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Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.

Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H.

Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11.


Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).

Palacios DS, Meredith EL, Kawanami T, Adams CM, Chen X, Darsigny V, Palermo M, Baird D, George EL, Guy C, Hewett J, Tierney L, Thigale S, Wang L, Weihofen WA.

ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529. doi: 10.1021/acsmedchemlett.9b00325. eCollection 2019 Nov 14.


Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Harrison SA, Bashir MR, Guy CD, Zhou R, Moylan CA, Frias JP, Alkhouri N, Bansal MB, Baum S, Neuschwander-Tetri BA, Taub R, Moussa SE.

Lancet. 2019 Nov 30;394(10213):2012-2024. doi: 10.1016/S0140-6736(19)32517-6. Epub 2019 Nov 11.


Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress.

Du X, Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H.

J Exp Med. 2020 Feb 3;217(2). pii: e20190969. doi: 10.1084/jem.20190969.


Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.

Jewell ML, Gibson JR, Guy CD, Hyun J, Du K, Oh SH, Premont RT, Hsu DS, Ribar T, Gregory SG, Diehl AME.

Am J Pathol. 2020 Jan;190(1):93-107. doi: 10.1016/j.ajpath.2019.09.018. Epub 2019 Oct 24.


Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb.

Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H.

Immunity. 2019 Dec 17;51(6):1012-1027.e7. doi: 10.1016/j.immuni.2019.10.001. Epub 2019 Oct 24.


A fast and scalable method for quality assurance of deformable image registration on lung CT scans using convolutional neural networks.

Galib SM, Lee HK, Guy CL, Riblett MJ, Hugo GD.

Med Phys. 2020 Jan;47(1):99-109. doi: 10.1002/mp.13890. Epub 2019 Nov 19.


Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis.

Guy CS, Murray K, Gibson MI, Fullam E.

Org Biomol Chem. 2019 Nov 6;17(43):9524-9528. doi: 10.1039/c9ob02222h.


Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis.

Siddiqui MS, Van Natta ML, Connelly MA, Vuppalanchi R, Neuschwander-Tetri BA, Tonascia J, Guy C, Loomba R, Dasarathy S, Wattacheril J, Chalasani N, Sanyal AJ; NASH CRN.

J Hepatol. 2020 Jan;72(1):25-33. doi: 10.1016/j.jhep.2019.10.006. Epub 2019 Oct 18.


Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease.

Kleiner DE, Brunt EM, Wilson LA, Behling C, Guy C, Contos M, Cummings O, Yeh M, Gill R, Chalasani N, Neuschwander-Tetri BA, Diehl AM, Dasarathy S, Terrault N, Kowdley K, Loomba R, Belt P, Tonascia J, Lavine JE, Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network.

JAMA Netw Open. 2019 Oct 2;2(10):e1912565. doi: 10.1001/jamanetworkopen.2019.12565.


Evolving Roles of Genetic Counselors in the Clinical Laboratory.

Cho MT, Guy C.

Cold Spring Harb Perspect Med. 2019 Sep 30. pii: a036574. doi: 10.1101/cshperspect.a036574. [Epub ahead of print]


The vaginal cylinder: Misunderstood, misused, or trivial? An in-depth dosimetric and multiinstitutional outcome investigation.

Guy CL, Fields EC, Quinn BA, Fisher CM, Ladbury CJ, Romano KD, Todor D.

Brachytherapy. 2019 Nov - Dec;18(6):763-770. doi: 10.1016/j.brachy.2019.08.007. Epub 2019 Sep 23.


DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD.

Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11.


Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB.

Fenn JS, Nepravishta R, Guy CS, Harrison J, Angulo J, Cameron AD, Fullam E.

ACS Chem Biol. 2019 Sep 20;14(9):1879-1887. doi: 10.1021/acschembio.9b00204. Epub 2019 Aug 21.


Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis.

Guy CS, Gibson MI, Fullam E.

