Kessel C, Wittkowski H, Lainka E, Baehr M, Hügle B, Haas JP, Ganser G, Weißbarth-Riedel E, Jansson A, Foell D.

Arthritis Rheumatol. 2019 Oct 10. doi: 10.1002/art.41130. [Epub ahead of print]

PMID:
31599092
2.

Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM.

Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6.

3.

[MTX intolerance in children and adolescents with juvenile idiopathic arthritis].

Hügle B.

Z Rheumatol. 2019 Sep;78(7):620-626. doi: 10.1007/s00393-019-0644-5. Review. German.

PMID:
31065791
4.

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis.

Hügle B, Schippers A, Fischer N, Ohl K, Denecke B, Ticconi F, Vastert B, Costa IG, Haas JP, Tenbrock K.

Arthritis Res Ther. 2018 May 30;20(1):98. doi: 10.1186/s13075-018-1603-2.

5.

Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis Despite IRAK-4 Deficiency.

Hügle B, Händel N, Schwarz K, Borte M, Schuster V.

J Clin Immunol. 2018 May;38(4):450-453. doi: 10.1007/s10875-018-0501-3. Epub 2018 Apr 29. No abstract available.

PMID:
29707745
6.

The German version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).

Holzinger D, Foell D, Horneff G, Foeldvari I, Tzaribachev N, Tzaribachev C, Minden K, Kallinich T, Ganser G, Clara L, Haas JP, Hügle B, Huppertz HI, Weller F, Consolaro A, Bovis F, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO).

Rheumatol Int. 2018 Apr;38(Suppl 1):211-218. doi: 10.1007/s00296-018-3953-0. Epub 2018 Apr 7.

7.

IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry).

Bielak M, Husmann E, Weyandt N, Haas JP, Hügle B, Horneff G, Neudorf U, Lutz T, Lilienthal E, Kallinich T, Tenbrock K, Berendes R, Niehues T, Wittkowski H, Weißbarth-Riedel E, Heubner G, Oommen P, Klotsche J, Foell D, Lainka E.

Pediatr Rheumatol Online J. 2018 Apr 5;16(1):22. doi: 10.1186/s12969-018-0236-y.

8.

Successful treatment of methotrexate intolerance in juvenile idiopathic arthritis using eye movement desensitization and reprocessing - treatment protocol and preliminary results.

Höfel L, Eppler B, Storf M, Schnöbel-Müller E, Haas JP, Hügle B.

Pediatr Rheumatol Online J. 2018 Feb 13;16(1):11. doi: 10.1186/s12969-018-0228-y.

9.

Successful use of secukinumab in a 4-year-old patient with deficiency of interleukin-36 antagonist.

Köstner K, Prelog M, Almanzar G, Fesq H, Haas JP, Hügle B.

Rheumatology (Oxford). 2018 May 1;57(5):936-938. doi: 10.1093/rheumatology/kex510. No abstract available.

PMID:
29415227
10.

Isolated Arthritis of the Temporomandibular Joint as the Initial Manifestation of Juvenile Idiopathic Arthritis.

Hügle B, Spiegel L, Hotte J, Wiens S, Herlin T, Cron RQ, Stoll ML, Vinod S, Stoustrup P, Pedersen TK, Twilt M.

J Rheumatol. 2017 Nov;44(11):1632-1635. doi: 10.3899/jrheum.170263. Epub 2017 Sep 1.

PMID:
28864647
11.

Education and employment in patients with juvenile idiopathic arthritis - a standardized comparison to the German general population.

Schlichtiger J, Haas JP, Barth S, Bisdorff B, Hager L, Michels H, Hügle B, Radon K.

Pediatr Rheumatol Online J. 2017 May 22;15(1):45. doi: 10.1186/s12969-017-0172-2.

12.

Inflammatory bowel disease following anti-interleukin-1-treatment in systemic juvenile idiopathic arthritis.

Hügle B, Speth F, Haas JP.

Pediatr Rheumatol Online J. 2017 Mar 14;15(1):16. doi: 10.1186/s12969-017-0147-3.

13.

Countermeasures against methotrexate intolerance in juvenile idiopathic arthritis instituted by parents show no effect.

