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Items: 1 to 50 of 108

1.

Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides.

Correa W, Brandenburg J, Behrends J, Heinbockel L, Reiling N, Paulowski L, Schwudke D, Stephan K, Martinez-de-Tejada G, Brandenburg K, Gutsmann T.

Biophys J. 2019 Oct 18. pii: S0006-3495(19)30859-8. doi: 10.1016/j.bpj.2019.10.012. [Epub ahead of print]

PMID:
31676134
2.

The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity.

de Miguel Catalina A, Forbrig E, Kozuch J, Nehls C, Paulowski L, Gutsmann T, Hildebrandt P, Mroginski MA.

Biochemistry. 2019 May 14;58(19):2447-2462. doi: 10.1021/acs.biochem.8b01297. Epub 2019 May 1.

PMID:
31016971
3.

Synthetic Anti-lipopolysaccharide Peptides (SALPs) as Effective Inhibitors of Pathogen-Associated Molecular Patterns (PAMPs).

Correa W, Heinbockel L, Martinez-de-Tejada G, Sánchez S, Garidel P, Schürholz T, Mier W, Dupont A, Hornef M, Gutsmann T, Mauss K, Weindl G, Brandenburg K.

Adv Exp Med Biol. 2019;1117:111-129. doi: 10.1007/978-981-13-3588-4_8. Review.

PMID:
30980356
4.

Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins.

Correa W, Heinbockel L, Behrends J, Kaconis Y, Barcena-Varela S, Gutsmann T, Mauss K, Schürholz T, Schromm AB, Martinez de Tejada G, Brandenburg K.

FEBS J. 2019 Apr;286(8):1576-1593. doi: 10.1111/febs.14805. Epub 2019 Mar 20.

PMID:
30843356
5.

ADAM10 sheddase activation is controlled by cell membrane asymmetry.

Bleibaum F, Sommer A, Veit M, Rabe B, Andrä J, Kunzelmann K, Nehls C, Correa W, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

J Mol Cell Biol. 2019 Feb 12. doi: 10.1093/jmcb/mjz008. [Epub ahead of print]

PMID:
30753537
6.

Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor.

von Bargen K, Scraba M, Krämer I, Ketterer M, Nehls C, Krokowski S, Repnik U, Wittlich M, Maaser A, Zapka P, Bunge M, Schlesinger M, Huth G, Klees A, Hansen P, Jeschke A, Bendas G, Utermöhlen O, Griffiths G, Gutsmann T, Wohlmann J, Haas A.

Cell Microbiol. 2019 Jan;21(1):e12958. doi: 10.1111/cmi.12958. Epub 2018 Nov 9.

PMID:
30251327
7.

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5.

Heinbockel L, Weindl G, Martinez-de-Tejada G, Correa W, Sanchez-Gomez S, Bárcena-Varela S, Goldmann T, Garidel P, Gutsmann T, Brandenburg K.

Front Immunol. 2018 Jul 26;9:1704. doi: 10.3389/fimmu.2018.01704. eCollection 2018. Review.

8.

Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo.

Pfalzgraff A, Bárcena-Varela S, Heinbockel L, Gutsmann T, Brandenburg K, Martinez-de-Tejada G, Weindl G.

Br J Pharmacol. 2018 Sep;175(17):3581-3593. doi: 10.1111/bph.14425. Epub 2018 Jul 20.

9.

Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation.

Kuhlmann N, Heinbockel L, Correa W, Gutsmann T, Goldmann T, Englisch U, Brandenburg K.

Eur J Pharm Sci. 2018 Mar 30;115:240-247. doi: 10.1016/j.ejps.2018.01.022. Epub 2018 Jan 12.

PMID:
29337217
10.

Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates.

Langer MN, Blodkamp S, Bayerbach M, Feßler AT, de Buhr N, Gutsmann T, Kreienbrock L, Schwarz S, von Köckritz-Blickwede M.

Vet Microbiol. 2017 Oct;210:107-115. doi: 10.1016/j.vetmic.2017.08.022. Epub 2017 Sep 8.

