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Items: 1 to 50 of 92

1.

Iron accumulation promotes TACE-mediated TNF-α secretion and neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Gwag BJ, Choi EJ.

Neurobiol Dis. 2015 Aug;80:63-9. doi: 10.1016/j.nbd.2015.05.009. Epub 2015 May 20.

PMID:
26002422
2.

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12066-71. doi: 10.1073/pnas.1300894110. Epub 2013 Jul 1.

3.

AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease.

Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL.

Exp Neurobiol. 2013 Mar;22(1):31-7. doi: 10.5607/en.2013.22.1.31. Epub 2013 Mar 31.

4.

Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage.

Visavadiya NP, McEwen ML, Pandya JD, Sullivan PG, Gwag BJ, Springer JE.

Toxicol In Vitro. 2013 Mar;27(2):788-97. doi: 10.1016/j.tiv.2012.12.011. Epub 2012 Dec 23.

PMID:
23268106
5.

Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis.

Lee JH, An CS, Yun BS, Kang KS, Lee YA, Won SM, Gwag BJ, Cho SI, Hahm KB.

Eur J Pharmacol. 2012 Jul 15;687(1-3):28-38. doi: 10.1016/j.ejphar.2012.04.048. Epub 2012 May 3.

PMID:
22575522
6.

Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.

Shin JH, Lee YA, Lee JK, Lee YB, Cho W, Im DS, Lee JH, Yun BS, Springer JE, Gwag BJ.

J Neurochem. 2012 Sep;122(5):952-61. doi: 10.1111/j.1471-4159.2012.07771.x. Epub 2012 May 23.

7.

Role of the NMDA receptor and iron on free radical production and brain damage following transient middle cerebral artery occlusion.

Im DS, Jeon JW, Lee JS, Won SJ, Cho SI, Lee YB, Gwag BJ.

Brain Res. 2012 May 21;1455:114-23. doi: 10.1016/j.brainres.2012.03.025. Epub 2012 Mar 17.

PMID:
22483792
8.

Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice.

Park SM, Shin JH, Moon GJ, Cho SI, Lee YB, Gwag BJ.

BMC Neurosci. 2011 Oct 27;12:106. doi: 10.1186/1471-2202-12-106.

9.

Identification of oxidized serum albumin in the cerebrospinal fluid of ischaemic stroke patients.

Moon GJ, Shin DH, Im DS, Bang OY, Nam HS, Lee JH, Joo IS, Huh K, Gwag BJ.

Eur J Neurol. 2011 Sep;18(9):1151-8. doi: 10.1111/j.1468-1331.2011.03357.x. Epub 2011 Feb 8.

PMID:
21299736
10.
11.

Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke.

Cho SI, Park UJ, Chung JM, Gwag BJ.

Drug News Perspect. 2010 Nov;23(9):549-56. doi: 10.1358/dnp.2010.23.9.1513493. Review.

PMID:
21152450
12.

Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: an additional contributing factor of cognitive impairment.

Lee JS, Im DS, An YS, Hong JM, Gwag BJ, Joo IS.

Neurosci Lett. 2011 Feb 4;489(2):84-8. doi: 10.1016/j.neulet.2010.11.071. Epub 2010 Dec 4.

PMID:
21134418
13.

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat.

Park UJ, Lee YA, Won SM, Lee JH, Kang SH, Springer JE, Lee YB, Gwag BJ.

Acta Neuropathol. 2011 Apr;121(4):459-73. doi: 10.1007/s00401-010-0785-8. Epub 2010 Dec 1.

PMID:
21120509
15.

Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing.

Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ.

J Neurochem. 2010 Jul;114(1):160-70. doi: 10.1111/j.1471-4159.2010.06732.x. Epub 2010 Apr 3.

16.

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.

Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ.

Exp Mol Med. 2010 May 31;42(5):386-94.

17.

Influence of recanalization on uric acid patterns in acute ischemic stroke.

Hong JM, Bang OY, Chung CS, Joo IS, Gwag BJ, Ovbiagele B.

Cerebrovasc Dis. 2010;29(5):431-9. doi: 10.1159/000289346. Epub 2010 Mar 4.

PMID:
20203485
18.