Scheuern A, Tyrrell PN, Haas JP, Hügle B.

Rheumatology (Oxford). 2017 Jun 1;56(6):901-906. doi: 10.1093/rheumatology/kew507.

PMID:
28122960
14.

Cathechol-O-methyltransferase Val158Met polymorphism is associated with nocebo effects, but not with methotrexate intolerance in patients with juvenile idiopathic arthritis.

Hügle B, Scheuern A, Dollinger S, Fischer N, Haas JP.

Scand J Rheumatol. 2017 Nov;46(6):502-503. doi: 10.1080/03009742.2016.1275775. Epub 2017 Jan 20. No abstract available.

PMID:
28105896
15.

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.

Dworski S, Lu P, Khan A, Maranda B, Mitchell JJ, Parini R, Di Rocco M, Hugle B, Yoshimitsu M, Magnusson B, Makay B, Arslan N, Guelbert N, Ehlert K, Jarisch A, Gardner-Medwin J, Dagher R, Terreri MT, Lorenco CM, Barillas-Arias L, Tanpaiboon P, Solyom A, Norris JS, He X, Schuchman EH, Levade T, Medin JA.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):386-394. doi: 10.1016/j.bbadis.2016.11.031. Epub 2016 Dec 1.

16.

Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).

Kuemmerle-Deschner JB, Ozen S, Tyrrell PN, Kone-Paut I, Goldbach-Mansky R, Lachmann H, Blank N, Hoffman HM, Weissbarth-Riedel E, Hugle B, Kallinich T, Gattorno M, Gul A, Ter Haar N, Oswald M, Dedeoglu F, Cantarini L, Benseler SM.

Ann Rheum Dis. 2017 Jun;76(6):942-947. doi: 10.1136/annrheumdis-2016-209686. Epub 2016 Oct 4. Review.

PMID:
27707729
17.

Incidence of malignancies in patients with juvenile idiopathic arthritis: A retrospective single-center cohort study in Germany.

Barth S, Schlichtiger J, Hartmann B, Bisdorff B, Michels H, Radon K, Hügle B, Walsh L, Haas JP.

Mod Rheumatol. 2017 Jan;27(1):60-65. doi: 10.1080/14397595.2016.1204711. Epub 2016 Jul 7.

PMID:
27388690
18.

Functional limitations in children and adolescents suffering from chronic pain: validation and psychometric properties of the German Functional Disability Inventory (FDI-G).

Offenbächer M, Kohls N, Walker L, Hermann C, Hügle B, Jäger N, Richter M, Haas JP.

Rheumatol Int. 2016 Oct;36(10):1439-48. doi: 10.1007/s00296-016-3504-5. Epub 2016 Jun 4.

PMID:
27262712
19.

Long-Term Health-Related Quality of Life in German Patients with Juvenile Idiopathic Arthritis in Comparison to German General Population.

Barth S, Haas JP, Schlichtiger J, Molz J, Bisdorff B, Michels H, Hügle B, Radon K.

PLoS One. 2016 Apr 26;11(4):e0153267. doi: 10.1371/journal.pone.0153267. eCollection 2016.

20.

Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis.

Scheuern A, Fischer N, McDonald J, Brunner HI, Haas JP, Hügle B.

Pediatr Rheumatol Online J. 2016 Feb 29;14(1):11. doi: 10.1186/s12969-016-0071-y.

21.

Methotrexate intolerance in oral and subcutaneous administration in patients with juvenile idiopathic arthritis: a cross-sectional, observational study.

van Dijkhuizen EH, Pouw JN, Scheuern A, Hügle B, Hardt S, Ganser G, Kümmerle-Deschner JB, Horneff G, Holzinger D, Bulatović Ćalasan M, Wulffraat NM.

Clin Exp Rheumatol. 2016 Jan-Feb;34(1):148-54. Epub 2016 Feb 2.

PMID:
26843067
22.

Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case-control study.

Barth S, Schlichtiger J, Bisdorff B, Hügle B, Michels H, Radon K, Haas JP.

Pediatr Rheumatol Online J. 2016 Feb 3;14(1):6. doi: 10.1186/s12969-016-0066-8.

23.

