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Items: 26

1.

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors.

Leytin V, Gyulkhandanyan AV, Freedman J.

Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619853641. doi: 10.1177/1076029619853641. Review.

2.

How to Avoid False-Negative and False-Positive Diagnoses of Platelet Apoptosis: Illustrative Experimental and Clinically Relevant Cases.

Leytin V, Gyulkhandanyan AV, Freedman J.

Clin Appl Thromb Hemost. 2018 Oct;24(7):1009-1013. doi: 10.1177/1076029618778140. Epub 2018 May 30. Review.

3.

Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis.

Leytin V, Gyulkhandanyan AV, Freedman J.

Br J Haematol. 2018 Apr;181(2):281-285. doi: 10.1111/bjh.14903. Epub 2017 Aug 23. No abstract available.

PMID:
28832974
4.

Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis : Disclosure of Nonapoptotic Membrane Depolarization

Gyulkhandanyan AV, Allen DJ, Mykhaylov S, Lyubimov E, Ni H, Freedman J, Leytin V.

Clin Appl Thromb Hemost. 2017 Mar;23(2):139-147. doi: 10.1177/1076029616665924. Epub 2016 Sep 24.

PMID:
27637909
5.

Mitochondrial permeability transition pore (MPTP)-dependent and -independent pathways of mitochondrial membrane depolarization, cell shrinkage and microparticle formation during platelet apoptosis.

Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V.

Br J Haematol. 2015 Apr;169(1):142-5. doi: 10.1111/bjh.13180. Epub 2014 Oct 10. No abstract available.

PMID:
25776535
6.

BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation.

Gyulkhandanyan AV, Mutlu A, Allen DJ, Freedman J, Leytin V.

Thromb Res. 2014 Jan;133(1):73-9. doi: 10.1016/j.thromres.2013.10.041. Epub 2013 Nov 6.

PMID:
24268298
7.

Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface.

Mutlu A, Gyulkhandanyan AV, Freedman J, Leytin V.

Br J Haematol. 2013 Nov;163(3):377-84. doi: 10.1111/bjh.12529. Epub 2013 Aug 23.

PMID:
24033315
8.

Selective triggering of platelet apoptosis, platelet activation or both.

Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V.

Br J Haematol. 2013 Apr;161(2):245-54. doi: 10.1111/bjh.12237. Epub 2013 Feb 8.

PMID:
23398569
9.

Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors.

Mutlu A, Gyulkhandanyan AV, Freedman J, Leytin V.

Br J Haematol. 2012 Dec;159(5):565-71. doi: 10.1111/bjh.12066. Epub 2012 Oct 1.

PMID:
23025479
10.

Markers of platelet apoptosis: methodology and applications.

Gyulkhandanyan AV, Mutlu A, Freedman J, Leytin V.

J Thromb Thrombolysis. 2012 May;33(4):397-411. doi: 10.1007/s11239-012-0688-8. Review.

PMID:
22383127
11.

The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.

Leytin V, Mutlu A, Mykhaylov S, Allen DJ, Gyulkhandanyan AV, Freedman J.

Haematologica. 2009 Dec;94(12):1783-4. doi: 10.3324/haematol.2009.012708. No abstract available.

12.

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.

13.

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB.

J Biol Chem. 2009 Oct 30;284(44):30441-52. doi: 10.1074/jbc.M109.040659. Epub 2009 Aug 18.

14.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

15.

Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore.

Leytin V, Allen DJ, Mutlu A, Gyulkhandanyan AV, Mykhaylov S, Freedman J.

Lab Invest. 2009 Apr;89(4):374-84. doi: 10.1038/labinvest.2009.13. Epub 2009 Feb 23.

16.

Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.

Zhang Y, Zhang N, Gyulkhandanyan AV, Xu E, Gaisano HY, Wheeler MB, Wang Q.

Diabetologia. 2008 Dec;51(12):2290-8. doi: 10.1007/s00125-008-1166-x. Epub 2008 Oct 11.

PMID:
18850083
17.

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB.

J Biol Chem. 2008 Apr 11;283(15):10184-97. doi: 10.1074/jbc.M707005200. Epub 2008 Feb 4.

18.

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.

20.

Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat.

Manning Fox JE, Gyulkhandanyan AV, Satin LS, Wheeler MB.

Endocrinology. 2006 Oct;147(10):4655-63. Epub 2006 Jul 20.

PMID:
16857746
21.

alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

Targonsky ED, Dai F, Koshkin V, Karaman GT, Gyulkhandanyan AV, Zhang Y, Chan CB, Wheeler MB.

Diabetologia. 2006 Jul;49(7):1587-98. Epub 2006 May 13.

PMID:
16752177
22.

The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.

Gyulkhandanyan AV, Lee SC, Bikopoulos G, Dai F, Wheeler MB.

J Biol Chem. 2006 Apr 7;281(14):9361-72. Epub 2005 Dec 30.

23.
24.

Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes.

Gyulkhandanyan AV, Feeney CJ, Pennefather PS.

J Neurochem. 2003 Oct;87(2):448-60.

25.

A cuvette-based fluorometric analysis of mitochondrial membrane potential measured in cultured astrocyte monolayers.

Feeney CJ, Pennefather PS, Gyulkhandanyan AV.

J Neurosci Methods. 2003 May 30;125(1-2):13-25.

PMID:
12763226
26.

The effects of adriamycin and adriamycin complexes with transitional metals on Ca(2+)-dependent K+ channels of human erythrocytes.

Davtyan TK, Gyulkhandanyan AV, Gambarov SS, Avanessian LA, Alexanyan YT.

Biochim Biophys Acta. 1996 Oct 17;1297(2):182-90.

PMID:
8917620

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