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Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1.

Payne JM, Hearps SJC, Walsh KS, Paltin I, Barton B, Ullrich NJ, Haebich KM, Coghill D, Gioia GA, Cantor A, Cutter G, Tonsgard JH, Viskochil D, Rey-Casserly C, Schorry EK, Ackerson JD, Klesse L, Fisher MJ, Gutmann DH, Rosser T, Packer RJ, Korf B, Acosta MT, North KN; NF Clinical Trials Consortium.

Ann Clin Transl Neurol. 2019 Dec 3. doi: 10.1002/acn3.50952. [Epub ahead of print]


Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology.

Gutmann DH, Kettenmann H.

Neuron. 2019 Nov 6;104(3):442-449. doi: 10.1016/j.neuron.2019.08.028. Review.


Pain symptomology, functional impact, and treatment of people with Neurofibromatosis type 1.

Buono FD, Grau LE, Sprong ME, Morford KL, Johnson KJ, Gutmann DH.

J Pain Res. 2019 Aug 22;12:2555-2561. doi: 10.2147/JPR.S209540. eCollection 2019. Review.


NF1 glioblastoma clonal profiling reveals KMT2B mutations as potential somatic oncogenic events.

Wong WH, Junck L, Druley TE, Gutmann DH.

Neurology. 2019 Nov 5. pii: 10.1212/WNL.0000000000008623. doi: 10.1212/WNL.0000000000008623. [Epub ahead of print] No abstract available.


Microglia as Dynamic Cellular Mediators of Brain Function.

Wright-Jin EC, Gutmann DH.

Trends Mol Med. 2019 Nov;25(11):967-979. doi: 10.1016/j.molmed.2019.08.013. Epub 2019 Oct 6. Review.


Understanding a complicated Gal-1.

Hirbe AC, Gutmann DH.

Neuro Oncol. 2019 Nov 4;21(11):1341-1343. doi: 10.1093/neuonc/noz165. No abstract available.


Neurofibromatosis 2 in children presenting during the first decade of life.

Gaudioso C, Listernick R, Fisher MJ, Campen CJ, Paz A, Gutmann DH.

Neurology. 2019 Sep 3;93(10):e964-e967. doi: 10.1212/WNL.0000000000008065. Epub 2019 Jul 30.


Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1.

Haage V, Elmadany N, Roll L, Faissner A, Gutmann DH, Semtner M, Kettenmann H.

Brain Behav Immun. 2019 Oct;81:470-483. doi: 10.1016/j.bbi.2019.06.047. Epub 2019 Jul 2.


Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):522-523. doi: 10.1038/s41571-019-0236-y. No abstract available.


Commentary: Identification of Mutation Regions on NF1 Responsible for High- and Low-Risk Development of Optic Pathway Glioma in Neurofibromatosis Type I.

Anastasaki C, Gao F, Gutmann DH.

Front Genet. 2019 Mar 1;10:115. doi: 10.3389/fgene.2019.00115. eCollection 2019. No abstract available.


Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.

Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH.

Acta Neuropathol Commun. 2019 Feb 14;7(1):20. doi: 10.1186/s40478-019-0665-y.


Challenges to curing primary brain tumours.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):509-520. doi: 10.1038/s41571-019-0177-5. Review.


Adaptive functioning in children with neurofibromatosis type 1: relationship to cognition, behavior, and magnetic resonance imaging.

Eby NS, Griffith JL, Gutmann DH, Morris SM.

Dev Med Child Neurol. 2019 Aug;61(8):972-978. doi: 10.1111/dmcn.14144. Epub 2019 Jan 18.


Clearing the Fog surrounding Chemobrain.

Gutmann DH.

Cell. 2019 Jan 10;176(1-2):2-4. doi: 10.1016/j.cell.2018.12.027.


Neurofibromatosis type 1 (Nf1)-mutant mice exhibit increased sleep fragmentation.