The role of synthetic drugs in the biologic era: therapeutic strategies for treating juvenile idiopathic arthritis.

Hügle B, Horneff G.

Expert Opin Pharmacother. 2016;17(5):703-14. doi: 10.1517/14656566.2016.1133592. Epub 2016 Jan 13. Review.

PMID:
26678914
24.

Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis.

Bichler J, Benseler SM, Krumrey-Langkammerer M, Haas JP, Hügle B.

Scand J Rheumatol. 2015;44(4):280-3. doi: 10.3109/03009742.2015.1013983. Epub 2015 May 20.

PMID:
25993023
25.

A new form of shoulder dysplasia in an 11-year-old boy.

Bichler J, Arbogast M, Krumrey-Langkammerer M, Hugle B.

J Radiol Case Rep. 2014 Jul 31;8(7):14-9. doi: 10.3941/jrcr.v8i7.1771. eCollection 2014 Jul.

26.

Development of positive antinuclear antibodies and rheumatoid factor in systemic juvenile idiopathic arthritis points toward an autoimmune phenotype later in the disease course.

Hügle B, Hinze C, Lainka E, Fischer N, Haas JP.

Pediatr Rheumatol Online J. 2014 Jul 16;12:28. doi: 10.1186/1546-0096-12-28. eCollection 2014.

27.

Presentation and outcome of paediatric membranous non-proliferative lupus nephritis.

Hugle B, Silverman ED, Tyrrell PN, Harvey EA, Hébert D, Benseler SM.

Pediatr Nephrol. 2015 Jan;30(1):113-21. doi: 10.1007/s00467-014-2908-2. Epub 2014 Jul 31.

PMID:
25080370
28.

Long-term outcome of anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondyloarthritis.

Hugle B, Burgos-Vargas R, Inman RD, O'Shea F, Laxer RM, Stimec J, Whitney-Mahoney K, Duvnjak M, Anderson M, Tse SM.

Clin Exp Rheumatol. 2014 May-Jun;32(3):424-31. Epub 2014 Jan 3.

PMID:
24387974
29.

Treatment preferences in juvenile idiopathic arthritis - a comparative analysis in two health care systems.

Hugle B, Haas JP, Benseler SM.

Pediatr Rheumatol Online J. 2013 Jan 15;11(1):3. doi: 10.1186/1546-0096-11-3.

30.

Clinical images: Joint calcifications in a patient with a mutation in the COL2A1 gene.

Hugle B, Krumrey-Langkammerer M.

Arthritis Rheum. 2011 Oct;63(10):3077. doi: 10.1002/art.30553. No abstract available.

31.

Isoelectric focusing pattern of plasminogen mutants of patients with hypoplasminogenemia: correlation of in-vitro data with computer-predicted isoelectric points (pI).

Tefs K, Ott-Gueorguieva M, Kobelt L, Ziegler M, Hintze C, Hügle B, Schuster V.

Blood Coagul Fibrinolysis. 2011 Sep;22(6):499-505. doi: 10.1097/MBC.0b013e3283472c53.

PMID:
21537161
32.

Hoffman syndrome: New patients, new insights.

Hügle B, Hoffman H, Bird LM, Gebauer C, Suchowerskyj P, Sack U, Kohlhase J, Schuster V.

Am J Med Genet A. 2011 Jan;155A(1):149-53. doi: 10.1002/ajmg.a.33678. Epub 2010 Dec 10.

PMID:
21204224
33.

Pneumocystis jiroveci pneumonia following rituximab treatment in Wegener's granulomatosis.

Hugle B, Solomon M, Harvey E, James A, Wadhwa A, Amin R, Bell-Peter A, Benseler S.

Arthritis Care Res (Hoboken). 2010 Nov;62(11):1661-4. doi: 10.1002/acr.20279. Epub 2010 Jun 25.

34.

Lipoatrophy resulting from steroid injection into the temporomandibular joint.

Hugle B, Laxer RM.

Arthritis Rheum. 2009 Nov;60(11):3512. doi: 10.1002/art.24987. No abstract available.

35.

[Varicella vaccination: who should be vaccinated these days?].

Hügle B, Suchowerskyj P, Schuster V.

