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Items: 1 to 50 of 232

1.

Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.

Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20700-20706. doi: 10.1073/pnas.1908549116. Epub 2019 Sep 16.

PMID:
31527267
2.

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.

Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A.

EMBO Rep. 2019 Aug;20(8):e47026. doi: 10.15252/embr.201847026. Epub 2019 Jun 17.

3.

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.

Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A, Garcia-Saez AJ, Häcker G.

Cell Death Differ. 2019 Jun 12. doi: 10.1038/s41418-019-0365-y. [Epub ahead of print]

PMID:
31189926
4.

A non-death function of the mitochondrial apoptosis apparatus in immunity.

Brokatzky D, Dörflinger B, Haimovici A, Weber A, Kirschnek S, Vier J, Metz A, Henschel J, Steinfeldt T, Gentle IE, Häcker G.

EMBO J. 2019 Jun 3;38(11). pii: e100907. doi: 10.15252/embj.2018100907. Epub 2019 Apr 12.

PMID:
30979778
5.

Gene expression profiling meta-analysis reveals novel gene signatures and pathways shared between tuberculosis and rheumatoid arthritis.

Badr MT, Häcker G.

PLoS One. 2019 Mar 7;14(3):e0213470. doi: 10.1371/journal.pone.0213470. eCollection 2019.

6.

Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways.

Ohmer M, Tzivelekidis T, Niedenführ N, Volceanov-Hahn L, Barth S, Vier J, Börries M, Busch H, Kook L, Biniossek ML, Schilling O, Kirschnek S, Häcker G.

Cell Microbiol. 2019 Apr;21(4):e12993. doi: 10.1111/cmi.12993. Epub 2019 Jan 7.

PMID:
30551267
7.

Pathways of host cell exit by intracellular pathogens.

Flieger A, Frischknecht F, Häcker G, Hornef MW, Pradel G.

Microb Cell. 2018 Oct 18;5(12):525-544. doi: 10.15698/mic2018.12.659. Review.

8.

Case Report and Genetic Sequence Analysis of Candidatus Borrelia kalaharica, Southern Africa.

Stete K, Rieg S, Margos G, Häcker G, Wagner D, Kern WV, Fingerle V.

Emerg Infect Dis. 2018 Sep;24(9):1659-1664. doi: 10.3201/eid2409.171381.

9.

The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis.

Singh PK, Weber A, Häcker G.

Cell Cycle. 2018;17(9):1037-1047. doi: 10.1080/15384101.2018.1464851. Epub 2018 Jul 18.

10.

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Häcker G, Gentle IE.

Cell Death Dis. 2018 May 1;9(5):529. doi: 10.1038/s41419-018-0508-y.

11.

Spatial clustering of Borrelia burgdorferi sensu lato within populations of Allen's chipmunks and dusky-footed woodrats in northwestern California.

Hacker GM, Brown RN, Fedorova N, Girard YA, Higley M, Clueit B, Lane RS.

PLoS One. 2018 Apr 10;13(4):e0195586. doi: 10.1371/journal.pone.0195586. eCollection 2018.

12.

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R.

Nat Med. 2018 Apr 10;24(4):526. doi: 10.1038/nm0418-526c.

PMID:
29634689
13.

Apoptosis Modulation in the Immune System Reveals a Role of Neutrophils in Tissue Damage in a Murine Model of Chlamydial Genital Infection.

Zortel T, Schmitt-Graeff A, Kirschnek S, Häcker G.

J Infect Dis. 2018 May 5;217(11):1832-1843. doi: 10.1093/infdis/jiy126.

PMID:
29522221
14.

Activation of neutrophils by Chlamydia trachomatis-infected epithelial cells is modulated by the chlamydial plasmid.

Lehr S, Vier J, Häcker G, Kirschnek S.

Microbes Infect. 2018 May;20(5):284-292. doi: 10.1016/j.micinf.2018.02.007. Epub 2018 Mar 2.

PMID:
29499390
15.

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.

Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R.

Blood. 2018 Apr 19;131(16):1858-1869. doi: 10.1182/blood-2017-10-812891. Epub 2018 Feb 20.

16.

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R.

Nat Med. 2018 Mar;24(3):282-291. doi: 10.1038/nm.4484. Epub 2018 Feb 12. Erratum in: Nat Med. 2018 Apr 10;24(4):526.

17.

Apoptosis in infection.

Häcker G.

Microbes Infect. 2018 Oct - Nov;20(9-10):552-559. doi: 10.1016/j.micinf.2017.10.006. Epub 2017 Nov 4. Review.

PMID:
29109017
18.

Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival.

Rubel F, Kern JS, Technau-Hafsi K, Uhrich S, Thoma K, Häcker G, von Bubnoff N, Meiss F, von Bubnoff D.

