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Items: 1 to 50 of 145

1.

Evidence-based causation in toxicology: A 10-year retrospective.

James RC, Britt JK, Halmes NC, Guzelian PS.

Hum Exp Toxicol. 2015 Dec;34(12):1245-52. doi: 10.1177/0960327115601767. Review.

PMID:
26614812
2.

Comments on recent discussions providing differing causation methodologies.

James RC, Britt J, Halmes NC, Guzelian PS.

Hum Exp Toxicol. 2014 Jan;33(1):109-12. doi: 10.1177/0960327113491511. Epub 2013 Jun 7. No abstract available.

PMID:
23749455
3.

4.5 Evidence-based individual toxicological analysis.

Guzelian P.

Hum Exp Toxicol. 2009 Feb;28(2-3):136-8. doi: 10.1177/0960327109105772. No abstract available.

PMID:
19713380
4.

1.3 Consensus, opinion, and evidence-based science - three methods of reaching conclusions in toxicology.

Guzelian P.

Hum Exp Toxicol. 2009 Feb;28(2-3):97-9. doi: 10.1177/0960327109105758. No abstract available.

PMID:
19713369
5.

Clear path: towards an evidence-based toxicology (EBT).

Guzelian PS, Victoroff MS, Halmes C, James RC.

Hum Exp Toxicol. 2009 Feb;28(2-3):71-9. doi: 10.1177/0960327109102802. No abstract available.

PMID:
19713364
6.

Prevention of false scientific speech: a new role for an evidence-based approach.

Guzelian C, Guzelian P.

Hum Exp Toxicol. 2008 Oct;27(10):733-6. doi: 10.1177/0960327107084580. No abstract available.

PMID:
19042956
7.

Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.

Guzelian J, Barwick JL, Hunter L, Phang TL, Quattrochi LC, Guzelian PS.

Toxicol Sci. 2006 Dec;94(2):379-87. Epub 2006 Sep 22.

8.

Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion.

Guzelian P, Quattrochi L, Karch N, Aylward L, Kaley R.

Hum Exp Toxicol. 2006 Feb;25(2):99-105.

PMID:
16539215
9.

Evidence-based toxicology: a comprehensive framework for causation.

Guzelian PS, Victoroff MS, Halmes NC, James RC, Guzelian CP.

Hum Exp Toxicol. 2005 Apr;24(4):161-201. Review.

PMID:
15957536
10.

Authority-based explanation.

Guzelian PS, Guzelian CP.

Science. 2004 Mar 5;303(5663):1468-9. No abstract available.

PMID:
15001760
11.

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

Sonoda J, Xie W, Rosenfeld JM, Barwick JL, Guzelian PS, Evans RM.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13801-6. Epub 2002 Oct 7.

13.

Cyp3A regulation: from pharmacology to nuclear receptors.

Quattrochi LC, Guzelian PS.

Drug Metab Dispos. 2001 May;29(5):615-22. Review.

PMID:
11302925
14.

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.

Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM.

Genes Dev. 2000 Dec 1;14(23):3014-23.

15.
16.

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM.

Nature. 2000 Jul 27;406(6794):435-9.

PMID:
10935643
17.

Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23.

Quattrochi LC, Yockey CB, Barwick JL, Guzelian PS.

Arch Biochem Biophys. 1998 Jan 15;349(2):251-60.

PMID:
9448712
18.
19.

Relevance of rat liver tumors to human hepatic and endometrial cancer.

Guzelian PS.

Semin Oncol. 1997 Feb;24(1 Suppl 1):S1-105-S1-21. Review.

PMID:
9045309
20.

Mechanisms of alcohol impairment of recovery from mechanically denuded areas made within cultured rat hepatocytes.

Anderson RJ, Sponsel HT, Brown SE, Breckon R, Ray C, Simon FR, Guzelian PS.

Hepatology. 1997 Jan;25(1):128-32.

PMID:
8985278
21.

Mechanisms of recovery from mechanical injury of cultured rat hepatocytes.

Sponsel HT, Guzelian PS, Brown SE, Breckon R, Ray C, Simon FR, Anderson RJ.

Am J Physiol. 1996 Sep;271(3 Pt 1):C721-7.

PMID:
8843700
23.
24.

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.

Schuetz JD, Schuetz EG, Thottassery JV, Guzelian PS, Strom S, Sun D.

Mol Pharmacol. 1996 Jan;49(1):63-72.

PMID:
8569713
25.

Critical role of extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes.

Brown SE, Guzelian CP, Schuetz E, Quattrochi LC, Kleinman HK, Guzelian PS.

Lab Invest. 1995 Dec;73(6):818-27.

