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Best matches for Hübner MP[au]:

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes? Surendar J et al. Parasite Immunol. (2017)

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes. Berbudi A et al. Diabetes Metab Res Rev. (2016)

Genome-wide transcriptome induced by nickel in human monocytes. Gölz L et al. Acta Biomater. (2016)

Search results

Items: 45

1.

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, Hoerauf A.

PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007636. doi: 10.1371/journal.pntd.0007636. eCollection 2019 Aug.

2.

Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation.

Karunakaran I, Alam S, Jayagopi S, Frohberger SJ, Hansen JN, Kuehlwein J, Hölbling BV, Schumak B, Hübner MP, Gräler MH, Halle A, van Echten-Deckert G.

Glia. 2019 Oct;67(10):1859-1872. doi: 10.1002/glia.23663. Epub 2019 Jun 24.

PMID:
31231866
3.

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.

Frohberger SJ, Ajendra J, Surendar J, Stamminger W, Ehrens A, Buerfent BC, Gentil K, Hoerauf A, Hübner MP.

Parasit Vectors. 2019 May 20;12(1):248. doi: 10.1186/s13071-019-3502-z.

4.

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW.

Sci Transl Med. 2019 May 8;11(491). pii: eaav3523. doi: 10.1126/scitranslmed.aav3523.

PMID:
31068442
5.

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.

Taylor MJ, von Geldern TW, Ford L, Hübner MP, Marsh K, Johnston KL, Sjoberg HT, Specht S, Pionnier N, Tyrer HE, Clare RH, Cook DAN, Murphy E, Steven A, Archer J, Bloemker D, Lenz F, Koschel M, Ehrens A, Metuge HM, Chunda VC, Ndongmo Chounna PW, Njouendou AJ, Fombad FF, Carr R, Morton HE, Aljayyoussi G, Hoerauf A, Wanji S, Kempf DJ, Turner JD, Ward SA.

Sci Transl Med. 2019 Mar 13;11(483). pii: eaau2086. doi: 10.1126/scitranslmed.aau2086.

PMID:
30867321
6.

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ.

PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb.

7.

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE-knockout mice.

Kuehn C, Tauchi M, Furtmair R, Urschel K, Raaz-Schrauder D, Neumann AL, Frohberger SJ, Hoerauf A, Regus S, Lang W, Sagban TA, Stumpfe FM, Achenbach S, Hübner MP, Dietel B.

FASEB J. 2019 May;33(5):6497-6513. doi: 10.1096/fj.201800947RR. Epub 2019 Feb 26.

PMID:
30807258
8.

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.

Buerfent BC, Gölz L, Hofmann A, Rühl H, Stamminger W, Fricker N, Hess T, Oldenburg J, Nöthen MM, Schumacher J, Hübner MP, Hoerauf A.

Sci Rep. 2019 Feb 22;9(1):2562. doi: 10.1038/s41598-019-38985-x.

9.

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

Jacobs RT, Lunde CS, Freund YR, Hernandez V, Li X, Xia Y, Carter DS, Berry PW, Halladay J, Rock F, Stefanakis R, Easom E, Plattner JJ, Ford L, Johnston KL, Cook DAN, Clare R, Cassidy A, Myhill L, Tyrer H, Gamble J, Guimaraes AF, Steven A, Lenz F, Ehrens A, Frohberger SJ, Koschel M, Hoerauf A, Hübner MP, McNamara CW, Bakowski MA, Turner JD, Taylor MJ, Ward SA.

J Med Chem. 2019 Mar 14;62(5):2521-2540. doi: 10.1021/acs.jmedchem.8b01854. Epub 2019 Feb 26.

10.

Comparative study on serum-induced arthritis in the temporomandibular and limb joint of mice.

Safi S, Frommholz D, Reimann S, Götz W, Bourauel C, Neumann AL, Hoerauf A, Ilges H, Safi AF, Jäger A, Hübner MP, Gölz L.

Int J Rheum Dis. 2019 Apr;22(4):636-645. doi: 10.1111/1756-185X.13486. Epub 2019 Jan 21. Erratum in: Int J Rheum Dis. 2019 Jul;22(7):1348.

PMID:
30666791
11.

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

Hübner MP, Ehrens A, Koschel M, Dubben B, Lenz F, Frohberger SJ, Specht S, Quirynen L, Lachau-Durand S, Tekle F, Baeten B, Engelen M, Mackenzie CD, Hoerauf A.

PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006320. doi: 10.1371/journal.pntd.0006320. eCollection 2019 Jan.

12.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.

13.

IL-6 is required for protective immune responses against early filarial infection.

Muhsin M, Ajendra J, Gentil K, Berbudi A, Neumann AL, Klaas L, Schmidt KE, Hoerauf A, Hübner MP.

Int J Parasitol. 2018 Oct;48(12):925-935. doi: 10.1016/j.ijpara.2018.05.011. Epub 2018 Sep 1.

