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Best matches for Hübscher U[au]:

DNA polymerases: Biology, diseases and biomedical applications. van Loon B et al. DNA Repair (Amst). (2015)

Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis. van Loon B et al. Chem Res Toxicol. (2017)

Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Maga G et al. J Cell Sci. (2003)

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Items: 1 to 50 of 266


Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.

van Loon B, Hübscher U, Maga G.

Chem Res Toxicol. 2017 Nov 20;30(11):1936-1941. doi: 10.1021/acs.chemrestox.7b00152. Epub 2017 Sep 8. Review.


Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.

Mentegari E, Crespan E, Bavagnoli L, Kissova M, Bertoletti F, Sabbioneda S, Imhof R, Sturla SJ, Nilforoushan A, Hübscher U, van Loon B, Maga G.

Nucleic Acids Res. 2017 Mar 17;45(5):2600-2614. doi: 10.1093/nar/gkw1275.


Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.

Crespan E, Furrer A, Rösinger M, Bertoletti F, Mentegari E, Chiapparini G, Imhof R, Ziegler N, Sturla SJ, Hübscher U, van Loon B, Maga G.

Nat Commun. 2016 Feb 26;7:10805. doi: 10.1038/ncomms10805.


The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

Fu D, Samson LD, Hübscher U, van Loon B.

DNA Repair (Amst). 2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14.


DNA polymerases: Biology, diseases and biomedical applications.

van Loon B, Woodgate R, Hübscher U.

DNA Repair (Amst). 2015 May;29:1-3. doi: 10.1016/j.dnarep.2015.04.001. No abstract available.


Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.

Crespan E, Hübscher U, Maga G.

DNA Repair (Amst). 2015 May;29:101-11. doi: 10.1016/j.dnarep.2015.01.005. Epub 2015 Jan 29.


Agnoprotein of polyomavirus BK interacts with proliferating cell nuclear antigen and inhibits DNA replication.

Gerits N, Johannessen M, Tümmler C, Walquist M, Kostenko S, Snapkov I, van Loon B, Ferrari E, Hübscher U, Moens U.

Virol J. 2015 Feb 1;12:7. doi: 10.1186/s12985-014-0220-1.


Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.

Villani G, Shevelev I, Orlando E, Pospiech H, Syvaoja JE, Markkanen E, Hubscher U, Le Gac NT.

PLoS One. 2014 Apr 7;9(4):e93908. doi: 10.1371/journal.pone.0093908. eCollection 2014.


Regulation of human MutYH DNA glycosylase by the E3 ubiquitin ligase mule.

Dorn J, Ferrari E, Imhof R, Ziegler N, Hübscher U.

J Biol Chem. 2014 Mar 7;289(10):7049-58. doi: 10.1074/jbc.M113.536094. Epub 2014 Jan 17.


DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.

Maga G, Crespan E, Markkanen E, Imhof R, Furrer A, Villani G, Hübscher U, van Loon B.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18850-5. doi: 10.1073/pnas.1308760110. Epub 2013 Nov 4.


Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies.

Simonelli V, Camerini S, Mazzei F, Van Loon B, Allione A, D'Errico M, Barone F, Minoprio A, Ricceri F, Guarrera S, Russo A, Dalhus B, Crescenzi M, Hübscher U, Bjørås M, Matullo G, Dogliotti E.

Free Radic Biol Med. 2013 Oct;63:401-9. doi: 10.1016/j.freeradbiomed.2013.05.031. Epub 2013 May 28.


The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.

Aria V, De Felice M, Di Perna R, Uno S, Masai H, Syväoja JE, van Loon B, Hübscher U, Pisani FM.

J Biol Chem. 2013 May 3;288(18):12742-52. doi: 10.1074/jbc.M112.398073. Epub 2013 Mar 19.


MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.

Markkanen E, Dorn J, Hübscher U.

Front Genet. 2013 Feb 28;4:18. doi: 10.3389/fgene.2013.00018. eCollection 2013.


Mammalian base excision repair: the forgotten archangel.

Dianov GL, Hübscher U.

Nucleic Acids Res. 2013 Apr 1;41(6):3483-90. doi: 10.1093/nar/gkt076. Epub 2013 Feb 13. Review.


