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Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

Antoine M, Patrick KL, Soret J, Duc P, Rage F, Cacciottolo R, Nissen KE, Cauchi RJ, Krogan NJ, Guthrie C, Gachet Y, Bordonné R.

iScience. 2020 Jan 24;23(1):100809. doi: 10.1016/j.isci.2019.100809. Epub 2019 Dec 28.


Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.

Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B.

Sci Transl Med. 2019 Dec 18;11(523). pii: eaao6545. doi: 10.1126/scitranslmed.aao6545.


Associations Between Environmental Conditions and Executive Cognitive Functioning and Behavior During Late Childhood: A Pilot Study.

Fishbein DH, Michael L, Guthrie C, Carr C, Raymer J.

Front Psychol. 2019 May 31;10:1263. doi: 10.3389/fpsyg.2019.01263. eCollection 2019.


Prp8 impacts cryptic but not alternative splicing frequency.

Mayerle M, Yitiz S, Soulette C, Rogel LE, Ramirez A, Ragle JM, Katzman S, Guthrie C, Zahler AM.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2193-2199. doi: 10.1073/pnas.1819020116. Epub 2019 Jan 23.


The Use of Procalcitonin for Prediction of Pulmonary Bacterial Coinfection in Children With Respiratory Failure Associated With Viral Bronchiolitis.

Ericksen RT, Guthrie C, Carroll T.

Clin Pediatr (Phila). 2018 Dec 14:9922818816432. doi: 10.1177/0009922818816432. [Epub ahead of print]


Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.

de Bruyn Kops A, Burke JE, Guthrie C.

Mol Biol Cell. 2018 Oct 15;29(21):2578-2590. doi: 10.1091/mbc.E18-04-0258. Epub 2018 Aug 22.


Identification of the Novel Nup188-brr7 Allele in a Screen for Cold-Sensitive mRNA Export Mutants in Saccharomyces cerevisiae.

de Bruyn Kops A, Guthrie C.

G3 (Bethesda). 2018 Aug 30;8(9):2991-3003. doi: 10.1534/g3.118.200447.


Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.

MacRae AJ, Mayerle M, Hrabeta-Robinson E, Chalkley RJ, Guthrie C, Burlingame AL, Jurica MS.

RNA. 2018 Jun;24(6):769-777. doi: 10.1261/rna.065458.117. Epub 2018 Feb 27.


"Yes, and …" Exploring the Future of Learning Analytics in Medical Education.

Cirigliano MM, Guthrie C, Pusic MV, Cianciolo AT, Lim-Dunham JE, Spickard A 3rd, Terry V.

Teach Learn Med. 2017 Oct-Dec;29(4):368-372. doi: 10.1080/10401334.2017.1384731.


Effect of handling intensity at the time of transport for slaughter on physiological response and carcass characteristics in beef cattle fed ractopamine hydrochloride.

Hagenmaier JA, Reinhardt CD, Bartle SJ, Henningson JN, Ritter MJ, Calvo-Lorenzo MS, Vogel GJ, Guthrie CA, Siemens MG, Thomson DU.

J Anim Sci. 2017 May;95(5):1963-1976. doi: 10.2527/jas.2016.0821.


Effects of ractopamine hydrochloride on growth performance, carcass characteristics, and physiological response to different handling techniques.

Hagenmaier JA, Reinhardt CD, Ritter MJ, Calvo-Lorenzo MS, Vogel GJ, Guthrie CA, Siemens MG, Lechtenberg KF, Rezac DJ, Thomson DU.

J Anim Sci. 2017 May;95(5):1977-1992. doi: 10.2527/jas.2016.0936.


Otolith shape variability and associated body growth differences in giant grenadier, Albatrossia pectoralis.

Rodgveller CJ, Hutchinson CE, Harris JP, Vulstek SC, Guthrie CM 3rd.

PLoS One. 2017 Jun 28;12(6):e0180020. doi: 10.1371/journal.pone.0180020. eCollection 2017.


The histone variant H2A.Z promotes splicing of weak introns.

Nissen KE, Homer CM, Ryan CJ, Shales M, Krogan NJ, Patrick KL, Guthrie C.

Genes Dev. 2017 Apr 1;31(7):688-701. doi: 10.1101/gad.295287.116.


Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.

