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Items: 1 to 50 of 112

2.

Isolation, Structure Elucidation, and (Bio)Synthesis of Haprolid, a Cell-Type-Specific Myxobacterial Cytotoxin.

Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Höfle G, Kalesse M, Müller R.

Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10113-7. doi: 10.1002/anie.201603288. Epub 2016 Jul 12.

PMID:
27404448
3.

Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species.

Tautz T, Hoffmann J, Hoffmann T, Steinmetz H, Washausen P, Kunze B, Huch V, Kitsche A, Reichenbach H, Höfle G, Müller R, Kalesse M.

Org Lett. 2016 Jun 3;18(11):2560-3. doi: 10.1021/acs.orglett.6b00810. Epub 2016 May 24.

PMID:
27220069
4.

Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin.

Ranade AR, Higgins L, Markowski TW, Glaser N, Kashin D, Bai R, Hong KH, Hamel E, Höfle G, Georg GI.

J Med Chem. 2016 Apr 14;59(7):3499-514. doi: 10.1021/acs.jmedchem.6b00188. Epub 2016 Mar 17.

5.

Amethystin, the coloring principle of Stentor amethystinus.

Höfle G, Reinecke S, Laude U, Spitzner D.

J Nat Prod. 2014 Jun 27;77(6):1383-9. doi: 10.1021/np5001363. Epub 2014 Jun 2.

6.

Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763.

Pesic A, Steinhaus B, Kemper S, Nachtigall J, Kutzner HJ, Höfle G, Süssmuth RD.

J Antibiot (Tokyo). 2014 Jun;67(6):471-7. doi: 10.1038/ja.2014.16. Epub 2014 Mar 5.

PMID:
24594582
7.

Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.

Höfle G, Gerth K, Reichenbach H, Kunze B, Sasse F, Forche E, Prusov EV.

Chemistry. 2012 Sep 3;18(36):11362-70. doi: 10.1002/chem.201201879. Epub 2012 Aug 13.

PMID:
22890974
8.

Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum.

Jahns C, Hoffmann T, Müller S, Gerth K, Washausen P, Höfle G, Reichenbach H, Kalesse M, Müller R.

Angew Chem Int Ed Engl. 2012 May 21;51(21):5239-43. doi: 10.1002/anie.201200327. Epub 2012 Apr 5. No abstract available.

PMID:
22488911
9.

Sulfangolids, macrolide sulfate esters from Sorangium cellulosum.

Zander W, Irschik H, Augustiniak H, Herrmann M, Jansen R, Steinmetz H, Gerth K, Kessler W, Kalesse M, Höfle G, Müller R.

Chemistry. 2012 May 14;18(20):6264-71. doi: 10.1002/chem.201100851. Epub 2012 Apr 4.

PMID:
22488821
10.

Isolation and total synthesis of icumazoles and noricumazoles--antifungal antibiotics and cation-channel blockers from Sorangium cellulosum.

Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B, Höfle G, Reichenbach H, Wegner J, Zeilinger C, Kirschning A, Müller R.

Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1256-60. doi: 10.1002/anie.201106435. Epub 2011 Dec 23. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6035.

PMID:
22213143
11.

[Prophylaxis and therapy of the glucocorticoid-induced osteoporosis - a review of recent guidelines].

Rintelen B, Bobacz K, Höfle G, Peichl P, Rainer F, Weber K, Gaugg M; (Arbeitsgruppe Osteologie der Österreichischen Gesellschaft für Rheumatologie und Rehabilitation – ÖGR).

Wien Klin Wochenschr. 2011 Nov;123(21-22):633-44. doi: 10.1007/s00508-011-0042-8. Epub 2011 Aug 25. Review. German.

PMID:
21858426
12.

Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition/macrolactonization.

Dehn R, Katsuyama Y, Weber A, Gerth K, Jansen R, Steinmetz H, Höfle G, Müller R, Kirschning A.

Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3882-7. doi: 10.1002/anie.201006880. Epub 2011 Mar 29. No abstract available.

PMID:
21472917
13.

Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part II): Total synthesis of gephyronic acid.

Anderl T, Nicolas L, Münkemer J, Baro A, Sasse F, Steinmetz H, Jansen R, Höfle G, Taylor RE, Laschat S.