Chem Sci. 2019 May 16;10(23):5935-5942. doi: 10.1039/c9sc00415g. eCollection 2019 Jun 21.


Milk production per cow and per hectare of spring-calving dairy cows grazing swards differing in Lolium perenne L. ploidy and Trifolium repens L. composition.

McClearn B, Gilliland TJ, Delaby L, Guy C, Dineen M, Coughlan F, McCarthy B.

J Dairy Sci. 2019 Sep;102(9):8571-8585. doi: 10.3168/jds.2018-16184. Epub 2019 Jul 10.


LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Heckmann BL, Teubner BJW, Tummers B, Boada-Romero E, Harris L, Yang M, Guy CS, Zakharenko SS, Green DR.

Cell. 2019 Jul 25;178(3):536-551.e14. doi: 10.1016/j.cell.2019.05.056. Epub 2019 Jun 27.


Erratum for Shen et al., "Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression".

Shen Y, Bassett MA, Gurumurthy A, Nar R, Knudson IJ, Guy CR, Perez A, Mellen RW, Ikeda M, Hossain MA, Huang S, Igarashi K, Bungert J.

Mol Cell Biol. 2019 May 14;39(11). pii: e00168-19. doi: 10.1128/MCB.00168-19. Print 2019 Jun 1. No abstract available.


Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis.

Kuriakose J, Redecke V, Guy C, Zhou J, Wu R, Ippagunta SK, Tillman H, Walker PD, Vogel P, Häcker H.

J Clin Invest. 2019 Apr 29;129(6):2251-2265. doi: 10.1172/JCI125116. eCollection 2019 Apr 29.


LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity.

Wang Y, Du X, Wei J, Long L, Tan H, Guy C, Dhungana Y, Qian C, Neale G, Fu YX, Yu J, Peng J, Chi H.

Cell Res. 2019 May;29(5):391-405. doi: 10.1038/s41422-019-0157-4. Epub 2019 Mar 25.


Dynamic Modulated Brachytherapy (DMBT) Balloon Applicator for Accelerated Partial Breast Irradiation.

Guy CL, Oh S, Han DY, Kim S, Arthur D, Song WY.

Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):953-961. doi: 10.1016/j.ijrobp.2019.03.026. Epub 2019 Mar 22.


Phylogeny matters: revisiting 'a comparison of bats and rodents as reservoirs of zoonotic viruses'.

Guy C, Thiagavel J, Mideo N, Ratcliffe JM.

R Soc Open Sci. 2019 Feb 13;6(2):181182. doi: 10.1098/rsos.181182. eCollection 2019 Feb.


NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis.

Harrison SA, Rossi SJ, Paredes AH, Trotter JF, Bashir MR, Guy CD, Banerjee R, Jaros MJ, Owers S, Baxter BA, Ling L, DePaoli AM.

Hepatology. 2019 Feb 25. doi: 10.1002/hep.30590. [Epub ahead of print]


MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.

Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P.

Cell Mol Gastroenterol Hepatol. 2019;7(4):803-817. doi: 10.1016/j.jcmgh.2019.01.008. Epub 2019 Feb 11.


Prenatal cell-free DNA screening for fetal aneuploidy in pregnant women at average or high risk: Results from a large US clinical laboratory.

Guy C, Haji-Sheikhi F, Rowland CM, Anderson B, Owen R, Lacbawan FL, Alagia DP.

Mol Genet Genomic Med. 2019 Mar;7(3):e545. doi: 10.1002/mgg3.545. Epub 2019 Jan 31.


Evaluation of Image Registration Accuracy for Tumor and Organs at Risk in the Thorax for Compliance With TG 132 Recommendations.

Guy CL, Weiss E, Che S, Jan N, Zhao S, Rosu-Bubulac M.

Adv Radiat Oncol. 2018 Sep 7;4(1):177-185. doi: 10.1016/j.adro.2018.08.023. eCollection 2019 Jan-Mar.


