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Items: 48

1.

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.

Vinci M, Burford A, Molinari V, Kessler K, Popov S, Clarke M, Taylor KR, Pemberton HN, Lord CJ, Gutteridge A, Forshew T, Carvalho D, Marshall LV, Qin EY, Ingram WJ, Moore AS, Ng HK, Trabelsi S, H'mida-Ben Brahim D, Entz-Werle N, Zacharoulis S, Vaidya S, Mandeville HC, Bridges LR, Martin AJ, Al-Sarraj S, Chandler C, Sunol M, Mora J, de Torres C, Cruz O, Carcaboso AM, Monje M, Mackay A, Jones C.

Nat Med. 2018 Aug;24(8):1204-1215. doi: 10.1038/s41591-018-0086-7. Epub 2018 Jul 2.

PMID:
29967352
2.

Control Materials and Digital PCR Methods for Evaluation of Circulating Cell-Free DNA Extractions from Plasma.

Whale AS, Fernandez-Gonzalez A, Gutteridge A, Devonshire AS.

Methods Mol Biol. 2018;1768:45-65. doi: 10.1007/978-1-4939-7778-9_4.

PMID:
29717437
3.

Single-cell RNAseq reveals seven classes of colonic sensory neuron.

Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ.

Gut. 2018 Feb 26. pii: gutjnl-2017-315631. doi: 10.1136/gutjnl-2017-315631. [Epub ahead of print]

4.

A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells.

Kurtz A, Seltmann S, Bairoch A, Bittner MS, Bruce K, Capes-Davis A, Clarke L, Crook JM, Daheron L, Dewender J, Faulconbridge A, Fujibuchi W, Gutteridge A, Hei DJ, Kim YO, Kim JH, Kokocinski AK, Lekschas F, Lomax GP, Loring JF, Ludwig T, Mah N, Matsui T, Müller R, Parkinson H, Sheldon M, Smith K, Stachelscheid H, Stacey G, Streeter I, Veiga A, Xu RH.

Stem Cell Reports. 2018 Jan 9;10(1):1-6. doi: 10.1016/j.stemcr.2017.12.002. Review.

5.

Molecular and functional variation in iPSC-derived sensory neurons.

Schwartzentruber J, Foskolou S, Kilpinen H, Rodrigues J, Alasoo K, Knights AJ, Patel M, Goncalves A, Ferreira R, Benn CL, Wilbrey A, Bictash M, Impey E, Cao L, Lainez S, Loucif AJ, Whiting PJ, Gutteridge A, Gaffney DJ; HIPSCI Consortium.

Nat Genet. 2018 Jan;50(1):54-61. doi: 10.1038/s41588-017-0005-8. Epub 2017 Dec 11.

6.

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.

Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A.

Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29.

7.

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.

Stone TJ, Keeley A, Virasami A, Harkness W, Tisdall M, Izquierdo Delgado E, Gutteridge A, Brooks T, Kristiansen M, Chalker J, Wilkhu L, Mifsud W, Apps J, Thom M, Hubank M, Forshew T, Cross JH, Hargrave D, Ham J, Jacques TS.

Acta Neuropathol. 2018 Jan;135(1):115-129. doi: 10.1007/s00401-017-1773-z. Epub 2017 Oct 20.

8.

Digital PCR analysis of circulating tumor DNA: a biomarker for chondrosarcoma diagnosis, prognostication, and residual disease detection.

Gutteridge A, Rathbone VM, Gibbons R, Bi M, Archard N, Davies KEJ, Brown J, Plagnol V, Pillay N, Amary F, O'Donnell P, Gupta M, Tirabosco R, Flanagan AM, Forshew T.

Cancer Med. 2017 Oct;6(10):2194-2202. doi: 10.1002/cam4.1146. Epub 2017 Aug 23.

9.

Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle.

Fisher AG, Seaborne RA, Hughes TM, Gutteridge A, Stewart C, Coulson JM, Sharples AP, Jarvis JC.

FASEB J. 2017 Dec;31(12):5268-5282. doi: 10.1096/fj.201700089RR. Epub 2017 Aug 17.

PMID:
28821632
10.

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP.

Development. 2017 Jun 15;144(12):2141-2152. doi: 10.1242/dev.150490. Epub 2017 May 15.

