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Items: 1 to 50 of 52

1.

Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors.

Schwab US, Callaway JC, Erkkilä AT, Gynther J, Uusitupa MI, Järvinen T.

Eur J Nutr. 2006 Dec;45(8):470-7. Epub 2006 Nov 10.

PMID:
17103080
2.

3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.

Salo OM, Savinainen JR, Parkkari T, Nevalainen T, Lahtela-Kakkonen M, Gynther J, Laitinen JT, Järvinen T, Poso A.

J Med Chem. 2006 Jan 26;49(2):554-66.

PMID:
16420041
3.

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EA, Jarho EM, Christiaans JA, Gynther J, Männistö PT.

Biochem Pharmacol. 2006 Feb 28;71(5):683-92. Epub 2006 Jan 6.

PMID:
16405869
4.

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

Jarho EM, Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J, Poso A.

J Med Chem. 2005 Jul 28;48(15):4772-82.

PMID:
16033257
5.

Prediction of contact angle for pharmaceutical solids from their molecular structure.

Suihko E, Forbes RT, Korhonen O, Ketolainen J, Paronen P, Gynther J, Poso A.

J Pharm Sci. 2005 Apr;94(4):745-58.

PMID:
15682381
6.

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Huuskonen J, Christiaans JA, Garcia-Horsman JA, Forsberg MM, Järvinen T, Gynther J, Männistö PT, Wallén EA.

J Med Chem. 2004 Nov 4;47(23):5605-7.

PMID:
15509157
7.

2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride.

Kovalainen JT, Wegelius E, Christiaans JA, Huuskonen J, Gynther J.

Acta Crystallogr C. 2000 May 15;56(Pt 5):E216-7. Epub 2000 May 15.

PMID:
15263158
8.

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.

Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallén EA, Christiaans JA, Jarho EM, Gynther J, Männistö PT.

Biochem J. 2004 Sep 15;382(Pt 3):1003-8.

9.

Development of a 3D model for the human cannabinoid CB1 receptor.

Salo OM, Lahtela-Kakkonen M, Gynther J, Järvinen T, Poso A.

J Med Chem. 2004 Jun 3;47(12):3048-57.

PMID:
15163186
10.

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.

Parkkari T, Savinainen JR, Rauhala AL, Tolonen TL, Nevalainen T, Laitinen JT, Gynther J, Järvinen T.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3231-4.

PMID:
15149681
11.

Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.

Jyrkkärinne J, Mäkinen J, Gynther J, Savolainen H, Poso A, Honkakoski P.

J Med Chem. 2003 Oct 23;46(22):4687-95.

PMID:
14561088
12.

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.

Wallén EA, Christiaans JA, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J.

J Med Chem. 2003 Oct 9;46(21):4543-51.

PMID:
14521416
13.

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saarinen TJ, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J.

Bioorg Med Chem. 2003 Aug 15;11(17):3611-9.

PMID:
12901906
14.

Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.

Forsberg M, Savolainen J, Järvinen T, Leppänen J, Gynther J, Männistö PT.

Pharmacol Toxicol. 2002 Jun;90(6):327-32.

PMID:
12403054
15.

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J.

J Med Chem. 2002 Sep 26;45(20):4581-4.

PMID:
12238937
16.

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

Venäläinen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EA, Gynther J, Männistö PT.

Biochem Pharmacol. 2002 Aug 1;64(3):463-71.

PMID:
12147298
17.

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors.

Mäkinen J, Frank C, Jyrkkärinne J, Gynther J, Carlberg C, Honkakoski P.

Mol Pharmacol. 2002 Aug;62(2):366-78.

PMID:
12130690
18.

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saario SM, Forsberg MM, Venäläinen JI, Paso HM, Männistö PT, Gynther J.

Bioorg Med Chem. 2002 Jul;10(7):2199-206.

PMID:
11983517
19.

Design and synthesis of a novel L-dopa-entacapone codrug.

Leppänen J, Huuskonen J, Nevalainen T, Gynther J, Taipale H, Järvinen T.

J Med Chem. 2002 Mar 14;45(6):1379-82.

PMID:
11882007
20.

Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.

Leppänen J, Savolainen J, Nevalainen T, Forsberg M, Huuskonen J, Taipale H, Gynther J, Männistö PT, Järvinen T.

J Pharm Pharmacol. 2001 Nov;53(11):1489-98.

PMID:
11732751
21.

A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors.

Poso A, Gynther J, Juvonen R.

J Comput Aided Mol Des. 2001 Mar;15(3):195-202.

PMID:
11289074
22.

Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions.

Suihko E, Poso A, Korhonen O, Gynther J, Ketolainen J, Paronen P.

Pharm Res. 2000 Aug;17(8):942-8.

PMID:
11028939
23.

Synthesis of a water-soluble prodrug of entacapone.

Leppänen J, Huuskonen J, Savolainen J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Järvinen T.

Bioorg Med Chem Lett. 2000 Sep 4;10(17):1967-9.

PMID:
10987428
24.

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation.

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T.

Eur J Pharm Sci. 2000 Aug;11(2):157-63.

PMID:
10915963
25.

Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone.

Savolainen J, Leppanen J, Forsberg M, Taipale H, Nevalainen T, Huuskonen J, Gynther J, Mannisto PT, Jarvinen T.

Life Sci. 2000;67(2):205-16.

PMID:
10901288
26.

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (Naproxen) for topical drug delivery.

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Laine K, Järvinen T.