The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury.

Springer JE, Rao RR, Lim HR, Cho SI, Moon GJ, Lee HY, Park EJ, Noh JS, Gwag BJ.

J Neurotrauma. 2010 Jan;27(1):139-49. doi: 10.1089/neu.2009.0952. Erratum in: J Neurotrauma. 2010 Mar;27(3):653.

19.

Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice.

Kim J, Kim TY, Hwang JJ, Lee JY, Shin JH, Gwag BJ, Koh JY.

Neurobiol Dis. 2009 May;34(2):221-9. doi: 10.1016/j.nbd.2009.01.004. Epub 2009 Jan 21.

PMID:
19344646
20.

Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex.

Ji KA, Eu MY, Kang SH, Gwag BJ, Jou I, Joe EH.

Glia. 2008 Aug 1;56(10):1039-47. doi: 10.1002/glia.20677.

PMID:
18381656
21.

In vivo tracking of human mesenchymal stem cells in experimental stroke.

Kim D, Chun BG, Kim YK, Lee YH, Park CS, Jeon I, Cheong C, Hwang TS, Chung H, Gwag BJ, Hong KS, Song J.

Cell Transplant. 2008;16(10):1007-12.

PMID:
18351016
22.
23.

Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia.

Wang HK, Park UJ, Kim SY, Lee JH, Kim SU, Gwag BJ, Lee YB.

J Neurosci. 2008 Feb 13;28(7):1721-7. doi: 10.1523/JNEUROSCI.4973-07.2008.

24.

Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice.

Choi CI, Lee YD, Gwag BJ, Cho SI, Kim SS, Suh-Kim H.

J Neurol Sci. 2008 May 15;268(1-2):40-7. Epub 2007 Dec 4.

PMID:
18054961
25.

In Vivo Tracking of Human Mesenchymal Stem Cells in Experimental Stroke.

Kim D, Chun BG, Kim YK, Lee YH, Park CS, Jeon I, Cheong C, Hwang TS, Chung H, Gwag BJ, Hong KS, Song J.

Cell Transplant. 2007 Nov;16(10):1007-1012. doi: 10.3727/000000007783472381.

PMID:
28866921
26.

Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.

Gwag BJ, Lee YA, Ko SY, Lee MJ, Im DS, Yun BS, Lim HR, Park SM, Byun HY, Son SJ, Kwon HJ, Lee JY, Cho JY, Won SJ, Kim KW, Ahn YM, Moon HS, Lee HU, Yoon SH, Noh JH, Chung JM, Cho SI.

J Cereb Blood Flow Metab. 2007 Jun;27(6):1142-51. Epub 2006 Nov 15.

PMID:
17106444
27.

Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis.

Shin JH, Cho SI, Lim HR, Lee JK, Lee YA, Noh JS, Joo IS, Kim KW, Gwag BJ.

Mol Pharmacol. 2007 Apr;71(4):965-75. Epub 2006 Nov 14.

PMID:
17105868
28.

Neuronal nitric oxide synthase (nNOS) modulates the JNK1 activity through redox mechanism: a cGMP independent pathway.

Park HS, Huh SH, Kim MS, Kim DY, Gwag BJ, Cho SG, Choi EJ.

Biochem Biophys Res Commun. 2006 Jul 28;346(2):408-14. Epub 2006 May 30.

PMID:
16764826
29.

Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein.

Lee KW, Im JY, Song JS, Lee SH, Lee HJ, Ha HY, Koh JY, Gwag BJ, Yang SD, Paik SG, Han PL.

Neurobiol Dis. 2006 Apr;22(1):10-24. Epub 2005 Nov 11.

PMID:
16289866
30.

Cellular and molecular pathways of ischemic neuronal death.

Won SJ, Kim DY, Gwag BJ.

J Biochem Mol Biol. 2002 Jan 31;35(1):67-86. Review.

PMID:
16248972
31.

Underlying mechanism for NMDA receptor antagonism by the anti-inflammatory drug, sulfasalazine, in mouse cortical neurons.

Noh JH, Gwag BJ, Chung JM.

Neuropharmacology. 2006 Jan;50(1):1-15. Epub 2005 Sep 19.

