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Items: 1 to 50 of 148

1.

Combining Conformational Profiling of GPCRs with CRISPR/Cas9 Gene Editing Approaches.

Bourque K, Devost D, Inoue A, Hébert TE.

Methods Mol Biol. 2019;1947:169-182. doi: 10.1007/978-1-4939-9121-1_9.

PMID:
30969416
2.

Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer.

Fillion D, Devost D, Sleno R, Inoue A, Hébert TE.

Front Endocrinol (Lausanne). 2019 Mar 18;10:162. doi: 10.3389/fendo.2019.00162. eCollection 2019.

3.

Measuring Recruitment of β-Arrestin to G Protein-Coupled Heterodimers Using Bioluminescence Resonance Energy Transfer.

Fillion D, Devost D, Hébert TE.

Methods Mol Biol. 2019;1957:83-91. doi: 10.1007/978-1-4939-9158-7_5.

PMID:
30919348
4.

Shaky ground - The nature of metastable GPCR signalling complexes.

Sleno R, Hébert TE.

Neuropharmacology. 2019 Jan 17. pii: S0028-3908(19)30021-8. doi: 10.1016/j.neuropharm.2019.01.018. [Epub ahead of print] Review.

PMID:
30659839
5.

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.

Merlino F, Billard É, Yousif AM, Di Maro S, Brancaccio D, Abate L, Carotenuto A, Bellavita R, d'Emmanuele di Villa Bianca R, Santicioli P, Marinelli L, Novellino E, Hébert TE, Lubell WD, Chatenet D, Grieco P.

J Med Chem. 2019 Feb 14;62(3):1455-1467. doi: 10.1021/acs.jmedchem.8b01601. Epub 2019 Jan 23.

PMID:
30615452
6.

Combining Optical Approaches with Human Inducible Pluripotent Stem Cells in G Protein-Coupled Receptor Drug Screening and Development.

Bourque K, Jones-Tabah J, Mnasri N, Martin RD, Hébert TE.

Biomolecules. 2018 Dec 18;8(4). pii: E180. doi: 10.3390/biom8040180. Review.

7.

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.

PMID:
30514808
8.

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.

O'Brien SL, Johnstone EKM, Devost D, Conroy J, Reichelt ME, Purdue BW, Ayoub MA, Kawai T, Inoue A, Eguchi S, Hébert TE, Pfleger KDG, Thomas WG.

Biochem Pharmacol. 2018 Dec;158:232-242. doi: 10.1016/j.bcp.2018.10.017. Epub 2018 Oct 19.

PMID:
30347205
9.

Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue.

Billard E, Hébert TE, Chatenet D.

J Med Chem. 2018 Oct 11;61(19):8707-8716. doi: 10.1021/acs.jmedchem.8b00789. Epub 2018 Sep 19.

PMID:
30183282
10.

New insights about the peculiar role of the 28-38 C-terminal segment and some selected residues in PACAP for signaling and neuroprotection.

Poujol de Molliens M, Létourneau M, Devost D, Hébert TE, Fournier A, Chatenet D.

Biochem Pharmacol. 2018 Aug;154:193-202. doi: 10.1016/j.bcp.2018.04.024. Epub 2018 Apr 25.

PMID:
29704474
11.

The Dynamics of GPCR Oligomerization and Their Functional Consequences.

Sleno R, Hébert TE.

Int Rev Cell Mol Biol. 2018;338:141-171. doi: 10.1016/bs.ircmb.2018.02.005. Epub 2018 Apr 7. Review.

PMID:
29699691
12.

Receptor- and cellular compartment-specific activation of the cAMP/PKA pathway by α1-adrenergic and ETA endothelin receptors.

Martin RD, Sun Y, Bourque K, Audet N, Inoue A, Tanny JC, Hébert TE.

Cell Signal. 2018 Apr;44:43-50. doi: 10.1016/j.cellsig.2018.01.002. Epub 2018 Jan 9.

PMID:
29329779
13.

