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Items: 13


The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development.

Rubio R, Gutierrez-Aranda I, Sáez-Castillo AI, Labarga A, Rosu-Myles M, Gonzalez-Garcia S, Toribio ML, Menendez P, Rodriguez R.

Oncogene. 2013 Oct 10;32(41):4970-80. doi: 10.1038/onc.2012.507. Epub 2012 Dec 10.


SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells.

Real PJ, Ligero G, Ayllon V, Ramos-Mejia V, Bueno C, Gutierrez-Aranda I, Navarro-Montero O, Lako M, Menendez P.

Mol Ther. 2012 Jul;20(7):1443-53. doi: 10.1038/mt.2012.49. Epub 2012 Apr 10.


A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification.

Bueno C, Montes R, Melen GJ, Ramos-Mejia V, Real PJ, Ayllón V, Sanchez L, Ligero G, Gutierrez-Aranda I, Fernández AF, Fraga MF, Moreno-Gimeno I, Burks D, Plaza-Calonge Mdel C, Rodríguez-Manzaneque JC, Menendez P.

Cell Res. 2012 Jun;22(6):986-1002. doi: 10.1038/cr.2012.4. Epub 2012 Jan 3.


Maintenance of human embryonic stem cells in media conditioned by human mesenchymal stem cells obviates the requirement of exogenous basic fibroblast growth factor supplementation.

Sánchez L, Gutierrez-Aranda I, Ligero G, Martín M, Ayllón V, Real PJ, Ramos-Mejía V, Bueno C, Menendez P.

Tissue Eng Part C Methods. 2012 May;18(5):387-96. doi: 10.1089/ten.TEC.2011.0546. Epub 2012 Jan 26.


Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.

Sánchez L, Gutierrez-Aranda I, Ligero G, Rubio R, Muñoz-López M, García-Pérez JL, Ramos V, Real PJ, Bueno C, Rodríguez R, Delgado M, Menendez P.

Stem Cells. 2011 Feb;29(2):251-62. doi: 10.1002/stem.569.


FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.

Rodriguez R, Rubio R, Gutierrez-Aranda I, Melen GJ, Elosua C, García-Castro J, Menendez P.

Stem Cells. 2011 Feb;29(2):179-92. doi: 10.1002/stem.571.


Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Montes R, Ayllón V, Gutierrez-Aranda I, Prat I, Hernández-Lamas MC, Ponce L, Bresolin S, Te Kronnie G, Greaves M, Bueno C, Menendez P.

Blood. 2011 May 5;117(18):4746-58. doi: 10.1182/blood-2010-12-322230. Epub 2011 Mar 9.


The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells.

Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P.

FASEB J. 2011 May;25(5):1497-508. doi: 10.1096/fj.10-172221. Epub 2011 Jan 25.


Nodal/Activin signaling predicts human pluripotent stem cell lines prone to differentiate toward the hematopoietic lineage.

Ramos-Mejia V, Melen GJ, Sanchez L, Gutierrez-Aranda I, Ligero G, Cortes JL, Real PJ, Bueno C, Menendez P.

Mol Ther. 2010 Dec;18(12):2173-81. doi: 10.1038/mt.2010.179. Epub 2010 Aug 24.


Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection.

Gutierrez-Aranda I, Ramos-Mejia V, Bueno C, Munoz-Lopez M, Real PJ, Mácia A, Sanchez L, Ligero G, Garcia-Parez JL, Menendez P.

Stem Cells. 2010 Sep;28(9):1568-70. doi: 10.1002/stem.471. No abstract available.


Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

Rubio R, García-Castro J, Gutiérrez-Aranda I, Paramio J, Santos M, Catalina P, Leone PE, Menendez P, Rodríguez R.

Cancer Res. 2010 May 15;70(10):4185-94. doi: 10.1158/0008-5472.CAN-09-4640. Epub 2010 May 4.


Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation.

Bueno C, Montes R, de la Cueva T, Gutierrez-Aránda I, Menendez P.

Cytotherapy. 2010;12(1):45-9. doi: 10.3109/14653240903377052.


Mesenchymal stem cells facilitate the derivation of human embryonic stem cells from cryopreserved poor-quality embryos.

Cortes JL, Sanchez L, Ligero G, Gutierrez-Aranda I, Catalina P, Elosua C, Leone PE, Montes R, Bueno C, Ramos-Mejía V, Maleno I, García-Pérez JL, Menendez P.

Hum Reprod. 2009 Aug;24(8):1844-51. doi: 10.1093/humrep/dep107. Epub 2009 Apr 28.


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