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Items: 1 to 50 of 68

1.

Sex as a determinant of type 1 diabetes at diagnosis.

Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Jun 3. doi: 10.1111/pedi.12697. [Epub ahead of print]

PMID:
29862628
2.

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.

Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.

Sci Rep. 2018 Apr 12;8(1):5883. doi: 10.1038/s41598-018-24019-5.

3.

Seroprevalence for Brucella spp. in Baltic ringed seals (Phoca hispida) and East Greenland harp (Pagophilus groenlandicus) and hooded (Cystophora cristata) seals.

Sonne C, Andersen-Ranberg E, Rajala EL, Agerholm JS, Bonefeld-Jørgensen E, Desforges JP, Eulaers I, Jenssen BM, Koch A, Rosing-Asvid A, Siebert U, Tryland M, Mulvad G, Härkönen T, Acquarone M, Nordøy ES, Dietz R, Magnusson U.

Vet Immunol Immunopathol. 2018 Apr;198:14-18. doi: 10.1016/j.vetimm.2018.02.005. Epub 2018 Feb 12.

PMID:
29571513
4.

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

PMID:
29300921
5.

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes.

Parkkola A, Laine AP, Karhunen M, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

PLoS One. 2017 Nov 28;12(11):e0188402. doi: 10.1371/journal.pone.0188402. eCollection 2017.

6.

Early life origin of type 1 diabetes.

Knip M, Luopajärvi K, Härkönen T.

Semin Immunopathol. 2017 Nov;39(6):653-667. doi: 10.1007/s00281-017-0665-6. Epub 2017 Nov 23. Review.

PMID:
29170800
7.

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members.

Parkkola A, Härkönen T, Ryhänen SJ, Uibo R, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):305-313. doi: 10.1111/pedi.12563. Epub 2017 Jul 26.

PMID:
28745034
8.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Zhao G, Vatanen T, Droit L, Park A, Kostic AD, Poon TW, Vlamakis H, Siljander H, Härkönen T, Hämäläinen AM, Peet A, Tillmann V, Ilonen J, Wang D, Knip M, Xavier RJ, Virgin HW.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6166-E6175. doi: 10.1073/pnas.1706359114. Epub 2017 Jul 10.

9.

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Hyytinen M, Savilahti E, Virtanen SM, Härkönen T, Ilonen J, Luopajärvi K, Uibo R, Vaarala O, Åkerblom HK, Knip M; Finnish TRIGR Pilot Study Group.

Gastroenterology. 2017 Oct;153(4):961-970.e3. doi: 10.1053/j.gastro.2017.06.049. Epub 2017 Jul 5.

PMID:
28687275
10.

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Ilonen J, Hyöty H, Knip M; DIABIMMUNE Study Group.

Pediatr Diabetes. 2018 Mar;19(2):293-299. doi: 10.1111/pedi.12547. Epub 2017 Jun 9.

PMID:
28597957
11.

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Ilonen J, Lempainen J, Hammais A, Laine AP, Härkönen T, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):284-292. doi: 10.1111/pedi.12545. Epub 2017 Jun 9.

PMID:
28597949
12.

Antarctic seals: Molecular biomarkers as indicators for pollutant exposure, health effects and diet.

Lehnert K, Weirup L, Harding KC, Härkönen T, Karlsson O, Teilmann J.

Sci Total Environ. 2017 Dec 1;599-600:1693-1704. doi: 10.1016/j.scitotenv.2017.04.224. Epub 2017 May 19.

PMID:
28535598
13.

The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.

HLA. 2017 Apr;89(4):215-224. doi: 10.1111/tan.12967. Epub 2017 Feb 10.

PMID:
28185422
14.

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M.

Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2872. Epub 2017 Jan 23.

PMID:
27883367
15.

Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study.

Simre K, Uibo O, Peet A, Tillmann V, Kool P, Hämäläinen AM, Härkönen T, Siljander H, Virtanen S, Ilonen J, Knip M, Uibo R; DIABIMMUNE Study Group.

Dig Liver Dis. 2016 Nov;48(11):1296-1301. doi: 10.1016/j.dld.2016.06.029. Epub 2016 Jul 6.

PMID:
27499360
16.

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes.

Galli E, Härkönen T, Sainio MT, Ustav M, Toots U, Urtti A, Yliperttula M, Lindahl M, Knip M, Saarma M, Lindholm P.

Sci Rep. 2016 Jun 30;6:29058. doi: 10.1038/srep29058.

17.

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.

Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M; DIABIMMUNE Study Group, Xavier RJ.

Sci Transl Med. 2016 Jun 15;8(343):343ra81. doi: 10.1126/scitranslmed.aad0917.

18.

Spatiotemporal Analysis of the Genetic Diversity of Seal Influenza A(H10N7) Virus, Northwestern Europe.

Bodewes R, Zohari S, Krog JS, Hall MD, Harder TC, Bestebroer TM, van de Bildt MWG, Spronken MI, Larsen LE, Siebert U, Wohlsein P, Puff C, Seehusen F, Baumgärtner W, Härkönen T, Smits SL, Herfst S, Osterhaus ADME, Fouchier RAM, Koopmans MP, Kuiken T.