PMID:
8558843
26.

A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids.

Quattrochi LC, Mills AS, Barwick JL, Yockey CB, Guzelian PS.

J Biol Chem. 1995 Dec 1;270(48):28917-23.

27.

Science funding. The National Advisory Environmental Health Sciences Council.

Barfield NC, Buffler PA, Graham DG, Gray-Little B, Greenberger P, Guzelian PS, Henderson M, Henderson R, Jones L, Lieberman M, et al.

Environ Health Perspect. 1995 Nov;103(11):984-5. No abstract available.

28.

Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes.

Ginès P, Li X, Zamarripa JL, Brown SE, Wieder ED, Nakamura T, Guzelian PS, Schrier RW, Heasley LE, Nemenoff RA.

Hepatology. 1995 Oct;22(4 Pt 1):1296-303.

PMID:
7557884
29.

Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats.

Ghosh SS, Basu AK, Ghosh S, Hagley R, Kramer L, Schuetz J, Grogan WM, Guzelian P, Watlington CO.

Biochem Pharmacol. 1995 Jun 29;50(1):49-54.

PMID:
7605344
30.

Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene.

Schuetz JD, Guzelian PS.

Biochim Biophys Acta. 1995 Mar 14;1261(1):161-5.

PMID:
7893755
31.

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

Kocarek TA, Schuetz EG, Strom SC, Fisher RA, Guzelian PS.

Drug Metab Dispos. 1995 Mar;23(3):415-21.

PMID:
7628309
32.

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

Jounaïdi Y, Guzelian PS, Maurel P, Vilarem MJ.

Biochem Biophys Res Commun. 1994 Dec 30;205(3):1741-7.

PMID:
7811260
33.
34.
35.

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.

Schuetz JD, Beach DL, Guzelian PS.

Pharmacogenetics. 1994 Feb;4(1):11-20.

PMID:
8004129
36.

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes.

Schuetz EG, Schuetz JD, Strom SC, Thompson MT, Fisher RA, Molowa DT, Li D, Guzelian PS.

Hepatology. 1993 Nov;18(5):1254-62.

PMID:
8225233
37.

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.

Schuetz JD, Kauma S, Guzelian PS.

J Clin Invest. 1993 Aug;92(2):1018-24.

38.

Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes.

Pan J, Hong JY, Li D, Schuetz EG, Guzelian PS, Huang W, Yang CS.

Biochem Pharmacol. 1993 Jun 9;45(11):2323-9.

PMID:
8390837
39.
40.

Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel.

Kocarek TA, Schuetz EG, Guzelian PS.

Mol Pharmacol. 1993 Mar;43(3):328-34.

PMID:
8450830
41.

Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes.

Kocarek TA, Schuetz EG, Guzelian PS.

In Vitro Cell Dev Biol. 1993 Jan;29A(1):62-6.

PMID:
8444746
42.
43.

Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity.

Watkins PB, Turgeon DK, Saenger P, Lown KS, Kolars JC, Hamilton T, Fishman K, Guzelian PS, Voorhees JJ.

Clin Pharmacol Ther. 1992 Sep;52(3):265-73.

44.

Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats.

Watlington CO, Kramer LB, Schuetz EG, Zilai J, Grogan WM, Guzelian P, Gizek F, Schoolwerth AC.

Am J Physiol. 1992 Jun;262(6 Pt 2):F927-31.

PMID:
1621817
45.

Expression of cytochrome P450 3A in amphibian, rat, and human kidney.

Schuetz EG, Schuetz JD, Grogan WM, Naray-Fejes-Toth A, Fejes-Toth G, Raucy J, Guzelian P, Gionela K, Watlington CO.

Arch Biochem Biophys. 1992 Apr;294(1):206-14.

PMID:
1550347
47.

Developmental toxicants risk assessment.

Guzelian PS, Henry CJ, Farland WH, Olin SS.

Pediatrics. 1992 Feb;89(2):353. No abstract available.

PMID:
1734414
48.

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.

Hunt CM, Watkins PB, Saenger P, Stave GM, Barlascini N, Watlington CO, Wright JT Jr, Guzelian PS.

Clin Pharmacol Ther. 1992 Jan;51(1):18-23.

49.

Characterization of human liver cytochromes P-450 involved in theophylline metabolism.

Sarkar MA, Hunt C, Guzelian PS, Karnes HT.

Drug Metab Dispos. 1992 Jan-Feb;20(1):31-7.

PMID:
1346993
50.

Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture.

Hunt CM, Guzelian PS, Molowa DT, Wright SA.

Xenobiotica. 1991 Dec;21(12):1621-31.

PMID:
1785207

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