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Items: 1 to 50 of 53

1.

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.

Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001.

PMID:
31526758
2.

Targeting the Tumor Microenvironment of Leukemia and Lymphoma.

Höpken UE, Rehm A.

Trends Cancer. 2019 Jun;5(6):351-364. doi: 10.1016/j.trecan.2019.05.001. Epub 2019 Jun 5. Review.

PMID:
31208697
3.

CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin's Lymphoma and Multiple Myeloma.

Bluhm J, Kieback E, Marino SF, Oden F, Westermann J, Chmielewski M, Abken H, Uckert W, Höpken UE, Rehm A.

Mol Ther. 2018 Aug 1;26(8):1906-1920. doi: 10.1016/j.ymthe.2018.06.012. Epub 2018 Jun 18.

4.

The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival.

Stache V, Verlaat L, Gätjen M, Heinig K, Westermann J, Rehm A, Höpken UE.

Oncoimmunology. 2017 May 2;6(6):e1323155. doi: 10.1080/2162402X.2017.1323155. eCollection 2017.

5.
6.

Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia.

Gätjen M, Brand F, Grau M, Gerlach K, Kettritz R, Westermann J, Anagnostopoulos I, Lenz P, Lenz G, Höpken UE, Rehm A.

Cancer Res. 2016 Sep 15;76(18):5253-65. doi: 10.1158/0008-5472.CAN-15-3486. Epub 2016 Aug 3.

7.

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.

Stauss D, Brunner C, Berberich-Siebelt F, Höpken UE, Lipp M, Müller G.

EMBO J. 2016 Apr 15;35(8):881-98. doi: 10.15252/embj.201591459. Epub 2016 Mar 8.

8.

Loss of Gadkin Affects Dendritic Cell Migration In Vitro.

Schachtner H, Weimershaus M, Stache V, Plewa N, Legler DF, Höpken UE, Maritzen T.

PLoS One. 2015 Dec 1;10(12):e0143883. doi: 10.1371/journal.pone.0143883. eCollection 2015.

9.

Dysregulated development of IL-17- and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.

Wichner K, Stauss D, Kampfrath B, Krüger K, Müller G, Rehm A, Lipp M, Höpken UE.

FASEB J. 2016 Feb;30(2):761-74. doi: 10.1096/fj.15-274001. Epub 2015 Oct 23.

PMID:
26499265
10.

Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.

Oden F, Marino SF, Brand J, Scheu S, Kriegel C, Olal D, Takvorian A, Westermann J, Yilmaz B, Hinz M, Daumke O, Höpken UE, Müller G, Lipp M.

Mol Oncol. 2015 Aug;9(7):1348-58. doi: 10.1016/j.molonc.2015.03.010. Epub 2015 Mar 31.

11.

Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.

Höpken UE.

Blood. 2014 Nov 6;124(19):2897-8. doi: 10.1182/blood-2014-09-597682.

PMID:
25377557
12.

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.

Rehm A, Gätjen M, Gerlach K, Scholz F, Mensen A, Gloger M, Heinig K, Lamprecht B, Mathas S, Bégay V, Leutz A, Lipp M, Dörken B, Höpken UE.

Nat Commun. 2014 Sep 30;5:5057. doi: 10.1038/ncomms6057.

PMID:
25266931
13.

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.

Heinig K, Gätjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K, Niesner RA, Cseresnyes Z, Hauser AE, Lenz P, Hehlgans T, Brink R, Westermann J, Dörken B, Lipp M, Lenz G, Rehm A, Höpken UE.

Cancer Discov. 2014 Dec;4(12):1448-65. doi: 10.1158/2159-8290.CD-14-0096. Epub 2014 Sep 24.

14.

B-cell-intrinsic STAT6 signaling controls germinal center formation.

Turqueti-Neves A, Otte M, Prazeres da Costa O, Höpken UE, Lipp M, Buch T, Voehringer D.

Eur J Immunol. 2014 Jul;44(7):2130-8. doi: 10.1002/eji.201344203. Epub 2014 May 21.

15.

Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells.

Halvorsen B, Dahl TB, Smedbakken LM, Singh A, Michelsen AE, Skjelland M, Krohg-Sørensen K, Russell D, Höpken UE, Lipp M, Damås JK, Holm S, Yndestad A, Biessen EA, Aukrust P.

