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Items: 1 to 50 of 71

1.

Stability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations.

Yun S, Guy HR.

J Mol Graph Model. 2011 Feb;29(5):663-75. doi: 10.1016/j.jmgm.2010.12.002. Epub 2010 Dec 13.

2.

Analysis of the stabilities of hexameric amyloid-β(1-42) models using discrete molecular dynamics simulations.

Yun S, Yun S, Guy HR.

J Mol Graph Model. 2011 Feb;29(5):657-62. doi: 10.1016/j.jmgm.2010.11.008. Epub 2010 Nov 26.

3.

Structural models of TREK channels and their gating mechanism.

Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HR.

Channels (Austin). 2011 Jan-Feb;5(1):23-33. Epub 2011 Jan 1.

4.

Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.

Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev S.

Channels (Austin). 2011 Jan-Feb;5(1):34-42. Epub 2011 Jan 1.

5.

Models of membrane-bound Alzheimer's Abeta peptide assemblies.

Shafrir Y, Durell S, Arispe N, Guy HR.

Proteins. 2010 Dec;78(16):3473-87. doi: 10.1002/prot.22853. Epub 2010 Oct 11.

6.

Beta-barrel models of soluble amyloid beta oligomers and annular protofibrils.

Shafrir Y, Durell SR, Anishkin A, Guy HR.

Proteins. 2010 Dec;78(16):3458-72. doi: 10.1002/prot.22832.

7.
8.

The KtrA and KtrE subunits are required for Na+-dependent K+ uptake by KtrB across the plasma membrane in Synechocystis sp. strain PCC 6803.

Zulkifli L, Akai M, Yoshikawa A, Shimojima M, Ohta H, Guy HR, Uozumi N.

J Bacteriol. 2010 Oct;192(19):5063-70. doi: 10.1128/JB.00569-10. Epub 2010 Jul 23.

9.

Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.

Anishkin A, Milac AL, Guy HR.

Proteins. 2010 Mar;78(4):932-49. doi: 10.1002/prot.22618.

10.

Pore stability and gating in voltage-activated calcium channels.

Hering S, Beyl S, Stary A, Kudrnac M, Hohaus A, Guy HR, Timin E.

Channels (Austin). 2008 Mar-Apr;2(2):61-9. Epub 2008 Mar 14. Review.

11.

Structural model of the Ca V 1.2 pore.

Stary A, Shafrir Y, Hering S, Wolschann P, Guy HR.

Channels (Austin). 2008 May-Jun;2(3):210-5. Epub 2008 May 18.

PMID:
18836302
12.

Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2.

Stary A, Kudrnac M, Beyl S, Hohaus A, Timin EN, Wolschann P, Guy HR, Hering S.

Channels (Austin). 2008 May-Jun;2(3):216-23. Epub 2008 May 18.

13.

Role of positively charged amino acids in the M2D transmembrane helix of Ktr/Trk/HKT type cation transporters.

Kato N, Akai M, Zulkifli L, Matsuda N, Kato Y, Goshima S, Hazama A, Yamagami M, Guy HR, Uozumi N.

Channels (Austin). 2007 May-Jun;1(3):161-71. Epub 2007 Apr 30.

PMID:
18690031
14.

Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.

Shafrir Y, Durell SR, Guy HR.

Biophys J. 2008 Oct;95(8):3650-62. doi: 10.1529/biophysj.108.135327. Epub 2008 Jul 18.

15.

Models of voltage-dependent conformational changes in NaChBac channels.

Shafrir Y, Durell SR, Guy HR.

Biophys J. 2008 Oct;95(8):3663-76. doi: 10.1529/biophysj.108.135335. Epub 2008 Jul 18.

16.

Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.

Tseng GN, Sonawane KD, Korolkova YV, Zhang M, Liu J, Grishin EV, Guy HR.

Biophys J. 2007 May 15;92(10):3524-40. Epub 2007 Feb 9.

17.

Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel.

Zhang M, Liu J, Jiang M, Wu DM, Sonawane K, Guy HR, Tseng GN.

J Membr Biol. 2005 Oct;207(3):169-81.

PMID:
16550488
18.

Structure-function studies of the outer mouth and voltage sensor domain of hERG.

Tseng GN, Guy HR.

Novartis Found Symp. 2005;266:19-35; discussion 35-45.

PMID:
16050260
19.

Transmembrane interactions of alpha/beta integrin signaling.

Guy HR.

Structure. 2005 May;13(5):683-4. No abstract available.

20.

A model of voltage gating developed using the KvAP channel crystal structure.

Shrivastava IH, Durell SR, Guy HR.

Biophys J. 2004 Oct;87(4):2255-70.

21.

Models of the structure and voltage-gating mechanism of the shaker K+ channel.

Durell SR, Shrivastava IH, Guy HR.

Biophys J. 2004 Oct;87(4):2116-30.