PMID:
29103679
11.

Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides.

Bang C, Vierbuchen T, Gutsmann T, Heine H, Schmitz RA.

PLoS One. 2017 Oct 5;12(10):e0185919. doi: 10.1371/journal.pone.0185919. eCollection 2017.

12.

Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151.

Metwally NG, Tilly AK, Lubiana P, Roth LK, Dörpinghaus M, Lorenzen S, Schuldt K, Witt S, Bachmann A, Tidow H, Gutsmann T, Burmester T, Roeder T, Tannich E, Bruchhaus I.

Sci Rep. 2017 Jun 22;7(1):4069. doi: 10.1038/s41598-017-04241-3.

13.

Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits.

Bárcena-Varela S, Martínez-de-Tejada G, Martin L, Schuerholz T, Gil-Royo AG, Fukuoka S, Goldmann T, Droemann D, Correa W, Gutsmann T, Brandenburg K, Heinbockel L.

Exp Mol Med. 2017 Jun 16;49(6):e345. doi: 10.1038/emm.2017.75.

14.

Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock.

Yamada N, Martin LB, Zechendorf E, Purvis GSD, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L, Gutsmann T, Correa W, Brandenburg K, Marx G, Schuerholz T, Brohi K, Thiemermann C.

Ann Surg. 2018 Aug;268(2):348-356. doi: 10.1097/SLA.0000000000002186.

15.

Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling.

Ito H, Murakami R, Sakuma S, Tsai CD, Gutsmann T, Brandenburg K, Pöschl JM, Arai F, Kaneko M, Tanaka M.

Sci Rep. 2017 Feb 24;7:43134. doi: 10.1038/srep43134.

16.

Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration.

Pfalzgraff A, Heinbockel L, Su Q, Gutsmann T, Brandenburg K, Weindl G.

Sci Rep. 2016 Aug 11;6:31577. doi: 10.1038/srep31577.

17.

Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment.

de Buhr N, Reuner F, Neumann A, Stump-Guthier C, Tenenbaum T, Schroten H, Ishikawa H, Müller K, Beineke A, Hennig-Pauka I, Gutsmann T, Valentin-Weigand P, Baums CG, von Köckritz-Blickwede M.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12649. Epub 2016 Aug 31.

PMID:
27450700
18.

Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.

19.

Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus.

Blodkamp S, Kadlec K, Gutsmann T, Quiblier C, Naim HY, Schwarz S, von Köckritz-Blickwede M.

Vet Microbiol. 2017 Feb;200:52-58. doi: 10.1016/j.vetmic.2016.03.021. Epub 2016 Mar 31.

PMID:
27062479
20.

Candidalysin is a fungal peptide toxin critical for mucosal infection.

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR.

Nature. 2016 Apr 7;532(7597):64-8. doi: 10.1038/nature17625. Epub 2016 Mar 30.

21.

Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A.

Ulmer AJ, Kaconis Y, Heinbockel L, Correa W, Alexander C, Rietschel ET, Mach JP, Gorczynski RM, Heini A, Rössle M, Richter W, Gutsmann T, Brandenburg K.

Innate Immun. 2016 Apr;22(3):168-80. doi: 10.1177/1753425916632304. Epub 2016 Feb 25.

PMID:
26921253
22.

Interaction between antimicrobial peptides and mycobacteria.

Gutsmann T.

Biochim Biophys Acta. 2016 May;1858(5):1034-43. doi: 10.1016/j.bbamem.2016.01.031. Epub 2016 Feb 4. Review.

23.

Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5.

Brandenburg K, Heinbockel L, Correa W, Fukuoka S, Gutsmann T, Zähringer U, Koch MH.

J Struct Biol. 2016 Apr;194(1):68-77. doi: 10.1016/j.jsb.2016.01.014. Epub 2016 Jan 29.

PMID:
26828112
24.

Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum.

Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I.

Sci Rep. 2015 Nov 16;5:16766. doi: 10.1038/srep16766.

25.

In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus.