J Invest Dermatol. 2018 Mar;138(3):679-687. doi: 10.1016/j.jid.2017.09.036. Epub 2017 Oct 18. Erratum in: J Invest Dermatol. 2018 Jun;138(6):1450.

19.

Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.

Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G.

Genes Dev. 2017 Sep 1;31(17):1754-1769. doi: 10.1101/gad.302497.117.

20.

The role of septins in infections with vacuole-dwelling intracellular bacteria.

Häcker G.

Int J Med Microbiol. 2018 Jan;308(1):25-31. doi: 10.1016/j.ijmm.2017.07.010. Epub 2017 Jul 29. Review.

PMID:
28784332
21.

Whipple's disease mimicking rheumatoid arthritis can cause misdiagnosis and treatment failure.

Glaser C, Rieg S, Wiech T, Scholz C, Endres D, Stich O, Hasselblatt P, Geißdörfer W, Bogdan C, Serr A, Häcker G, Voll RE, Thiel J, Venhoff N.

Orphanet J Rare Dis. 2017 May 25;12(1):99. doi: 10.1186/s13023-017-0630-4.

22.

TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy.

Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Häcker G.

FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19.

23.

Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.

Wiesmeier M, Gautam S, Kirschnek S, Häcker G.

PLoS One. 2016 Dec 12;11(12):e0168055. doi: 10.1371/journal.pone.0168055. eCollection 2016.

24.

Investigation of and Response to 2 Plague Cases, Yosemite National Park, California, USA, 2015.

Danforth M, Novak M, Petersen J, Mead P, Kingry L, Weinburke M, Buttke D, Hacker G, Tucker J, Niemela M, Jackson B, Padgett K, Liebman K, Vugia D, Kramer V.

Emerg Infect Dis. 2016 Dec;22(12). doi: 10.3201/eid2212.160560.

25.

Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact.

Waguia Kontchou C, Tzivelekidis T, Gentle IE, Häcker G.

Cell Microbiol. 2016 Nov;18(11):1583-1595. doi: 10.1111/cmi.12598. Epub 2016 May 25.

PMID:
27062399
26.

Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis.

Ohmer M, Weber A, Sutter G, Ehrhardt K, Zimmermann A, Häcker G.

Cell Death Dis. 2016 Aug 18;7(8):e2340. doi: 10.1038/cddis.2016.242.

27.

A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.

Büchsel M, Pletschen L, Fleiner M, Häcker G, Serr A.

Diagn Microbiol Infect Dis. 2016 Sep;86(1):115-7. doi: 10.1016/j.diagmicrobio.2016.05.018. Epub 2016 May 30.

PMID:
27342785
28.

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G.

EMBO Rep. 2016 May;17(5):724-38. doi: 10.15252/embr.201541392. Epub 2016 Mar 24.

29.

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins.

Senft D, Weber A, Saathoff F, Berking C, Heppt MV, Kammerbauer C, Rothenfusser S, Kellner S, Kurgyis Z, Besch R, Häcker G.

Cell Death Dis. 2015 Nov 26;6:e1996. doi: 10.1038/cddis.2015.341.

30.

In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport.

Dille S, Kleinschnitz EM, Kontchou CW, Nölke T, Häcker G.

Infect Immun. 2015 Aug;83(8):3268-80. doi: 10.1128/IAI.00322-15. Epub 2015 Jun 8.

31.

Diagnosis of prosthetic joint infections using UMD-Universal Kit and the automated multiplex-PCR Unyvero i60 ITI(®) cartridge system: a pilot study.

Borde JP, Häcker GA, Guschl S, Serr A, Danner T, Hübner J, Burrack-Lange S, Lüdke G, Helwig P, Hauschild O, Kern WV.

Infection. 2015 Oct;43(5):551-60. doi: 10.1007/s15010-015-0796-4. Epub 2015 May 29.

PMID:
26021312
32.

The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.

Haschka MD, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava LL.

Nat Commun. 2015 Apr 29;6:6891. doi: 10.1038/ncomms7891.

33.

The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM).

Frank DO, Dengjel J, Wilfling F, Kozjak-Pavlovic V, Häcker G, Weber A.

PLoS One. 2015 Apr 15;10(4):e0123341. doi: 10.1371/journal.pone.0123341. eCollection 2015.

34.

Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion.

Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G.

MBio. 2014 Oct 7;5(5):e01802-14. doi: 10.1128/mBio.01802-14.

35.

ER-stress and apoptosis: molecular mechanisms and potential relevance in infection.

Häcker G.

Microbes Infect. 2014 Oct;16(10):805-10. doi: 10.1016/j.micinf.2014.08.009. Epub 2014 Aug 27.

PMID:
25172397
36.

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib.