11.

H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone.

Amary F, Berisha F, Ye H, Gupta M, Gutteridge A, Baumhoer D, Gibbons R, Tirabosco R, O'Donnell P, Flanagan AM.

Am J Surg Pathol. 2017 Aug;41(8):1059-1068. doi: 10.1097/PAS.0000000000000859.

12.

GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.

Jones AV, Tilley M, Gutteridge A, Hyde C, Nagle M, Ziemek D, Gorman D, Fauman EB, Chen X, Miller MR, Tian C, Hu Y, Hinds DA, Cox P, Scollen S.

Hum Mol Genet. 2017 Apr 1;26(7):1391-1406. doi: 10.1093/hmg/ddx036.

13.

Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.

Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, Kerby J, Whiting PJ.

Stem Cells Transl Med. 2017 Feb;6(2):490-501. doi: 10.5966/sctm.2016-0088. Epub 2016 Aug 24.

14.

Interpreting transcriptional changes using causal graphs: new methods and their practical utility on public networks.

Fakhry CT, Choudhary P, Gutteridge A, Sidders B, Chen P, Ziemek D, Zarringhalam K.

BMC Bioinformatics. 2016 Aug 24;17(1):318. doi: 10.1186/s12859-016-1181-8.

15.

The use of digital PCR to improve the application of quantitative molecular diagnostic methods for tuberculosis.

Devonshire AS, O'Sullivan DM, Honeyborne I, Jones G, Karczmarczyk M, Pavšič J, Gutteridge A, Milavec M, Mendoza P, Schimmel H, Van Heuverswyn F, Gorton R, Cirillo DM, Borroni E, Harris K, Barnard M, Heydenrych A, Ndusilo N, Wallis CL, Pillay K, Barry T, Reddington K, Richter E, Mozioğlu E, Akyürek S, Yalçınkaya B, Akgoz M, Žel J, Foy CA, McHugh TD, Huggett JF.

BMC Infect Dis. 2016 Aug 3;16:366. doi: 10.1186/s12879-016-1696-7.

16.

Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.

Choudhary P, Gutteridge A, Impey E, Storer RI, Owen RM, Whiting PJ, Bictash M, Benn CL.

Stem Cells Transl Med. 2016 Jul;5(7):925-37. doi: 10.5966/sctm.2015-0247. Epub 2016 Apr 25.

17.

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.

Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.

PMID:
27099175
18.

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.

Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB.

PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016.

19.

GNAS mutations are not detected in parosteal and low-grade central osteosarcomas.

Salinas-Souza C, De Andrea C, Bihl M, Kovac M, Pillay N, Forshew T, Gutteridge A, Ye H, Amary MF, Tirabosco R, Toledo SR, Baumhoer D, Flanagan AM.

Mod Pathol. 2015 Oct;28(10):1336-42. doi: 10.1038/modpathol.2015.91. Epub 2015 Aug 7.

20.

Age and growth of the tiger shark Galeocerdo cuvier off the east coast of Australia.

Holmes BJ, Peddemors VM, Gutteridge AN, Geraghty PT, Chan RW, Tibbetts IR, Bennett MB.

J Fish Biol. 2015 Aug;87(2):422-48. doi: 10.1111/jfb.12732.

PMID:
26248806
21.

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.

Tassoni A, Gutteridge A, Barber AC, Osborne A, Martin KR.

Stem Cells. 2015 Oct;33(10):3006-16. doi: 10.1002/stem.2095. Epub 2015 Jul 29.

22.

A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.

Choudhary P, Dodsworth BT, Sidders B, Gutteridge A, Michaelides C, Duckworth JK, Whiting PJ, Benn CL.

PLoS One. 2015 Jun 29;10(6):e0130379. doi: 10.1371/journal.pone.0130379. eCollection 2015.

23.

Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.

Favero F, McGranahan N, Salm M, Birkbak NJ, Sanborn JZ, Benz SC, Becq J, Peden JF, Kingsbury Z, Grocok RJ, Humphray S, Bentley D, Spencer-Dene B, Gutteridge A, Brada M, Roger S, Dietrich PY, Forshew T, Gerlinger M, Rowan A, Stamp G, Eklund AC, Szallasi Z, Swanton C.