Cardiovasc Res. 2014 Apr 1;102(1):148-56. doi: 10.1093/cvr/cvu036. Epub 2014 Feb 11.

PMID:
24518141
16.

Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota.

Wichner K, Fischer A, Winter S, Tetzlaff S, Heimesaat MM, Bereswill S, Rehm A, Lipp M, Höpken UE.

J Autoimmun. 2013 Dec;47:58-72. doi: 10.1016/j.jaut.2013.08.007. Epub 2013 Sep 24.

PMID:
24075646
17.

The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A.

Immunity. 2012 Nov 16;37(5):854-66. doi: 10.1016/j.immuni.2012.07.012. Epub 2012 Oct 16.

18.

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.

Höpken UE, Rehm A.

J Mol Med (Berl). 2012 Nov;90(11):1237-45. doi: 10.1007/s00109-012-0906-z. Epub 2012 May 11. Review.

PMID:
22577036
19.

CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis.

Schumann M, Winter S, Wichner K, May C, Kühl AA, Batra A, Siegmund B, Zeitz M, Schulzke JD, Lipp M, Höpken UE.

Mucosal Immunol. 2012 Jul;5(4):377-87. doi: 10.1038/mi.2012.15. Epub 2012 Mar 7.

PMID:
22395421
20.

Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.

Winter S, Rehm A, Wichner K, Scheel T, Batra A, Siegmund B, Berek C, Lipp M, Höpken UE.

Am J Pathol. 2011 Aug;179(2):754-65. doi: 10.1016/j.ajpath.2011.04.012. Epub 2011 Jun 12.

21.

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.

Rehm A, Mensen A, Schradi K, Gerlach K, Wittstock S, Winter S, Büchner G, Dörken B, Lipp M, Höpken UE.

Blood. 2011 Jul 28;118(4):1020-33. doi: 10.1182/blood-2010-11-321265. Epub 2011 May 17.

PMID:
21586747
22.

The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation.

Winter S, Loddenkemper C, Aebischer A, Räbel K, Hoffmann K, Meyer TF, Lipp M, Höpken UE.

J Mol Med (Berl). 2010 Nov;88(11):1169-80. doi: 10.1007/s00109-010-0658-6. Epub 2010 Aug 27.

23.

CCR7 regulates lymphocyte egress and recirculation through body cavities.

Höpken UE, Winter S, Achtman AH, Krüger K, Lipp M.

J Leukoc Biol. 2010 Apr;87(4):671-82. doi: 10.1189/jlb.0709505. Epub 2009 Dec 22.

PMID:
20028772
24.

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.

van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, Höpken UE, Lipp M, Niederreither K, Blomhoff R, Sitnik K, Agace WW, Randall TD, de Jonge WJ, Mebius RE.

Nat Immunol. 2009 Nov;10(11):1193-9. doi: 10.1038/ni.1789. Epub 2009 Sep 27.

25.

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.

Rüder C, Höpken UE, Wolf J, Mittrücker HW, Engels B, Erdmann B, Wollenzin S, Uckert W, Dörken B, Rehm A.

J Clin Invest. 2009 Aug;119(8):2184-203. doi: 10.1172/JCI37760. Epub 2009 Jul 20.

26.

Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.

Rehm A, Anagnostopoulos I, Gerlach K, Broemer M, Scheidereit C, Jöhrens K, Hübler M, Hetzer R, Stein H, Lipp M, Dörken B, Höpken UE.

Int J Cancer. 2009 Nov 15;125(10):2367-74. doi: 10.1002/ijc.24652.

27.

CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.

Achtman AH, Höpken UE, Bernert C, Lipp M.

J Leukoc Biol. 2009 Mar;85(3):409-17. doi: 10.1189/jlb.0308162. Epub 2008 Dec 12.

PMID:
19074554
28.

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.

van Zwam M, Huizinga R, Melief MJ, Wierenga-Wolf AF, van Meurs M, Voerman JS, Biber KP, Boddeke HW, Höpken UE, Meisel C, Meisel A, Bechmann I, Hintzen RQ, 't Hart BA, Amor S, Laman JD, Boven LA.

J Mol Med (Berl). 2009 Mar;87(3):273-86. doi: 10.1007/s00109-008-0421-4. Epub 2008 Dec 3.

