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Items: 1 to 50 of 81

1.

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.

Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH, Houck KA, Kane A, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M.

Cancer Epidemiol Biomarkers Prev. 2020 Mar 9. pii: cebp.1346.2019. doi: 10.1158/1055-9965.EPI-19-1346. [Epub ahead of print]

PMID:
32152214
2.

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.

La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, Guyton KZ, Kortenkamp A, Cogliano VJ, Woodruff TJ, Rieswijk L, Sone H, Korach KS, Gore AC, Zeise L, Zoeller RT.

Nat Rev Endocrinol. 2020 Jan;16(1):45-57. doi: 10.1038/s41574-019-0273-8. Epub 2019 Nov 12. Review.

3.

The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification.

Samet JM, Chiu WA, Cogliano V, Jinot J, Kriebel D, Lunn RM, Beland FA, Bero L, Browne P, Fritschi L, Kanno J, Lachenmeier DW, Lan Q, Lasfargues G, Le Curieux F, Peters S, Shubat P, Sone H, White MC, Williamson J, Yakubovskaya M, Siemiatycki J, White PA, Guyton KZ, Schubauer-Berigan MK, Hall AL, Grosse Y, Bouvard V, Benbrahim-Tallaa L, El Ghissassi F, Lauby-Secretan B, Armstrong B, Saracci R, Zavadil J, Straif K, Wild CP.

J Natl Cancer Inst. 2020 Jan 1;112(1):30-37. doi: 10.1093/jnci/djz169.

4.

Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.

Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, Zavadil J.

Genome Res. 2019 Apr;29(4):521-531. doi: 10.1101/gr.242453.118. Epub 2019 Mar 7.

5.

Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates.

Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2018 Aug;19(8):1020-1022. doi: 10.1016/S1470-2045(18)30491-1. Epub 2018 Jun 28. No abstract available.

PMID:
30700372
6.

Key Characteristics Approach to Carcinogenic Hazard Identification.

Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT.

Chem Res Toxicol. 2018 Dec 17;31(12):1290-1292. doi: 10.1021/acs.chemrestox.8b00321. Epub 2018 Dec 6.

7.

Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification.

Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N.

Environ Health Perspect. 2018 Oct;126(10):104501. doi: 10.1289/EHP4224.

8.

Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Jul 30;39(8):1091-1093. doi: 10.1093/carcin/bgy082. No abstract available.

9.

Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals.

Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA.

Environ Health Perspect. 2018 May 29;126(5):057008. doi: 10.1289/EHP2998. eCollection 2018 May.

10.

Application of the key characteristics of carcinogens in cancer hazard identification.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Apr 5;39(4):614-622. doi: 10.1093/carcin/bgy031.

11.

Carcinogenicity of benzene.

Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Vilahur N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2017 Dec;18(12):1574-1575. doi: 10.1016/S1470-2045(17)30832-X. Epub 2017 Oct 26. No abstract available.

PMID:
29107678
12.

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop.

Corvi R, Madia F, Guyton KZ, Kasper P, Rudel R, Colacci A, Kleinjans J, Jennings P.

Toxicol In Vitro. 2017 Dec;45(Pt 3):278-286. doi: 10.1016/j.tiv.2017.09.010. Epub 2017 Sep 12.

13.

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I.

ALTEX. 2018;35(1):51-64. doi: 10.14573/altex.1703231. Epub 2017 Jul 24.

14.

Some chemicals that cause tumours of the urinary tract in rodents.

Grosse Y, Loomis D, Guyton KZ, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2017 Aug;18(8):1003-1004. doi: 10.1016/S1470-2045(17)30505-3. Epub 2017 Jun 27. No abstract available.

PMID:
28666821
15.

Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide.

Guha N, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Vilahur N, Muller K, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2017 May;18(5):581-582. doi: 10.1016/S1470-2045(17)30255-3. Epub 2017 Apr 10. No abstract available.

PMID:
28408286
16.

Classification schemes for carcinogenicity based on hazard identification serve science and society.

Loomis D, Guyton KZ, Straif K, Wild CP.

