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Items: 1 to 50 of 66

1.

Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.

Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK.

FASEB J. 2019 Jun 28:fj201900154RR. doi: 10.1096/fj.201900154RR. [Epub ahead of print]

PMID:
31251083
2.

Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.

Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y.

J Immunol. 2019 Jul 1;203(1):293. doi: 10.4049/jimmunol.1900492. Epub 2019 May 24. No abstract available.

PMID:
31127031
3.

A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype.

Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S.

J Clin Immunol. 2019 Apr;39(3):249-256. doi: 10.1007/s10875-019-00618-3. Epub 2019 Apr 4. No abstract available.

PMID:
30949876
4.

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.

Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y.

Nat Immunol. 2019 Feb;20(2):152-162. doi: 10.1038/s41590-018-0287-8. Epub 2019 Jan 14.

5.

SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development.

He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z.

J Immunol. 2019 Feb 1;202(3):760-769. doi: 10.4049/jimmunol.1801187. Epub 2018 Dec 19.

PMID:
30567733
6.

Modulation of Orai1 and STIM1 by Cellular Factors.

Woo JS, Srikanth S, Gwack Y.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 4.

7.

CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.

Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y.

J Immunol. 2018 Aug 15;201(4):1174-1185. doi: 10.4049/jimmunol.1800659. Epub 2018 Jul 9. Erratum in: J Immunol. 2019 Jul 1;203(1):293.

PMID:
29987160
8.

Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells.

Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S.

Bone Rep. 2018 Apr 5;8:147-155. doi: 10.1016/j.bonr.2018.03.007. eCollection 2018 Jun.

9.

SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner.

Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E458-E467. doi: 10.1073/pnas.1717789115. Epub 2017 Dec 27.

10.

Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.

Srikanth S, Woo JS, Sun Z, Gwack Y.

Adv Exp Med Biol. 2017;993:397-424. doi: 10.1007/978-3-319-57732-6_21. Review.

PMID:
28900926
11.

Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt.

He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z.

J Immunol. 2017 Aug 1;199(3):955-964. doi: 10.4049/jimmunol.1700457. Epub 2017 Jun 30.

12.

Laminar flow downregulates Notch activity to promote lymphatic sprouting.

Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK.

J Clin Invest. 2017 Apr 3;127(4):1225-1240. doi: 10.1172/JCI87442. Epub 2017 Mar 6.

13.

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.

Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK.

Circ Res. 2017 Apr 28;120(9):1426-1439. doi: 10.1161/CIRCRESAHA.116.309548. Epub 2017 Feb 6.

14.

Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.

He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z.

J Immunol. 2016 Aug 15;197(4):1148-58. doi: 10.4049/jimmunol.1600548. Epub 2016 Jul 18.

15.

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma.

Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH.

Oncotarget. 2016 Jul 12;7(28):43239-43255. doi: 10.18632/oncotarget.9755.

16.

A large Rab GTPase family in a small GTPase world.

Srikanth S, Woo JS, Gwack Y.

Small GTPases. 2017 Jan 2;8(1):43-48. doi: 10.1080/21541248.2016.1192921. Epub 2016 May 24.

17.

Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.

Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH.

Biochem Biophys Res Commun. 2016 May 13;473(4):1309-1314. doi: 10.1016/j.bbrc.2016.04.068. Epub 2016 Apr 14.

18.

A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.

Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y.

Sci Signal. 2016 Mar 22;9(420):ra31. doi: 10.1126/scisignal.aac9171.

19.

Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.

Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2762-7. doi: 10.1073/pnas.1524229113. Epub 2016 Feb 29.

20.

Dental enamel cells express functional SOCE channels.

Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS.

Sci Rep. 2015 Oct 30;5:15803. doi: 10.1038/srep15803.

21.

The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells.

Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin KH, Kang MK, Wang C, Gwack Y, Park NH, Kim RH.

J Dent Res. 2015 Nov;94(11):1560-7. doi: 10.1177/0022034515608128. Epub 2015 Sep 24.

22.

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.

Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E.

Nat Immunol. 2014 Nov;15(11):1055-1063. doi: 10.1038/ni.3009. Epub 2014 Oct 5.

23.

Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes.

Srikanth S, Kim KD, Gwack Y.

Methods Enzymol. 2014;543:1-20. doi: 10.1016/B978-0-12-801329-8.00001-5.

PMID:
24924125
24.

Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.

Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M.

Sci Signal. 2014 Jun 10;7(329):ra54. doi: 10.1126/scisignal.2004983.

