Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 136

1.

In vitro-in vivo extrapolation method to predict human renal clearance of drugs.

Kunze A, Huwyler J, Poller B, Gutmann H, Camenisch G.

J Pharm Sci. 2014 Mar;103(3):994-1001. doi: 10.1002/jps.23851. Epub 2014 Jan 13.

PMID:
24549735
2.

The potential of Hypoxis hemerocallidea for herb-drug interaction.

Fasinu PS, Gutmann H, Schiller H, Bouic PJ, Rosenkranz B.

Pharm Biol. 2013 Dec;51(12):1499-507. doi: 10.3109/13880209.2013.796393. Epub 2013 Jul 11.

PMID:
23844611
3.

The potential of Sutherlandia frutescens for herb-drug interaction.

Fasinu PS, Gutmann H, Schiller H, James AD, Bouic PJ, Rosenkranz B.

Drug Metab Dispos. 2013 Feb;41(2):488-97. doi: 10.1124/dmd.112.049593. Epub 2012 Dec 3.

PMID:
23209194
4.

Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters.

Kunze A, Huwyler J, Camenisch G, Gutmann H.

Biochem Pharmacol. 2012 Oct 15;84(8):1096-102. doi: 10.1016/j.bcp.2012.07.032. Epub 2012 Aug 4.

PMID:
22902721
5.

In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes.

Schmitt U, Kirschbaum KM, Poller B, Kusch-Poddar M, Drewe J, Hiemke C, Gutmann H.

Pharmacol Biochem Behav. 2012 Aug;102(2):312-20. doi: 10.1016/j.pbb.2012.04.002. Epub 2012 Apr 15.

PMID:
22525746
6.

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).

Steinert RE, Gerspach AC, Gutmann H, Asarian L, Drewe J, Beglinger C.

Clin Nutr. 2011 Aug;30(4):524-32. doi: 10.1016/j.clnu.2011.01.007. Epub 2011 Feb 15.

PMID:
21324568
7.

Improvement of toughness and electrical properties of epoxy composites with carbon nanotubes prepared by industrially relevant processes.

Hollertz R, Chatterjee S, Gutmann H, Geiger T, Nüesch FA, Chu BT.

Nanotechnology. 2011 Mar 25;22(12):125702. doi: 10.1088/0957-4484/22/12/125702. Epub 2011 Feb 14.

PMID:
21317490
8.

A new intestinal cell culture model to discriminate the relative contribution of P-gp and BCRP on transport of substrates such as imatinib.

Graber-Maier A, Gutmann H, Drewe J.

Mol Pharm. 2010 Oct 4;7(5):1618-28. doi: 10.1021/mp100040f. Epub 2010 Aug 11.

PMID:
20701289
9.

Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood-brain barrier.

Camenzind RS, Chip S, Gutmann H, Kapfhammer JP, Nitsch C, Bendfeldt K.

Neuroscience. 2010 Sep 29;170(1):361-71. doi: 10.1016/j.neuroscience.2010.06.073. Epub 2010 Jul 9.

PMID:
20603190
10.

Effects of Curcuma extracts and curcuminoids on expression of P-glycoprotein and cytochrome P450 3A4 in the intestinal cell culture model LS180.

Graber-Maier A, Büter KB, Aeschlimann J, Bittel C, Kreuter M, Drewe J, Gutmann H.

Planta Med. 2010 Nov;76(16):1866-70. doi: 10.1055/s-0030-1249980. Epub 2010 May 27.

PMID:
20509107
11.

Prediction of adverse drug reactions using decision tree modeling.

Hammann F, Gutmann H, Vogt N, Helma C, Drewe J.

Clin Pharmacol Ther. 2010 Jul;88(1):52-9. doi: 10.1038/clpt.2009.248. Epub 2010 Mar 10.

PMID:
20220749
12.

Classification of cytochrome p(450) activities using machine learning methods.

Hammann F, Gutmann H, Baumann U, Helma C, Drewe J.

Mol Pharm. 2009 Nov-Dec;6(6):1920-6. doi: 10.1021/mp900217x.

PMID:
19813762
13.

Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier.

Poller B, Drewe J, Krähenbühl S, Huwyler J, Gutmann H.

Cell Mol Neurobiol. 2010 Jan;30(1):63-70. doi: 10.1007/s10571-009-9431-1. Epub 2009 Jul 23.

PMID:
19629677
14.

Development of decision tree models for substrates, inhibitors, and inducers of p-glycoprotein.

Hammann F, Gutmann H, Jecklin U, Maunz A, Helma C, Drewe J.