Mayerle M, Raghavan M, Ledoux S, Price A, Stepankiw N, Hadjivassiliou H, Moehle EA, Mendoza SD, Pleiss JA, Guthrie C, Abelson J.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4739-4744. doi: 10.1073/pnas.1701462114. Epub 2017 Apr 17.


Genetics and biochemistry remain essential in the structural era of the spliceosome.

Mayerle M, Guthrie C.

Methods. 2017 Aug 1;125:3-9. doi: 10.1016/j.ymeth.2017.01.006. Epub 2017 Jan 26. Review.


Short-Term Intervention Effects of the PATHS Curriculum in Young Low-Income Children: Capitalizing on Plasticity.

Fishbein DH, Domitrovich C, Williams J, Gitukui S, Guthrie C, Shapiro D, Greenberg M.

J Prim Prev. 2016 Dec;37(6):493-511.


The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.

Soucek S, Zeng Y, Bellur DL, Bergkessel M, Morris KJ, Deng Q, Duong D, Seyfried NT, Guthrie C, Staley JP, Fasken MB, Corbett AH.

Mol Cell Biol. 2016 Nov;36(21):2697-2714. doi: 10.1128/MCB.00402-16. Epub 2016 Aug 15.


Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.

Ledoux S, Guthrie C.

J Biol Chem. 2016 Jun 3;291(23):11954-65. doi: 10.1074/jbc.M115.710848. Epub 2016 Apr 12.


Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.

Mayerle M, Guthrie C.

RNA. 2016 May;22(5):793-809. doi: 10.1261/rna.055459.115. Epub 2016 Mar 11.


A new communication hub in the RNA world.

Mayerle M, Guthrie C.

Nat Struct Mol Biol. 2016 Mar;23(3):189-90. doi: 10.1038/nsmb.3178. No abstract available.


Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D.

PLoS Genet. 2015 Dec 22;11(12):e1005735. doi: 10.1371/journal.pgen.1005735. eCollection 2015 Dec.


SR protein kinases promote splicing of nonconsensus introns.

Lipp JJ, Marvin MC, Shokat KM, Guthrie C.

Nat Struct Mol Biol. 2015 Aug;22(8):611-7. doi: 10.1038/nsmb.3057. Epub 2015 Jul 13.


Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast.

Patrick KL, Ryan CJ, Xu J, Lipp JJ, Nissen KE, Roguev A, Shales M, Krogan NJ, Guthrie C.

PLoS Genet. 2015 Mar 31;11(3):e1005074. doi: 10.1371/journal.pgen.1005074. eCollection 2015 Mar.


Present at the creation.

Guthrie C.

RNA. 2015 Apr;21(4):481. doi: 10.1261/rna.049676.115. No abstract available.


BBX19 interacts with CONSTANS to repress FLOWERING LOCUS T transcription, defining a flowering time checkpoint in Arabidopsis.

Wang CQ, Guthrie C, Sarmast MK, Dehesh K.

Plant Cell. 2014 Sep;26(9):3589-602. doi: 10.1105/tpc.114.130252. Epub 2014 Sep 16.


A key general stress response motif is regulated non-uniformly by CAMTA transcription factors.

Benn G, Wang CQ, Hicks DR, Stein J, Guthrie C, Dehesh K.

Plant J. 2014 Oct;80(1):82-92. doi: 10.1111/tpj.12620. Epub 2014 Aug 19.


Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate.

Moehle EA, Braberg H, Krogan NJ, Guthrie C.

RNA Biol. 2014;11(4):313-9. doi: 10.4161/rna.28646. Epub 2014 Apr 2. Review.


The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.

Hadjivassiliou H, Rosenberg OS, Guthrie C.

RNA. 2014 May;20(5):656-69. doi: 10.1261/rna.042838.113. Epub 2014 Mar 28.


H2B ubiquitylation modulates spliceosome assembly and function in budding yeast.

Hérissant L, Moehle EA, Bertaccini D, Van Dorsselaer A, Schaeffer-Reiss C, Guthrie C, Dargemont C.

Biol Cell. 2014 Apr;106(4):126-38. doi: 10.1111/boc.201400003. Epub 2014 Feb 25.


Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing.

Krishnan R, Blanco MR, Kahlscheuer ML, Abelson J, Guthrie C, Walter NG.

Nat Struct Mol Biol. 2013 Dec;20(12):1450-7. doi: 10.1038/nsmb.2704. Epub 2013 Nov 17.