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.

Douchez A, Billard E, Hébert TE, Chatenet D, Lubell WD.

J Med Chem. 2017 Dec 14;60(23):9838-9859. doi: 10.1021/acs.jmedchem.7b01525. Epub 2017 Dec 5.

PMID:
29131958
14.

Nucleoligands-repurposing G Protein-coupled Receptor Ligands to Modulate Nuclear-localized G Protein-coupled Receptors in the Cardiovascular System.

Audet N, Dabouz R, Allen BG, Hébert TE.

J Cardiovasc Pharmacol. 2018 Apr;71(4):193-204. doi: 10.1097/FJC.0000000000000535. Review.

PMID:
28858907
15.

Insight into the role of urotensin II-related peptide tyrosine residue in UT activation.

Billard E, Létourneau M, Hébert TE, Chatenet D.

Biochem Pharmacol. 2017 Nov 15;144:100-107. doi: 10.1016/j.bcp.2017.08.003. Epub 2017 Aug 4.

PMID:
28784291
16.

Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.

Sleno R, Devost D, Pétrin D, Zhang A, Bourque K, Shinjo Y, Aoki J, Inoue A, Hébert TE.

J Biol Chem. 2017 Jul 21;292(29):12139-12152. doi: 10.1074/jbc.M117.793877. Epub 2017 Jun 5.

17.

Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors.

Bourque K, Pétrin D, Sleno R, Devost D, Zhang A, Hébert TE.

Front Endocrinol (Lausanne). 2017 Apr 7;8:61. doi: 10.3389/fendo.2017.00061. eCollection 2017.

18.

Understanding GPCR signaling in the brain- the path to CNS drug discovery.

Chatenet D, Hébert TE.

Curr Opin Pharmacol. 2017 Feb;32:v-vii. doi: 10.1016/j.coph.2017.03.001. No abstract available.

PMID:
28417881
19.

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.

Devost D, Sleno R, Pétrin D, Zhang A, Shinjo Y, Okde R, Aoki J, Inoue A, Hébert TE.

J Biol Chem. 2017 Mar 31;292(13):5443-5456. doi: 10.1074/jbc.M116.763854. Epub 2017 Feb 17.

20.

VCP/p97 regulates β2AR quality control during receptor biosynthesis.

Wargachuk R, Glazkova I, Audet N, Pétrin D, Trieu P, Hébert TE.

Cell Signal. 2017 Jan;30:50-58. doi: 10.1016/j.cellsig.2016.11.015. Epub 2016 Nov 22.

PMID:
27887991
21.

PPIP5K1 Suppresses Etoposide-triggered Apoptosis.

Machkalyan G, Hèbert TE, Miller GJ.

J Mol Signal. 2016 Nov 23;11:4. doi: 10.5334/1750-2187-11-4.

22.

Measuring G protein-coupled receptor signalling in the brain with resonance energy transfer based biosensors.

Jones-Tabah J, Clarke PB, Hébert TE.

Curr Opin Pharmacol. 2017 Feb;32:44-48. doi: 10.1016/j.coph.2016.10.008. Epub 2016 Nov 9. Review.

PMID:
27837687
23.

Mass spectrometry analysis of PPIP5K1 interactions and data on cell motility of PPIP5K1-deficient cells.

Machkalyan G, Trieu P, Pétrin D, Hébert TE, Miller GJ.

Data Brief. 2016 Apr 2;7:1443-1446. eCollection 2016 Jun.

24.

The Louis and Artur Lucian Award in Cardiovascular Diseases at McGill University.

Genest J, Hébert TE, Martin J.

Circ Res. 2016 Oct 14;119(9):975-977. No abstract available.

PMID:
27737939
25.

Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.

Génier S, Degrandmaison J, Moreau P, Labrecque P, Hébert TE, Parent JL.

Mol Biol Cell. 2016 Dec 1;27(24):3800-3812. Epub 2016 Oct 5.

26.

Gβγ subunits-Different spaces, different faces.

