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Items: 1 to 50 of 56

1.

Building de novo cryo-electron microscopy structures collaboratively with citizen scientists.

Khatib F, Desfosses A; Foldit Players, Koepnick B, Flatten J, Popović Z, Baker D, Cooper S, Gutsche I, Horowitz S.

PLoS Biol. 2019 Nov 12;17(11):e3000472. doi: 10.1371/journal.pbio.3000472. eCollection 2019 Nov.

2.

Structure, Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA.

Kandiah E, Carriel D, Garcia PS, Felix J, Banzhaf M, Kritikos G, Bacia-Verloop M, Brochier-Armanet C, Elsen S, Gutsche I.

Structure. 2019 Dec 3;27(12):1842-1854.e4. doi: 10.1016/j.str.2019.10.003. Epub 2019 Oct 22.

PMID:
31653338
3.

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.

Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.

Sci Adv. 2019 Sep 4;5(9):eaaw3818. doi: 10.1126/sciadv.aaw3818. eCollection 2019 Sep.

4.

Target highlights in CASP13: Experimental target structures through the eyes of their authors.

Lepore R, Kryshtafovych A, Alahuhta M, Veraszto HA, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN Jr, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T.

Proteins. 2019 Dec;87(12):1037-1057. doi: 10.1002/prot.25805. Epub 2019 Sep 9.

5.

Atomic structures of an entire contractile injection system in both the extended and contracted states.

Desfosses A, Venugopal H, Joshi T, Felix J, Jessop M, Jeong H, Hyun J, Heymann JB, Hurst MRH, Gutsche I, Mitra AK.

Nat Microbiol. 2019 Nov;4(11):1885-1894. doi: 10.1038/s41564-019-0530-6. Epub 2019 Aug 5.

PMID:
31384001
6.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.

Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.

FEBS Lett. 2020 Jan;594(1):189-198. doi: 10.1002/1873-3468.13565. Epub 2019 Aug 9.

PMID:
31369681
7.

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K.

Nature. 2019 Apr;568(7753):571-575. doi: 10.1038/s41586-019-1095-5. Epub 2019 Apr 3.

PMID:
30944476
8.

The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis.

Laddomada F, Miyachiro MM, Jessop M, Patin D, Job V, Mengin-Lecreulx D, Le Roy A, Ebel C, Breyton C, Gutsche I, Dessen A.

Sci Rep. 2019 Mar 15;9(1):4656. doi: 10.1038/s41598-019-40966-z.

9.

Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication.

Desfosses A, Milles S, Jensen MR, Guseva S, Colletier JP, Maurin D, Schoehn G, Gutsche I, Ruigrok RWH, Blackledge M.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4256-4264. doi: 10.1073/pnas.1816417116. Epub 2019 Feb 20.

10.

High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms.

Arragain B, Reguera J, Desfosses A, Gutsche I, Schoehn G, Malet H.

Elife. 2019 Jan 14;8. pii: e43075. doi: 10.7554/eLife.43075.

11.

First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies.

Richard CA, Hervet C, Ménard D, Gutsche I, Normand V, Renois F, Meurens F, Eléouët JF.

Vet Res. 2018 Dec 5;49(1):118. doi: 10.1186/s13567-018-0615-x.

12.

A Novel Subfamily of Bacterial AAT-Fold Basic Amino Acid Decarboxylases and Functional Characterization of Its First Representative: Pseudomonas aeruginosa LdcA.

Carriel D, Simon Garcia P, Castelli F, Lamourette P, Fenaille F, Brochier-Armanet C, Elsen S, Gutsche I.

Genome Biol Evol. 2018 Nov 1;10(11):3058-3075. doi: 10.1093/gbe/evy228.

13.

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.

Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S.

Nat Commun. 2018 Oct 2;9(1):4043. doi: 10.1038/s41467-018-06451-3.

14.

Molecular architecture and regulation of BCL10-MALT1 filaments.

Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K.

Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8.

15.

Robo1 Forms a Compact Dimer-of-Dimers Assembly.

Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA.

Structure. 2018 Feb 6;26(2):320-328.e4. doi: 10.1016/j.str.2017.12.003. Epub 2018 Jan 4.

16.

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.

Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN.

Nat Commun. 2016 Nov 7;7:13228. doi: 10.1038/ncomms13228.

17.

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.

Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I.

Sci Rep. 2016 Apr 15;6:24601. doi: 10.1038/srep24601.

18.

Solid-state NMR chemical-shift perturbations indicate domain reorientation of the DnaG primase in the primosome of Helicobacter pylori.

Gardiennet C, Wiegand T, Bazin A, Cadalbert R, Kunert B, Lacabanne D, Gutsche I, Terradot L, Meier BH, Böckmann A.