Ann Oncol. 2015 May;26(5):880-7. doi: 10.1093/annonc/mdv127. Epub 2015 Mar 2.

24.

Highly reproducible absolute quantification of Mycobacterium tuberculosis complex by digital PCR.

Devonshire AS, Honeyborne I, Gutteridge A, Whale AS, Nixon G, Wilson P, Jones G, McHugh TD, Foy CA, Huggett JF.

Anal Chem. 2015 Apr 7;87(7):3706-13. doi: 10.1021/ac5041617. Epub 2015 Mar 10.

PMID:
25646934
25.

Optimizing the leveraging of real-world data to improve the development and use of medicines.

Berger ML, Lipset C, Gutteridge A, Axelsen K, Subedi P, Madigan D.

Value Health. 2015 Jan;18(1):127-30. doi: 10.1016/j.jval.2014.10.009. Epub 2014 Nov 27. Review.

26.

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification.

Devonshire AS, Whale AS, Gutteridge A, Jones G, Cowen S, Foy CA, Huggett JF.

Anal Bioanal Chem. 2014 Oct;406(26):6499-512. doi: 10.1007/s00216-014-7835-3. Epub 2014 May 24.

27.

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Young GT, Gutteridge A, Fox H, Wilbrey AL, Cao L, Cho LT, Brown AR, Benn CL, Kammonen LR, Friedman JH, Bictash M, Whiting P, Bilsland JG, Stevens EB.

Mol Ther. 2014 Aug;22(8):1530-1543. doi: 10.1038/mt.2014.86. Epub 2014 May 15.

28.

Precompetitive activity to address the biological data needs of drug discovery.

Sidders B, Brockel C, Gutteridge A, Harland L, Jansen PG, McEwen R, Michalovich D, Seidel H, Weiss B, Williams-Jones B, Woodwark M.

Nat Rev Drug Discov. 2014 Feb;13(2):83-4. doi: 10.1038/nrd4230. No abstract available.

PMID:
24481293
29.

Molecular causes of transcriptional response: a Bayesian prior knowledge approach.

Zarringhalam K, Enayetallah A, Gutteridge A, Sidders B, Ziemek D.

Bioinformatics. 2013 Dec 15;29(24):3167-73. doi: 10.1093/bioinformatics/btt557. Epub 2013 Sep 26.

30.

Functional implications of ontogenetically and sexually dimorphic dentition in the eastern shovelnose ray, Aptychotrema rostrata.

Gutteridge AN, Bennett MB.

J Exp Biol. 2014 Jan 15;217(Pt 2):192-200. doi: 10.1242/jeb.089326. Epub 2013 Sep 26.

31.

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, Elia G, Nye E, Jeffery R, Poulsom R, Novelli MR, Rodriguez-Justo M, McDonald SA, Wright NA, Graham TA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2490-9. doi: 10.1073/pnas.1220353110. Epub 2013 Jun 13.

32.

Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.

Gutteridge A, Rukstalis JM, Ziemek D, Tié M, Ji L, Ramos-Zayas R, Nardone NA, Norquay LD, Brenner MB, Tang K, McNeish JD, Rowntree RK.

PLoS One. 2013;8(2):e56024. doi: 10.1371/journal.pone.0056024. Epub 2013 Feb 13.

33.

Modelling the evolution of genetic instability during tumour progression.

S Datta R, Gutteridge A, Swanton C, Maley CC, Graham TA.

Evol Appl. 2013 Jan;6(1):20-33. doi: 10.1111/eva.12024. Epub 2012 Nov 26.

34.

Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules.

Surmacz B, Fox H, Gutteridge A, Fish P, Lubitz S, Whiting P.

Stem Cells. 2012 Sep;30(9):1875-84. doi: 10.1002/stem.1166. Erratum in: Stem Cells. 2013 Jul;31(7):1446. Fish, Paul [added].

35.

The genetic control of growth rate: a systems biology study in yeast.

Pir P, Gutteridge A, Wu J, Rash B, Kell DB, Zhang N, Oliver SG.

BMC Syst Biol. 2012 Jan 13;6:4. doi: 10.1186/1752-0509-6-4.

36.

Functional expression of parasite drug targets and their human orthologs in yeast.

Bilsland E, Pir P, Gutteridge A, Johns A, King RD, Oliver SG.