Curr Drug Metab. 2009 May;10(4):339-46.

PMID:
19519342
15.

Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients.

Wojtal KA, Eloranta JJ, Hruz P, Gutmann H, Drewe J, Staumann A, Beglinger C, Fried M, Kullak-Ublick GA, Vavricka SR.

Drug Metab Dispos. 2009 Sep;37(9):1871-7. doi: 10.1124/dmd.109.027367. Epub 2009 Jun 1.

16.

In vitro interactions with repeated grapefruit juice administration--to peel or not to peel?

Brill S, Zimmermann C, Berger K, Drewe J, Gutmann H.

Planta Med. 2009 Mar;75(4):332-5. doi: 10.1055/s-0028-1112210. Epub 2009 Jan 15.

PMID:
19148864
17.

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.

Zimmermann C, van Waterschoot RA, Harmsen S, Maier A, Gutmann H, Schinkel AH.

Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71. doi: 10.1016/j.ejps.2008.12.007. Epub 2008 Dec 24.

PMID:
19138736
18.

Breast cancer resistance protein and P-glycoprotein expression in patients with newly diagnosed and therapy-refractory ulcerative colitis compared with healthy controls.

Gutmann H, Hruz P, Zimmermann C, Straumann A, Terracciano L, Hammann F, Lehmann F, Beglinger C, Drewe J.

Digestion. 2008;78(2-3):154-62. doi: 10.1159/000179361. Epub 2008 Dec 3.

PMID:
19052456
19.

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.

Poller B, Gutmann H, Krähenbühl S, Weksler B, Romero I, Couraud PO, Tuffin G, Drewe J, Huwyler J.

J Neurochem. 2008 Dec;107(5):1358-68.

20.

Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells.

Schlatter P, Beglinger C, Drewe J, Gutmann H.

Regul Pept. 2007 Jun 7;141(1-3):120-8. Epub 2007 Jan 10.

PMID:
17276524
21.

Effects of budesonide on P-glycoprotein expression in intestinal cell lines.

Maier A, Zimmermann C, Beglinger C, Drewe J, Gutmann H.

Br J Pharmacol. 2007 Feb;150(3):361-8. Epub 2006 Dec 18.

22.

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis.

Zimmermann C, Hruz P, Gutmann H, Terracciano L, Beuers U, Lehmann F, Beglinger C, Drewe J.

Digestion. 2006;74(2):101-8. Epub 2006 Dec 7.

PMID:
17159348
23.

Glucagon-like peptide-1 is involved in sodium and water homeostasis in humans.

Gutzwiller JP, Hruz P, Huber AR, Hamel C, Zehnder C, Drewe J, Gutmann H, Stanga Z, Vogel D, Beglinger C.

Digestion. 2006;73(2-3):142-50.

24.

Induction of CYP1A by green tea extract in human intestinal cell lines.

Netsch MI, Gutmann H, Schmidlin CB, Aydogan C, Drewe J.

Planta Med. 2006 May;72(6):514-20.

PMID:
16773535
25.

Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?

Gutmann H, Poller B, Büter KB, Pfrunder A, Schaffner W, Drewe J.

Planta Med. 2006 Jun;72(8):685-90. Epub 2006 Jun 1.

PMID:
16755466
26.

Green tea extract induces interleukin-8 (IL-8) mRNA and protein expression but specifically inhibits IL-8 secretion in caco-2 cells.

Netsch MI, Gutmann H, Aydogan C, Drewe J.

Planta Med. 2006 Jun;72(8):697-702. Epub 2006 May 31.

PMID:
16739069
27.

Primary porcine proximal tubular cells as a model for transepithelial drug transport in human kidney.

Schlatter P, Gutmann H, Drewe J.

Eur J Pharm Sci. 2006 May;28(1-2):141-54. Epub 2006 Feb 28.

PMID:
16510270
28.

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin.

Huwyler J, Wright MB, Gutmann H, Drewe J.

Curr Drug Metab. 2006 Feb;7(2):119-26.

PMID:
16472102
29.

Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier.

Kusch-Poddar M, Drewe J, Fux I, Gutmann H.

Brain Res. 2005 Dec 7;1064(1-2):21-31. Epub 2005 Nov 14.

PMID:
16289483
30.

Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis.

Hruz P, Zimmermann C, Gutmann H, Degen L, Beuers U, Terracciano L, Drewe J, Beglinger C.

Gut. 2006 Mar;55(3):395-402. Epub 2005 Sep 8.

31.

Thalidomide does not interact with P-glycoprotein.

Zimmermann C, Gutmann H, Drewe J.

