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Items: 9

1.

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Gutu AD, Hertzog P, Purcell T, Shen HH, Moskowitz SM, Velkov T, Li J.

mSystems. 2019 Jan 8;4(1). pii: e00149-18. doi: 10.1128/mSystems.00149-18. eCollection 2019 Jan-Feb.

2.

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Anderson D, Shen HH, Tsuji B, Gutu AD, Moskowitz SM, Velkov T, Li J.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02656-17. doi: 10.1128/AAC.02656-17. Print 2018 Jun.

3.

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

Han ML, Velkov T, Zhu Y, Roberts KD, Le Brun AP, Chow SH, Gutu AD, Moskowitz SM, Shen HH, Li J.

ACS Chem Biol. 2018 Jan 19;13(1):121-130. doi: 10.1021/acschembio.7b00836. Epub 2017 Dec 11.

PMID:
29182311
4.

An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.

Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00987-17. doi: 10.1128/AAC.00987-17. Print 2017 Dec.

5.

Pseudomonas aeruginosa high-level resistance to polymyxins and other antimicrobial peptides requires cprA, a gene that is disrupted in the PAO1 strain.

Gutu AD, Rodgers NS, Park J, Moskowitz SM.

Antimicrob Agents Chemother. 2015 Sep;59(9):5377-87. doi: 10.1128/AAC.00904-15. Epub 2015 Jun 22.

6.

Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.

Gutu AD, Sgambati N, Strasbourger P, Brannon MK, Jacobs MA, Haugen E, Kaul RK, Johansen HK, Høiby N, Moskowitz SM.

Antimicrob Agents Chemother. 2013 May;57(5):2204-15. doi: 10.1128/AAC.02353-12. Epub 2013 Mar 4.

7.

DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis.

Hsueh YH, Cozy LM, Sham LT, Calvo RA, Gutu AD, Winkler ME, Kearns DB.

Mol Microbiol. 2011 Aug;81(4):1092-108. doi: 10.1111/j.1365-2958.2011.07755.x. Epub 2011 Jul 18.

8.

Localization and cellular amounts of the WalRKJ (VicRKX) two-component regulatory system proteins in serotype 2 Streptococcus pneumoniae.

Wayne KJ, Sham LT, Tsui HC, Gutu AD, Barendt SM, Keen SK, Winkler ME.

J Bacteriol. 2010 Sep;192(17):4388-94. doi: 10.1128/JB.00578-10. Epub 2010 Jul 9.

9.

Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.

Gutu AD, Wayne KJ, Sham LT, Winkler ME.

J Bacteriol. 2010 May;192(9):2346-58. doi: 10.1128/JB.01690-09. Epub 2010 Feb 26.

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