J Virol. 2016 Apr 14;90(9):4269-4277. doi: 10.1128/JVI.03046-15. Print 2016 May.

19.

Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes.

Juusola M, Parkkola A, Härkönen T, Siljander H, Ilonen J, Åkerblom HK, Knip M; Childhood Diabetes in Finland Study Group.

Diabetes Care. 2016 Jan;39(1):118-21. doi: 10.2337/dc15-1027. Epub 2015 Oct 30.

20.

Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies.

Wiberg A, Granstam A, Ingvast S, Härkönen T, Knip M, Korsgren O, Skog O.

Clin Exp Immunol. 2015 Dec;182(3):278-88. doi: 10.1111/cei.12698. Epub 2015 Oct 6.

21.

Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Borg DJ, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M.

Diabetes Care. 2015 Apr;38(4):665-70. doi: 10.2337/dc14-1186. Epub 2015 Jan 8.

PMID:
25573878
22.

Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans.

Reinert-Hartwall L, Honkanen J, Salo HM, Nieminen JK, Luopajärvi K, Härkönen T, Veijola R, Simell O, Ilonen J, Peet A, Tillmann V, Knip M, Vaarala O; DIABIMMUNE Study Group; DIABIMMUNE Study Group.

J Immunol. 2015 Jan 1;194(1):68-75. doi: 10.4049/jimmunol.1401653. Epub 2014 Dec 5.

23.

Avian influenza A(H10N7) virus involvement in mass mortality of harbour seals (Phoca vitulina) in Sweden, March through October 2014.

Zohari S, Neimanis A, Härkönen T, Moraeus C, Valarcher JF.

Euro Surveill. 2014 Nov 20;19(46). pii: 20967.

24.

Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype.

El-Amir MI, El-Feky MA, Laine AP, Härkönen T, El-Badawy O, Eltayeb AA, El-Melegy TT, Kiviniemi M, Knip M, Ilonen J.

Diabetes Metab Res Rev. 2015 Mar;31(3):287-94. doi: 10.1002/dmrr.2609. Epub 2014 Nov 24.

PMID:
25256132
25.

Standard of hygiene and immune adaptation in newborn infants.

Kallionpää H, Laajala E, Öling V, Härkönen T, Tillmann V, Dorshakova NV, Ilonen J, Lähdesmäki H, Knip M, Lahesmaa R; DIABIMMUNE Study Group.

Clin Immunol. 2014 Nov;155(1):136-47. doi: 10.1016/j.clim.2014.09.009. Epub 2014 Sep 22.

26.

Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Laine AP, Groop PH, Knip M; Finnish Pediatric Diabetes Register.

Diabetes Care. 2014 Jul;37(7):1975-81. doi: 10.2337/dc13-3049. Epub 2014 Apr 17.

PMID:
24742661
27.

No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children.

Reinert-Hartwall L, Honkanen J, Härkönen T, Ilonen J, Simell O, Peet A, Tillmann V, Lamberg-Allardt C, Virtanen SM, Knip M, Vaarala O; DIABIMMUNE Study Group.

Diabetes Metab Res Rev. 2014 Nov;30(8):749-60. doi: 10.1002/dmrr.2550.

PMID:
24692218
28.

Integrating genetic data and population viability analyses for the identification of harbour seal (Phoca vitulina) populations and management units.

Olsen MT, Andersen LW, Dietz R, Teilmann J, Härkönen T, Siegismund HR.

Mol Ecol. 2014 Feb;23(4):815-31. doi: 10.1111/mec.12644.

PMID:
24382213
29.

The HLA-B*39 allele increases type 1 diabetes risk conferred by HLA-DRB1*04:04-DQB1*03:02 and HLA-DRB1*08-DQB1*04 class II haplotypes.

Mikk ML, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Simell O, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.

Hum Immunol. 2014 Jan;75(1):65-70. doi: 10.1016/j.humimm.2013.09.008. Epub 2013 Sep 19.

PMID:
24055898
30.

Autoantibodies against zinc transporter 8 are related to age, metabolic state and HLA DR genotype in children with newly diagnosed type 1 diabetes.

Salonen KM, Ryhänen S, Härkönen T, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Diabetes Metab Res Rev. 2013 Nov;29(8):646-54. doi: 10.1002/dmrr.2440.

PMID:
23861236
31.

Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies.

Lempainen J, Härkönen T, Laine A, Knip M, Ilonen J; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2013 Nov;14(7):490-6. doi: 10.1111/pedi.12046. Epub 2013 May 31.

PMID:
23721563
32.

Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes.

Parkkola A, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Eur J Endocrinol. 2013 Jun 29;169(2):171-8. doi: 10.1530/EJE-13-0089. Print 2013 Aug.

33.

Fecal microbiota composition differs between children with β-cell autoimmunity and those without.

de Goffau MC, Luopajärvi K, Knip M, Ilonen J, Ruohtula T, Härkönen T, Orivuori L, Hakala S, Welling GW, Harmsen HJ, Vaarala O.

