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Items: 44


Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas.

Harter PN, Baumgarten P, Zinke J, Schilling K, Baader S, Hartmetz AK, Schittenhelm J, Beschorner R, Liebner S, Schulte D, Plate KH, Gutwein P, Korshunov A, Pfister SM, Jones DT, Doberstein K, Mittelbronn M.

Neuropathol Appl Neurobiol. 2015 Feb;41(2):165-79. doi: 10.1111/nan.12186.


MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.

Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, Gutwein P.

Neoplasia. 2013 Feb;15(2):218-30.


The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.

Doberstein K, Pfeilschifter J, Gutwein P.

Carcinogenesis. 2011 Nov;32(11):1713-23. doi: 10.1093/carcin/bgr195. Epub 2011 Aug 30.


PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.

Lee SB, Doberstein K, Baumgarten P, Wieland A, Ungerer C, Bürger C, Hardt K, Boehncke WH, Pfeilschifter J, Mihic-Probst D, Mittelbronn M, Gutwein P.

PLoS One. 2011;6(8):e22312. doi: 10.1371/journal.pone.0022312. Epub 2011 Aug 18.


L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.

Doberstein K, Wieland A, Lee SB, Blaheta RA, Wedel S, Moch H, Schraml P, Pfeilschifter J, Kristiansen G, Gutwein P.

Carcinogenesis. 2011 Mar;32(3):262-70. doi: 10.1093/carcin/bgq249. Epub 2010 Nov 19.


ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma.

Ungerer C, Doberstein K, Bürger C, Hardt K, Boehncke WH, Böhm B, Pfeilschifter J, Dummer R, Mihic-Probst D, Gutwein P.

Biochem Biophys Res Commun. 2010 Oct 22;401(3):363-9. doi: 10.1016/j.bbrc.2010.09.055. Epub 2010 Sep 17.


Overexpression of CXCL16 in lesional psoriatic skin.

Oh ST, Schramme A, Tilgen W, Gutwein P, Reichrath J.

Dermatoendocrinol. 2009 Mar;1(2):114-8.


ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.

Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W, Pfeilschifter J.

J Biomed Sci. 2010 Jan 13;17:3. doi: 10.1186/1423-0127-17-3.


Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ.

Oh ST, Cho BK, Schramme A, Gutwein P, Tilgen W, Reichrath J.

Dermatoendocrinol. 2009 Jan;1(1):46-53.


ADAM10 is upregulated in melanoma metastasis compared with primary melanoma.

Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P.

J Invest Dermatol. 2010 Mar;130(3):763-73. doi: 10.1038/jid.2009.335. Epub 2009 Oct 29.


CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein.

Gutwein P, Abdel-Bakky MS, Schramme A, Doberstein K, Kämpfer-Kolb N, Amann K, Hauser IA, Obermüller N, Bartel C, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J.

Am J Pathol. 2009 Jun;174(6):2061-72. doi: 10.2353/ajpath.2009.080960. Epub 2009 May 12.


CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.

Gutwein P, Abdel-Bakky MS, Doberstein K, Schramme A, Beckmann J, Schaefer L, Amann K, Doller A, Kämpfer-Kolb N, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J.

J Cell Mol Med. 2009 Sep;13(9B):3809-25. doi: 10.1111/j.1582-4934.2009.00761.x. Epub 2009 May 1.


The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.

Oh ST, Schramme A, Stark A, Tilgen W, Gutwein P, Reichrath J.

J Cutan Pathol. 2009 Apr;36(4):395-401. doi: 10.1111/j.1600-0560.2008.01082.x.


Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity.

Riedle S, Kiefel H, Gast D, Bondong S, Wolterink S, Gutwein P, Altevogt P.

Biochem J. 2009 May 27;420(3):391-402. doi: 10.1042/BJ20081625.


Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.

Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, Pfeilschifter J.

Biochem Biophys Res Commun. 2009 Mar 6;380(2):387-91. doi: 10.1016/j.bbrc.2009.01.100. Epub 2009 Jan 23.


Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.

Jespersen C, Doller A, Akool el-S, Bachmann M, Müller R, Gutwein P, Mühl H, Pfeilschifter J, Eberhardt W.

J Cell Physiol. 2009 May;219(2):276-87. doi: 10.1002/jcp.21658.


Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients.

Gutwein P, Schramme A, Sinke N, Abdel-Bakky MS, Voss B, Obermüller N, Doberstein K, Koziolek M, Fritzsche F, Johannsen M, Jung K, Schaider H, Altevogt P, Ludwig A, Pfeilschifter J, Kristiansen G.

Eur J Cancer. 2009 Feb;45(3):478-89. doi: 10.1016/j.ejca.2008.10.023. Epub 2008 Dec 11.


Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice.

Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, Frank S.

J Invest Dermatol. 2009 Mar;129(3):752-64. doi: 10.1038/jid.2008.230. Epub 2008 Jul 31.


Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney.

Schramme A, Abdel-Bakky MS, Gutwein P, Obermüller N, Baer PC, Hauser IA, Ludwig A, Gauer S, Schäfer L, Sobkowiak E, Altevogt P, Koziolek M, Kiss E, Gröne HJ, Tikkanen R, Goren I, Radeke H, Pfeilschifter J.

Kidney Int. 2008 Aug;74(3):328-38. doi: 10.1038/ki.2008.181. Epub 2008 May 14.


The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells.

Schramme A, Abdel-Bakky MS, Kämpfer-Kolb N, Pfeilschifter J, Gutwein P.

Biochem Biophys Res Commun. 2008 May 30;370(2):311-6. doi: 10.1016/j.bbrc.2008.03.088. Epub 2008 Mar 26.


Overexpression of ADAM 10 and ADAM 12 in lesional psoriatic skin.