PMID:
16169564
32.

Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures.

Suh J, Lee YA, Gwag BJ.

J Neurochem. 2005 Nov;95(3):684-94. Epub 2005 Sep 2.

33.

Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease.

Kang HJ, Yoon WJ, Moon GJ, Kim DY, Sohn S, Kwon HJ, Gwag BJ.

Neurobiol Dis. 2005 Apr;18(3):450-8.

PMID:
15755671
34.

Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease.

Yang SP, Bae DG, Kang HJ, Gwag BJ, Gho YS, Chae CB.

Neurobiol Aging. 2004 Mar;25(3):283-90.

PMID:
15123332
35.

Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.

Kang HJ, Choi YS, Hong SB, Kim KW, Woo RS, Won SJ, Kim EJ, Jeon HK, Jo SY, Kim TK, Bachoo R, Reynolds IJ, Gwag BJ, Lee HW.

J Neurosci. 2004 Feb 11;24(6):1280-7.

36.

Antiapoptotic and pronecrotic actions of neurotrophins.

Gwag BJ, Kim SH.

Antioxid Redox Signal. 2003 Oct;5(5):621-7. Review.

PMID:
14580318
37.
40.

The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.

Ryu BR, Lee YA, Won SJ, Noh JH, Chang SY, Chung JM, Choi JS, Joo CK, Yoon SH, Gwag BJ.

J Pharmacol Exp Ther. 2003 Apr;305(1):48-56.

PMID:
12649352
41.

Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase.

Kim SH, Won SJ, Sohn S, Kwon HJ, Lee JY, Park JH, Gwag BJ.

J Cell Biol. 2002 Dec 9;159(5):821-31. Epub 2002 Dec 2.

42.

Caffeine-induced neuronal death in neonatal rat brain and cortical cell cultures.

Kang SH, Lee YA, Won SJ, Rhee KH, Gwag BJ.

Neuroreport. 2002 Oct 28;13(15):1945-50.

PMID:
12395097
43.

Analysis of mitochondrial free radical generation in animal models of neuronal disease.

Kim DY, Won SJ, Gwag BJ.

Free Radic Biol Med. 2002 Sep 1;33(5):715-23.

PMID:
12208358
44.

Structural requirements for the neuroprotective effects of aspirin analogues against N-methyl-D-aspartate and zinc ion neurotoxicity.

Moon HS, Nam SI, Kim SD, Kim D, Gwag BJ, Lee YA, Yoon SH.

J Pharm Pharmacol. 2002 Jul;54(7):935-44.

PMID:
12162712
45.

Attenuation of Zn2+ neurotoxicity by aspirin: role of N-type Ca2+ channel and the carboxyl acid group.

Kim EY, Chang SY, Chung JM, Ryu BR, Joo CK, Moon HS, Kang K, Yoon SH, Han PL, Gwag BJ.

Neurobiol Dis. 2001 Oct;8(5):774-83.

PMID:
11592847
46.

Complestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors: secure blockade of ischemic neuronal death.

Seo SY, Yun BS, Ryoo IJ, Choi JS, Joo CK, Chang SY, Chung JM, Oh S, Gwag BJ, Yoo ID.

J Pharmacol Exp Ther. 2001 Oct;299(1):377-84.

PMID:
11561102
47.
48.

High abundance of GluR1 mRNA and reduced Q/R editing of GluR2 mRNA in individual NADPH-diaphorase neurons.

Kim DY, Kim SH, Choi HB, Min C, Gwag BJ.

Mol Cell Neurosci. 2001 Jun;17(6):1025-33.

PMID:
11414791
49.

Zn(2+) induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-Kinase.

Eom SJ, Kim EY, Lee JE, Kang HJ, Shim J, Kim SU, Gwag BJ, Choi EJ.

Mol Pharmacol. 2001 May;59(5):981-6.

PMID:
11306679
50.

5-Hydroxytryptamine attenuates free radical injury in primary mouse cortical cultures.

Kang JY, Kang HJ, Chung YK, Gwag BJ, Noh JS.

Neuroreport. 2001 Apr 17;12(5):963-6.

PMID:
11303769

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