Diabetes. 2013 Apr;62(4):1238-44. doi: 10.2337/db12-0526. Epub 2012 Dec 28.

34.

Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes.

Andersen MK, Härkönen T, Forsblom C, Groop PH, Knip M, Tuomi T.

Autoimmunity. 2013 Jun;46(4):251-8. doi: 10.3109/08916934.2012.741155. Epub 2013 Jan 10.

PMID:
23194113
35.

Extended family history of type 1 diabetes and phenotype and genotype of newly diagnosed children.

Parkkola A, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Diabetes Care. 2013 Feb;36(2):348-54. doi: 10.2337/dc12-0445. Epub 2012 Oct 1.

36.

Collapse of a marine mammal species driven by human impacts.

Harkonen T, Harding KC, Wilson S, Baimukanov M, Dmitrieva L, Svensson CJ, Goodman SJ.

PLoS One. 2012;7(9):e43130. doi: 10.1371/journal.pone.0043130. Epub 2012 Sep 19.

37.

Linking climate trends to population dynamics in the Baltic ringed seal: impacts of historical and future winter temperatures.

Sundqvist L, Harkonen T, Svensson CJ, Harding KC.

Ambio. 2012 Dec;41(8):865-72. doi: 10.1007/s13280-012-0334-x. Epub 2012 Aug 1.

38.

Altered phenotype of peripheral blood dendritic cells in pediatric type 1 diabetes.

Nieminen JK, Vakkila J, Salo HM, Ekström N, Härkönen T, Ilonen J, Knip M, Vaarala O.

Diabetes Care. 2012 Nov;35(11):2303-10. doi: 10.2337/dc11-2460. Epub 2012 Jul 11.

39.

Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study.

Vaarala O, Ilonen J, Ruohtula T, Pesola J, Virtanen SM, Härkönen T, Koski M, Kallioinen H, Tossavainen O, Poussa T, Järvenpää AL, Komulainen J, Lounamaa R, Akerblom HK, Knip M.

Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):608-14. doi: 10.1001/archpediatrics.2011.1559.

PMID:
22393174
40.

Metabolic regulation in progression to autoimmune diabetes.

Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M.

PLoS Comput Biol. 2011 Oct;7(10):e1002257. doi: 10.1371/journal.pcbi.1002257. Epub 2011 Oct 27.

41.

Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes.

Ryhänen SJ, Härkönen T, Siljander H, Näntö-Salonen K, Simell T, Hyöty H, Ilonen J, Veijola R, Simell O, Knip M.

Diabetes Care. 2011 Jun;34(6):1383-8. doi: 10.2337/dc10-1449. Epub 2011 Apr 22.

42.

Detecting density dependence in recovering seal populations.

Svensson CJ, Eriksson A, Harkonen T, Harding KC.

Ambio. 2011 Feb;40(1):52-9.

43.

Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility.

Siljander H, Härkönen T, Hermann R, Simell S, Hekkala A, Salonsaari RT, Simell T, Simell O, Ilonen J, Veijola R, Knip M.

Diabetes Metab Res Rev. 2009 Oct;25(7):615-22. doi: 10.1002/dmrr.998.

PMID:
19637309
44.

Pup production and breeding distribution of the Caspian seal (Phoca caspica) in relation to human impacts.

Harkonen T, Jüssi M, Baimukanov M, Bignert A, Dmitrieva L, Kasimbekov Y, Verevkin M, Wilson S, Goodman SJ.

Ambio. 2008 Jul;37(5):356-61.

PMID:
18828281
45.

Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.

Mäkinen A, Härkönen T, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Eur J Endocrinol. 2008 Jul;159(1):19-26. doi: 10.1530/EJE-07-0853.

46.

Decreasing ice coverage will reduce the breeding success of Baltic grey seal (Halichoerus grypus) females.

Jüssi M, Härkönen T, Helle E, Jüssi I.

Ambio. 2008 Mar;37(2):80-5.

PMID:
18488549
47.

Mass mortality in harbour seals and harbour porpoises caused by an unknown pathogen.

Harkonen T, Bäcklin BM, Barrett T, Bergman A, Corteyn M, Dietz R, Harding KC, Malmsten J, Roos A, Teilmann J.

Vet Rec. 2008 Apr 26;162(17):555-6. No abstract available.

PMID:
18441352
48.

Seasonal activity budget of adult baltic ringed seals.

Harkonen T, Jüssi M, Jüssi I, Verevkin M, Dmitrieva L, Helle E, Sagitov R, Harding KC.

PLoS One. 2008 Apr 16;3(4):e2006. doi: 10.1371/journal.pone.0002006.

49.

Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis.

Aberg L, Talling M, Härkönen T, Lönnqvist T, Knip M, Alen R, Rantala H, Tyynelä J.

Neurology. 2008 Apr 1;70(14):1218-20. doi: 10.1212/01.wnl.0000307753.88839.29. No abstract available.

PMID:
18378887
50.

Phocid seals, seal lice and heartworms: a terrestrial host-parasite system conveyed to the marine environment.

Leidenberger S, Harding K, Härkönen T.

Dis Aquat Organ. 2007 Oct 15;77(3):235-53. Review.

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