25.

Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.

Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y.

J Immunol. 2014 Jan 1;192(1):110-22. doi: 10.4049/jimmunol.1302586. Epub 2013 Dec 4.

26.

Molecular regulation of the pore component of CRAC channels, Orai1.

Srikanth S, Gwack Y.

Curr Top Membr. 2013;71:181-207. doi: 10.1016/B978-0-12-407870-3.00008-1. Review.

PMID:
23890116
27.

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.

Srikanth S, Gwack Y.

Mol Cells. 2013 Mar;35(3):182-94. doi: 10.1007/s10059-013-0073-2. Epub 2013 Mar 11. Review.

28.

Regulation of CRAC channels by protein interactions and post-translational modification.

Srikanth S, Ribalet B, Gwack Y.

Channels (Austin). 2013 Sep-Oct;7(5):354-63. doi: 10.4161/chan.23801. Epub 2013 Mar 1. Review.

29.

Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes.

Srikanth S, Gwack Y.

Methods Mol Biol. 2013;963:3-14. doi: 10.1007/978-1-62703-230-8_1.

PMID:
23296601
30.

Orai1, STIM1, and their associating partners.

Srikanth S, Gwack Y.

J Physiol. 2012 Sep 1;590(17):4169-77. doi: 10.1113/jphysiol.2012.231522. Epub 2012 May 14. Review.

31.

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).

Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8682-7. doi: 10.1073/pnas.1200667109. Epub 2012 May 14.

32.

ORAI1 deficiency impairs activated T cell death and enhances T cell survival.

Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y.

J Immunol. 2011 Oct 1;187(7):3620-30. doi: 10.4049/jimmunol.1100847. Epub 2011 Aug 26.

33.

The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties.

Srikanth S, Yee MK, Gwack Y, Ribalet B.

J Biol Chem. 2011 Oct 7;286(40):35318-28. doi: 10.1074/jbc.M111.265884. Epub 2011 Aug 24.

34.

Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM.

J Immunol. 2011 Jan 15;186(2):940-50. doi: 10.4049/jimmunol.1000942. Epub 2010 Dec 10.

35.

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.

Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y.

Nat Cell Biol. 2010 May;12(5):436-46. doi: 10.1038/ncb2045. Epub 2010 Apr 25.

36.

The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels.

Srikanth S, Jung HJ, Ribalet B, Gwack Y.

J Biol Chem. 2010 Feb 12;285(7):5066-75. doi: 10.1074/jbc.M109.072736. Epub 2009 Dec 10.

37.

Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68.

E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C.

PLoS Pathog. 2009 Oct;5(10):e1000609. doi: 10.1371/journal.ppat.1000609. Epub 2009 Oct 9.

38.

Hair loss and defective T- and B-cell function in mice lacking ORAI1.

Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A.

Mol Cell Biol. 2008 Sep;28(17):5209-22. doi: 10.1128/MCB.00360-08. Epub 2008 Jun 30.

39.

Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.

Mol Biol Cell. 2008 Jul;19(7):2802-17. doi: 10.1091/mbc.E08-02-0146. Epub 2008 Apr 30.

40.

Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.

Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A.

Cell Calcium. 2007 Aug;42(2):145-56. Epub 2007 Jun 18. Review.

PMID:
17572487
41.

Biochemical and functional characterization of Orai proteins.

Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A.

J Biol Chem. 2007 Jun 1;282(22):16232-43. Epub 2007 Feb 9.

42.

Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.

Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS.

J Biol Chem. 2007 Mar 23;282(12):9105-16. Epub 2007 Jan 15. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald [corrected to Gill, Donald L].

43.

Orai1 is an essential pore subunit of the CRAC channel.

Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG.

Nature. 2006 Sep 14;443(7108):230-3. Epub 2006 Aug 20.

PMID:
16921383
44.

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.

Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.

Nature. 2006 May 11;441(7090):179-85. Epub 2006 Apr 2.

PMID:
16582901
45.

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.

Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A.

Nature. 2006 Jun 1;441(7093):646-50. Epub 2006 Mar 1.

PMID:
16511445
46.

Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA.

Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU.

J Virol. 2005 Apr;79(8):4651-63.

47.

Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.

Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU.

Mol Cell Biol. 2004 Jun;24(12):5369-82.

48.

Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication.

Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU.

Mol Cell Biol. 2003 Nov;23(22):8282-94.

49.
50.

Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation.

Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU.

Mol Cell Biol. 2003 Mar;23(6):2055-67.

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