Cancer Chemother Pharmacol. 2006 May;57(5):599-606. Epub 2005 Sep 1.

PMID:
16136308
32.

Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract.

Gutmann H, Hruz P, Zimmermann C, Beglinger C, Drewe J.

Biochem Pharmacol. 2005 Sep 1;70(5):695-9.

PMID:
15998509
33.

Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality.

Netsch MI, Gutmann H, Luescher S, Brill S, Schmidlin CB, Kreuter MH, Drewe J.

Planta Med. 2005 Feb;71(2):135-41.

PMID:
15729621
34.

P-glycoprotein and surfactants: effect on intestinal talinolol absorption.

Bogman K, Zysset Y, Degen L, Hopfgartner G, Gutmann H, Alsenz J, Drewe J.

Clin Pharmacol Ther. 2005 Jan;77(1):24-32.

PMID:
15637528
35.

Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract.

Zimmermann C, Gutmann H, Hruz P, Gutzwiller JP, Beglinger C, Drewe J.

Drug Metab Dispos. 2005 Feb;33(2):219-24. Epub 2004 Nov 2.

PMID:
15523049
36.

Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men.

Gutzwiller JP, Tschopp S, Bock A, Zehnder CE, Huber AR, Kreyenbuehl M, Gutmann H, Drewe J, Henzen C, Goeke B, Beglinger C.

J Clin Endocrinol Metab. 2004 Jun;89(6):3055-61.

PMID:
15181098
37.

Vasospastic persons exhibit differential expression of ABC-transport proteins.

Wunderlich K, Zimmerman C, Gutmann H, Teuchner B, Flammer J, Drewe J.

Mol Vis. 2003 Dec 31;9:756-61.

38.
39.

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines.

Pfrunder A, Gutmann H, Beglinger C, Drewe J.

J Pharm Pharmacol. 2003 Jan;55(1):59-66.

PMID:
12625868
40.

Transport of amentoflavone across the blood-brain barrier in vitro.

Gutmann H, Bruggisser R, Schaffner W, Bogman K, Botomino A, Drewe J.

Planta Med. 2002 Sep;68(9):804-7.

PMID:
12357391
41.

HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.

Drewe J, Gutmann H, Fricker G, Török M, Beglinger C, Huwyler J.

Biochem Pharmacol. 1999 May 15;57(10):1147-52.

PMID:
11230802
42.

Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.

Miller DS, Nobmann SN, Gutmann H, Toeroek M, Drewe J, Fricker G.

Mol Pharmacol. 2000 Dec;58(6):1357-67.

PMID:
11093774
43.

P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule.

Gutmann H, Miller DS, Droulle A, Drewe J, Fahr A, Fricker G.

Br J Pharmacol. 2000 Jan;129(2):251-6.

44.

Epithelial transport of anthelmintic ivermectin in a novel model of isolated proximal kidney tubules.

Fricker G, Gutmann H, Droulle A, Drewe J, Miller DS.

Pharm Res. 1999 Oct;16(10):1570-5.

PMID:
10554099
45.

Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro.

Gutmann H, Török M, Fricker G, Huwyler J, Beglinger C, Drewe J.

Drug Metab Dispos. 1999 Aug;27(8):937-41.

PMID:
10421622
46.

Interactions of HIV protease inhibitors with ATP-dependent drug export proteins.

Gutmann H, Fricker G, Drewe J, Toeroek M, Miller DS.

Mol Pharmacol. 1999 Aug;56(2):383-9.

PMID:
10419558
47.

Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake.

Gutmann H, Fricker G, Török M, Michael S, Beglinger C, Drewe J.

Pharm Res. 1999 Mar;16(3):402-7.

PMID:
10213371
48.

Sister of P-glycoprotein expression in different tissues.

Török M, Gutmann H, Fricker G, Drewe J.

Biochem Pharmacol. 1999 Apr 1;57(7):833-5.

PMID:
10075089
49.

Transport of the beta-lactam antibiotic benzylpenicillin and the dipeptide glycylsarcosine by brain capillary endothelial cells in vitro.

Török M, Huwyler J, Drewe J, Gutmann H, Fricker G.

Drug Metab Dispos. 1998 Nov;26(11):1144-8.

PMID:
9806958
50.

Modulation of morphine-6-glucuronide penetration into the brain by P-glycoprotein.

Huwyler J, Drewe J, Gutmann H, Thöle M, Fricker G.

Int J Clin Pharmacol Ther. 1998 Feb;36(2):69-70. No abstract available.

PMID:
9520146

Supplemental Content

Loading ...
Support Center