22.

STAM: simple transmembrane alignment method.

Shafrir Y, Guy HR.

Bioinformatics. 2004 Mar 22;20(5):758-69. Epub 2004 Jan 29.

PMID:
14751993
23.

On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.

Anishkin A, Gendel V, Sharifi NA, Chiang CS, Shirinian L, Guy HR, Sukharev S.

J Gen Physiol. 2003 Mar;121(3):227-44.

24.

A common architecture for K+ channels and ionotropic glutamate receptors?

Kuner T, Seeburg PH, Guy HR.

Trends Neurosci. 2003 Jan;26(1):27-32. Review. No abstract available.

PMID:
12495860
25.
26.

A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension.

Betanzos M, Chiang CS, Guy HR, Sukharev S.

Nat Struct Biol. 2002 Sep;9(9):704-10.

PMID:
12172538
27.

A family of putative Kir potassium channels in prokaryotes.

Durell SR, Guy HR.

BMC Evol Biol. 2001;1:14. Epub 2001 Dec 20.

28.

Structural models of the MscL gating mechanism.

Sukharev S, Durell SR, Guy HR.

Biophys J. 2001 Aug;81(2):917-36.

29.

A putative prokaryote voltage-gated Ca(2+) channel with only one 6TM motif per subunit.

Durell SR, Guy HR.

Biochem Biophys Res Commun. 2001 Mar 2;281(3):741-6.

PMID:
11237720
30.

The gating mechanism of the large mechanosensitive channel MscL.

Sukharev S, Betanzos M, Chiang CS, Guy HR.

Nature. 2001 Feb 8;409(6821):720-4.

PMID:
11217861
31.

Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1.

Cho HC, Tsushima RG, Nguyen TT, Guy HR, Backx PH.

Biochemistry. 2000 Apr 25;39(16):4649-57.

PMID:
10769120
34.

Evolutionary relationship between K(+) channels and symporters.

Durell SR, Hao Y, Nakamura T, Bakker EP, Guy HR.

Biophys J. 1999 Aug;77(2):775-88.

35.

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.

Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P, Berg E, Liu G, Guy HR, Durell SR, Parmentier M, Chang CN, Price K, Tsang M, Doms RW.

J Biol Chem. 1999 Apr 2;274(14):9617-26.

36.
37.

NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.

Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR.

Nature. 1997 Jan 16;385(6613):272-5.

PMID:
9000078
38.

Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli.

Blount P, Sukharev SI, Moe PC, Schroeder MJ, Guy HR, Kung C.

EMBO J. 1996 Sep 16;15(18):4798-805.

39.
40.

MscL: a mechanosensitive channel in Escherichia coli.

Sukharev SI, Blount P, Martinac B, Guy HR, Kung C.

Soc Gen Physiol Ser. 1996;51:133-41. Review. No abstract available.

PMID:
8809939
41.

Developing three-dimensional models of ion channel proteins.

Guy HR, Durell SR.

Ion Channels. 1996;4:1-40. Review. No abstract available.

PMID:
8744205
42.

The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains.

Reid JD, Lukas W, Shafaatian R, Bertl A, Scheurmann-Kettner C, Guy HR, North RA.

Receptors Channels. 1996;4(1):51-62.

PMID:
8723646
43.

min K channels form by assembly of at least 14 subunits.

Tzounopoulos T, Guy HR, Durell S, Adelman JP, Maylie J.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9593-7.

44.

Structural models of Na+, Ca2+, and K+ channels.

Guy HR, Durell SR.

Soc Gen Physiol Ser. 1995;50:1-16. Review.

PMID:
7676315
45.

Theoretical models of the ion channel structure of amyloid beta-protein.

Durell SR, Guy HR, Arispe N, Rojas E, Pollard HB.

Biophys J. 1994 Dec;67(6):2137-45.

46.

Using sequence homology to analyze the structure and function of voltage-gated ion channel proteins.

Guy HR, Durell SR.

Soc Gen Physiol Ser. 1994;49:197-212. Review.

PMID:
7524164
47.

Modeling the ion channel structure of cecropin.

Durell SR, Raghunathan G, Guy HR.

Biophys J. 1992 Dec;63(6):1623-31.

48.

Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes.

Cruciani RA, Barker JL, Durell SR, Raghunathan G, Guy HR, Zasloff M, Stanley EF.

Eur J Pharmacol. 1992 Aug 3;226(4):287-96.

PMID:
1383011
49.

Analyzing the fusion process of influenza hemagglutinin by mutagenesis and molecular modeling.

Guy HR, Durell SR, Schoch C, Blumenthal R.

Biophys J. 1992 Apr;62(1):95-7. No abstract available.

50.

Atomic scale structure and functional models of voltage-gated potassium channels.

Durell SR, Guy HR.

Biophys J. 1992 Apr;62(1):238-47; discussion 247-50.

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