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Items: 1 to 50 of 92

1.

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG.

FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2.

2.

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, Gutman GA, Laudet V, Neubig RR, Ohlstein EH, Olsen RW, Peters J, Pin JP, Ruffolo RR, Searls DB, Wright MW, Spedding M.

Nucleic Acids Res. 2009 Jan;37(Database issue):D680-5. doi: 10.1093/nar/gkn728. Epub 2008 Oct 23.

3.
4.

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.

Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9. Epub 2006 Nov 6.

5.

The sense of place in the immune system.

Cahalan MD, Gutman GA.

Nat Immunol. 2006 Apr;7(4):329-32. Review.

6.

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, St├╝hmer W, Wang X.

Pharmacol Rev. 2005 Dec;57(4):473-508. Review. No abstract available.

7.

International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.

Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H.

Pharmacol Rev. 2005 Dec;57(4):463-72. Review. No abstract available.

8.

Overview of molecular relationships in the voltage-gated ion channel superfamily.

Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA.

Pharmacol Rev. 2005 Dec;57(4):387-95. Review. No abstract available.

9.

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG.

Mol Pharmacol. 2005 Apr;67(4):1369-81. Epub 2005 Jan 21.

10.

Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA.

Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL.

J Biol Chem. 2004 Nov 12;279(46):47419-30. Epub 2004 Aug 31.

11.

K+ channels as targets for specific immunomodulation.

Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD.

Trends Pharmacol Sci. 2004 May;25(5):280-9. Review.

12.

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.

Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG.

J Clin Invest. 2004 Feb;113(4):582-90.

13.

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of Pharmacology.

Pharmacol Rev. 2003 Dec;55(4):583-6.

14.

SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels.

Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG.

J Biol Chem. 2004 Feb 20;279(8):6893-904. Epub 2003 Nov 24.

15.

Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.

Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ.

Mol Psychiatry. 2003 May;8(5):524-35, 460. Erratum in: Mol Psychiatry. 2003 Aug;8(8):766.

PMID:
12808432
16.

A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.

Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG.

J Biol Chem. 2003 Mar 14;278(11):9928-37. Epub 2003 Jan 2.

17.

Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1.

Wulff H, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 2001 Aug 24;276(34):32040-5. Epub 2001 Jun 25.

18.

Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.

Miller MJ, Rauer H, Tomita H, Rauer H, Gargus JJ, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 2001 Jul 27;276(30):27753-6. Epub 2001 Jun 6.

19.

Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants.

Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA.

Toxicon. 2001 Sep;39(9):1269-76. Review. No abstract available.

PMID:
11384714
20.

Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.

Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 2000 Nov 24;275(47):37137-49.

21.

A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.

Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD.

Trends Pharmacol Sci. 1999 Nov;20(11):444-7.

PMID:
10542442
22.

hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21.

Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy KG, Gargus JJ, Gutman GA, Navon R.

Mol Psychiatry. 1999 May;4(3):254-60.

PMID:
10395215
23.

UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.

Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG.

Br J Pharmacol. 1999 Apr;126(8):1707-16.

24.

A piece in the puzzle: an ion channel candidate gene for schizophrenia.

Gargus JJ, Fantino E, Gutman GA.

Mol Med Today. 1998 Dec;4(12):518-24.

PMID:
9866821
25.

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.

Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG.

J Biol Chem. 1998 Dec 4;273(49):32697-707.

26.

Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia.

Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG.

Genomics. 1998 Jul 1;51(1):160-1. No abstract available.

PMID:
9693050
27.

Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry.

Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA.

J Biol Chem. 1998 Aug 7;273(32):20109-13.

28.

Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.

Bowen T, Guy CA, Craddock N, Cardno AG, Williams NM, Spurlock G, Murphy KC, Jones LA, Gray M, Sanders RD, McCarthy G, Chandy KG, Fantino E, Kalman K, Gutman GA, Gargus JJ, Williams J, McGuffin P, Owen MJ, O'Donovan MC.

Mol Psychiatry. 1998 May;3(3):266-9.

PMID:
9672903
29.

Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.

Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG.

J Biol Chem. 1998 Mar 6;273(10):5851-7.

30.

Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?

Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ.

Mol Psychiatry. 1998 Jan;3(1):32-7.

PMID:
9491810
31.

Purification, visualization, and biophysical characterization of Kv1.3 tetramers.

Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, Chandy KG.

J Biol Chem. 1997 Jan 24;272(4):2389-95.

32.

The signature sequence of voltage-gated potassium channels projects into the external vestibule.

Aiyar J, Rizzi JP, Gutman GA, Chandy KG.

J Biol Chem. 1996 Dec 6;271(49):31013-6.

33.

Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.

Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG.

Mol Pharmacol. 1996 Dec;50(6):1672-9.

PMID:
8967992
34.

Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene.

Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG.

J Biol Chem. 1996 Jun 28;271(26):15629-34.

35.

Transduction of a human RNA sequence by poliovirus.

Charini WA, Todd S, Gutman GA, Semler BL.

J Virol. 1994 Oct;68(10):6547-52.

36.

Genetic characterization of inbred strains of the rat (Rattus norvegicus).

Bender K, Balogh P, Bertrand MF, den Bieman M, von Deimling O, Eghtessadi S, Gutman GA, Hedrich HJ, Hunt SV, Kluge R, et al.

J Exp Anim Sci. 1994 Aug;36(4-5):151-65. No abstract available.

PMID:
7948066
37.

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG.

Mol Pharmacol. 1994 Jun;45(6):1227-34.

PMID:
7517498
38.
39.

Nomenclature for mammalian potassium channel genes.

Chandy KG, Gutman GA.

Trends Pharmacol Sci. 1993 Dec;14(12):434. No abstract available.

PMID:
8122319
40.

Missing link in ion channels.

Strong M, Gutman GA.

Nature. 1993 Mar 4;362(6415):26. No abstract available.

PMID:
7680430
41.
42.

Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.

Strong M, Chandy KG, Gutman GA.

Mol Biol Evol. 1993 Jan;10(1):221-42.

PMID:
7680747
43.

The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells.

Grissmer S, Ghanshani S, Dethlefs B, McPherson JD, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG.

J Biol Chem. 1992 Oct 15;267(29):20971-9.

44.

Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.

Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, Chandy KG.

Genomics. 1992 Feb;12(2):190-6.

PMID:
1740329
45.

Transcription and diversity of immunoglobulin lambda chain variable genes in the rat.

Aguilar BA, Gutman GA.

Immunogenetics. 1992;37(1):39-48.

PMID:
1428010
46.

Alleles of the rat T-cell receptor beta chain gene complex.

Blankenhorn EP, Smith PD, Williams CB, Gutman GA.

Immunogenetics. 1992;35(5):324-31.

PMID:
1348495
47.

Organization and nucleotide sequence of the rat T cell receptor beta-chain complex.

Williams CB, Blankenhorn EP, Byrd KE, Levinson G, Gutman GA.

J Immunol. 1991 Jun 15;146(12):4406-13.

PMID:
1828265
48.

Expression and chromosomal localization of a lymphocyte K+ channel gene.

Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG.

Proc Natl Acad Sci U S A. 1990 Dec;87(23):9411-5.

49.

A family of three mouse potassium channel genes with intronless coding regions.

Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA.

Science. 1990 Feb 23;247(4945):973-5.

PMID:
2305265
50.

Duplication of Tcra-V gene segments in the rat.

Williams CB, Khurana S, Gutman GA.

Immunogenetics. 1990;32(2):134-7. No abstract available.

PMID:
1975798

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