MMW Fortschr Med. 2005 Feb 24;147(8):31-2, 34-5. Review. German.

PMID:
18441563
36.

Plasminogen deficiency.

Schuster V, Hügle B, Tefs K.

J Thromb Haemost. 2007 Dec;5(12):2315-22. Epub 2007 Sep 26. Review.

37.

Difficulties in mutation screening of the plasminogen (PLG) gene in patients with ligneous conjunctivitis and severe hypoplasminogenemia.

Tefs K, Kobelt L, Ziegler M, Hügle B, Schuster V.

Arch Ophthalmol. 2007 Sep;125(9):1303; author reply 1303. No abstract available.

PMID:
17846386
38.

Juvenile colloid milium and ligneous conjunctivitis are caused by severe hypoplasminogenemia--no evidence for causal relationship to non-Hodgkin's lymphoma.

Schuster V, Tefs K, Hügle B.

J Eur Acad Dermatol Venereol. 2006 Nov;20(10):1368. No abstract available.

PMID:
17062083
39.

Simultaneous manifestation of fulminant infectious mononucleosis with haemophagocytic syndrome and B-cell lymphoma in X-linked lymphoproliferative disease.

Hügle B, Astigarraga I, Henter JI, Porwit-MacDonald A, Meindl A, Schuster V.

Eur J Pediatr. 2007 Jun;166(6):589-93. Epub 2006 Oct 21.

PMID:
17058098
40.

Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

Tefs K, Gueorguieva M, Klammt J, Allen CM, Aktas D, Anlar FY, Aydogdu SD, Brown D, Ciftci E, Contarini P, Dempfle CE, Dostalek M, Eisert S, Gökbuget A, Günhan O, Hidayat AA, Hügle B, Isikoglu M, Irkec M, Joss SK, Klebe S, Kneppo C, Kurtulus I, Mehta RP, Ornek K, Schneppenheim R, Seregard S, Sweeney E, Turtschi S, Veres G, Zeitler P, Ziegler M, Schuster V.

Blood. 2006 Nov 1;108(9):3021-6. Epub 2006 Jul 18.

PMID:
16849641
41.
42.

Persistent hypogammaglobulinemia following mononucleosis in boys is highly suggestive of X-linked lymphoproliferative disease--report of three cases.

Hügle B, Suchowerskyj P, Hellebrand H, Adler B, Borte M, Sack U, Overberg-Schmidt US, Strnad N, Otto J, Meindl A, Schuster V.

J Clin Immunol. 2004 Sep;24(5):515-22.

PMID:
15359110
43.

Characterization of plasminogen variants in healthy subjects and plasminogen mutants in patients with inherited plasminogen deficiency by isoelectric focusing gel electrophoresis.

Tefs K, Georgieva M, Seregard S, Tait CR, Luchtman-Jones L, Ziegler M, Hügle B, Schuster V.

Thromb Haemost. 2004 Aug;92(2):352-7.

PMID:
15269832
44.

A nucleic acid exchange in Intron F (Intron F-14T>G) in the human plasminogen gene is only a common polymorphism and not a true mutation.

Tefs K, Ziegler M, Georgieva M, Hügle B, Schuster V.

Thromb Haemost. 2004 Apr;91(4):830-1; author reply 832. No abstract available.

PMID:
15045152
45.
46.

A boy with coinciding neurofibromatosis and hypogammaglobulinemia.

Borte M, Hügle B, Steppberger K, Schuster V.

Pediatr Int. 2002 Aug;44(4):465. No abstract available.

PMID:
12139582
47.

Rapid-onset dystonia-parkinsonism: a clinical and genetic analysis of a new kindred.

Pittock SJ, Joyce C, O'Keane V, Hugle B, Hardiman MO, Brett F, Green AJ, Barton DE, King MD, Webb DW.

Neurology. 2000 Oct 10;55(7):991-5.

PMID:
11061257
48.

A closer look at the insertion within helix 54 of the 23S-rRNA of the genus Corynebacterium (and related taxa).

Hügle B, Weizenegger M, Hengstler K, Fahr A, Bartel J.

Clin Lab. 2000;46(5-6):255-60.

PMID:
10853233
49.
50.

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