Anastasaki C, Rensing N, Johnson KJ, Wong M, Gutmann DH.

J Sleep Res. 2019 Aug;28(4):e12816. doi: 10.1111/jsr.12816. Epub 2019 Jan 4.


KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.

Chen R, Keoni C, Waker CA, Lober RM, Chen YH, Gutmann DH.

Neoplasia. 2019 Jan;21(1):52-60. doi: 10.1016/j.neo.2018.11.007. Epub 2018 Nov 30.


Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

Durón C, Pan Y, Gutmann DH, Hardin J, Radunskaya A.

Bull Math Biol. 2019 Sep;81(9):3655-3673. doi: 10.1007/s11538-018-0526-z. Epub 2018 Oct 22.


Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.

Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, Stemmer-Rachamimov AO, Fahrenkrug SC, Gutmann DH, Giovannini M, Moertel CL, Largaespada DA, Watson AL.

Commun Biol. 2018 Oct 2;1:158. doi: 10.1038/s42003-018-0163-y. eCollection 2018.


Increased prevalence of brain tumors classified as T2 hyperintensities in neurofibromatosis 1.

Griffith JL, Morris SM, Mahdi J, Goyal MS, Hershey T, Gutmann DH.

Neurol Clin Pract. 2018 Aug;8(4):283-291. doi: 10.1212/CPJ.0000000000000494.


Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1.

Freret ME, Anastasaki C, Gutmann DH.

Neurol Genet. 2018 Jul 23;4(4):e261. doi: 10.1212/NXG.0000000000000261. eCollection 2018 Aug. No abstract available.


Height Growth Impairment in Children With Neurofibromatosis Type 1 Is Characterized by Decreased Pubertal Growth Velocity in Both Sexes.

Zessis NR, Gao F, Vadlamudi G, Gutmann DH, Hollander AS.

J Child Neurol. 2018 Oct;33(12):762-766. doi: 10.1177/0883073818786807. Epub 2018 Jul 16.


Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.

Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J.

PLoS One. 2018 May 22;13(5):e0190001. doi: 10.1371/journal.pone.0190001. eCollection 2018.


Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1.

Freret ME, Gutmann DH.

J Neurosci Res. 2019 Jan;97(1):45-56. doi: 10.1002/jnr.24250. Epub 2018 Apr 28. Review.


Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.

Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH.

Genes Dev. 2018 Apr 1;32(7-8):491-496. doi: 10.1101/gad.310797.117. Epub 2018 Apr 9.


β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.

Hirbe AC, Zhang X, Dahiya S, Godec A, Chrisinger J, Tao Y, Luo J, Gutmann DH.

Neuro Oncol. 2018 May 18;20(6):858-860. doi: 10.1093/neuonc/noy038. No abstract available.


A Conserved Circadian Function for the Neurofibromatosis 1 Gene.

Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A.

Cell Rep. 2018 Mar 27;22(13):3416-3426. doi: 10.1016/j.celrep.2018.03.014.


Neurofibromatosis type 1.

Cimino PJ, Gutmann DH.

Handb Clin Neurol. 2018;148:799-811. doi: 10.1016/B978-0-444-64076-5.00051-X. Review.


A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1.

Morris SM, Gutmann DH.

Neurology. 2018 Feb 20;90(8):377-379. doi: 10.1212/WNL.0000000000005000. Epub 2018 Jan 24. No abstract available.


Optic Pathway Gliomas in Neurofibromatosis Type 1.

Campen CJ, Gutmann DH.

J Child Neurol. 2018 Jan;33(1):73-81. doi: 10.1177/0883073817739509. Review.


Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M.

EMBO J. 2017 Dec 15;36(24):3650-3665. doi: 10.15252/embj.201796700. Epub 2017 Nov 10.


Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.

Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djx124. Review.


Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights.

Khatua S, Gutmann DH, Packer RJ.

Pediatr Blood Cancer. 2018 Mar;65(3). doi: 10.1002/pbc.26838. Epub 2017 Oct 19. Review.


Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner.

Zou J, Zhang B, Gutmann DH, Wong M.

Epilepsia. 2017 Dec;58(12):2053-2063. doi: 10.1111/epi.13923. Epub 2017 Oct 12.


Children with 5'-end NF1 gene mutations are more likely to have glioma.

Anastasaki C, Morris SM, Gao F, Gutmann DH.

Neurol Genet. 2017 Sep 22;3(5):e192. doi: 10.1212/NXG.0000000000000192. eCollection 2017 Oct.


Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.

Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH.

Oncotarget. 2017 Apr 18;8(32):52474-52487. doi: 10.18632/oncotarget.17193. eCollection 2017 Aug 8.


Neurodevelopmental disorders in children with neurofibromatosis type 1.

Vogel AC, Gutmann DH, Morris SM.

Dev Med Child Neurol. 2017 Nov;59(11):1112-1116. doi: 10.1111/dmcn.13526. Epub 2017 Aug 27. Review.


Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.

Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD.

Autism Res. 2018 Jan;11(1):44-58. doi: 10.1002/aur.1853. Epub 2017 Aug 26.


The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion.

Gutmann DH.

Cell. 2017 Aug 24;170(5):821-822. doi: 10.1016/j.cell.2017.08.011.


Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.

de Blank PMK, Fisher MJ, Liu GT, Gutmann DH, Listernick R, Ferner RE, Avery RA.

J Neuroophthalmol. 2017 Sep;37 Suppl 1:S23-S32. doi: 10.1097/WNO.0000000000000550. Review.


Updated nomenclature for human and mouse neurofibromatosis type 1 genes.

Anastasaki C, Le LQ, Kesterson RA, Gutmann DH.

Neurol Genet. 2017 Jul 26;3(4):e169. doi: 10.1212/NXG.0000000000000169. eCollection 2017 Aug. No abstract available.


The power of the few.

Chen R, Pan Y, Gutmann DH.

Genes Dev. 2017 Jun 15;31(12):1177-1179. doi: 10.1101/gad.303453.117. Review.


CNS Tumors in Neurofibromatosis.

Campian J, Gutmann DH.

J Clin Oncol. 2017 Jul 20;35(21):2378-2385. doi: 10.1200/JCO.2016.71.7199. Epub 2017 Jun 22. Review.


Caddyshack therapeutics: overcoming glioblastoma adaptation.

Gutmann DH.

Neuro Oncol. 2017 Oct 19;19(11):1429-1431. doi: 10.1093/neuonc/nox096. No abstract available.


Oligodendroglial myelination requires astrocyte-derived lipids.

Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG.

PLoS Biol. 2017 May 26;15(5):e1002605. doi: 10.1371/journal.pbio.1002605. eCollection 2017 May.


KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.

Anastasaki C, Dahiya S, Gutmann DH.

Oncotarget. 2017 Jul 18;8(29):47574-47585. doi: 10.18632/oncotarget.17736.


The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.

Oncotarget. 2017 Jul 18;8(29):47206-47215. doi: 10.18632/oncotarget.17589.


Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.

Chheda MG, Gutmann DH.

Cancer Cell. 2017 May 8;31(5):609-611. doi: 10.1016/j.ccell.2017.04.008.


Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.

Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A.

Biophys J. 2017 Apr 25;112(8):1535-1538. doi: 10.1016/j.bpj.2017.03.017.


The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis.

Blakeley JO, Bakker A, Barker A, Clapp W, Ferner R, Fisher MJ, Giovannini M, Gutmann DH, Karajannis MA, Kissil JL, Legius E, Lloyd AC, Packer RJ, Ramesh V, Riccardi VM, Stevenson DA, Ullrich NJ, Upadhyaya M, Stemmer-Rachamimov A.

Am J Med Genet A. 2017 Jun;173(6):1714-1721. doi: 10.1002/ajmg.a.38239. Epub 2017 Apr 24.

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