Wirth M, Stojanovic N, Christian J, Paul MC, Stauber RH, Schmid RM, Häcker G, Krämer OH, Saur D, Schneider G.

Nucleic Acids Res. 2014;42(16):10433-47. doi: 10.1093/nar/gku763. Epub 2014 Aug 21.

37.

Is the hoopla over CPAF justified?

Häcker G, Heuer D, Ojcius DM.

Pathog Dis. 2014 Oct;72(1):1-2. doi: 10.1111/2049-632X.12211. Epub 2014 Sep 15. No abstract available.

PMID:
25113036
38.

Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF.

Dille S, Herbst K, Volceanov L, Nölke T, Kretz O, Häcker G.

PLoS One. 2014 Jul 28;9(7):e103220. doi: 10.1371/journal.pone.0103220. eCollection 2014.

39.

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.

Schwab L, Goroncy L, Palaniyandi S, Gautam S, Triantafyllopoulou A, Mocsai A, Reichardt W, Karlsson FJ, Radhakrishnan SV, Hanke K, Schmitt-Graeff A, Freudenberg M, von Loewenich FD, Wolf P, Leonhardt F, Baxan N, Pfeifer D, Schmah O, Schönle A, Martin SF, Mertelsmann R, Duyster J, Finke J, Prinz M, Henneke P, Häcker H, Hildebrandt GC, Häcker G, Zeiser R.

Nat Med. 2014 Jun;20(6):648-54. doi: 10.1038/nm.3517. Epub 2014 May 18.

PMID:
24836575
40.

IL-15 regulates Bcl-2 family members Bim and Mcl-1 through JAK/STAT and PI3K/AKT pathways in T cells.

Shenoy AR, Kirschnek S, Häcker G.

Eur J Immunol. 2014 Aug;44(8):2500-7. doi: 10.1002/eji.201344238. Epub 2014 Jun 10.

41.

Predictive coding explains auditory and tactile influences on vision during binocular rivalry.

Jack BN, Hacker G.

J Neurosci. 2014 May 7;34(19):6423-4. doi: 10.1523/JNEUROSCI.1040-14.2014. No abstract available.

42.

Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.

Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Häcker G, Schmetzer H, Häcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U.

PLoS One. 2014 Apr 3;9(4):e93057. doi: 10.1371/journal.pone.0093057. eCollection 2014.

43.

The chlamydial protease CPAF: important or not, important for what?

Häcker G.

Microbes Infect. 2014 May;16(5):367-70. doi: 10.1016/j.micinf.2014.02.008. Epub 2014 Mar 7.

PMID:
24607702
44.

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice.

Gentle IE, Moelter I, Lechler N, Bambach S, Vucikuja S, Häcker G, Aichele P.

Blood. 2014 Jan 30;123(5):659-68. doi: 10.1182/blood-2013-01-479543. Epub 2013 Dec 12.

PMID:
24335231
45.

Purulent pericarditis and pneumonia caused by Streptococcus equi subsp. zooepidemicus.

Held J, Schmitz R, van der Linden M, Nührenberg T, Häcker G, Neumann FJ.

J Med Microbiol. 2014 Feb;63(Pt 2):313-6. doi: 10.1099/jmm.0.066290-0. Epub 2013 Nov 15.

PMID:
24243287
46.

Roscovitine-induced apoptosis in neutrophils and neutrophil progenitors is regulated by the Bcl-2-family members Bim, Puma, Noxa and Mcl-1.

Gautam S, Kirschnek S, Wiesmeier M, Vier J, Häcker G.

PLoS One. 2013 Nov 1;8(11):e79352. doi: 10.1371/journal.pone.0079352. eCollection 2013. Erratum in: PLoS One. 2014; 9(1). doi: 10.1371/annotation/5188aea6-9eb2-41e5-995b-86634bf3e0cf.

47.

Travel-acquired subcutaneous Sparganum proliferum infection diagnosed by molecular methods.

Schauer F, Poppert S, Technau-Hafsi K, Mockenhaupt M, Muntau B, Häcker G, Tappe D, Jakob T.

Br J Dermatol. 2014 Mar;170(3):741-3. doi: 10.1111/bjd.12679. No abstract available.

PMID:
24124973
48.

A Bim-activating mould.

Häcker G.

Cell Death Differ. 2013 Oct;20(10):1289-90. doi: 10.1038/cdd.2013.98. No abstract available.

49.

Is there, and should there be, apoptosis in bacteria?

Häcker G.

Microbes Infect. 2013 Jul-Aug;15(8-9):640-4. doi: 10.1016/j.micinf.2013.05.005. Epub 2013 Jun 6.

PMID:
23747737
50.

Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.

Weber A, Ausländer D, Häcker G.

Apoptosis. 2013 Sep;18(9):1093-105. doi: 10.1007/s10495-013-0868-9.

PMID:
23733106

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