PMID:
30176234
14.

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A.

PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan.

15.

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae.

Ajendra J, Specht S, Ziewer S, Schiefer A, Pfarr K, Parčina M, Kufer TA, Hoerauf A, Hübner MP.

Sci Rep. 2016 Dec 22;6:39648. doi: 10.1038/srep39648.

16.

Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

Surendar J, Indulekha K, Hoerauf A, Hübner MP.

Parasite Immunol. 2017 May;39(5). doi: 10.1111/pim.12401. Epub 2016 Dec 15. Review.

17.

Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice.

Berbudi A, Surendar J, Ajendra J, Gondorf F, Schmidt D, Neumann AL, Wardani AP, Layland LE, Hoffmann LS, Pfeifer A, Hoerauf A, Hübner MP.

J Innate Immun. 2016;8(6):601-616. Epub 2016 Aug 20.

18.

Genome-wide transcriptome induced by nickel in human monocytes.

Gölz L, Buerfent BC, Hofmann A, Rühl H, Fricker N, Stamminger W, Oldenburg J, Deschner J, Hoerauf A, Nöthen MM, Schumacher J, Hübner MP, Jäger A.

Acta Biomater. 2016 Oct 1;43:369-382. doi: 10.1016/j.actbio.2016.07.047. Epub 2016 Jul 28.

PMID:
27477848
19.

Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.

Ajendra J, Berbudi A, Hoerauf A, Hübner MP.

Clin Immunol. 2016 Mar;164:119-22. doi: 10.1016/j.clim.2016.02.005. Epub 2016 Feb 16.

PMID:
26898311
20.

Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases.

Gölz L, Buerfent BC, Hofmann A, Hübner MP, Rühl H, Fricker N, Schmidt D, Johannes O, Jepsen S, Deschner J, Hoerauf A, Nöthen MM, Schumacher J, Jäger A.

Innate Immun. 2016 Jan;22(1):72-84. doi: 10.1177/1753425915616685. Epub 2015 Nov 24.

PMID:
26608307
21.

A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.

Lutz P, Krämer B, Kaczmarek DJ, Hübner MP, Langhans B, Appenrodt B, Lammert F, Nattermann J, Hoerauf A, Strassburg CP, Spengler U, Nischalke HD.

Dig Liver Dis. 2016 Jan;48(1):62-8. doi: 10.1016/j.dld.2015.09.011. Epub 2015 Sep 28.

PMID:
26493630
22.

Correction: Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.

Fox EM, Morris CP, Hübner MP, Mitre E.

PLoS Negl Trop Dis. 2015 Aug 19;9(8):e0004034. doi: 10.1371/journal.pntd.0004034. eCollection 2015 Aug. No abstract available.

23.

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses.

Layland LE, Ajendra J, Ritter M, Wiszniewsky A, Hoerauf A, Hübner MP.

Parasit Vectors. 2015 Jul 25;8:396. doi: 10.1186/s13071-015-1011-2.

24.

Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.

Fox EM, Morris CP, Hübner MP, Mitre E.

PLoS Negl Trop Dis. 2015 Jul 23;9(7):e0003932. doi: 10.1371/journal.pntd.0003932. eCollection 2015. Erratum in: PLoS Negl Trop Dis. 2015 Aug;9(8):e0004034.

25.

Parasitic helminths and their beneficial impact on type 1 and type 2 diabetes.

Berbudi A, Ajendra J, Wardani AP, Hoerauf A, Hübner MP.

Diabetes Metab Res Rev. 2016 Mar;32(3):238-50. doi: 10.1002/dmrr.2673. Epub 2015 Aug 19. Review.

PMID:
26119261
26.

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.

Gondorf F, Berbudi A, Buerfent BC, Ajendra J, Bloemker D, Specht S, Schmidt D, Neumann AL, Layland LE, Hoerauf A, Hübner MP.

PLoS Pathog. 2015 Jan 22;11(1):e1004616. doi: 10.1371/journal.ppat.1004616. eCollection 2015 Jan.

27.

Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection.

Buerfent BC, Gondorf F, Wohlleber D, Schumak B, Hoerauf A, Hübner MP.

Immunology. 2015 May;145(1):150-60. doi: 10.1111/imm.12435.

28.

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.

Ajendra J, Specht S, Neumann AL, Gondorf F, Schmidt D, Gentil K, Hoffmann WH, Taylor MJ, Hoerauf A, Hübner MP.

PLoS One. 2014 Mar 24;9(3):e93072. doi: 10.1371/journal.pone.0093072. eCollection 2014.

29.

Eotaxin-1 is involved in parasite clearance during chronic filarial infection.

Gentil K, Lentz CS, Rai R, Muhsin M, Kamath AD, Mutluer O, Specht S, Hübner MP, Hoerauf A.

Parasite Immunol. 2014 Feb;36(2):60-77. doi: 10.1111/pim.12079.