Angew Chem Int Ed Engl. 2011 Jan 24;50(4):942-5. doi: 10.1002/anie.201005605. Epub 2010 Dec 29. No abstract available.

PMID:
21246697
14.

Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part I): Structural revision and stereochemical assignment of gephyronic acid.

Nicolas L, Anderl T, Sasse F, Steinmetz H, Jansen R, Höfle G, Laschat S, Taylor RE.

Angew Chem Int Ed Engl. 2011 Jan 24;50(4):938-41. doi: 10.1002/anie.201005530. Epub 2010 Dec 23. No abstract available.

PMID:
21246696
15.

The epothilones: an outstanding family of anti-tumor agents. General aspects.

Höfle G.

Fortschr Chem Org Naturst. 2009;90:5-28. No abstract available.

PMID:
19209839
16.

Biosynthesis of aurachins A-L in Stigmatella aurantiaca: a feeding study.

Höfle G, Kunze B.

J Nat Prod. 2008 Nov;71(11):1843-9. doi: 10.1021/np8003084. Epub 2008 Nov 6.

PMID:
18989924
17.

Isolation and biosynthesis of aurachin P and 5-nitroresorcinol from Stigmatella erecta.

Höfle G, Irschik H.

J Nat Prod. 2008 Nov;71(11):1946-8. doi: 10.1021/np800325z. Epub 2008 Nov 6.

PMID:
18986196
18.

Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E.

Höfle G, Bööhlendorf B, Fecker T, Sasse F, Kunze B.

J Nat Prod. 2008 Nov;71(11):1967-9. doi: 10.1021/np8004612. Epub 2008 Oct 15.

PMID:
18922036
19.

Pedein A and B: production, isolation, structure elucidation and biological properties of new antifungal cyclopeptides from Chondromyces pediculatus (Myxobacteria).

Kunze B, Böhlendorf B, Reichenbach H, Höfle G.

J Antibiot (Tokyo). 2008 Jan;61(1):18-26. doi: 10.1038/ja.2008.104.

PMID:
18305355
20.

The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected Gram-positive bacteria.

Irschik H, Reichenbach H, Höfle G, Jansen R.

J Antibiot (Tokyo). 2007 Dec;60(12):733-8. doi: 10.1038/ja.2007.95.

PMID:
18276996
21.

Discovery and development of the epothilones : a novel class of antineoplastic drugs.

Reichenbach H, Höfle G.

Drugs R D. 2008;9(1):1-10. Review.

PMID:
18095749
22.

Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525.

Gerth K, Steinmetz H, Höfle G, Jansen R.

Angew Chem Int Ed Engl. 2008;47(3):600-2. No abstract available.

PMID:
18058875
23.

Side-chain truncation of apicularen A by olefin cross-metathesis with ethylene.

Jundt L, Höfle G.

J Nat Prod. 2007 Aug;70(8):1377-9. Epub 2007 Aug 10.

PMID:
17691744
24.

Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.

Irschik H, Schummer D, Höfle G, Reichenbach H, Steinmetz H, Jansen R.

J Nat Prod. 2007 Jun;70(6):1060-3. Epub 2007 Jun 5.

PMID:
17547459
25.
26.
27.

Microtubule stabilizer ameliorates synaptic function and behavior in a mouse model for schizophrenia.

Andrieux A, Salin P, Schweitzer A, Bégou M, Pachoud B, Brun P, Gory-Fauré S, Kujala P, Suaud-Chagny MF, Höfle G, Job D.

Biol Psychiatry. 2006 Dec 1;60(11):1224-30. Epub 2006 Jun 27.

28.

Bisphosphonates routine in prevention of post-transplant osteoporosis?

Höfle G, Holzmüller H, Drexel H.

J Bone Miner Res. 2005 Aug;20(8):1482; author reply 1483. Epub 2005 Apr 18. No abstract available.

30.

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.

Yang CP, Verdier-Pinard P, Wang F, Lippaine-Horvath E, He L, Li D, Höfle G, Ojima I, Orr GA, Horwitz SB.

Mol Cancer Ther. 2005 Jun;4(6):987-95.

31.

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.

Heinz DW, Schubert WD, Höfle G.

Angew Chem Int Ed Engl. 2005 Feb 18;44(9):1298-301. No abstract available.

PMID:
15714588
32.
33.

Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.

Steinmetz H, Glaser N, Herdtweck E, Sasse F, Reichenbach H, Höfle G.