J Med Chem. 2000 Apr 20;43(8):1489-94.

PMID:
10780905
27.
28.

Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery.

Rautio J, Nevalainen T, Taipale H, Vepsäläinen J, Gynther J, Pedersen T, Järvinen T.

Pharm Res. 1999 Aug;16(8):1172-8.

PMID:
10468016
29.

Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.

Kovalainen JT, Christiaans JA, Kotisaari S, Laitinen JT, Männistö PT, Tuomisto L, Gynther J.

J Med Chem. 1999 Apr 8;42(7):1193-202.

PMID:
10197963
30.

In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen.

Rautio J, Taipale H, Gynther J, Vepsalainen J, Nevalainen T, Jarvinen T.

J Pharm Sci. 1998 Dec;87(12):1622-8.

PMID:
10189277
31.

A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor.

Navajas C, Kokkola T, Poso A, Honka N, Gynther J, Laitinen JT.

Eur J Pharmacol. 1996 May 23;304(1-3):173-83.

PMID:
8813600
32.

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

Honkakoski P, Moore R, Gynther J, Negishi M.

J Biol Chem. 1996 Apr 19;271(16):9746-53.

33.

Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6.

Kinonen T, Pasanen M, Gynther J, Poso A, Järvinen T, Alhava E, Juvonen RO.

Br J Pharmacol. 1995 Nov;116(6):2625-30.

34.

An empirical and theoretical study on mechanisms of mutagenic activity of hydrazine compounds.

Poso A, von Wright A, Gynther J.

Mutat Res. 1995 Nov;332(1-2):63-71.

PMID:
7500993
35.

Changes in solid-state structure of cyclophosphamide monohydrate induced by mechanical treatment and storage.

Ketolainen J, Poso A, Viitasaari V, Gynther J, Pirttimäki J, Laine E, Paronen P.

Pharm Res. 1995 Feb;12(2):299-304.

PMID:
7784349
36.

Electrostatic requirements for high benzodiazepine receptor affinity among betacarboline-3-carboxylic acid derivatives.

Gynther J, Konschin H, Tylli H, Rouvinen J.

Acta Pharm Nord. 1990;2(1):45-52.

PMID:
2160247
37.

Contaminant found in antiserum.

Mustelin T, Lapinjoki SP, Gynther J, Andersson LC.

Cell. 1988 Mar 11;52(5):640. No abstract available.

PMID:
3345566
38.

Two phases of ornithine decarboxylase activation during lymphocyte mitogenesis.

Mustelin T, Pessa T, Lapinjoki S, Gynther J, Järvinen T, Eloranta T, Andersson LC.

Adv Exp Med Biol. 1988;250:301-13. No abstract available.

PMID:
3267128
39.

Growth signal transduction: rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown.

Mustelin T, Pösö H, Lapinjoki SP, Gynther J, Andersson LC.

Cell. 1987 Apr 24;49(2):171-6. Erratum in: Cell 1988 Mar 11;52(5):640.

PMID:
3494521
40.

Tremorigenic effect and inhibition of tryptamine and serotonin receptor binding by beta-carbolines.

Airaksinen MM, Lecklin A, Saano V, Tuomisto L, Gynther J.

Pharmacol Toxicol. 1987 Jan;60(1):5-8.

PMID:
3562389
41.

Decarboxylation of 1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acids in brain homogenate and catalysis by pyridoxal-5'-phosphate.

Gynther J, Lapinjoki SP, Airaksinen MM, Peura P.

Biochem Pharmacol. 1986 Aug 15;35(16):2671-5.

PMID:
3091030
42.
43.

Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method.

Leino M, Aho IM, Kari E, Gynther J, Markkanen S.

Life Sci. 1984 Nov 12;35(20):1997-2001.

PMID:
6493002
44.

Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type.

Airaksinen MM, Saano V, Steidel E, Juvonen H, Huhtikangas A, Gynther J.

Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5.

PMID:
6099027
45.

Light microscopic autoradiography of rat retinae after intravitreal injection of [3H]6-methoxy-tetrahydro-beta-carboline.

Leino M, Markkanen S, Airaksinen MM, Gynther J, Kari I.

Acta Ophthalmol (Copenh). 1984 Jun;62(3):364-72.

PMID:
6464685
46.

Distribution of 1,2,3,4-tetrahydro-beta-carboline and 6-methoxy-1,2,3,4-tetrahydro-beta-carboline in mice.

Leino M, Airaksinen MM, Antikainen R, Gynther J, Kari E, Kari I, Peura P.

Acta Pharmacol Toxicol (Copenh). 1984 May;54(5):361-71.

PMID:
6464781
47.

Fluoroacetic acid in guar gum.

Vartiainen T, Gynther J.

Food Chem Toxicol. 1984 Apr;22(4):307-8.

PMID:
6539279
48.

Effect of guar gum on the gastric transit time in mice.

Gynther J, Huhtikangas A.

Planta Med. 1984 Feb;50(1):116. No abstract available.

PMID:
17340275
49.

Effect of guar gum on the gastric transit time in mice.

Gynther J, Huhtikangas A.

Planta Med. 1984 Feb;50(1):116. No abstract available.

PMID:
6739573
50.

Pinoline, a beta-carboline derivative in the serum and cerebrospinal fluid of patients with schizophrenia.

Rimón R, Airaksinen MM, Kari I, Gynther J, Venäläinen E, Heikkilä L, Ryyppö J, Palo J.

Ann Clin Res. 1984;16(3):171-5.

PMID:
6476781

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