Blodkamp S, Kadlec K, Gutsmann T, Naim HY, von Köckritz-Blickwede M, Schwarz S.

Vet Microbiol. 2016 Oct 15;194:107-111. doi: 10.1016/j.vetmic.2015.09.018. Epub 2015 Sep 28.

PMID:
26453316
26.

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K.

Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292.

27.

Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G.

PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. eCollection 2015.

28.

Bacterial lipopolysaccharides form physically cross-linked, two-dimensional gels in the presence of divalent cations.

Herrmann M, Schneck E, Gutsmann T, Brandenburg K, Tanaka M.

Soft Matter. 2015 Aug 14;11(30):6037-44. doi: 10.1039/c5sm01002k. Epub 2015 Jul 2.

PMID:
26136185
29.

Peanut defensins: Novel allergens isolated from lipophilic peanut extract.

Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U.

J Allergy Clin Immunol. 2015 Nov;136(5):1295-301.e1-5. doi: 10.1016/j.jaci.2015.04.010. Epub 2015 May 30.

30.

Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells.

Ito H, Kuss N, Rapp BE, Ichikawa M, Gutsmann T, Brandenburg K, Pöschl JM, Tanaka M.

J Phys Chem B. 2015 Jun 25;119(25):7837-45. doi: 10.1021/acs.jpcb.5b01544. Epub 2015 Jun 11.

PMID:
26024425
31.

Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization.

Gutsmann T, Heimburg T, Keyser U, Mahendran KR, Winterhalter M.

Nat Protoc. 2015 Jan;10(1):188-98. doi: 10.1038/nprot.2015.003. Epub 2014 Dec 31.

PMID:
25551663
32.

Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins.

Heinbockel L, Palacios-Chaves L, Alexander C, Rietschel E, Behrends J, Correa W, Fukuoka S, Gutsmann T, Ulmer AJ, Brandenburg K.

Innate Immun. 2015 Apr;21(3):305-13. doi: 10.1177/1753425914535957. Epub 2014 Jul 16.

PMID:
25034969
33.

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. I) biophysical characterization of the interaction mechanisms with bacterial model membranes.

Correa W, Manrique-Moreno M, Patiño E, Peláez-Jaramillo C, Kaconis Y, Gutsmann T, Garidel P, Heinbockel L, Brandenburg K.

Biochim Biophys Acta. 2014 Oct;1838(10):2728-38. doi: 10.1016/j.bbamem.2014.07.006. Epub 2014 Jul 10.

34.

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects.

Correa W, Manrique-Moreno M, Behrends J, Patiño E, Marella C, Peláez-Jaramillo C, Garidel P, Gutsmann T, Brandenburg K, Heinbockel L.

Biochim Biophys Acta. 2014 Oct;1838(10):2739-44. doi: 10.1016/j.bbamem.2014.07.005. Epub 2014 Jul 10.

35.

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide.

Gries A, Prassl R, Fukuoka S, Rössle M, Kaconis Y, Heinbockel L, Gutsmann T, Brandenburg K.

FEBS Open Bio. 2014 May 2;4:432-40. doi: 10.1016/j.fob.2014.04.008. eCollection 2014.

36.

The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells.

Bang C, Weidenbach K, Gutsmann T, Heine H, Schmitz RA.

PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.

37.

Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines.

Sil D, Heinbockel L, Kaconis Y, Rössle M, Garidel P, Gutsmann T, David SA, Brandenburg K.

Open Biochem J. 2013 Sep 30;7:82-93. doi: 10.2174/1874091X01307010082. eCollection 2013.

38.

Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence.

Abuillan W, Schneck E, Körner A, Brandenburg K, Gutsmann T, Gill T, Vorobiev A, Konovalov O, Tanaka M.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jul;88(1):012705. Epub 2013 Jul 8.

PMID:
23944490
39.

Surface activity and structures of two fragments of the human antimicrobial LL-37.

Dannehl C, Gutsmann T, Brezesinski G.

