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Fibroblast Growth Factor 21-Metabolic Role in Mice and Men. Staiger H et al. Endocr Rev. (2017)

The impact of insulin resistance on the kidney and vasculature. Artunc F et al. Nat Rev Nephrol. (2016)

The role of hepatokines in metabolism. Stefan N et al. Nat Rev Endocrinol. (2013)

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Items: 1 to 50 of 871


Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing.

Volta F, Scerbo MJ, Seelig A, Wagner R, O'Brien N, Gerst F, Fritsche A, Häring HU, Zeigerer A, Ullrich S, Gerdes JM.

Nat Commun. 2019 Dec 12;10(1):5686. doi: 10.1038/s41467-019-12953-5.


Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism.

Hu C, Hoene M, Plomgaard P, Hansen JS, Zhao X, Li J, Wang X, Clemmesen JO, Secher NH, Häring HU, Lehmann R, Xu G, Weigert C.

J Clin Endocrinol Metab. 2019 Dec 11. pii: dgz266. doi: 10.1210/clinem/dgz266. [Epub ahead of print]


Monitoring of low dabigatran concentrations: diagnostic performance at clinically relevant decision thresholds.

Härtig F, Poli S, Ebner M, Birschmann I, Kuhn J, Ziemann U, Häring HU, Lehmann R, Peter A, Hörber S.

J Thromb Thrombolysis. 2019 Nov 6. doi: 10.1007/s11239-019-01981-z. [Epub ahead of print]


Insulin action in the hypothalamus increases second phase insulin secretion in humans.

Heni M, Wagner R, Willmann C, Jaghutriz BA, Vosseler A, Kübler C, Hund V, Scheffler K, Peter A, Häring HU, Preissl H, Kullmann S, Fritsche A.

Neuroendocrinology. 2019 Nov 5. doi: 10.1159/000504551. [Epub ahead of print]


AMPK Subunits Harbor Largely Nonoverlapping Genetic Determinants for Body Fat Mass, Glucose Metabolism, and Cholesterol Metabolism.

Randrianarisoa E, Lehn-Stefan A, Krier J, Böhm A, Heni M, Hrabě De Angelis M, Fritsche A, Häring HU, Stefan N, Staiger H.

J Clin Endocrinol Metab. 2020 Jan 1;105(1). pii: dgz020. doi: 10.1210/clinem/dgz020.


Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Wang X, Malinowski AR, Beckenbauer J, Siehler J, Blöchinger A, Meitinger T, Häring HU, Staiger H, Burtscher I, Lickert H.

Stem Cell Res. 2019 Aug;39:101531. doi: 10.1016/j.scr.2019.101531. Epub 2019 Aug 7.


Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells.

Franko A, Hartwig S, Kotzka J, Ruoß M, Nüssler AK, Königsrainer A, Häring HU, Lehr S, Peter A.

Nutrients. 2019 Aug 3;11(8). pii: E1795. doi: 10.3390/nu11081795.


Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.

Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group.

Lancet Diabetes Endocrinol. 2019 Sep;7(9):684-694. doi: 10.1016/S2213-8587(19)30187-1. Epub 2019 Jul 22.


Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets.

Lorza-Gil E, Gerst F, Oquendo MB, Deschl U, Häring HU, Beilmann M, Ullrich S.

Sci Rep. 2019 Jul 16;9(1):10261. doi: 10.1038/s41598-019-46545-6.


Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.

Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E374-E387. doi: 10.1152/ajpendo.00088.2019. Epub 2019 Jun 18.


What role do fat cells play in pancreatic tissue?

Gerst F, Wagner R, Oquendo MB, Siegel-Axel D, Fritsche A, Heni M, Staiger H, Häring HU, Ullrich S.

Mol Metab. 2019 Jul;25:1-10. doi: 10.1016/j.molmet.2019.05.001. Epub 2019 May 7. Review.


Circulating FGF21 Levels in Human Health and Metabolic Disease.

Keuper M, Häring HU, Staiger H.

Exp Clin Endocrinol Diabetes. 2019 May 20. doi: 10.1055/a-0879-2968. [Epub ahead of print]


Metabolomic Characteristics of Fatty Pancreas.

Jaghutriz BA, Wagner R, Heni M, Lehmann R, Machann J, Stefan N, Häring HU, Fritsche A.

Exp Clin Endocrinol Diabetes. 2019 May 16. doi: 10.1055/a-0896-8671. [Epub ahead of print]


Glucose Responsiveness of β-Cells Depends on Fatty Acids.

