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Items: 1 to 50 of 177

1.

Validation of the Zung self-rating depression scale (SDS) in older adults.

Jokelainen J, Timonen M, Keinänen-Kiukaanniemi S, Härkönen P, Jurvelin H, Suija K.

Scand J Prim Health Care. 2019 Sep;37(3):353-357. doi: 10.1080/02813432.2019.1639923. Epub 2019 Jul 9.

2.

Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model.

Kähkönen TE, Tuomela JM, Grönroos TJ, Halleen JM, Ivaska KK, Härkönen PL.

J Bone Oncol. 2019 Mar 19;16:100232. doi: 10.1016/j.jbo.2019.100232. eCollection 2019 Jun.

3.

Alendronate-induced disruption of actin cytoskeleton and inhibition of migration/invasion are associated with cofilin downregulation in PC-3 prostate cancer cells.

Virtanen SS, Ishizu T, Sandholm JA, Löyttyniemi E, Väänänen HK, Tuomela JM, Härkönen PL.

Oncotarget. 2018 Aug 24;9(66):32593-32608. doi: 10.18632/oncotarget.25961. eCollection 2018 Aug 24.

4.

Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease.

Saukkonen T, Mutt SJ, Jokelainen J, Saukkonen AM, Raza GS, Karhu T, Härkönen P, Eckel J, Herzig KH, Rajala U, Keinänen-Kiukaanniemi S.

Sci Rep. 2018 Aug 24;8(1):12816. doi: 10.1038/s41598-018-31144-8.

5.

SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells.

Polari L, Wiklund A, Sousa S, Kangas L, Linnanen T, Härkönen P, Määttä J.

Inflammation. 2018 Aug;41(4):1157-1171. doi: 10.1007/s10753-018-0763-1.

6.

Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes.

Kähkönen TE, Ivaska KK, Jiang M, Büki KG, Väänänen HK, Härkönen PL.

Mol Cell Endocrinol. 2018 Feb 5;461:194-204. doi: 10.1016/j.mce.2017.09.015. Epub 2017 Sep 18.

PMID:
28923346
7.

Oncolytic alphavirus SFV-VA7 efficiently eradicates subcutaneous and orthotopic human prostate tumours in mice.

Martikainen M, Ruotsalainen J, Tuomela J, Härkönen P, Essand M, Heikkilä J, Hinkkanen A.

Br J Cancer. 2017 Jun 27;117(1):51-55. doi: 10.1038/bjc.2017.151. Epub 2017 May 30.

8.

Alcohol Consumption and Binge Drinking in Young Men as Predictors of Body Composition Changes During Military Service.

Hagnäs MP, Jokelainen J, Cederberg-Tamminen H, Niemelä S, Mikkola I, Härkönen P, Rajala U, Keinänen-Kiukaanniemi S.

Alcohol Alcohol. 2017 May 1;52(3):365-371. doi: 10.1093/alcalc/agx002.

PMID:
28430930
9.

Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors.

Uusitalo E, Kallionpää RA, Kurki S, Rantanen M, Pitkäniemi J, Kronqvist P, Härkönen P, Huovinen R, Carpen O, Pöyhönen M, Peltonen S, Peltonen J.

Br J Cancer. 2017 Jan 17;116(2):211-217. doi: 10.1038/bjc.2016.403. Epub 2016 Dec 8.

10.

Toll-like receptor 9 expression is associated with breast cancer sensitivity to the growth inhibitory effects of bisphosphonates in vitro and in vivo.

Sandholm J, Lehtimäki J, Ishizu T, Velu SE, Clark J, Härkönen P, Jukkola-Vuorinen A, Schrey A, Harris KW, Tuomela JM, Selander KS.

Oncotarget. 2016 Dec 27;7(52):87373-87389. doi: 10.18632/oncotarget.13570.

11.

Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo.

Eigeliene N, Kangas L, Hellmer C, Kauko T, Erkkola R, Härkönen P.

Menopause. 2016 Jul;23(7):719-30. doi: 10.1097/GME.0000000000000624.

PMID:
27163517
12.

Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density.

Määttä JA, Bendre A, Laanti M, Büki KG, Rantakari P, Tervola P, Saarimäki J, Poutanen M, Härkönen P, Väänänen K.

Bonekey Rep. 2016 Apr 6;5:787. doi: 10.1038/bonekey.2016.14. eCollection 2016.

13.

Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy.

Yu L, Toriseva M, Tuomala M, Seikkula H, Elo T, Tuomela J, Kallajoki M, Mirtti T, Taimen P, Boström PJ, Alanen K, Nurmi M, Nees M, Härkönen P.

Int J Cancer. 2016 Jul 1;139(1):140-52. doi: 10.1002/ijc.30048. Epub 2016 Mar 12.

14.

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

Valta MP, Zhao H, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimäki J, Härkönen P, Coleman I, Nelson PS, Corey E, Peehl DM.

Clin Exp Metastasis. 2016 Apr;33(4):325-37. doi: 10.1007/s10585-016-9781-2. Epub 2016 Feb 12.

PMID:
26873136
15.

Comparison of the Effects of the Selective Estrogen Receptor Modulators Ospemifene, Raloxifene, and Tamoxifen on Breast Tissue in Ex Vivo Culture.

Eigeliene N, Erkkola R, Härkönen P.

Methods Mol Biol. 2016;1366:327-336. doi: 10.1007/978-1-4939-3127-9_25.

PMID:
26585146
16.

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.

Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Härkönen P, Koskinen PJ.

PLoS One. 2015 Jun 15;10(6):e0130340. doi: 10.1371/journal.pone.0130340. eCollection 2015.

17.

Induction of morphological changes in death-induced cancer cells monitored by holographic microscopy.

El-Schich Z, Mölder A, Tassidis H, Härkönen P, Falck Miniotis M, Gjörloff Wingren A.

J Struct Biol. 2015 Mar;189(3):207-12. doi: 10.1016/j.jsb.2015.01.010. Epub 2015 Jan 28.

PMID:
25637284
18.

The association between erectile dysfunction, depressive symptoms and testosterone levels among middle-aged men.

Suija K, Kerkelä M, Rajala U, Jokelainen J, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Timonen M.

Scand J Public Health. 2014 Nov;42(7):677-82. doi: 10.1177/1403494814545103. Epub 2014 Aug 11.

PMID:
25114066
19.

Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.

Virtanen SS, Kukkonen-Macchi A, Vainio M, Elima K, Härkönen PL, Jalkanen S, Yegutkin GG.

Mol Cancer Res. 2014 Dec;12(12):1863-74. doi: 10.1158/1541-7786.MCR-14-0302-T. Epub 2014 Jul 30.

20.

The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.

Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98. doi: 10.1073/pnas.1405801111. Epub 2014 Jul 28.

21.

Deficiency of ERβ and prostate tumorigenesis in FGF8b transgenic mice.

Elo T, Yu L, Valve E, Mäkelä S, Härkönen P.

Endocr Relat Cancer. 2014 Aug;21(4):677-90. doi: 10.1530/ERC-13-0480. Epub 2014 Jun 17.

PMID:
24938408
22.

Tumor models for prostate cancer exemplified by fibroblast growth factor 8-induced tumorigenesis and tumor progression.

Tuomela J, Härkönen P.

Reprod Biol. 2014 Mar;14(1):16-24. doi: 10.1016/j.repbio.2014.01.002. Epub 2014 Jan 21. Review.

PMID:
24607251
23.

Effects of ospemifene on breast tissue morphology and proliferation: a comparative study versus other selective estrogen receptor modulators in ovariectomized rats.

Kangas L, Härkönen P, Väänänen K, Keskitalo J, Eigéliené N.

Horm Metab Res. 2014 May;46(5):328-32. doi: 10.1055/s-0034-1367032. Epub 2014 Feb 13.

PMID:
24526372
24.

Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice.

Määttä JA, Büki KG, Ivaska KK, Nieminen-Pihala V, Elo TD, Kähkönen T, Poutanen M, Härkönen P, Väänänen K.

Bonekey Rep. 2013 Nov 6;2:440. doi: 10.1038/bonekey.2013.174. eCollection 2013.

25.

Effects of the selective estrogen receptor modulator ospemifene on bone in rats.

Kangas L, Härkönen P, Väänänen K, Peng Z.

Horm Metab Res. 2014 Jan;46(1):27-35. doi: 10.1055/s-0033-1355356. Epub 2013 Oct 9.

PMID:
24108389
26.

Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer.

Syed Khaja AS, Dizeyi N, Kopparapu PK, Anagnostaki L, Härkönen P, Persson JL.