J Biomol NMR. 2016 Mar;64(3):189-95. doi: 10.1007/s10858-016-0018-0. Epub 2016 Mar 10.

PMID:
26961129
19.

Structure and primase-mediated activation of a bacterial dodecameric replicative helicase.

Bazin A, Cherrier MV, Gutsche I, Timmins J, Terradot L.

Nucleic Acids Res. 2015 Sep 30;43(17):8564-76. doi: 10.1093/nar/gkv792. Epub 2015 Aug 11.

20.

Structural virology. Near-atomic cryo-EM structure of the helical measles virus nucleocapsid.

Gutsche I, Desfosses A, Effantin G, Ling WL, Haupt M, Ruigrok RW, Sachse C, Schoehn G.

Science. 2015 May 8;348(6235):704-7. doi: 10.1126/science.aaa5137. Epub 2015 Apr 16.

21.

Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.

Malet H, Liu K, El Bakkouri M, Chan SW, Effantin G, Bacia M, Houry WA, Gutsche I.

Elife. 2014 Aug 5;3:e03653. doi: 10.7554/eLife.03653. Erratum in: Elife. 2014;3:e05179.

22.

Crystallization of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein gp34.

Granell M, Namura M, Alvira S, Garcia-Doval C, Singh AK, Gutsche I, van Raaij MJ, Kanamaru S.

Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):970-5. doi: 10.1107/S2053230X14010449. Epub 2014 Jun 19.

23.

SPRING - an image processing package for single-particle based helical reconstruction from electron cryomicrographs.

Desfosses A, Ciuffa R, Gutsche I, Sachse C.

J Struct Biol. 2014 Jan;185(1):15-26. doi: 10.1016/j.jsb.2013.11.003. Epub 2013 Nov 21.

24.

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor.

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN.

Structure. 2013 Apr 2;21(4):528-39. doi: 10.1016/j.str.2013.01.018. Epub 2013 Mar 7.

25.

Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape.

Desfosses A, Ribeiro EA Jr, Schoehn G, Blondel D, Guilligay D, Jamin M, Ruigrok RW, Gutsche I.

Nat Commun. 2013;4:1429. doi: 10.1038/ncomms2435.

PMID:
23385574
26.

Low-resolution structure of vaccinia virus DNA replication machinery.

Sèle C, Gabel F, Gutsche I, Ivanov I, Burmeister WP, Iseni F, Tarbouriech N.

J Virol. 2013 Feb;87(3):1679-89. doi: 10.1128/JVI.01533-12. Epub 2012 Nov 21.

27.

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN.

Nat Struct Mol Biol. 2012 Sep;19(9):938-47. doi: 10.1038/nsmb.2367. Epub 2012 Aug 19.

PMID:
22902366
28.

Architecture of a dodecameric bacterial replicative helicase.

Stelter M, Gutsche I, Kapp U, Bazin A, Bajic G, Goret G, Jamin M, Timmins J, Terradot L.

Structure. 2012 Mar 7;20(3):554-64. doi: 10.1016/j.str.2012.01.020.

29.

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.

Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN.

Structure. 2011 Dec 7;19(12):1762-72. doi: 10.1016/j.str.2011.10.012.

30.

The enzymatic activities of the Escherichia coli basic aliphatic amino acid decarboxylases exhibit a pH zone of inhibition.

Kanjee U, Gutsche I, Ramachandran S, Houry WA.

Biochemistry. 2011 Nov 1;50(43):9388-98. doi: 10.1021/bi201161k. Epub 2011 Oct 5.

PMID:
21957966
31.

Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity.

Sulák O, Cioci G, Lameignère E, Balloy V, Round A, Gutsche I, Malinovská L, Chignard M, Kosma P, Aubert DF, Marolda CL, Valvano MA, Wimmerová M, Imberty A.

PLoS Pathog. 2011 Sep;7(9):e1002238. doi: 10.1371/journal.ppat.1002238. Epub 2011 Sep 1.

32.

Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein.

Gutsche I, Coulibaly F, Voss JE, Salmon J, d'Alayer J, Ermonval M, Larquet E, Charneau P, Krey T, Mégret F, Guittet E, Rey FA, Flamand M.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):8003-8. doi: 10.1073/pnas.1017338108. Epub 2011 Apr 25.

33.

Membrane-associated DegP in Bordetella chaperones a repeat-rich secretory protein.

Baud C, Gutsche I, Willery E, de Paepe D, Drobecq H, Gilleron M, Locht C, Jamin M, Jacob-Dubuisson F.

Mol Microbiol. 2011 Jun;80(6):1625-36. doi: 10.1111/j.1365-2958.2011.07672.x. Epub 2011 May 12.

34.