A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions.

Markkanen E, Castrec B, Villani G, Hübscher U.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20401-6. doi: 10.1073/pnas.1211532109. Epub 2012 Nov 21.


Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.

Zucca E, Bertoletti F, Wimmer U, Ferrari E, Mazzini G, Khoronenkova S, Grosse N, van Loon B, Dianov G, Hübscher U, Maga G.

Nucleic Acids Res. 2013 Jan 7;41(1):229-41. doi: 10.1093/nar/gks1016. Epub 2012 Oct 30.


Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.

Crespan E, Pasi E, Imoto S, Hübscher U, Greenberg MM, Maga G.

ACS Chem Biol. 2013 Feb 15;8(2):336-44. doi: 10.1021/cb300542k. Epub 2012 Nov 7.


Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.

Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, Hübscher U, Janscak P.

Nucleic Acids Res. 2012 Sep 1;40(17):8449-59. Epub 2012 Jun 29.


Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.

Crespan E, Czabany T, Maga G, Hübscher U.

Nucleic Acids Res. 2012 Jul;40(12):5577-90. doi: 10.1093/nar/gks186. Epub 2012 Feb 28.


Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

Markkanen E, Hübscher U, van Loon B.

Cell Cycle. 2012 Mar 15;11(6):1070-5. doi: 10.4161/cc.11.6.19448. Epub 2012 Mar 15.


Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

Markkanen E, van Loon B, Ferrari E, Parsons JL, Dianov GL, Hübscher U.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):437-42. doi: 10.1073/pnas.1110449109. Epub 2011 Dec 27.


A new proofreading mechanism for lesion bypass by DNA polymerase-λ.

Crespan E, Maga G, Hübscher U.

EMBO Rep. 2011 Dec 23;13(1):68-74. doi: 10.1038/embor.2011.226.


Generation of a mono-ubiquitinated PCNA mimic by click chemistry.

Eger S, Castrec B, Hübscher U, Scheffner M, Rubini M, Marx A.

Chembiochem. 2011 Dec 16;12(18):2807-12. doi: 10.1002/cbic.201100444. Epub 2011 Nov 3. Erratum in: Chembiochem. 2011 Dec 16;12(18):2716.


The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H, Ramadan K.

Nat Cell Biol. 2011 Oct 23;13(11):1376-82. doi: 10.1038/ncb2367.


DNA replication and repair bypass machines.

Hübscher U, Maga G.

Curr Opin Chem Biol. 2011 Oct;15(5):627-35. doi: 10.1016/j.cbpa.2011.08.009. Epub 2011 Sep 1. Review.


In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.

Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, di Cicco G, Markkanen E, Syväoja JE, Tanguy Le Gac N.

J Biol Chem. 2011 Sep 16;286(37):32094-104. doi: 10.1074/jbc.M111.246611. Epub 2011 Jul 13.


Ubiquitylation of DNA polymerase λ.

Markkanen E, van Loon B, Ferrari E, Hübscher U.

FEBS Lett. 2011 Sep 16;585(18):2826-30. doi: 10.1016/j.febslet.2011.03.069. Epub 2011 Apr 8. Review.


Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen.

Locatelli GA, Pospiech H, Tanguy Le Gac N, van Loon B, Hubscher U, Parkkinen S, Syväoja JE, Villani G.

Biochem J. 2010 Aug 1;429(3):573-82. doi: 10.1042/BJ20100405.


Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.

van Loon B, Markkanen E, Hübscher U.

DNA Repair (Amst). 2010 Jun 4;9(6):604-16. doi: 10.1016/j.dnarep.2010.03.004. Review.


[Is health really the most important value? - Results of a representative survey of the German general population concerning the subjective meaning of health].

Hinz A, Hübscher U, Brähler E, Berth H.

Gesundheitswesen. 2010 Dec;72(12):897-903. doi: 10.1055/s-0029-1246151. Epub 2010 Jan 26. German.


An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.

van Loon B, Hübscher U.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18201-6. doi: 10.1073/pnas.0907280106. Epub 2009 Oct 9.


Isolation of recombinant DNA elongation proteins.

van Loon B, Ferrari E, Hübscher U.