30.

Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?

Hübner MP, Layland LE, Hoerauf A.

Pathog Dis. 2013 Nov;69(2):127-41. doi: 10.1111/2049-632X.12080. Epub 2013 Sep 10. Review.

31.

Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis.

Torrero MN, Morris CP, Mitre BK, Hübner MP, Fox EM, Karasuyama H, Mitre E.

Vaccine. 2013 Aug 12;31(36):3675-82. doi: 10.1016/j.vaccine.2013.06.010. Epub 2013 Jun 15.

32.

Chronic helminth infection does not exacerbate Mycobacterium tuberculosis infection.

Hübner MP, Killoran KE, Rajnik M, Wilson S, Yim KC, Torrero MN, Morris CP, Nikonenko B, Blanco JC, Hemming VG, Mitre E.

PLoS Negl Trop Dis. 2012;6(12):e1970. doi: 10.1371/journal.pntd.0001970. Epub 2012 Dec 20.

33.

Helminth infection is associated with decreased basophil responsiveness in human beings.

Larson D, Cooper PJ, Hübner MP, Reyes J, Vaca M, Chico M, Kong HH, Mitre E.

J Allergy Clin Immunol. 2012 Jul;130(1):270-2. doi: 10.1016/j.jaci.2012.04.017. Epub 2012 May 16. No abstract available.

34.

Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.

Larson D, Hübner MP, Torrero MN, Morris CP, Brankin A, Swierczewski BE, Davies SJ, Vonakis BM, Mitre E.

J Immunol. 2012 May 1;188(9):4188-99. doi: 10.4049/jimmunol.1101859. Epub 2012 Mar 28.

35.

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis.

Ziewer S, Hübner MP, Dubben B, Hoffmann WH, Bain O, Martin C, Hoerauf A, Specht S.

PLoS Negl Trop Dis. 2012;6(3):e1558. doi: 10.1371/journal.pntd.0001558. Epub 2012 Mar 6.

36.

Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β.

Hübner MP, Shi Y, Torrero MN, Mueller E, Larson D, Soloviova K, Gondorf F, Hoerauf A, Killoran KE, Stocker JT, Davies SJ, Tarbell KV, Mitre E.

J Immunol. 2012 Jan 15;188(2):559-68. doi: 10.4049/jimmunol.1100335. Epub 2011 Dec 14.

37.

Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice.

Hübner MP, Larson D, Torrero MN, Mueller E, Shi Y, Killoran KE, Mitre E.

Clin Immunol. 2011 Nov;141(2):205-17. doi: 10.1016/j.clim.2011.08.004. Epub 2011 Aug 23.

38.

Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response.

Teran R, Mitre E, Vaca M, Erazo S, Oviedo G, Hübner MP, Chico ME, Mattapallil JJ, Bickle Q, Rodrigues LC, Cooper PJ.

Clin Immunol. 2011 Mar;138(3):299-310. doi: 10.1016/j.clim.2010.12.011. Epub 2011 Jan 17.

39.

Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis.

Torrero MN, Hübner MP, Larson D, Karasuyama H, Mitre E.

J Immunol. 2010 Dec 15;185(12):7426-34. doi: 10.4049/jimmunol.0903864. Epub 2010 Nov 5. Erratum in: J Immunol. 2011 Dec 1;187(11):6159.

40.

Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures.

Hübner MP, Torrero MN, Mitre E.

Vaccine. 2010 Feb 17;28(7):1746-57. doi: 10.1016/j.vaccine.2009.12.016. Epub 2009 Dec 23.

41.

Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus).

Hübner MP, Torrero MN, McCall JW, Mitre E.

Exp Parasitol. 2009 Sep;123(1):95-8. doi: 10.1016/j.exppara.2009.05.009. Epub 2009 May 20.

42.

CD200R surface expression as a marker of murine basophil activation.

Torrero MN, Larson D, Hübner MP, Mitre E.

Clin Exp Allergy. 2009 Mar;39(3):361-9. doi: 10.1111/j.1365-2222.2008.03154.x. Epub 2008 Dec 23.

43.

Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells.

Hübner MP, Stocker JT, Mitre E.

Immunology. 2009 Aug;127(4):512-22. doi: 10.1111/j.1365-2567.2008.02958.x. Epub 2008 Nov 7.

44.

Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice.

Hübner MP, Pasche B, Kalaydjiev S, Soboslay PT, Lengeling A, Schulz-Key H, Mitre E, Hoffmann WH.

Infect Immun. 2008 Apr;76(4):1668-77. doi: 10.1128/IAI.01042-07. Epub 2008 Feb 4.

45.

Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients.

Hübner MP, Manfras BJ, Margos MC, Eiffler D, Hoffmann WH, Schulz-Key H, Kern P, Soboslay PT.

Clin Exp Immunol. 2006 Aug;145(2):243-51.

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