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.

Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN.

Blood. 2011 Jul 7;118(1):60-8. doi: 10.1182/blood-2011-01-329532. Epub 2011 Mar 9.

PMID:
21389326
35.

Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.

Kanjee U, Gutsche I, Alexopoulos E, Zhao B, El Bakkouri M, Thibault G, Liu K, Ramachandran S, Snider J, Pai EF, Houry WA.

EMBO J. 2011 Mar 2;30(5):931-44. doi: 10.1038/emboj.2011.5. Epub 2011 Jan 28.

36.

Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.

El Bakkouri M, Gutsche I, Kanjee U, Zhao B, Yu M, Goret G, Schoehn G, Burmeister WP, Houry WA.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22499-504. doi: 10.1073/pnas.1009092107. Epub 2010 Dec 9.

37.

Nucleoprotein-RNA orientation in the measles virus nucleocapsid by three-dimensional electron microscopy.

Desfosses A, Goret G, Farias Estrozi L, Ruigrok RW, Gutsche I.

J Virol. 2011 Feb;85(3):1391-5. doi: 10.1128/JVI.01459-10. Epub 2010 Nov 24.

38.

Maximum likelihood based classification of electron tomographic data.

Stölken M, Beck F, Haller T, Hegerl R, Gutsche I, Carazo JM, Baumeister W, Scheres SH, Nickell S.

J Struct Biol. 2011 Jan;173(1):77-85. doi: 10.1016/j.jsb.2010.08.005. Epub 2010 Aug 16.

PMID:
20719249
39.

Double superhelix model of high density lipoprotein.

Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL.

J Biol Chem. 2009 Dec 25;284(52):36605-19. doi: 10.1074/jbc.M109.039537. Epub 2009 Oct 7.

40.

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S.

EMBO J. 2009 Aug 5;28(15):2293-306. doi: 10.1038/emboj.2009.175. Epub 2009 Jun 25.

41.

Complex oligomeric structure of a truncated form of DdrA: a protein required for the extreme radiotolerance of Deinococcus.

Gutsche I, Vujicić-Zagar A, Siebert X, Servant P, Vannier F, Castaing B, Gallet B, Heulin T, de Groot A, Sommer S, Serre L.

Biochim Biophys Acta. 2008 Jul-Aug;1784(7-8):1050-8. doi: 10.1016/j.bbapap.2008.03.009. Epub 2008 Apr 3.

PMID:
18424274
42.

Unphosphorylated rhabdoviridae phosphoproteins form elongated dimers in solution.

Gerard FC, Ribeiro Ede A Jr, Albertini AA, Gutsche I, Zaccai G, Ruigrok RW, Jamin M.

Biochemistry. 2007 Sep 11;46(36):10328-38. Epub 2007 Aug 17.

PMID:
17705401
43.

Structural similarity between the DnaA-binding proteins HobA (HP1230) from Helicobacter pylori and DiaA from Escherichia coli.

Natrajan G, Hall DR, Thompson AC, Gutsche I, Terradot L.

Mol Microbiol. 2007 Aug;65(4):995-1005.

44.

Combining experimental data for structure determination of flexible multimeric macromolecules by molecular replacement.

Trapani S, Abergel C, Gutsche I, Horcajada C, Fita I, Navaza J.

Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):467-75. Epub 2006 Apr 19.

45.

Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase.

Snider J, Gutsche I, Lin M, Baby S, Cox B, Butland G, Greenblatt J, Emili A, Houry WA.

J Biol Chem. 2006 Jan 20;281(3):1532-46. Epub 2005 Nov 21.

46.

The birnavirus crystal structure reveals structural relationships among icosahedral viruses.

Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA.

Cell. 2005 Mar 25;120(6):761-72.

47.

ATP-induced structural change of the thermosome is temperature-dependent.

Gutsche I, Holzinger J, Rauh N, Baumeister W, May RP.

J Struct Biol. 2001 Aug;135(2):139-46.

PMID:
11580263
48.

The Chaperones of the archaeon Thermoplasma acidophilum.

Ruepp A, Rockel B, Gutsche I, Baumeister W, Lupas AN.

J Struct Biol. 2001 Aug;135(2):126-38. Review.

PMID:
11580262
49.

Conformational rearrangements of an archaeal chaperonin upon ATPase cycling.

Gutsche I, Holzinger J, Rössle M, Heumann H, Baumeister W, May RP.

Curr Biol. 2000 Apr 6;10(7):405-8.

50.

ATPase cycle controls the conformation of an archaeal chaperonin as visualized by cryo-electron microscopy.

Gutsche I, Mihalache O, Hegerl R, Typke D, Baumeister W.

FEBS Lett. 2000 Jul 21;477(3):278-82.

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