Methods Mol Biol. 2009;521:345-59. doi: 10.1007/978-1-60327-815-7_19.


DNA replication fork proteins.

Hübscher U.

Methods Mol Biol. 2009;521:19-33. doi: 10.1007/978-1-60327-815-7_2. Review.


The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1.

Maga G, van Loon B, Crespan E, Villani G, Hübscher U.

J Biol Chem. 2009 May 22;284(21):14267-75. doi: 10.1074/jbc.M900759200. Epub 2009 Mar 27.


The family X DNA polymerase from Deinococcus radiodurans adopts a non-standard extended conformation.

Leulliot N, Cladière L, Lecointe F, Durand D, Hübscher U, van Tilbeurgh H.

J Biol Chem. 2009 May 1;284(18):11992-9. doi: 10.1074/jbc.M809342200. Epub 2009 Feb 26.


Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.

Maga G, Crespan E, Wimmer U, van Loon B, Amoroso A, Mondello C, Belgiovine C, Ferrari E, Locatelli G, Villani G, Hübscher U.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20689-94. doi: 10.1073/pnas.0811241106. Epub 2008 Dec 22.


Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle.

Wimmer U, Ferrari E, Hunziker P, Hübscher U.

EMBO Rep. 2008 Oct;9(10):1027-33. doi: 10.1038/embor.2008.148. Epub 2008 Aug 8.


The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.

Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, Hübscher U, Hoheisel JD, Hickson ID, Stagljar I.

Nucleic Acids Res. 2008 Sep;36(16):5166-79. doi: 10.1093/nar/gkn498. Epub 2008 Aug 5.


Deinococcus radiodurans: what belongs to the survival kit?

Blasius M, Sommer S, Hübscher U.

Crit Rev Biochem Mol Biol. 2008 May-Jun;43(3):221-38. doi: 10.1080/10409230802122274 . Review.


Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.

Zanoli S, Gemma S, Butini S, Brindisi M, Joshi BP, Campiani G, Fattorusso C, Persico M, Crespan E, Cancio R, Spadari S, Hübscher U, Maga G.

Biochem Pharmacol. 2008 Jul 15;76(2):156-68. doi: 10.1016/j.bcp.2008.04.009. Epub 2008 Apr 29.


DNA polymerases and oxidative damage: friends or foes?

Amoroso A, Crespan E, Wimmer U, Hubscher U, Maga G.

Curr Mol Pharmacol. 2008 Jun;1(2):162-70. Review.


Repair and translesion DNA polymerases as anticancer drug targets.

Maga G, Hübscher U.

Anticancer Agents Med Chem. 2008 May;8(4):431-47. Review.


Photoreactive DNA probes as a tool for studying the translesion synthesis system in Mammalian cell extracts.

Belousova EA, Crespan E, Lebedeva NA, Rechkunova NI, Hübscher U, Magaand G, Lavrik OI.

Med Chem. 2008 Mar;4(2):155-62.


Proteomic analysis of p16ink4a-binding proteins.

Souza-Rodrígues E, Estanyol JM, Friedrich-Heineken E, Olmedo E, Vera J, Canela N, Brun S, Agell N, Hübscher U, Bachs O, Jaumot M.

Proteomics. 2007 Nov;7(22):4102-11.


A novel proteomic approach identifies new interaction partners for proliferating cell nuclear antigen.

Meslet-Cladiére L, Norais C, Kuhn J, Briffotaux J, Sloostra JW, Ferrari E, Hübscher U, Flament D, Myllykallio H.

J Mol Biol. 2007 Oct 5;372(5):1137-48. Epub 2007 Jun 27.


8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins.

Maga G, Villani G, Crespan E, Wimmer U, Ferrari E, Bertocci B, Hübscher U.

Nature. 2007 May 31;447(7144):606-8. Epub 2007 May 16.


The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair.

Gembka A, Toueille M, Smirnova E, Poltz R, Ferrari E, Villani G, Hübscher U.

Nucleic Acids Res. 2007;35(8):2596-608. Epub 2007 Apr 10.


Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.

Cancio R, Mai A, Rotili D, Artico M, Sbardella G, Clotet-Codina I, Esté JA, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G.

ChemMedChem. 2007 Apr;2(4):445-8. No abstract available.


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