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Items: 1 to 50 of 124

1.

Tick-Tock Hedgehog-Mutual crosstalk with liver circadian clock promotes liver steatosis.

Marbach-Breitrück E, Matz-Soja M, Abraham U, Schmidt-Heck W, Sales S, Rennert C, Kern M, Aleithe S, Spormann L, Thiel C, Gerlini R, Arnold K, Klöting N, Guthke R, Rozman D, Teperino R, Shevchenko A, Kramer A, Gebhardt R.

J Hepatol. 2019 Jan 31. pii: S0168-8278(19)30065-0. doi: 10.1016/j.jhep.2019.01.022. [Epub ahead of print]

PMID:
30711403
2.

Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.

Barber AE, Weber M, Kaerger K, Linde J, Gölz H, Duerschmied D, Markert A, Guthke R, Walther G, Kurzai O.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01628-18. doi: 10.1128/AAC.01628-18. Print 2019 Feb.

PMID:
30478162
3.

Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin.

Conrad T, Kniemeyer O, Henkel SG, Krüger T, Mattern DJ, Valiante V, Guthke R, Jacobsen ID, Brakhage AA, Vlaic S, Linde J.

BMC Syst Biol. 2018 Oct 20;12(1):88. doi: 10.1186/s12918-018-0620-8.

4.

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M.

Cell Metab. 2018 Apr 3;27(4):914-925.e5. doi: 10.1016/j.cmet.2018.02.004. Epub 2018 Mar 15.

PMID:
29551589
5.

Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion.

Schmidt H, Vlaic S, Krüger T, Schmidt F, Balkenhol J, Dandekar T, Guthke R, Kniemeyer O, Heinekamp T, Brakhage AA.

Mol Cell Proteomics. 2018 Jun;17(6):1084-1096. doi: 10.1074/mcp.RA117.000069. Epub 2018 Mar 5.

PMID:
29507050
6.

Verticillium dahliae-Arabidopsis Interaction Causes Changes in Gene Expression Profiles and Jasmonate Levels on Different Time Scales.

Scholz SS, Schmidt-Heck W, Guthke R, Furch ACU, Reichelt M, Gershenzon J, Oelmüller R.

Front Microbiol. 2018 Feb 13;9:217. doi: 10.3389/fmicb.2018.00217. eCollection 2018.

7.

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.

Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C.

Nat Commun. 2018 Jan 30;9(1):327. doi: 10.1038/s41467-017-02395-2.

8.

ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks.

Vlaic S, Conrad T, Tokarski-Schnelle C, Gustafsson M, Dahmen U, Guthke R, Schuster S.

Sci Rep. 2018 Jan 11;8(1):433. doi: 10.1038/s41598-017-18370-2.

9.

Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells.

Lehmann R, Müller MM, Klassert TE, Driesch D, Stock M, Heinrich A, Conrad T, Moore C, Schier UK, Guthke R, Slevogt H.

Mucosal Immunol. 2018 May;11(3):627-642. doi: 10.1038/mi.2017.100. Epub 2018 Jan 3.

PMID:
29297499
10.

Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake.

Schleicher J, Dahmen U, Guthke R, Schuster S.

J R Soc Interface. 2017 Aug;14(133). pii: 20170443. doi: 10.1098/rsif.2017.0443.

11.

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility.

Rennert C, Eplinius F, Hofmann U, Johänning J, Rolfs F, Schmidt-Heck W, Guthke R, Gebhardt R, Ricken AM, Matz-Soja M.

Arch Toxicol. 2017 Nov;91(11):3677-3687. doi: 10.1007/s00204-017-1999-5. Epub 2017 May 30.

PMID:
28560483
12.

Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression.

Müller MM, Lehmann R, Klassert TE, Reifenstein S, Conrad T, Moore C, Kuhn A, Behnert A, Guthke R, Driesch D, Slevogt H.

Sci Rep. 2017 Apr 12;7(1):838. doi: 10.1038/s41598-017-00828-y.

13.

Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells.

Dix A, Czakai K, Leonhardt I, Schäferhoff K, Bonin M, Guthke R, Einsele H, Kurzai O, Löffler J, Linde J.

Front Microbiol. 2017 Feb 23;8:270. doi: 10.3389/fmicb.2017.00270. eCollection 2017.

14.

Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus.

Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA.

ACS Chem Biol. 2017 May 19;12(5):1227-1234. doi: 10.1021/acschembio.7b00003. Epub 2017 Mar 15.

PMID:
28233494
15.

Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior.