PMID:
19050840
29.

CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis.

Wengner AM, Höpken UE, Petrow PK, Hartmann S, Schurigt U, Bräuer R, Lipp M.

Arthritis Rheum. 2007 Oct;56(10):3271-83.

30.

Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.

Menning A, Höpken UE, Siegmund K, Lipp M, Hamann A, Huehn J.

Eur J Immunol. 2007 Jun;37(6):1575-83.

31.

CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity.

Westermann J, Nguyen-Hoai T, Baldenhofer G, Höpken UE, Lipp M, Dörken B, Pezzutto A.

Cancer Gene Ther. 2007 Jun;14(6):523-32. Epub 2007 Mar 23.

PMID:
17384577
32.

Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.

Kahnert A, Höpken UE, Stein M, Bandermann S, Lipp M, Kaufmann SH.

J Infect Dis. 2007 Jan 1;195(1):46-54. Epub 2006 Nov 14.

PMID:
17152008
33.

Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.

Zhao C, Wood MW, Galyov EE, Höpken UE, Lipp M, Bodmer HC, Tough DF, Carter RW.

Eur J Immunol. 2006 Nov;36(11):2939-50.

34.

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.

Höpken UE, Wengner AM, Loddenkemper C, Stein H, Heimesaat MM, Rehm A, Lipp M.

Blood. 2007 Feb 1;109(3):886-95. Epub 2006 Oct 3.

PMID:
17018859
35.

The ratio between dendritic cells and T cells determines the outcome of their encounter: proliferation versus deletion.

Höpken UE, Lehmann I, Droese J, Lipp M, Schüler T, Rehm A.

Eur J Immunol. 2005 Oct;35(10):2851-63.

36.

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.

Kursar M, Höpken UE, Koch M, Köhler A, Lipp M, Kaufmann SH, Mittrücker HW.

J Exp Med. 2005 May 2;201(9):1447-57. Epub 2005 Apr 25.

37.

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.

Droese J, Mokros T, Hermosilla R, Schülein R, Lipp M, Höpken UE, Rehm A.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):42-9.

PMID:
15313171
38.

Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.

Höpken UE, Achtman AH, Krüger K, Lipp M.

J Leukoc Biol. 2004 Sep;76(3):709-18. Epub 2004 Jun 14.

PMID:
15197239
39.

All roads lead to Rome: triggering dendritic cell migration.

Höpken UE, Lipp M.

Immunity. 2004 Mar;20(3):244-6.

40.

The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.

Höpken UE, Droese J, Li JP, Joergensen J, Breitfeld D, Zerwes HG, Lipp M.

Eur J Immunol. 2004 Feb;34(2):461-70.

41.

The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity.

Müller G, Höpken UE, Lipp M.

Immunol Rev. 2003 Oct;195:117-35. Review. Erratum in: Immunol Rev. 2003 Dec;196:265.

PMID:
12969315
42.

Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming.

MartIn-Fontecha A, Sebastiani S, Höpken UE, Uguccioni M, Lipp M, Lanzavecchia A, Sallusto F.

J Exp Med. 2003 Aug 18;198(4):615-21.

43.

Role of homeostatic chemokine and sphingosine-1-phosphate receptors in the organization of lymphoid tissue.

Müller G, Reiterer P, Höpken UE, Golfier S, Lipp M.

Ann N Y Acad Sci. 2003 Apr;987:107-16. Review.

PMID:
12727629
44.

Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.

Mokros T, Rehm A, Droese J, Oppermann M, Lipp M, Höpken UE.

J Biol Chem. 2002 Nov 22;277(47):45122-8. Epub 2002 Sep 18.

45.

Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors.

Müller G, Höpken UE, Stein H, Lipp M.

J Leukoc Biol. 2002 Jul;72(1):1-8. Review.

PMID:
12101256
46.

In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7.

Debes GF, Höpken UE, Hamann A.

J Immunol. 2002 Jun 1;168(11):5441-7.

47.

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.

Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE.

J Virol. 2002 May;76(10):5043-50.

48.

Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.

Ueno T, Hara K, Willis MS, Malin MA, Höpken UE, Gray DH, Matsushima K, Lipp M, Springer TA, Boyd RL, Yoshie O, Takahama Y.

Immunity. 2002 Feb;16(2):205-18.

49.
50.

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