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Items: 1 to 50 of 130

1.

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes.

Kumar N, Dougherty JA, Manring HR, Elmadbouh I, Mergaye M, Czirok A, Greta Isai D, Belevych AE, Yu L, Janssen PML, Fadda P, Gyorke S, Ackermann MA, Angelos MG, Khan M.

Sci Rep. 2019 Sep 12;9(1):13188. doi: 10.1038/s41598-019-49653-5.

2.

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.

Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC.

Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30.

PMID:
31401388
3.

Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.

Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S.

Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x.

4.

Cardiac Arrhythmias as Manifestations of Nanopathies: An Emerging View.

Radwański PB, Johnson CN, Györke S, Veeraraghavan R.

Front Physiol. 2018 Sep 4;9:1228. doi: 10.3389/fphys.2018.01228. eCollection 2018. Review.

5.

Synchronization of Intracellular Ca2+ Release in Multicellular Cardiac Preparations.

Slabaugh JL, Brunello L, Elnakish MT, Milani-Nejad N, Gyorke S, Janssen PML.

Front Physiol. 2018 Jul 20;9:968. doi: 10.3389/fphys.2018.00968. eCollection 2018.

6.

Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models.

Koleske M, Bonilla I, Thomas J, Zaman N, Baine S, Knollmann BC, Veeraraghavan R, Györke S, Radwański PB.

J Gen Physiol. 2018 Jul 2;150(7):991-1002. doi: 10.1085/jgp.201711909. Epub 2018 May 23.

7.

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.

Liu B, Walton SD, Ho HT, Belevych AE, Tikunova SB, Bonilla I, Shettigar V, Knollmann BC, Priori SG, Volpe P, Radwański PB, Davis JP, Györke S.

J Am Heart Assoc. 2018 May 2;7(10). pii: e008155. doi: 10.1161/JAHA.117.008155.

8.

Sub-cellular Electrical Heterogeneity Revealed by Loose Patch Recording Reflects Differential Localization of Sarcolemmal Ion Channels in Intact Rat Hearts.

Kubasov IV, Stepanov A, Bobkov D, Radwanski PB, Terpilowski MA, Dobretsov M, Gyorke S.

Front Physiol. 2018 Feb 13;9:61. doi: 10.3389/fphys.2018.00061. eCollection 2018.

9.

Accentuated vagal antagonism paradoxically increases ryanodine receptor calcium leak in long-term exercised Calsequestrin2 knockout mice.

Ho HT, Thambidorai S, Knollmann BC, Billman GE, Györke S, Kalyanasundaram A.

Heart Rhythm. 2018 Mar;15(3):430-441. doi: 10.1016/j.hrthm.2017.10.008. Epub 2017 Oct 10.

10.

The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis.

Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB.

J Gen Physiol. 2017 Sep 4;149(9):877-888. doi: 10.1085/jgp.201711808. Epub 2017 Aug 10. Review. No abstract available.

11.

The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts.

Belevych AE, Ho HT, Bonilla IM, Terentyeva R, Schober KE, Terentyev D, Carnes CA, Györke S.

Basic Res Cardiol. 2017 Jul;112(4):44. doi: 10.1007/s00395-017-0633-2. Epub 2017 Jun 13.

12.

Neuronal sodium channels: emerging components of the nano-machinery of cardiac calcium cycling.

Veeraraghavan R, Györke S, Radwański PB.

J Physiol. 2017 Jun 15;595(12):3823-3834. doi: 10.1113/JP273058. Epub 2017 Mar 26. Review.

13.

Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.

Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S.

JACC Basic Transl Sci. 2016 Jun;1(4):251-266.

14.

Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.

Ho HT, Belevych AE, Liu B, Bonilla IM, Radwański PB, Kubasov IV, Valdivia HH, Schober K, Carnes CA, Györke S.

Hypertension. 2016 Nov;68(5):1171-1178. Epub 2016 Sep 19. Review.

15.

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.

Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP.

Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794.

16.

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

Khan M, Xu Y, Hua S, Johnson J, Belevych A, Janssen PM, Gyorke S, Guan J, Angelos MG.

PLoS One. 2015 Oct 16;10(10):e0141176. doi: 10.1371/journal.pone.0141176. eCollection 2015. No abstract available.

17.

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.

Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S.

Cardiovasc Res. 2015 Nov 1;108(2):299-311. doi: 10.1093/cvr/cvv222. Epub 2015 Sep 25.

18.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.

19.

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.

Glynn P, Musa H, Wu X, Unudurthi SD, Little S, Qian L, Wright PJ, Radwanski PB, Gyorke S, Mohler PJ, Hund TJ.

Circulation. 2015 Aug 18;132(7):567-77. doi: 10.1161/CIRCULATIONAHA.114.015218. Epub 2015 Jul 17.

20.

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch.