Schmidt-Heck W, Wönne EC, Hiller T, Menzel U, Koczan D, Damm G, Seehofer D, Knöspel F, Freyer N, Guthke R, Dooley S, Zeilinger K.

Alcohol Clin Exp Res. 2017 May;41(5):883-894. doi: 10.1111/acer.13361. Epub 2017 Mar 27.

PMID:
28226195
16.

Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus.

Manchanda H, Seidel N, Blaess MF, Claus RA, Linde J, Slevogt H, Sauerbrei A, Guthke R, Schmidtke M.

Front Microbiol. 2016 Aug 3;7:1167. doi: 10.3389/fmicb.2016.01167. eCollection 2016.

17.

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.

Marthandan S, Menzel U, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Kaether C, Diekmann S.

Biol Res. 2016 Jul 28;49(1):34. doi: 10.1186/s40659-016-0095-2.

18.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.

19.

Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

Matz-Soja M, Rennert C, Schönefeld K, Aleithe S, Boettger J, Schmidt-Heck W, Weiss TS, Hovhannisyan A, Zellmer S, Klöting N, Schulz A, Kratzsch J, Guthke R, Gebhardt R.

Elife. 2016 May 17;5. pii: e13308. doi: 10.7554/eLife.13308.

20.

Data-based Reconstruction of Gene Regulatory Networks of Fungal Pathogens.

Guthke R, Gerber S, Conrad T, Vlaic S, Durmuş S, Çakır T, Sevilgen FE, Shelest E, Linde J.

Front Microbiol. 2016 Apr 22;7:570. doi: 10.3389/fmicb.2016.00570. eCollection 2016.

21.

Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.

Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, Hemmerich P.

PLoS One. 2016 May 3;11(5):e0154531. doi: 10.1371/journal.pone.0154531. eCollection 2016.

22.

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.

Baumgart M, Priebe S, Groth M, Hartmann N, Menzel U, Pandolfini L, Koch P, Felder M, Ristow M, Englert C, Guthke R, Platzer M, Cellerino A.

Cell Syst. 2016 Feb 24;2(2):122-32. doi: 10.1016/j.cels.2016.01.014. Epub 2016 Feb 24.

23.

Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers.

Dix A, Vlaic S, Guthke R, Linde J.

Clin Microbiol Infect. 2016 Jul;22(7):600-6. doi: 10.1016/j.cmi.2016.04.014. Epub 2016 Apr 22. Review.

24.

How to Predict Molecular Interactions between Species?

Schulze S, Schleicher J, Guthke R, Linde J.

Front Microbiol. 2016 Mar 31;7:442. doi: 10.3389/fmicb.2016.00442. eCollection 2016. Review.

25.

Genome-Wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis.

Dix A, Czakai K, Springer J, Fliesser M, Bonin M, Guthke R, Schmitt AL, Einsele H, Linde J, Löffler J.

Front Microbiol. 2016 Mar 21;7:320. doi: 10.3389/fmicb.2016.00320. eCollection 2016.

26.

Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis.

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 May 6;15(5):1580-91. doi: 10.1021/acs.jproteome.6b00042. Epub 2016 Mar 24.

PMID:
26974881
27.

Draft Genome Sequences of Fungus Aspergillus calidoustus.

Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Scherlach K, Martin K, Brakhage AA, Petzke L, Valiante V.

Genome Announc. 2016 Mar 10;4(2). pii: e00102-16. doi: 10.1128/genomeA.00102-16.

28.

Editorial: Computational Systems Biology of Pathogen-Host Interactions.

Durmuş S, Çakır T, Guthke R.

Front Microbiol. 2016 Feb 4;7:21. doi: 10.3389/fmicb.2016.00021. eCollection 2016. No abstract available.

29.

Facing the challenges of multiscale modelling of bacterial and fungal pathogen-host interactions.

Schleicher J, Conrad T, Gustafsson M, Cedersund G, Guthke R, Linde J.

Brief Funct Genomics. 2017 Mar 1;16(2):57-69. doi: 10.1093/bfgp/elv064. Review.

30.

Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.

Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O.

Cell Microbiol. 2016 Jul;18(7):889-904. doi: 10.1111/cmi.12566. Epub 2016 Feb 26.

PMID:
26752615
31.

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M.

Nat Commun. 2015 Dec 1;6:10043. doi: 10.1038/ncomms10043.

32.

Hormetic effect of rotenone in primary human fibroblasts.

Marthandan S, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Diekmann S.

Immun Ageing. 2015 Sep 16;12:11. doi: 10.1186/s12979-015-0038-8. eCollection 2015.

33.

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus.