Oh ST, Schramme A, Stark A, Tilgen W, Gutwein P, Reichrath J.

Br J Dermatol. 2008 Jun;158(6):1371-3. doi: 10.1111/j.1365-2133.2008.08513.x. Epub 2008 Mar 20. No abstract available. Erratum in: Br J Dermatol. 2008 Aug;159(2):511.


CD24 is a marker of exosomes secreted into urine and amniotic fluid.

Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, Altevogt P.

Kidney Int. 2007 Nov;72(9):1095-102. Epub 2007 Aug 15.


Membranal cholesterol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions.

Dwir O, Grabovsky V, Pasvolsky R, Manevich E, Shamri R, Gutwein P, Feigelson SW, Altevogt P, Alon R.

J Immunol. 2007 Jul 15;179(2):1030-8.


Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors.

Zhang C, Wenger T, Mattern J, Ilea S, Frey C, Gutwein P, Altevogt P, Bodenmüller W, Gassler N, Schnabel PA, Dienemann H, Marmé A, Hohenfellner M, Haferkamp A, Pfitzenmaier J, Gröne HJ, Kolb A, Büchler P, Büchler M, Friess H, Rittgen W, Edler L, Debatin KM, Krammer PH, Rutz HP, Herr I.

Cancer Biol Ther. 2007 Feb;6(2):278-87. Epub 2007 Feb 27.


Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells.

Doller A, Akool el-S, Müller R, Gutwein P, Kurowski C, Pfeilschifter J, Eberhardt W.

J Am Soc Nephrol. 2007 Feb;18(2):581-92. Epub 2007 Jan 3.


L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.

Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P, Altevogt P.

Gynecol Oncol. 2007 Feb;104(2):461-9. Epub 2006 Oct 9.


Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas.

Zhang C, Marmé A, Wenger T, Gutwein P, Edler L, Rittgen W, Debatin KM, Altevogt P, Mattern J, Herr I.

Int J Oncol. 2006 Feb;28(2):551-8.


L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells.

Stoeck A, Schlich S, Issa Y, Gschwend V, Wenger T, Herr I, Marmé A, Bourbie S, Altevogt P, Gutwein P.

Cancer Lett. 2006 Aug 8;239(2):212-26. Epub 2005 Dec 27.


A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.

Stoeck A, Keller S, Riedle S, Sanderson MP, Runz S, Le Naour F, Gutwein P, Ludwig A, Rubinstein E, Altevogt P.

Biochem J. 2006 Feb 1;393(Pt 3):609-18.


Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.

Akool el-S, Doller A, Müller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W.

J Biol Chem. 2005 Nov 25;280(47):39403-16. Epub 2005 Sep 23.


Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.

Gutwein P, Stoeck A, Riedle S, Gast D, Runz S, Condon TP, Marmé A, Phong MC, Linderkamp O, Skorokhod A, Altevogt P.

Clin Cancer Res. 2005 Apr 1;11(7):2492-501.


L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas.

Gast D, Riedle S, Riedle S, Schabath H, Schlich S, Schneider A, Issa Y, Stoeck A, Fogel M, Joumaa S, Wenger T, Herr I, Gutwein P, Altevogt P.

Int J Cancer. 2005 Jul 1;115(4):658-65.


Brain development in mice lacking L1-L1 homophilic adhesion.

Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V.

J Cell Biol. 2004 Apr;165(1):145-54. Epub 2004 Apr 5.


L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.

Fogel M, Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Smirnov A, Edler L, Ben-Arie A, Huszar M, Altevogt P.

Lancet. 2003 Sep 13;362(9387):869-75.


Molecular mechanisms of L-selectin-induced co-localization in rafts and shedding [corrected].

Phong MC, Gutwein P, Kadel S, Hexel K, Altevogt P, Linderkamp O, Brenner B.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):563-9. Erratum in: Biochem Biophys Res Commun. 2003 Mar 21;302(4):916.


L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma.

Fogel M, Mechtersheimer S, Huszar M, Smirnov A, Abu-Dahi A, Tilgen W, Reichrath J, Georg T, Altevogt P, Gutwein P.

Cancer Lett. 2003 Jan 28;189(2):237-47.


ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.

Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M, Altevogt DP.

FASEB J. 2003 Feb;17(2):292-4. Epub 2002 Dec 3.


Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.

Mechtersheimer S, Gutwein P, Agmon-Levin N, Stoeck A, Oleszewski M, Riedle S, Postina R, Fahrenholz F, Fogel M, Lemmon V, Altevogt P.

J Cell Biol. 2001 Nov 12;155(4):661-73. Epub 2001 Nov 12. Erratum in: J Cell Biol 2001 Dec 24;155(7):1359.


Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin.

Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, Gutwein P, Altevogt P, Bar-Shavit R.

J Biol Chem. 2001 Apr 6;276(14):10952-62. Epub 2001 Jan 26.


Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding.

Oleszewski M, Gutwein P, von der Lieth W, Rauch U, Altevogt P.

J Biol Chem. 2000 Nov 3;275(44):34478-85.


Immunohistochemical analysis of DNA mismatch repair enzyme hMSH-2 in normal human skin and basal cell carcinomas.

Rass K, Gutwein P, Müller SM, Friedrich M, Meineke V, Welter C, Tilgen W, Reichrath J.

Histochem J. 2000 Feb;32(2):93-7.


Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.

Gutwein P, Oleszewski M, Mechtersheimer S, Agmon-Levin N, Krauss K, Altevogt P.

J Biol Chem. 2000 May 19;275(20):15490-7.


Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule.

Beer S, Oleszewski M, Gutwein P, Geiger C, Altevogt P.

J Cell Sci. 1999 Aug;112 ( Pt 16):2667-75.

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