Dysregulated activation of fetal liver programme in acute liver failure.

Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM.

Gut. 2019 Jun;68(6):1076-1087. doi: 10.1136/gutjnl-2018-317603. Epub 2019 Jan 22.


SENP3-mediated host defense response contains HBV replication and restores protein synthesis.

Xi R, Kadur Lakshminarasimha Murthy P, Tung KL, Guy CD, Wan J, Li F, Wang Z, Li X, Varanko A, Rakhilin N, Xin Y, Liu B, Qian SB, Su L, Han Y, Shen X.

PLoS One. 2019 Jan 14;14(1):e0209179. doi: 10.1371/journal.pone.0209179. eCollection 2019.


Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.

Siddiqui MS, Yamada G, Vuppalanchi R, Van Natta M, Loomba R, Guy C, Brandman D, Tonascia J, Chalasani N, Neuschwander-Tetri B, Sanyal AJ; NASH Clinical Research Network.

Clin Gastroenterol Hepatol. 2019 Aug;17(9):1877-1885.e5. doi: 10.1016/j.cgh.2018.12.031. Epub 2019 Jan 4.


Technical Note: A method for quality assurance of landmark sets for use in evaluation of deformable image registration accuracy of lung parenchyma.

Guy CL, Weiss E, Jan N, Christensen GE, Hugo GD.

Med Phys. 2019 Feb;46(2):766-773. doi: 10.1002/mp.13336. Epub 2018 Dec 28.


TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.

Sharma D, Malik A, Guy C, Vogel P, Kanneganti TD.

J Clin Invest. 2019 Jan 2;129(1):150-162. doi: 10.1172/JCI121372. Epub 2018 Nov 19.


Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.

Loomba R, Jain A, Diehl AM, Guy CD, Portenier D, Sudan R, Singh S, Faulkner C, Richards L, Hester KD, Okada L, Li XJ, Mimms L, Abdelmalek MF.

Clin Gastroenterol Hepatol. 2019 Aug;17(9):1867-1876.e3. doi: 10.1016/j.cgh.2018.11.004. Epub 2018 Nov 15.


Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

Shi H, Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W, Chi H.

Immunity. 2018 Nov 20;49(5):899-914.e6. doi: 10.1016/j.immuni.2018.10.010. Epub 2018 Nov 6.


Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Glass O, Henao R, Patel K, Guy CD, Gruss HJ, Syn WK, Moylan CA, Streilein R, Hall R, Mae Diehl A, Abdelmalek MF.

Hepatol Commun. 2018 Sep 21;2(11):1344-1355. doi: 10.1002/hep4.1237. eCollection 2018 Nov.


Laboratory alerts to guide early intensive care team review in surgical patients: A feasibility, safety, and efficacy pilot randomized controlled trial.

Bellomo R, Chan M, Guy C, Proimos H, Franceschi F, Crisman M, Nadkarni A, Ancona P, Pan K, Di Muzio F, Presello B, Bailey J, Young M, Hart GK.

Resuscitation. 2018 Dec;133:167-172. doi: 10.1016/j.resuscitation.2018.10.012. Epub 2018 Oct 11.


Partnership with African Countries: European Society of Gastrointestinal Endoscopy (ESGE) - Position Statement.

Hassan C, Aabakken L, Ebigbo A, Karstensen JG, Guy C, Dinis-Ribeiro M, Le Moine O, Vilmann P, Ponchon T.

Endosc Int Open. 2018 Oct;6(10):E1247-E1255. doi: 10.1055/a-0677-2026. Epub 2018 Oct 8.


LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

Cunha LD, Yang M, Carter R, Guy C, Harris L, Crawford JC, Quarato G, Boada-Romero E, Kalkavan H, Johnson MDL, Natarajan S, Turnis ME, Finkelstein D, Opferman JT, Gawad C, Green DR.

Cell. 2018 Oct 4;175(2):429-441.e16. doi: 10.1016/j.cell.2018.08.061. Epub 2018 Sep 20.


SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P, Kanneganti TD.

Immunity. 2018 Sep 18;49(3):515-530.e5. doi: 10.1016/j.immuni.2018.08.024.


Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD.

Kleinstein SE, Rein M, Abdelmalek MF, Guy CD, Goldstein DB, Mae Diehl A, Moylan CA.

Hepatol Commun. 2018 Sep 5;2(9):1021-1029. doi: 10.1002/hep4.1227. eCollection 2018 Sep.


Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis.

McNamara DE, Quarato G, Guy CS, Green DR, Moldoveanu T.

J Vis Exp. 2018 Aug 7;(138). doi: 10.3791/58088.


Temporal evaluation of estrogenic endocrine disruption markers in smallmouth bass (Micropterus dolomieu) reveals seasonal variability in intersex.

Iwanowicz LR, Pinkney AE, Guy CP, Major AM, Munney K, Blazer VS, Alvarez DA, Walsh HL, Sperry A, Braham R, Sanders LR, Smith DR.

Sci Total Environ. 2019 Jan 1;646:245-256. doi: 10.1016/j.scitotenv.2018.07.167. Epub 2018 Jul 26.


Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.

Shen Y, Bassett MA, Gurumurthy A, Nar R, Knudson IJ, Guy CR, Perez A, Mellen RW, Ikeda M, Hossain MA, Huang S, Igarashi K, Bungert J.

Mol Cell Biol. 2018 Sep 14;38(19). pii: e00197-18. doi: 10.1128/MCB.00197-18. Print 2018 Oct 1. Erratum in: Mol Cell Biol. 2019 May 14;39(11):.


Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.

Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn WK, Guy CD, Diehl AM.

Open Forum Infect Dis. 2018 Jun 11;5(7):ofy138. doi: 10.1093/ofid/ofy138. eCollection 2018 Jul.


Protocol of a randomised controlled trial of real-time continuous glucose monitoring in neonatal intensive care 'REACT'.

Beardsall K, Thomson L, Guy C, van Weissenbruch MM, Iglesias I, Muthukumar P, Somisetty SK, Bond S, Petrou S, Dunger D; REACT Investigators.

BMJ Open. 2018 Jun 4;8(6):e020816. doi: 10.1136/bmjopen-2017-020816.


Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home.

Willemsen RH, Burling K, Barker P, Ackland F, Dias RP, Edge J, Smith A, Todd J, Lopez B, Mander AP, Guy C, Dunger DB.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3350-3358. doi: 10.1210/jc.2018-00500.


Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.

Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H.

Nature. 2018 Jun;558(7708):141-145. doi: 10.1038/s41586-018-0177-0. Epub 2018 May 30.


Nicorandil-induced ulcerations: a 10-year observational study of all cases spontaneously reported to the French pharmacovigilance network.

Babic V, Petitpain N, Guy C, Trechot P, Bursztejn AC, Faillie JL, Vial T, Schmutz JL, Gillet P.

Int Wound J. 2018 Aug;15(4):508-518. doi: 10.1111/iwj.12845. Epub 2018 May 16. Review.


Nonalcoholic Steatohepatitis: Histopathology Basics Within a Broader Context.

Schild MH, Guy CD.

Surg Pathol Clin. 2018 Jun;11(2):267-285. doi: 10.1016/j.path.2018.02.013. Review.


Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

Ahangar MS, Furze CM, Guy CS, Cooper C, Maskew KS, Graham B, Cameron AD, Fullam E.

J Biol Chem. 2018 Jun 22;293(25):9770-9783. doi: 10.1074/jbc.RA118.002597. Epub 2018 May 4.


Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain.

Li B, Zhu X, Hossain MA, Guy CR, Xu H, Bungert J, Pace BS.

Haematologica. 2018 Sep;103(9):e384-e387. doi: 10.3324/haematol.2017.185967. Epub 2018 Apr 5. No abstract available.

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