Khan M, Xu Y, Hua S, Johnson J, Belevych A, Janssen PM, Gyorke S, Guan J, Angelos MG.

PLoS One. 2015 May 19;10(5):e0126338. doi: 10.1371/journal.pone.0126338. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141176.

21.

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium.

Haizlip KM, Milani-Nejad N, Brunello L, Varian KD, Slabaugh JL, Walton SD, Gyorke S, Davis JP, Biesiadecki BJ, Janssen PM.

Biomed Res Int. 2015;2015:468548. doi: 10.1155/2015/468548. Epub 2015 Apr 15.

22.

Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.

Long VP 3rd, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Györke S, Carnes CA.

Life Sci. 2015 Feb 15;123:61-71. doi: 10.1016/j.lfs.2014.12.024. Epub 2015 Jan 14.

23.

Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise.

Roof SR, Ho HT, Little SC, Ostler JE, Brundage EA, Periasamy M, Villamena FA, Györke S, Biesiadecki BJ, Heymes C, Houser SR, Davis JP, Ziolo MT.

J Mol Cell Cardiol. 2015 Apr;81:54-61. doi: 10.1016/j.yjmcc.2015.01.003. Epub 2015 Jan 14.

24.

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.

Radwański PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, Györke S.

Cardiovasc Res. 2015 Apr 1;106(1):143-52. doi: 10.1093/cvr/cvu262. Epub 2014 Dec 23.

25.

Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.

Lou Q, Belevych AE, Radwański PB, Liu B, Kalyanasundaram A, Knollmann BC, Fedorov VV, Györke S.

J Physiol. 2015 Mar 15;593(6):1443-58. doi: 10.1113/jphysiol.2014.280784. Epub 2014 Dec 2.

26.

Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

Bonilla IM, Long VP 3rd, Vargas-Pinto P, Wright P, Belevych A, Lou Q, Mowrey K, Yoo J, Binkley PF, Fedorov VV, Györke S, Janssen PM, Kilic A, Mohler PJ, Carnes CA.

PLoS One. 2014 Oct 1;9(10):e108824. doi: 10.1371/journal.pone.0108824. eCollection 2014.

27.

Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.

Milani-Nejad N, Brunello L, Gyorke S, Janssen PM.

J Muscle Res Cell Motil. 2014 Aug;35(3-4):225-34. doi: 10.1007/s10974-014-9386-9. Epub 2014 Jul 24.

28.

Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.

Lou Q, Hansen BJ, Fedorenko O, Csepe TA, Kalyanasundaram A, Li N, Hage LT, Glukhov AV, Billman GE, Weiss R, Mohler PJ, Györke S, Biesiadecki BJ, Carnes CA, Fedorov VV.

Circulation. 2014 Jul 22;130(4):315-24. doi: 10.1161/CIRCULATIONAHA.113.007086. Epub 2014 May 16.

29.

EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology.

Curran J, Makara MA, Little SC, Musa H, Liu B, Wu X, Polina I, Alecusan JS, Wright P, Li J, Billman GE, Boyden PA, Gyorke S, Band H, Hund TJ, Mohler PJ.

Circ Res. 2014 Jun 20;115(1):68-78. doi: 10.1161/CIRCRESAHA.115.304149. Epub 2014 Apr 23.

30.

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.

Liu B, Ho HT, Velez-Cortes F, Lou Q, Valdivia CR, Knollmann BC, Valdivia HH, Gyorke S.

J Physiol. 2014 May 1;592(9):1957-73. doi: 10.1113/jphysiol.2013.264689. Epub 2014 Jan 20.

31.

Ibandronate and ventricular arrhythmia risk.

Bonilla IM, Vargas-Pinto P, Nishijima Y, Pedraza-Toscano A, Ho HT, Long VP 3rd, Belevych AE, Glynn P, Houmsse M, Rhodes T, Weiss R, Hund TJ, Hamlin RL, Györke S, Carnes CA.

J Cardiovasc Electrophysiol. 2014 Mar;25(3):299-306. doi: 10.1111/jce.12327. Epub 2013 Dec 20.

32.

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV.

Eur Heart J. 2015 Mar 14;36(11):686-97. doi: 10.1093/eurheartj/eht452. Epub 2013 Nov 11.

33.

Dietary omega-3 fatty acids promote arrhythmogenic remodeling of cellular Ca2+ handling in a postinfarction model of sudden cardiac death.

Belevych AE, Ho HT, Terentyeva R, Bonilla IM, Terentyev D, Carnes CA, Gyorke S, Billman GE.

PLoS One. 2013 Oct 18;8(10):e78414. doi: 10.1371/journal.pone.0078414. eCollection 2013.

34.

Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.

Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG.

J Am Heart Assoc. 2013 Oct 14;2(5):e000460. doi: 10.1161/JAHA.113.000460.