Colloids Surf B Biointerfaces. 2013 Sep 1;109:129-35. doi: 10.1016/j.colsurfb.2013.03.030. Epub 2013 Apr 1.

PMID:
23624281
40.

Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling.

Richter W, Heinbockel L, Kaconis Y, Steiniger F, Gutsmann T, Brade L, Brandenburg K.

Innate Immun. 2013 Dec;19(6):588-95. doi: 10.1177/1753425912473851. Epub 2013 Feb 12.

PMID:
23405031
41.

Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors.

Heinbockel L, Sánchez-Gómez S, Martinez de Tejada G, Dömming S, Brandenburg J, Kaconis Y, Hornef M, Dupont A, Marwitz S, Goldmann T, Ernst M, Gutsmann T, Schürholz T, Brandenburg K.

Antimicrob Agents Chemother. 2013 Mar;57(3):1480-7. doi: 10.1128/AAC.02066-12. Epub 2013 Jan 14.

42.

Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes.

Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, Brandenburg J, Fritsch J, Schroeder J, Wiesmüller KH, Rosenkrands I, Walther P, Pott J, Krause E, Ehlers S, Schneider-Brachert W, Schütze S, Reiling N.

Traffic. 2013 Mar;14(3):321-36. doi: 10.1111/tra.12031. Epub 2012 Dec 28.

43.

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba.

Michalek M, Sönnichsen FD, Wechselberger R, Dingley AJ, Hung CW, Kopp A, Wienk H, Simanski M, Herbst R, Lorenzen I, Marciano-Cabral F, Gelhaus C, Gutsmann T, Tholey A, Grötzinger J, Leippe M.

Nat Chem Biol. 2013 Jan;9(1):37-42. doi: 10.1038/nchembio.1116. Epub 2012 Nov 11.

PMID:
23143413
44.

Modulation of enrofloxacin binding in OmpF by Mg2+ as revealed by the analysis of fast flickering single-porin current.

Brauser A, Schroeder I, Gutsmann T, Cosentino C, Moroni A, Hansen UP, Winterhalter M.

J Gen Physiol. 2012 Jul;140(1):69-82. doi: 10.1085/jgp.201210776. Epub 2012 Jun 11.

45.

Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects.

Schuerholz T, Dömming S, Hornef M, Dupont A, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Garidel P, Gutsmann T, David S, Sánchez-Gómez S, Martinez de Tejada G, Brandenburg K.

Curr Drug Targets. 2012 Aug;13(9):1131-7.

PMID:
22664073
46.

Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.

Martínez de Tejada G, Sánchez-Gómez S, Rázquin-Olazaran I, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Lohner K, Gutsmann T, David SA, Brandenburg K.

Curr Drug Targets. 2012 Aug;13(9):1121-30.

47.

Effects of antimicrobial peptides on methanogenic archaea.

Bang C, Schilhabel A, Weidenbach K, Kopp A, Goldmann T, Gutsmann T, Schmitz RA.

Antimicrob Agents Chemother. 2012 Aug;56(8):4123-30. doi: 10.1128/AAC.00661-12. Epub 2012 May 14.

48.

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U.

J Infect Dis. 2012 Jun;205(11):1654-64. doi: 10.1093/infdis/jis273. Epub 2012 Mar 28.

PMID:
22457281
49.

Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat.

Paulmann M, Arnold T, Linke D, Özdirekcan S, Kopp A, Gutsmann T, Kalbacher H, Wanke I, Schuenemann VJ, Habeck M, Bürck J, Ulrich AS, Schittek B.

J Biol Chem. 2012 Mar 9;287(11):8434-43. doi: 10.1074/jbc.M111.332270. Epub 2012 Jan 18.

50.

Biophysical investigations into the interactions of endotoxins with bile acids.

Fukuoka S, Richter W, Howe J, Andrä J, Rössle M, Alexander C, Gutsmann T, Brandenburg K.

Innate Immun. 2012 Apr;18(2):307-17. doi: 10.1177/1753425911404093. Epub 2011 Sep 27.

PMID:
21954318

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