Khan SM, Sung JY, Hébert TE.

Pharmacol Res. 2016 Sep;111:434-441. doi: 10.1016/j.phrs.2016.06.026. Epub 2016 Jul 1. Review.

PMID:
27378564
27.

Cellular and subcellular context determine outputs from signaling biosensors.

Devost D, Audet N, Zhou C, Kobayashi H, Bonin H, Lukashova V, Le Gouill C, Bouvier M, Hébert TE.

Methods Cell Biol. 2016;132:319-37. doi: 10.1016/bs.mcb.2015.11.010. Epub 2016 Jan 29.

PMID:
26928550
28.

Tracking GPCR biosynthesis and degradation using a nonradioactive pulse chase methodology.

Wargachuk R, Devost D, Zhou C, Hébert TE.

Methods Cell Biol. 2016;132:217-31. doi: 10.1016/bs.mcb.2015.11.011. Epub 2016 Jan 28.

PMID:
26928546
29.

PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.

Machkalyan G, Trieu P, Pétrin D, Hébert TE, Miller GJ.

Cell Signal. 2016 May;28(5):401-411. doi: 10.1016/j.cellsig.2016.02.002. Epub 2016 Feb 16.

PMID:
26854614
30.

Biasing the odds: Approaches to capturing, understanding and exploiting functional selectivity in GPCRs.

Hébert TE.

Methods. 2016 Jan 1;92:1-4. doi: 10.1016/j.ymeth.2015.09.024. Epub 2015 Sep 26. Review.

PMID:
26416495
31.

GPCR Retreat 2014: a good view leads to many discoveries!

Chidiac P, Hébert TE.

J Recept Signal Transduct Res. 2015 Jun;35(3):208-12. doi: 10.3109/10799893.2015.1072977. Epub 2015 Sep 14.

PMID:
26366680
32.

Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.

Chabot-Doré AJ, Millecamps M, Naso L, Devost D, Trieu P, Piltonen M, Diatchenko L, Fairbanks CA, Wilcox GL, Hébert TE, Stone LS.

Neuropharmacology. 2015 Dec;99:285-300. doi: 10.1016/j.neuropharm.2015.08.010. Epub 2015 Aug 6.

33.

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels.

Robertson DN, Sleno R, Nagi K, Pétrin D, Hébert TE, Pineyro G.

Methods. 2016 Jan 1;92:19-35. doi: 10.1016/j.ymeth.2015.07.011. Epub 2015 Jul 22.

PMID:
26210401
34.

Designing BRET-based conformational biosensors for G protein-coupled receptors.

Sleno R, Pétrin D, Devost D, Goupil E, Zhang A, Hébert TE.

Methods. 2016 Jan 1;92:11-8. doi: 10.1016/j.ymeth.2015.05.003. Epub 2015 May 8.

PMID:
25962643
35.

Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

Khan SM, Min A, Gora S, Houranieh GM, Campden R, Robitaille M, Trieu P, Pétrin D, Jacobi AM, Behlke MA, Angers S, Hébert TE.

Cell Signal. 2015 Aug;27(8):1597-608. doi: 10.1016/j.cellsig.2015.04.007. Epub 2015 Apr 23.

PMID:
25916507
36.

The interaction between delayed rectifier channel alpha-subunits does not involve hetero-tetramer formation.

Biliczki P, Rüdiger A, Girmatsion Z, Pourrier M, Mamarbachi AM, Hébert TE, Brandes RP, Hohnloser SH, Nattel S, Ehrlich JR.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep;388(9):973-81. doi: 10.1007/s00210-015-1108-3. Epub 2015 Mar 20.

PMID:
25790957
37.

Nuclear G protein signaling: new tricks for old dogs.

Campden R, Audet N, Hébert TE.

J Cardiovasc Pharmacol. 2015 Feb;65(2):110-22. doi: 10.1097/FJC.0000000000000198. Review.

PMID:
25590750
38.

Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.