PLoS One. 2013 Aug 8;8(8):e72210. doi: 10.1371/journal.pone.0072210. eCollection 2013.

27.

Novel interaction of Rab13 and Rab8 with endospanins.

Hirvonen MJ, Büki KG, Sun Y, Mulari MT, Härkönen PL, Väänänen KH.

FEBS Open Bio. 2013 Jan 22;3:83-8. doi: 10.1016/j.fob.2013.01.004. Print 2013.

28.

Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.

Tassidis H, Brokken LJ, Jirström K, Bjartell A, Ulmert D, Härkönen P, Wingren AG.

Tumour Biol. 2013 Apr;34(2):637-42. doi: 10.1007/s13277-012-0590-1. Epub 2012 Nov 29.

PMID:
23192641
29.

Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.

Tarkkonen KM, Nilsson EM, Kähkönen TE, Dey JH, Heikkilä JE, Tuomela JM, Liu Q, Hynes NE, Härkönen PL.

PLoS One. 2012;7(11):e49970. doi: 10.1371/journal.pone.0049970. Epub 2012 Nov 21.

30.

Validation of the Whooley questions and the Beck Depression Inventory in older adults.

Suija K, Rajala U, Jokelainen J, Liukkonen T, Härkönen P, Keinänen-Kiukaanniemi S, Timonen M.

Scand J Prim Health Care. 2012 Dec;30(4):259-64. doi: 10.3109/02813432.2012.732473. Epub 2012 Oct 31.

31.

Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice.

Määttä JA, Büki KG, Gu G, Alanne MH, Vääräniemi J, Liljenbäck H, Poutanen M, Härkönen P, Väänänen K.

FASEB J. 2013 Feb;27(2):478-88. doi: 10.1096/fj.12-213587. Epub 2012 Oct 16.

PMID:
23073829
32.

Reduction in metabolic syndrome among obese young men is associated with exercise-induced body composition changes during military service.

Hagnäs MP, Cederberg H, Mikkola I, Ikäheimo TM, Jokelainen J, Laakso M, Härkönen P, Peitso A, Rajala U, Keinänen-Kiukaanniemi S.

Diabetes Res Clin Pract. 2012 Nov;98(2):312-9. doi: 10.1016/j.diabres.2012.09.009. Epub 2012 Sep 23.

PMID:
23010560
33.

Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer.

Tuomela J, Sandholm J, Karihtala P, Ilvesaro J, Vuopala KS, Kauppila JH, Kauppila S, Chen D, Pressey C, Härkönen P, Harris KW, Graves D, Auvinen PK, Soini Y, Jukkola-Vuorinen A, Selander KS.

Breast Cancer Res Treat. 2012 Sep;135(2):481-93. doi: 10.1007/s10549-012-2181-7. Epub 2012 Jul 31.

PMID:
22847512
34.

Aerobic performance and body composition changes during military service.

Mikkola I, Keinänen-Kiukaanniemi S, Jokelainen J, Peitso A, Härkönen P, Timonen M, Ikäheimo T.

Scand J Prim Health Care. 2012 Jun;30(2):95-100. doi: 10.3109/02813432.2012.649631.

35.

Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells.

Hirvonen MJ, Mulari MT, Büki KG, Vihko P, Härkönen PL, Väänänen HK.

J Histochem Cytochem. 2012 Jul;60(7):537-49. doi: 10.1369/0022155412448069. Epub 2012 May 4.

36.

Androgens inhibit the stimulatory action of 17β-estradiol on normal human breast tissue in explant cultures.

Eigeliene N, Elo T, Linhala M, Hurme S, Erkkola R, Härkönen P.

J Clin Endocrinol Metab. 2012 Jul;97(7):E1116-27. doi: 10.1210/jc.2011-3228. Epub 2012 Apr 24.

PMID:
22535971
37.

Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells.

Nilsson EM, Brokken LJ, Narvi E, Kallio MJ, Härkönen PL.

Mol Cell Endocrinol. 2012 Jul 6;358(1):104-15. doi: 10.1016/j.mce.2012.03.009. Epub 2012 Mar 23.

PMID:
22465097
38.

Fibroblast growth factor 8b causes progressive stromal and epithelial changes in the epididymis and degeneration of the seminiferous epithelium in the testis of transgenic mice.

Elo T, Sipilä P, Valve E, Kujala P, Toppari J, Poutanen M, Härkönen P.