An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.

Price AM, Görnemann J, Guthrie C, Brow DA.

RNA. 2014 Jan;20(1):46-60. doi: 10.1261/rna.041970.113. Epub 2013 Nov 14.


Yeast-gene replacement using PCR products.

Bergkessel M, Guthrie C, Abelson J.

Methods Enzymol. 2013;533:43-55. doi: 10.1016/B978-0-12-420067-8.00005-2.


Chemical transformation of yeast.

Bergkessel M, Guthrie C.

Methods Enzymol. 2013;529:311-20. doi: 10.1016/B978-0-12-418687-3.00026-4.


Colony PCR.

Bergkessel M, Guthrie C.

Methods Enzymol. 2013;529:299-309. doi: 10.1016/B978-0-12-418687-3.00025-2.


From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.

Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ.

Cell. 2013 Aug 15;154(4):775-88. doi: 10.1016/j.cell.2013.07.033. Epub 2013 Aug 8.


The effect of anterior palatine blocks on bleeding in hereditary hemorrhagic telangiectasia nasal surgery.

Guthrie CC, Karnezis TT, Orosco RK, Bishop ML, Davidson TM.

Laryngoscope. 2013 Nov;123(11):2598-600. doi: 10.1002/lary.24076. Epub 2013 May 13.


CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

Liachko NF, McMillan PJ, Guthrie CR, Bird TD, Leverenz JB, Kraemer BC.

Ann Neurol. 2013 Jul;74(1):39-52. doi: 10.1002/ana.23870. Epub 2013 Jul 8.


The yeast SR-like protein Npl3 links chromatin modification to mRNA processing.

Moehle EA, Ryan CJ, Krogan NJ, Kress TL, Guthrie C.

PLoS Genet. 2012;8(11):e1003101. doi: 10.1371/journal.pgen.1003101. Epub 2012 Nov 29.


Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity.

McCormick AV, Wheeler JM, Guthrie CR, Liachko NF, Kraemer BC.

Biol Psychiatry. 2013 Mar 1;73(5):464-71. doi: 10.1016/j.biopsych.2012.08.027. Epub 2012 Nov 7.


A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa.

Noormahomed EV, Orlov M, do Rosario V, Petersen BW, Guthrie C, Badaro R, Schooley RT.

Malar J. 2012 Aug 1;11:252. doi: 10.1186/1475-2875-11-252.


Potential neuroprotective strategies against tauopathy.

Wheeler JM, Guthrie CR, Kraemer BC.

Biochem Soc Trans. 2012 Aug;40(4):656-60. doi: 10.1042/BST20120017.


Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ.

Mol Cell. 2012 Jun 8;46(5):691-704. doi: 10.1016/j.molcel.2012.05.028.


Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.

Watkins GR, Wang N, Mazalouskas MD, Gomez RJ, Guthrie CR, Kraemer BC, Schweiger S, Spiller BW, Wadzinski BE.

J Biol Chem. 2012 Jul 13;287(29):24207-15. doi: 10.1074/jbc.M112.368613. Epub 2012 May 21.


Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit.

Plocik AM, Guthrie C.

PLoS Genet. 2012;8(3):e1002620. doi: 10.1371/journal.pgen.1002620. Epub 2012 Mar 29.


Exploring clinical wisdom in nursing education.

McKie A, Baguley F, Guthrie C, Jackson C, Kirkpatrick P, Laing A, O'Brien S, Taylor R, Wimpenny P.

Nurs Ethics. 2012 Mar;19(2):252-67. doi: 10.1177/0969733011416841.


Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease.

McClary DG, Loneragan GH, Shryock TR, Carter BL, Guthrie CA, Corbin MJ, Mechor GD.

J Am Vet Med Assoc. 2011 Jul 1;239(1):129-35. doi: 10.2460/javma.239.1.129.


Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast.

Bergkessel M, Whitworth GB, Guthrie C.

RNA. 2011 Aug;17(8):1461-78. doi: 10.1261/rna.2754011. Epub 2011 Jun 22.


Almost thinking counterfactually: children's understanding of close counterfactuals.

Beck SR, Guthrie C.

Child Dev. 2011 Jul-Aug;82(4):1189-98. doi: 10.1111/j.1467-8624.2011.01590.x. Epub 2011 Apr 5.


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