Goupil E, Fillion D, Clément S, Luo X, Devost D, Sleno R, Pétrin D, Saragovi HU, Thorin É, Laporte SA, Hébert TE.

J Biol Chem. 2015 Jan 30;290(5):3137-48. doi: 10.1074/jbc.M114.631119. Epub 2014 Dec 15.

39.

Photoreleasable ligands to study intracrine angiotensin II signalling.

Tadevosyan A, Létourneau M, Folch B, Doucet N, Villeneuve LR, Mamarbachi AM, Pétrin D, Hébert TE, Fournier A, Chatenet D, Allen BG, Nattel S.

J Physiol. 2015 Feb 1;593(3):521-39. doi: 10.1113/jphysiol.2014.279109. Epub 2015 Jan 7.

40.

Examining the effects of nuclear GPCRs on gene expression using isolated nuclei.

Vaniotis G, Gora S, Nantel A, Hébert TE, Allen BG.

Methods Mol Biol. 2015;1234:185-95. doi: 10.1007/978-1-4939-1755-6_15.

PMID:
25304357
41.

Tandem affinity purification to identify cytosolic and nuclear gβγ-interacting proteins.

Campden R, Pétrin D, Robitaille M, Audet N, Gora S, Angers S, Hébert TE.

Methods Mol Biol. 2015;1234:161-84. doi: 10.1007/978-1-4939-1755-6_14.

PMID:
25304356
42.

Rebuttal from Michel Bouvier and Terence E. Hébert.

Bouvier M, Hébert TE.

J Physiol. 2014 Jun 15;592(12):2447. doi: 10.1113/jphysiol.2014.274233. No abstract available.

43.

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers.

Bouvier M, Hébert TE.

J Physiol. 2014 Jun 15;592(12):2439-41. doi: 10.1113/jphysiol.2014.272252. No abstract available.

44.

Kir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking.

Zylbergold P, Sleno R, Khan SM, Jacobi AM, Belhke MA, Hébert TE.

Front Cell Neurosci. 2014 Apr 14;8:108. doi: 10.3389/fncel.2014.00108. eCollection 2014.

45.

Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.

Wang Y, Ho CC, Bang E, Rejon CA, Libasci V, Pertchenko P, Hébert TE, Bernard DJ.

Endocrinology. 2014 May;155(5):1970-81. doi: 10.1210/en.2013-1741. Epub 2014 Mar 6.

PMID:
24601881
46.

A simple method to detect allostery in GPCR dimers.

Goupil E, Laporte SA, Hébert TE.

Methods Cell Biol. 2013;117:165-79. doi: 10.1016/B978-0-12-408143-7.00009-8.

PMID:
24143977
47.

Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells.

Rejon CA, Hancock MA, Li YN, Thompson TB, Hébert TE, Bernard DJ.

Cell Signal. 2013 Dec;25(12):2717-26. doi: 10.1016/j.cellsig.2013.09.002. Epub 2013 Sep 7.

PMID:
24018044
48.

Intradialytic clearance of opioids: methadone versus hydromorphone.

Perlman R, Giladi H, Brecht K, Ware MA, Hebert TE, Joseph L, Shir Y.

Pain. 2013 Dec;154(12):2794-800. doi: 10.1016/j.pain.2013.08.015. Epub 2013 Aug 20.

PMID:
23973378
49.

Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.

Roy SJ, Glazkova I, Fréchette L, Iorio-Morin C, Binda C, Pétrin D, Trieu P, Robitaille M, Angers S, Hébert TE, Parent JL.

Mol Endocrinol. 2013 Aug;27(8):1245-66. doi: 10.1210/me.2013-1091. Epub 2013 Jun 24.

50.

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.

Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve LR, Chatenet D, Therien M, Fournier A, Tadevosyan A, Trieu P, Nattel S, Hébert TE, Allen BG.

J Mol Cell Cardiol. 2013 Sep;62:58-68. doi: 10.1016/j.yjmcc.2013.05.003. Epub 2013 May 17.

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