Altwasser R, Baldin C, Weber J, Guthke R, Kniemeyer O, Brakhage AA, Linde J, Valiante V.

PLoS One. 2015 Sep 10;10(9):e0136932. doi: 10.1371/journal.pone.0136932. eCollection 2015.

34.

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.

Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, Hemmerich P, Diekmann S.

Biomed Res Int. 2015;2015:731938. doi: 10.1155/2015/731938. Epub 2015 Aug 3.

35.

Draft Genome Sequence of the Fungus Penicillium brasilianum MG11.

Horn F, Linde J, Mattern DJ, Walther G, Guthke R, Brakhage AA, Valiante V.

Genome Announc. 2015 Sep 3;3(5). pii: e00724-15. doi: 10.1128/genomeA.00724-15.

36.

Computing the various pathways of penicillin synthesis and their molar yields.

Prauße MT, Schäuble S, Guthke R, Schuster S.

Biotechnol Bioeng. 2016 Jan;113(1):173-81. doi: 10.1002/bit.25694. Epub 2015 Aug 19.

PMID:
26134880
37.

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.

Schmidt-Heck W, Matz-Soja M, Aleithe S, Marbach E, Guthke R, Gebhardt R.

Mol Biosyst. 2015 Aug;11(8):2190-7. doi: 10.1039/c5mb00129c.

PMID:
26010061
38.

A review on computational systems biology of pathogen-host interactions.

Durmuş S, Çakır T, Özgür A, Guthke R.

Front Microbiol. 2015 Apr 9;6:235. doi: 10.3389/fmicb.2015.00235. eCollection 2015. Review.

39.

Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study.

Dix A, Hünniger K, Weber M, Guthke R, Kurzai O, Linde J.

Front Microbiol. 2015 Mar 11;6:171. doi: 10.3389/fmicb.2015.00171. eCollection 2015.

40.

Computational prediction of molecular pathogen-host interactions based on dual transcriptome data.

Schulze S, Henkel SG, Driesch D, Guthke R, Linde J.

Front Microbiol. 2015 Feb 6;6:65. doi: 10.3389/fmicb.2015.00065. eCollection 2015.

41.

Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum.

Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J.

Genome Announc. 2015 Jan 22;3(1). pii: e01439-14. doi: 10.1128/genomeA.01439-14.

42.

Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417.

Horn F, Üzüm Z, Möbius N, Guthke R, Linde J, Hertweck C.

Genome Announc. 2015 Jan 22;3(1). pii: e01370-14. doi: 10.1128/genomeA.01370-14.

43.

Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.

Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O.

Nucleic Acids Res. 2015 Feb 18;43(3):1392-406. doi: 10.1093/nar/gku1357. Epub 2015 Jan 13.

44.

Data- and knowledge-based modeling of gene regulatory networks: an update.

Linde J, Schulze S, Henkel SG, Guthke R.

EXCLI J. 2015 Mar 2;14:346-78. doi: 10.17179/excli2015-168. eCollection 2015. Review.

45.

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant.

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B.

PLoS Genet. 2014 Dec 4;10(12):e1004824. doi: 10.1371/journal.pgen.1004824. eCollection 2014 Dec.

46.

FungiFun2: a comprehensive online resource for systematic analysis of gene lists from fungal species.

Priebe S, Kreisel C, Horn F, Guthke R, Linde J.

Bioinformatics. 2015 Feb 1;31(3):445-6. doi: 10.1093/bioinformatics/btu627. Epub 2014 Oct 7.

47.

RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.

Baumgart M, Groth M, Priebe S, Savino A, Testa G, Dix A, Ripa R, Spallotta F, Gaetano C, Ori M, Terzibasi Tozzini E, Guthke R, Platzer M, Cellerino A.

Aging Cell. 2014 Dec;13(6):965-74. doi: 10.1111/acel.12257. Epub 2014 Jul 25.

48.

Draft Genome Sequence of Streptomyces iranensis.

Horn F, Schroeckh V, Netzker T, Guthke R, Brakhage AA, Linde J.

Genome Announc. 2014 Jul 17;2(4). pii: e00616-14. doi: 10.1128/genomeA.00616-14.

49.

Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients.

Kupfer P, Huber R, Weber M, Vlaic S, Häupl T, Koczan D, Guthke R, Kinne RW.

BMC Med Genomics. 2014 Jul 3;7:40. doi: 10.1186/1755-8794-7-40.

50.

The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus.

Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA.

Mol Microbiol. 2014 Aug;93(3):539-53. doi: 10.1111/mmi.12679. Epub 2014 Jul 7.

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