Gerst F, Singer C, Noack K, Graf D, Kaiser G, Panse M, Kovarova M, Schleicher E, Häring HU, Drews G, Ullrich S.

Exp Clin Endocrinol Diabetes. 2019 Apr 15. doi: 10.1055/a-0884-2919. [Epub ahead of print]


Effect of SGLT2 inhibitors on body composition, fluid status and renin-angiotensin-aldosterone system in type 2 diabetes: a prospective study using bioimpedance spectroscopy.

Schork A, Saynisch J, Vosseler A, Jaghutriz BA, Heyne N, Peter A, Häring HU, Stefan N, Fritsche A, Artunc F.

Cardiovasc Diabetol. 2019 Apr 5;18(1):46. doi: 10.1186/s12933-019-0852-y.


Sex-Specific Associations of Testosterone With Metabolic Traits.

Lutz SZ, Wagner R, Fritsche L, Peter A, Rettig I, Willmann C, Fehlert E, Martus P, Todenhöfer T, Stefan N, Fritsche A, Häring HU, Heni M.

Front Endocrinol (Lausanne). 2019 Mar 13;10:90. doi: 10.3389/fendo.2019.00090. eCollection 2019.


Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Wang X, Sterr M, Ansarullah, Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H.

Mol Metab. 2019 Jun;24:80-97. doi: 10.1016/j.molmet.2019.03.006. Epub 2019 Mar 20.


Performance of a novel high sensitivity cardiac troponin I assay in asymptomatic hemodialysis patients - evidence for sex-specific differences.

Artunc F, Haag S, Friedrich B, Mueller C, Häring HU, Peter A.

Clin Chem Lab Med. 2019 Jul 26;57(8):1261-1270. doi: 10.1515/cclm-2018-1176.


Acquired arteriovenous fistula of a finger.

Rietig R, Hudak S, Hieronimus A, Lehn-Stefan A, Balletshofer B, Häring HU, Syha R, Randrianarisoa E.

Vasa. 2019 Jul;48(4):368-370. doi: 10.1024/0301-1526/a000784. Epub 2019 Mar 15.


Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion.

Jaghutriz BA, Heni M, Lutz SZ, Fritsche L, Machicao F, Staiger H, Peter A, Häring HU, Fritsche A, Wagner R.

Front Endocrinol (Lausanne). 2019 Feb 21;10:72. doi: 10.3389/fendo.2019.00072. eCollection 2019.


Visceral Adiposity Index as an Independent Marker of Subclinical Atherosclerosis in Individuals Prone to Diabetes Mellitus.

Randrianarisoa E, Lehn-Stefan A, Hieronimus A, Rietig R, Fritsche A, Machann J, Balletshofer B, Häring HU, Stefan N, Rittig K.

J Atheroscler Thromb. 2019 Sep 1;26(9):821-834. doi: 10.5551/jat.47274. Epub 2019 Feb 19.


Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content: a randomized and controlled dietary intervention study.

Willmann C, Heni M, Linder K, Wagner R, Stefan N, Machann J, Schulze MB, Joost HG, Häring HU, Fritsche A.

Am J Clin Nutr. 2019 Feb 1;109(2):288-296. doi: 10.1093/ajcn/nqy307.


Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention.

Linder K, Willmann C, Kantartzis K, Machann J, Schick F, Graf M, Kümmerle S, Häring HU, Fritsche A, Stefan N, Wagner R.

Sci Rep. 2019 Feb 4;9(1):1303. doi: 10.1038/s41598-018-38002-7.


Glucose Measurements at Various Time Points During the OGTT and Their Role in Capturing Glucose Response Patterns.

Hulman A, Wagner R, Vistisen D, Færch K, Balkau B, Manco M, Golay A, Häring HU, Heni M, Fritsche A, Witte DR.

Diabetes Care. 2019 Apr;42(4):e56-e57. doi: 10.2337/dc18-2397. Epub 2019 Jan 28. No abstract available.


A Polygenic Risk Score of Lipolysis-Increasing Alleles Determines Visceral Fat Mass and Proinsulin Conversion.

Kempe-Teufel D, Machicao F, Machann J, Böhm A, Schick F, Fritsche A, Stefan N, Hrabě de Angelis M, Häring HU, Staiger H.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1090-1098. doi: 10.1210/jc.2018-02042.


ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations.

