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Items: 12


Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.

Estoppey D, Hewett JW, Guy CT, Harrington E, Thomas JR, Schirle M, Cuttat R, Waldt A, Gerrits B, Yang Z, Schuierer S, Pan X, Xie K, Carbone W, Knehr J, Lindeman A, Russ C, Frias E, Hoffman GR, Varadarajan M, Ramadan N, Reece-Hoyes JS, Wang Q, Chen X, McAllister G, Roma G, Bouwmeester T, Hoepfner D.

Sci Rep. 2017 Feb 16;7:42728. doi: 10.1038/srep42728.


Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.

Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34. doi: 10.1073/pnas.1217072110. Epub 2013 Feb 19.


Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation.

Didiot MC, Hewett J, Varin T, Freuler F, Selinger D, Nick H, Reinhardt J, Buckler A, Myer V, Schuffenhauer A, Guy CT, Parker CN.

J Biomol Screen. 2013 Apr;18(4):407-19. doi: 10.1177/1087057112466698. Epub 2012 Nov 13.


NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.

Jensen MR, Schoepfer J, Radimerski T, Massey A, Guy CT, Brueggen J, Quadt C, Buckler A, Cozens R, Drysdale MJ, Garcia-Echeverria C, Chène P.

Breast Cancer Res. 2008;10(2):R33. doi: 10.1186/bcr1996. Epub 2008 Apr 22.


Transgenic animal models.

Guy CT, Cardoso G.

Methods Mol Med. 2001;58:231-49. doi: 10.1385/1-59259-137-X:231.


Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family.

Chen G, Guy CT, Chen HW, Hu N, Lee EY, Lee WH.

J Biol Chem. 1996 Apr 19;271(16):9567-72.


Activated neu induces rapid tumor progression.

Guy CT, Cardiff RD, Muller WJ.

J Biol Chem. 1996 Mar 29;271(13):7673-8.


E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes.

Guy CT, Zhou W, Kaufman S, Robinson MO.

Mol Cell Biol. 1996 Feb;16(2):685-93.


Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ.

Genes Dev. 1994 Jan;8(1):23-32.


PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.

Trimble MS, Xin JH, Guy CT, Muller WJ, Hassell JA.

Oncogene. 1993 Nov;8(11):3037-42.


Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ.

Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10578-82.

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