PLoS Negl Trop Dis. 2011 Oct;5(10):e1320. doi: 10.1371/journal.pntd.0001320. Epub 2011 Oct 4.

37.

The life histories of endangered hammerhead sharks (Carcharhiniformes, Sphyrnidae) from the east coast of Australia.

Harry AV, Macbeth WG, Gutteridge AN, Simpfendorfer CA.

J Fish Biol. 2011 Jun;78(7):2026-51. doi: 10.1111/j.1095-8649.2011.02992.x. Epub 2011 May 12.

PMID:
21651548
38.

Assessing the overlap between the diet of a coastal shark and the surrounding prey communities in a sub-tropical embayment.

Gutteridge AN, Bennett MB, Huveneers C, Tibbetts IR.

J Fish Biol. 2011 May;78(5):1405-22. doi: 10.1111/j.1095-8649.2011.02945.x. Epub 2011 Mar 31.

PMID:
21539550
39.

The DBCLS BioHackathon: standardization and interoperability for bioinformatics web services and workflows. The DBCLS BioHackathon Consortium*.

Katayama T, Arakawa K, Nakao M, Ono K, Aoki-Kinoshita KF, Yamamoto Y, Yamaguchi A, Kawashima S, Chun HW, Aerts J, Aranda B, Barboza LH, Bonnal RJ, Bruskiewich R, Bryne JC, Fernández JM, Funahashi A, Gordon PM, Goto N, Groscurth A, Gutteridge A, Holland R, Kano Y, Kawas EA, Kerhornou A, Kibukawa E, Kinjo AR, Kuhn M, Lapp H, Lehvaslaiho H, Nakamura H, Nakamura Y, Nishizawa T, Nobata C, Noguchi T, Oinn TM, Okamoto S, Owen S, Pafilis E, Pocock M, Prins P, Ranzinger R, Reisinger F, Salwinski L, Schreiber M, Senger M, Shigemoto Y, Standley DM, Sugawara H, Tashiro T, Trelles O, Vos RA, Wilkinson MD, York W, Zmasek CM, Asai K, Takagi T.

J Biomed Semantics. 2010 Aug 21;1(1):8. doi: 10.1186/2041-1480-1-8.

40.

Nutrient control of eukaryote cell growth: a systems biology study in yeast.

Gutteridge A, Pir P, Castrillo JI, Charles PD, Lilley KS, Oliver SG.

BMC Biol. 2010 May 24;8:68. doi: 10.1186/1741-7007-8-68.

41.

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

Yamanishi Y, Araki M, Gutteridge A, Honda W, Kanehisa M.

Bioinformatics. 2008 Jul 1;24(13):i232-40. doi: 10.1093/bioinformatics/btn162.

42.

Regulation of metabolic networks by small molecule metabolites.

Gutteridge A, Kanehisa M, Goto S.

BMC Bioinformatics. 2007 Mar 13;8:88.

43.

MIMOX: a web tool for phage display based epitope mapping.

Huang J, Gutteridge A, Honda W, Kanehisa M.

BMC Bioinformatics. 2006 Oct 12;7:451.

44.

Understanding nature's catalytic toolkit.

Gutteridge A, Thornton JM.

Trends Biochem Sci. 2005 Nov;30(11):622-9. Epub 2005 Oct 7. Review.

PMID:
16214343
45.

Effective function annotation through catalytic residue conservation.

George RA, Spriggs RV, Bartlett GJ, Gutteridge A, MacArthur MW, Porter CT, Al-Lazikani B, Thornton JM, Swindells MB.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12299-304. Epub 2005 Jul 21.

46.

Conformational changes observed in enzyme crystal structures upon substrate binding.

Gutteridge A, Thornton J.

J Mol Biol. 2005 Feb 11;346(1):21-8. Epub 2004 Dec 23.

PMID:
15663924
47.

Conformational change in substrate binding, catalysis and product release: an open and shut case?

Gutteridge A, Thornton J.

FEBS Lett. 2004 Jun 1;567(1):67-73. Review.

48.

Using a neural network and spatial clustering to predict the location of active sites in enzymes.

Gutteridge A, Bartlett GJ, Thornton JM.

J Mol Biol. 2003 Jul 18;330(4):719-34.

PMID:
12850142

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