Graae AS, Grarup N, Ribel-Madsen R, Lystbæk SH, Boesgaard T, Staiger H, Fritsche A, Wellner N, Sulek K, Kjolby M, Backe MB, Chubanava S, Prats C, Serup AK, Birk JB, Dubail J, Gillberg L, Vienberg SG, Nykjær A, Kiens B, Wojtaszewski JFP, Larsen S, Apte SS, Häring HU, Vaag A, Zethelius B, Pedersen O, Treebak JT, Hansen T, Holst B.

Diabetes. 2019 Mar;68(3):502-514. doi: 10.2337/db18-0418. Epub 2019 Jan 9.


An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial.

Karusheva Y, Kunstein L, Bierwagen A, Nowotny B, Kabisch S, Groener JB, Fleitmann AK, Herder C, Pacini G, Strassburger K, Häring HU, Nawroth PP, Pfeiffer AFH, Burkart V, Müssig K, Roden M, Szendroedi J.

Nutr Metab (Lond). 2018 Dec 29;15:90. doi: 10.1186/s12986-018-0324-5. eCollection 2018.


Predicting Early Mortality of Acute Ischemic Stroke.

Gattringer T, Posekany A, Niederkorn K, Knoflach M, Poltrum B, Mutzenbach S, Haring HP, Ferrari J, Lang W, Willeit J, Kiechl S, Enzinger C, Fazekas F; Austrian Stroke Unit Registry Collaborators.

Stroke. 2019 Feb;50(2):349-356. doi: 10.1161/STROKEAHA.118.022863.


Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels.

Plomgaard P, Hansen JS, Ingerslev B, Clemmesen JO, Secher NH, van Hall G, Fritsche A, Weigert C, Lehmann R, Häring HU, Heni M.

Diabetes Obes Metab. 2018 Dec 15. doi: 10.1111/dom.13615. [Epub ahead of print]


Family History of Diabetes Is Associated With Delayed Fetal Postprandial Brain Activity.

Schleger F, Linder K, Walter L, Heni M, Brändle J, Brucker S, Pauluschke-Fröhlich J, Weiss M, Häring HU, Preissl H, Fritsche A.

Front Endocrinol (Lausanne). 2018 Nov 20;9:673. doi: 10.3389/fendo.2018.00673. eCollection 2018.


The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.

Lutz SZ, Hennige AM, Peter A, Kovarova M, Totsikas C, Machann J, Kröber SM, Sperl B, Schleicher E, Schick F, Heni M, Ullrich A, Häring HU, Stefan N.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2041-2053. doi: 10.1210/jc.2018-01573.


Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Keuper M, Berti L, Raedle B, Sachs S, Böhm A, Fritsche L, Fritsche A, Häring HU, Hrabě de Angelis M, Jastroch M, Hofmann SM, Staiger H.

Mol Metab. 2019 Feb;20:28-37. doi: 10.1016/j.molmet.2018.11.006. Epub 2018 Nov 26.


Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.

Fritsche L, Sarief M, Wagner R, Stefan N, Lehmann R, Häring HU, Grallert H, Fritsche A, Lechner A.

Diabetes Res Clin Pract. 2018 Dec;146:251-257. doi: 10.1016/j.diabres.2018.11.003. Epub 2018 Nov 10.


Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice.

Neschen S, Wu M, Fuchs C, Kondofersky I, Theis FJ, de Angelis MH, Häring HU, Sartorius T.

Exp Clin Endocrinol Diabetes. 2018 Nov 5. doi: 10.1055/a-0735-9533. [Epub ahead of print]


Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression.

Sefried S, Häring HU, Weigert C, Eckstein SS.

Open Biol. 2018 Oct 24;8(10). pii: 180147. doi: 10.1098/rsob.180147.


Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension.

Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, Beaumont RN, Wood AR, Tuke MA, Ruth KS, Mahajan A, Murray A, Freathy RM, Weedon MN, Hattersley AT, Hayward C, Machann J, Häring HU, Franks P, de Mutsert R, Pearson E, Stefan N, Frayling TM, Allebrandt KV, Bell JD, Blakemore AI, Yaghootkar H.

Diabetes. 2019 Jan;68(1):207-219. doi: 10.2337/db18-0708. Epub 2018 Oct 23.


Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.

Gerlini R, Berti L, Darr J, Lassi M, Brandmaier S, Fritsche L, Scheid F, Böhm A, Königsrainer A, Grallert H, Häring HU, Hrabě de Angelis M, Staiger H, Teperino R.