Angew Chem Int Ed Engl. 2004 Sep 20;43(37):4888-92. No abstract available.

PMID:
15372566
34.

Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum.

Bode HB, Wenzel SC, Irschik H, Höfle G, Müller R.

Angew Chem Int Ed Engl. 2004 Aug 13;43(32):4163-7. No abstract available.

PMID:
15307077
35.

Relationship between various measures of bone mineral density and vertebral fractures in cardiac transplant recipients.

Höfle G, Saely CH, Tautermann G, Aczél S, Holzmüller H, Drexel H.

Swiss Med Wkly. 2004 Apr 17;134(15-16):215-20.

PMID:
15190439
36.

Ajudazols, new inhibitors of the mitochondrial electron transport from Chondromyces crocatus. Production, antimicrobial activity and mechanism of action.

Kunze B, Jansen R, Höfle G, Reichenbach H.

J Antibiot (Tokyo). 2004 Feb;57(2):151-5. No abstract available.

37.

Sex-hormone-binding globulin is negatively correlated with femoral bone-mineral density in male cardiac-transplant recipients.

Höfle G, Tautermann G, Saely CH, Drexel H.

Wien Klin Wochenschr. 2004 Mar 31;116(5-6):170-5.

PMID:
15088991
38.

Delayed recovery.

Höfle G.

J Neurosurg. 2004 Apr;100(4 Suppl Spine):398; author reply 398-9. No abstract available.

PMID:
15070154
39.

Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties.

Sasse F, Leibold T, Kunze B, Höfle G, Reichenbach H.

J Antibiot (Tokyo). 2003 Oct;56(10):827-31.

40.

The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.

Bode HB, Irschik H, Wenzel SC, Reichenbach H, Müller R, Höfle G.

J Nat Prod. 2003 Sep;66(9):1203-6.

PMID:
14510597
41.
42.

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.

Köster M, Lykke-Andersen S, Elnakady YA, Gerth K, Washausen P, Höfle G, Sasse F, Kjems J, Hauser H.

Exp Cell Res. 2003 Jun 10;286(2):321-31.

PMID:
12749860
43.

Lower serum beta-CrossLaps in male cardiac transplant recipients treated without prednisolone.

Höfle G, Holzmüller H, Gouya G, Hergan K, Hubmann M, Langer P, Drexel H.

Transpl Int. 2003 Jul;16(7):523-8. Epub 2003 Apr 4.

PMID:
12677365
44.

SAR and pH stability of cyano-substituted epothilones.

Regueiro-Ren A, Leavitt K, Kim SH, Höfle G, Kiffe M, Gougoutas JZ, DiMarco JD, Lee FY, Fairchild CR, Long BH, Vite GD.

Org Lett. 2002 Oct 31;4(22):3815-8.

PMID:
12599466
45.

Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry.

Vollbrecht L, Steinmetz H, Hofle G, Oberer L, Rihs G, Bovermann G, von Matt P.

J Antibiot (Tokyo). 2002 Aug;55(8):715-21.

46.

Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties.

Sasse F, Steinmetz H, Schupp T, Petersen F, Memmert K, Hofmann H, Heusser C, Brinkmann V, von Matt P, Höfle G, Reichenbach H.

J Antibiot (Tokyo). 2002 Jun;55(6):543-51.

47.

A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria.

Mahmud T, Bode HB, Silakowski B, Kroppenstedt RM, Xu M, Nordhoff S, Höfle G, Müller R.

J Biol Chem. 2002 Sep 6;277(36):32768-74. Epub 2002 Jun 25.

48.

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase.

Gaitatzis N, Silakowski B, Kunze B, Nordsiek G, Blöcker H, Höfle G, Müller R.

J Biol Chem. 2002 Apr 12;277(15):13082-90. Epub 2002 Jan 23.

49.

Quinolones and their N-oxides as inhibitors of photosystem II and the cytochrome b(6)/f-complex.

Reil E, Höfle G, Draber W, Oettmeier W.

Biochim Biophys Acta. 2001 Aug 17;1506(2):127-32.

50.

New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.

Hardt IH, Steinmetz H, Gerth K, Sasse F, Reichenbach H, Höfle G.

J Nat Prod. 2001 Jul;64(7):847-56.

PMID:
11473410

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