Biol Reprod. 2012 May 17;86(5):157, 1-12. doi: 10.1095/biolreprod.111.097352. Print 2012 May.

PMID:
22423049
39.

Prevalence of metabolic syndrome components among the elderly using three different definitions: a cohort study in Finland.

Saukkonen T, Jokelainen J, Timonen M, Cederberg H, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Rajala U.

Scand J Prim Health Care. 2012 Mar;30(1):29-34. doi: 10.3109/02813432.2012.654192. Epub 2012 Feb 12.

40.

Limited overlap between intermediate hyperglycemia as defined by A1C 5.7-6.4%, impaired fasting glucose, and impaired glucose tolerance.

Saukkonen T, Cederberg H, Jokelainen J, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Rajala U.

Diabetes Care. 2011 Oct;34(10):2314-6. doi: 10.2337/dc11-0183. Epub 2011 Aug 4.

41.

Ten-year natural course of habitual snoring and restless legs syndrome in a population aged 61-63 years at the baseline.

Juuti AK, Hiltunen L, Rajala U, Laakso M, Härkönen P, Keinänen-Kiukaanniemi S, Läärä E.

Sleep Breath. 2012 Sep;16(3):639-48. doi: 10.1007/s11325-011-0551-8. Epub 2011 Jul 3.

PMID:
21725862
42.

Tracer level electrophilic synthesis and pharmacokinetics of the hypoxia tracer [(18)F]EF5.

Eskola O, Grönroos TJ, Forsback S, Tuomela J, Komar G, Bergman J, Härkönen P, Haaparanta M, Minn H, Solin O.

Mol Imaging Biol. 2012 Apr;14(2):205-12. doi: 10.1007/s11307-011-0484-4.

PMID:
21448777
43.

Exercise during military training improves cardiovascular risk factors in young men.

Cederberg H, Mikkola I, Jokelainen J, Laakso M, Härkönen P, Ikäheimo T, Laakso M, Keinänen-Kiukaanniemi S.

Atherosclerosis. 2011 Jun;216(2):489-95. doi: 10.1016/j.atherosclerosis.2011.02.037. Epub 2011 Feb 24.

PMID:
21402378
44.

Multiparametric luminescence method for quantitative cell surface protein expression analysis and imaging.

Huttunen R, Soini J, Härkönen P, Hänninen P, Härmä H.

J Immunol Methods. 2011 Mar 31;367(1-2):40-6. doi: 10.1016/j.jim.2011.01.008. Epub 2011 Jan 28.

PMID:
21277303
45.

Stromal activation associated with development of prostate cancer in prostate-targeted fibroblast growth factor 8b transgenic mice.

Elo TD, Valve EM, Seppänen JA, Vuorikoski HJ, Mäkelä SI, Poutanen M, Kujala PM, Härkönen PL.

Neoplasia. 2010 Nov;12(11):915-27.

46.

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.

Tuomela J, Grönroos TJ, Valta MP, Sandholm J, Schrey A, Seppänen J, Marjamäki P, Forsback S, Kinnunen I, Solin O, Minn H, Härkönen PL.

BMC Cancer. 2010 Oct 30;10:596. doi: 10.1186/1471-2407-10-596.

47.

Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features.

Lehn S, Tobin NP, Berglund P, Nilsson K, Sims AH, Jirström K, Härkönen P, Lamb R, Landberg G.

Am J Pathol. 2010 Dec;177(6):2886-97. doi: 10.2353/ajpath.2010.100303. Epub 2010 Oct 22.

48.

Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells.

Tassidis H, Culig Z, Wingren AG, Härkönen P.

Prostate. 2010 Oct 1;70(14):1491-500. doi: 10.1002/pros.21184.

PMID:
20687222
49.

Postchallenge glucose, A1C, and fasting glucose as predictors of type 2 diabetes and cardiovascular disease: a 10-year prospective cohort study.

Cederberg H, Saukkonen T, Laakso M, Jokelainen J, Härkönen P, Timonen M, Keinänen-Kiukaanniemi S, Rajala U.

Diabetes Care. 2010 Sep;33(9):2077-83. doi: 10.2337/dc10-0262. Epub 2010 Jun 23.

50.

Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.

Virtanen SS, Sandholm J, Yegutkin G, Kalervo Väänänen H, Härkönen PL.

Cell Biol Int. 2010 Aug;34(8):815-26. doi: 10.1042/CBI20090288.

PMID:
20446922

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