Mol Metab. 2018 Dec;18:42-50. doi: 10.1016/j.molmet.2018.09.004. Epub 2018 Sep 19.


Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus

Hörber S, Hudak S, Kächele M, Overkamp D, Fritsche A, Häring HU, Peter A, Heni M.

Endocrinol Diabetes Metab Case Rep. 2018 Sep 25;2018. doi: 10.1530/EDM-18-0094.


Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond.

Liu X, Hoene M, Wang X, Yin P, Häring HU, Xu G, Lehmann R.

Anal Chim Acta. 2018 Dec 11;1037:293-300. doi: 10.1016/j.aca.2018.03.009. Epub 2018 Mar 21.


Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation.

Franko A, Merkel D, Kovarova M, Hoene M, Jaghutriz BA, Heni M, Königsrainer A, Papan C, Lehr S, Häring HU, Peter A.

Nutrients. 2018 Sep 17;10(9). pii: E1314. doi: 10.3390/nu10091314.


The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

Gerst F, Jaghutriz BA, Staiger H, Schulte AM, Lorza-Gil E, Kaiser G, Panse M, Haug S, Heni M, Schütz M, Stadion M, Schürmann A, Marzetta F, Ibberson M, Sipos B, Fend F, Fleming T, Nawroth PP, Königsrainer A, Nadalin S, Wagner S, Peter A, Fritsche A, Richter D, Solimena M, Häring HU, Ullrich S, Wagner R.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4373-4383. doi: 10.1210/jc.2018-00791.


cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.

Franko A, Kovarova M, Feil S, Feil R, Wagner R, Heni M, Königsrainer A, Ruoß M, Nüssler AK, Weigert C, Häring HU, Lutz SZ, Peter A.

Metabolism. 2018 Nov;88:22-30. doi: 10.1016/j.metabol.2018.09.001. Epub 2018 Sep 6.


Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.

Stefan N, Häring HU, Cusi K.

Lancet Diabetes Endocrinol. 2019 Apr;7(4):313-324. doi: 10.1016/S2213-8587(18)30154-2. Epub 2018 Aug 30. Review.


Chronic d-serine supplementation impairs insulin secretion.

Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S.

Mol Metab. 2018 Oct;16:191-202. doi: 10.1016/j.molmet.2018.07.002. Epub 2018 Jul 25.


BMI-Independent Effects of Gestational Diabetes on Human Placenta.

Stirm L, Kovárová M, Perschbacher S, Michlmaier R, Fritsche L, Siegel-Axel D, Schleicher E, Peter A, Pauluschke-Fröhlich J, Brucker S, Abele H, Wallwiener D, Preissl H, Wadsack C, Häring HU, Fritsche A, Ensenauer R, Desoye G, Staiger H.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3299-3309. doi: 10.1210/jc.2018-00397.


Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.

Panse M, Kluth O, Lorza-Gil E, Kaiser G, Mühlbauer E, Schürmann A, Häring HU, Ullrich S, Gerst F.

PLoS One. 2018 May 29;13(5):e0198016. doi: 10.1371/journal.pone.0198016. eCollection 2018.


Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans.

Lutz SZ, Falcenberg M, Machicao F, Peter A, Kächele M, Randrianarisoa E, Lehn-Stefan A, Wagner R, Machann J, Schick F, Heni M, Ullrich A, Fritsche A, Stefan N, Häring HU, Staiger H, Kantartzis K.

Sci Rep. 2018 May 17;8(1):7745. doi: 10.1038/s41598-018-26055-7.


A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice.

Hoene M, Irmler M, Beckers J, Hrabě de Angelis M, Häring HU, Weigert C.

Nutrients. 2018 Apr 28;10(5). pii: E547. doi: 10.3390/nu10050547.


Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test.

Babbar R, Heni M, Peter A, Hrabě de Angelis M, Häring HU, Fritsche A, Preissl H, Schölkopf B, Wagner R.

Front Endocrinol (Lausanne). 2018 Mar 19;9:82. doi: 10.3389/fendo.2018.00082. eCollection 2018.


A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.

Gottmann P, Ouni M, Saussenthaler S, Roos J, Stirm L, Jähnert M, Kamitz A, Hallahan N, Jonas W, Fritsche A, Häring HU, Staiger H, Blüher M, Fischer-Posovszky P, Vogel H, Schürmann A.

Mol Metab. 2018 May;11:145-159. doi: 10.1016/j.molmet.2018.03.005. Epub 2018 Mar 15.

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