Regul Toxicol Pharmacol. 2017 Aug;88:356-357. doi: 10.1016/j.yrtph.2017.02.010. Epub 2017 Feb 16. No abstract available.

17.

The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.

18.

Carcinogenicity of pentachlorophenol and some related compounds.

Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2016 Dec;17(12):1637-1638. doi: 10.1016/S1470-2045(16)30513-7. Epub 2016 Oct 23. No abstract available. Erratum in: Lancet Oncol. 2017 Dec;18(12 ):e711.

PMID:
27784619
19.

Reply to "the critical role of pre-publication peer review-a case study of glyphosate" by FN Dost.

Guyton KZ, Loomis D, Straif K.

Environ Sci Pollut Res Int. 2017 Mar;24(8):7850-7851. doi: 10.1007/s11356-016-7675-0. Epub 2016 Oct 10. No abstract available.

PMID:
27726074
20.

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.

Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH.

J Pharmacol Exp Ther. 2016 Oct;359(1):110-23. doi: 10.1124/jpet.116.232629. Epub 2016 Aug 10. Review.

21.

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.

Vandenberg LN, Ågerstrand M, Beronius A, Beausoleil C, Bergman Å, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Rudén C.

Environ Health. 2016 Jul 14;15(1):74. doi: 10.1186/s12940-016-0156-6. Review.

22.

Carcinogenicity of drinking coffee, mate, and very hot beverages.

Loomis D, Guyton KZ, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2016 Jul;17(7):877-878. doi: 10.1016/S1470-2045(16)30239-X. Epub 2016 Jun 15. No abstract available.

PMID:
27318851
23.

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.

Chappell G, Pogribny IP, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2016 Apr-Jun;768:27-45. doi: 10.1016/j.mrrev.2016.03.004. Epub 2016 Mar 31. Review.

24.

Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides.

Guha N, Guyton KZ, Loomis D, Barupal DK.

Environ Health Perspect. 2016 Dec;124(12):1823-1829. Epub 2016 May 10.

25.

Carcinogenicity of some industrial chemicals.

Grosse Y, Loomis D, Guyton KZ, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2016 Apr;17(4):419-20. doi: 10.1016/S1470-2045(16)00137-6. Epub 2016 Feb 24. No abstract available.

PMID:
26928709
26.

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.

Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K.

Environ Health Perspect. 2016 Jun;124(6):713-21. doi: 10.1289/ehp.1509912. Epub 2015 Nov 24.

27.

Carcinogenicity of consumption of red and processed meat.

Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2015 Dec;16(16):1599-600. doi: 10.1016/S1470-2045(15)00444-1. Epub 2015 Oct 29. No abstract available.

PMID:
26514947
28.

Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate.

Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group, IARC, Lyon, France.

Lancet Oncol. 2015 May;16(5):490-1. doi: 10.1016/S1470-2045(15)70134-8. Epub 2015 Mar 20. No abstract available.

PMID:
25801782
29.

Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes.

Grosse Y, Loomis D, Guyton KZ, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2014 Dec;15(13):1427-1428. doi: 10.1016/S1470-2045(14)71109-X. Epub 2014 Oct 31. No abstract available.

PMID:
25499275
30.

Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.

Lash LH, Chiu WA, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:22-36. Review.

31.

Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone.

Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2014 Aug;15(9):924-5. No abstract available.

PMID:
25225686
32.

Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure.

Thomas R, Hubbard AE, McHale CM, Zhang L, Rappaport SM, Lan Q, Rothman N, Vermeulen R, Guyton KZ, Jinot J, Sonawane BR, Smith MT.

PLoS One. 2014 May 1;9(5):e91828. doi: 10.1371/journal.pone.0091828. eCollection 2014.

33.

Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 25.

34.

Human health effects of tetrachloroethylene: key findings and scientific issues.

Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS, Kopylev L, Barone S, Makris SL, Glenn B, Subramaniam RP, Gwinn MR, Dzubow RC, Chiu WA.

Environ Health Perspect. 2014 Apr;122(4):325-34. doi: 10.1289/ehp.1307359. Epub 2014 Feb 14.

35.

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 11.

36.

Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ.

Pharmacol Ther. 2014 Jan;141(1):55-68. doi: 10.1016/j.pharmthera.2013.08.004. Epub 2013 Aug 23. Review.

37.

A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I.

Regul Toxicol Pharmacol. 2013 Nov;67(2):266-77. doi: 10.1016/j.yrtph.2013.08.005. Epub 2013 Aug 16.

38.

Human health effects of trichloroethylene: key findings and scientific issues.

Chiu WA, Jinot J, Scott CS, Makris SL, Cooper GS, Dzubow RC, Bale AS, Evans MV, Guyton KZ, Keshava N, Lipscomb JC, Barone S Jr, Fox JF, Gwinn MR, Schaum J, Caldwell JC.

Environ Health Perspect. 2013 Mar;121(3):303-11. doi: 10.1289/ehp.1205879. Epub 2012 Dec 18. Review.

39.

Addressing human variability in next-generation human health risk assessments of environmental chemicals.

Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ.

Environ Health Perspect. 2013 Jan;121(1):23-31. doi: 10.1289/ehp.1205687. Epub 2012 Oct 19.

40.

Upstream adverse effects in risk assessment: a model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans.

Wise A, Parham F, Axelrad DA, Guyton KZ, Portier C, Zeise L, Zoeller RT, Woodruff TJ.

Environ Res. 2012 Aug;117:90-9. doi: 10.1016/j.envres.2012.05.013. Epub 2012 Jul 7.

PMID:
22770859
41.

Approaches to human health risk assessment based on the signal-to-noise crossover dose.

Chiu WA, Guyton KZ, Hogan K, Jinot J.

Environ Health Perspect. 2012 Jul;120(7):a264; author reply a264-5. doi: 10.1289/ehp.1205212. No abstract available.

42.

Adverse effects in risk assessment: modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans.

Parham F, Wise A, Axelrad DA, Guyton KZ, Portier C, Zeise L, Thomas Zoeller R, Woodruff TJ.

Environ Res. 2012 Jul;116:74-84. doi: 10.1016/j.envres.2012.04.003. Epub 2012 May 9.

43.

Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data.

Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A.

Toxicol Sci. 2012 May;127(1):1-9. doi: 10.1093/toxsci/kfs095. Epub 2012 Mar 2.

44.

DNA repair during in utero development: a review of the current state of knowledge, research needs, and potential application in risk assessment.

Pachkowski BF, Guyton KZ, Sonawane B.

Mutat Res. 2011 Jul-Oct;728(1-2):35-46. doi: 10.1016/j.mrrev.2011.05.003. Epub 2011 Jun 6. Review.

PMID:
21679774
45.

A review of the genotoxicity of 1,2-dichloroethane (EDC).

Gwinn MR, Johns DO, Bateson TF, Guyton KZ.

Mutat Res. 2011 Jan-Apr;727(1-2):42-53. doi: 10.1016/j.mrrev.2011.01.001. Epub 2011 Jan 19. Review.

PMID:
21255676
46.

Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity.

Ginsberg G, Neafsey P, Hattis D, Guyton KZ, Johns DO, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):473-507. doi: 10.1080/10937400903158409. Review.

PMID:
20183530
47.

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.

Walker K, Ginsberg G, Hattis D, Johns DO, Guyton KZ, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):440-72. doi: 10.1080/10937400903158383. Review.

PMID:
20183529
48.

Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity.

Ginsberg G, Smolenski S, Hattis D, Guyton KZ, Johns DO, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):389-439. doi: 10.1080/10937400903158375. Review.

PMID:
20183528
49.

Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity.

Neafsey P, Ginsberg G, Hattis D, Johns DO, Guyton KZ, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):362-88. doi: 10.1080/10937400903158359. Review.

PMID:
20183527
50.

The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes.

Ginsberg G, Smolenski S, Neafsey P, Hattis D, Walker K, Guyton KZ, Johns DO, Sonawane B.

J Toxicol Environ Health B Crit Rev. 2009;12(5-6):307-33. doi: 10.1080/10937400903158318. Review.

PMID:
20183525

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