35.

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.

Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S.

Cardiovasc Res. 2014 Jan 1;101(1):165-74. doi: 10.1093/cvr/cvt233. Epub 2013 Oct 8.

36.

Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.

Chen H, Valle G, Furlan S, Nani A, Gyorke S, Fill M, Volpe P.

J Gen Physiol. 2013 Aug;142(2):127-36. doi: 10.1085/jgp.201311022. Epub 2013 Jul 15.

37.

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.

Brunello L, Slabaugh JL, Radwanski PB, Ho HT, Belevych AE, Lou Q, Chen H, Napolitano C, Lodola F, Priori SG, Fedorov VV, Volpe P, Fill M, Janssen PM, Györke S.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10312-7. doi: 10.1073/pnas.1300052110. Epub 2013 Jun 3.

38.

'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure.

Belevych AE, Radwański PB, Carnes CA, Györke S.

Cardiovasc Res. 2013 May 1;98(2):240-7. doi: 10.1093/cvr/cvt024. Epub 2013 Feb 12. Review.

39.

Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise.

Roof SR, Tang L, Ostler JE, Periasamy M, Györke S, Billman GE, Ziolo MT.

Basic Res Cardiol. 2013 Mar;108(2):332. doi: 10.1007/s00395-013-0332-6. Epub 2013 Feb 4.

40.

Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.

Bonilla IM, Sridhar A, Nishijima Y, Györke S, Cardounel AJ, Carnes CA.

J Cardiovasc Pharmacol. 2013 May;61(5):401-7. doi: 10.1097/FJC.0b013e31828748ca.

41.

Diesterified nitrone rescues nitroso-redox levels and increases myocyte contraction via increased SR Ca(2+) handling.

Traynham CJ, Roof SR, Wang H, Prosak RA, Tang L, Viatchenko-Karpinski S, Ho HT, Racoma IO, Catalano DJ, Huang X, Han Y, Kim SU, Gyorke S, Billman GE, Villamena FA, Ziolo MT.

PLoS One. 2012;7(12):e52005. doi: 10.1371/journal.pone.0052005. Epub 2012 Dec 27.

42.

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

Kalyanasundaram A, Lacombe VA, Belevych AE, Brunello L, Carnes CA, Janssen PM, Knollmann BC, Periasamy M, Gyørke S.

Cardiovasc Res. 2013 May 1;98(2):297-306. doi: 10.1093/cvr/cvs334. Epub 2012 Nov 6.

43.

Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling.

Radwański PB, Belevych AE, Brunello L, Carnes CA, Györke S.

J Mol Cell Cardiol. 2013 May;58:77-83. doi: 10.1016/j.yjmcc.2012.10.008. Epub 2012 Oct 27. Review.

44.

Endurance exercise training normalizes repolarization and calcium-handling abnormalities, preventing ventricular fibrillation in a model of sudden cardiac death.

Bonilla IM, Belevych AE, Sridhar A, Nishijima Y, Ho HT, He Q, Kukielka M, Terentyev D, Terentyeva R, Liu B, Long VP, Györke S, Carnes CA, Billman GE.

J Appl Physiol (1985). 2012 Dec 1;113(11):1772-83. doi: 10.1152/japplphysiol.00175.2012. Epub 2012 Oct 4.

45.

Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling.

Kranstuber AL, Del Rio C, Biesiadecki BJ, Hamlin RL, Ottobre J, Gyorke S, Lacombe VA.

Front Physiol. 2012 Jul 19;3:292. doi: 10.3389/fphys.2012.00292. eCollection 2012.

46.

Nitric oxide synthases and atrial fibrillation.

Bonilla IM, Sridhar A, Györke S, Cardounel AJ, Carnes CA.

Front Physiol. 2012 Apr 23;3:105. doi: 10.3389/fphys.2012.00105. eCollection 2012.

47.

Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency.

Slabaugh JL, Brunello L, Gyorke S, Janssen PM.

Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2267-75. doi: 10.1152/ajpheart.01004.2011. Epub 2012 Mar 30.

48.

Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Belevych AE, Terentyev D, Terentyeva R, Ho HT, Gyorke I, Bonilla IM, Carnes CA, Billman GE, Györke S.

Circ Res. 2012 Feb 17;110(4):569-77. doi: 10.1161/CIRCRESAHA.111.260455. Epub 2012 Jan 5.

49.

MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex.

Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D.

PLoS One. 2011;6(12):e28324. doi: 10.1371/journal.pone.0028324. Epub 2011 Dec 6.

50.

Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.

Kalyanasundaram A, Viatchenko-Karpinski S, Belevych AE, Lacombe VA, Hwang HS, Knollmann BC, Gyorke S, Periasamy M.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H253-61. doi: 10.1152/ajpheart.00578.2011. Epub 2011 Oct 7.

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