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mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5.

Hauser S, Poenisch M, Schelling Y, Höflinger P, Schuster S, Teegler A, Betten R, Gustafsson JÅ, Hübener-Schmid J, Schlake T, Chevessier-Tünnesen F, Horscroft N, Björkhem I, Schöls L.

Mol Ther Methods Clin Dev. 2019 Oct 31;15:359-370. doi: 10.1016/j.omtm.2019.10.011. eCollection 2019 Dec 13.


Selective estrogen receptor (ER)β activation provokes a redistribution of fat mass and modifies hepatic triglyceride composition in obese male mice.

González-Granillo M, Savva C, Li X, Ghosh Laskar M, Angelin B, Gustafsson JÅ, Korach-André M.

Mol Cell Endocrinol. 2020 Feb 15;502:110672. doi: 10.1016/j.mce.2019.110672. Epub 2019 Dec 5.


Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine.

Santinha D, Klopot A, Marques I, Ellis E, Jorns C, Johansson H, Melo T, Antonson P, Jakobsson T, Félix V, Gustafsson JÅ, Domingues MR, Mode A, Helguero LA.

J Steroid Biochem Mol Biol. 2019 Nov 26;198:105558. doi: 10.1016/j.jsbmb.2019.105558. [Epub ahead of print]


Immunoregulatory Functions of Nuclear Receptors: Mechanisms and Therapeutic Implications.

Zhao L, Gimple RC, Yang Z, Wei Y, Gustafsson JÅ, Zhou S.

Trends Endocrinol Metab. 2019 Nov 6. pii: S1043-2760(19)30205-X. doi: 10.1016/j.tem.2019.10.002. [Epub ahead of print] Review.


Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up-regulation of PPARγ signalling.

Bian X, Liu T, Zhou M, He G, Ma Y, Shi Y, Wang Y, Tang H, Kang X, Yang M, Gustafsson JÅ, Fan X, Tang K.

J Cell Mol Med. 2019 Nov;23(11):7406-7416. doi: 10.1111/jcmm.14604. Epub 2019 Sep 2.


Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE.

Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.


Differential activity of BPA, BPAF and BPC on zebrafish estrogen receptors in vitro and in vivo.

Pinto C, Hao R, Grimaldi M, Thrikawala S, Boulahtouf A, Aït-Aïssa S, Brion F, Gustafsson JÅ, Balaguer P, Bondesson M.

Toxicol Appl Pharmacol. 2019 Oct 1;380:114709. doi: 10.1016/j.taap.2019.114709. Epub 2019 Aug 12.


Retinal and optic nerve degeneration in liver X receptor β knockout mice.

Song XY, Wu WF, Gabbi C, Dai YB, So M, Chaurasiya SP, Wang L, Warner M, Gustafsson JÅ.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16507-16512. doi: 10.1073/pnas.1904719116. Epub 2019 Aug 1.


Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception.

Soriano S, Gil-Rivera M, Marroqui L, Alonso-Magdalena P, Fuentes E, Gustafsson JA, Nadal A, Martinez-Pinna J.

Sci Rep. 2019 Jul 16;9(1):10306. doi: 10.1038/s41598-019-46769-6.


Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.

Martinez-Pinna J, Marroqui L, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, Alonso-Magdalena P, Dos Santos RS, Quesada I, Martin F, Soria B, Gustafsson JÅ, Nadal A.

Diabetologia. 2019 Sep;62(9):1667-1680. doi: 10.1007/s00125-019-4925-y. Epub 2019 Jun 27.


Correction: Estrogen Signalling and the Metabolic Syndrome: Targeting the Hepatic Estrogen Receptor Alpha Action.

Matic M, Bryzgalova G, Gao H, Antonson P, Humire P, Omoto Y, Portwood N, Pramfalk C, Efendic S, Berggren PO, Gustafsson JÅ, Dahlman-Wright K.

PLoS One. 2019 Jun 19;14(6):e0217526. doi: 10.1371/journal.pone.0217526. eCollection 2019.


Update on ERbeta.

Gustafsson JA, Strom A, Warner M.

J Steroid Biochem Mol Biol. 2019 Jul;191:105312. doi: 10.1016/j.jsbmb.2019.02.007. Epub 2019 Apr 14. Review.


VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure.

Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8457-8462. doi: 10.1073/pnas.1902119116. Epub 2019 Apr 4.


Nuclear Receptors: Recent Drug Discovery for Cancer Therapies.

Zhao L, Zhou S, Gustafsson JÅ.

Endocr Rev. 2019 Oct 1;40(5):1207-1249. doi: 10.1210/er.2018-00222.


Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse.

González-Granillo M, Helguero LA, Alves E, Archer A, Savva C, Pedrelli M, Ahmed O, Li X, Domingues MR, Parini P, Gustafsson JÅ, Korach-André M.

Biol Sex Differ. 2019 Feb 26;10(1):11. doi: 10.1186/s13293-019-0225-y.


LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux.

Thomas DG, Doran AC, Fotakis P, Westerterp M, Antonson P, Jiang H, Jiang XC, Gustafsson JÅ, Tabas I, Tall AR.

Cell Rep. 2018 Dec 26;25(13):3774-3785.e4. doi: 10.1016/j.celrep.2018.11.100.


Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.

Griffiths WJ, Abdel-Khalik J, Yutuc E, Roman G, Warner M, Gustafsson JÅ, Wang Y.

Free Radic Biol Med. 2019 Apr;134:42-52. doi: 10.1016/j.freeradbiomed.2018.12.020. Epub 2018 Dec 19.


Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S.

Nat Commun. 2018 Dec 21;9(1):5457. doi: 10.1038/s41467-018-07581-4.


The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling.

Faria M, Shepherd P, Pan Y, Chatterjee SS, Navone N, Gustafsson JÅ, Strom A.

Oncotarget. 2018 Nov 20;9(91):36273-36288. doi: 10.18632/oncotarget.26345. eCollection 2018 Nov 20.


Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.

Ibrahim A, Hugerth LW, Hases L, Saxena A, Seifert M, Thomas Q, Gustafsson JÅ, Engstrand L, Williams C.

Int J Cancer. 2019 Jun 15;144(12):3086-3098. doi: 10.1002/ijc.32037. Epub 2019 Jan 11.


Role of HSD17B13 in the liver physiology and pathophysiology.

Su W, Mao Z, Liu Y, Zhang X, Zhang W, Gustafsson JA, Guan Y.

Mol Cell Endocrinol. 2019 Jun 1;489:119-125. doi: 10.1016/j.mce.2018.10.014. Epub 2018 Oct 24. Review.


ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis.

González-Granillo M, Savva C, Li X, Fitch M, Pedrelli M, Hellerstein M, Parini P, Korach-André M, Gustafsson JÅ.

Mol Cell Endocrinol. 2019 Jan 5;479:147-158. doi: 10.1016/j.mce.2018.10.007. Epub 2018 Oct 17.


Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure.

Conde-Vancells J, Vazquez-Chantada M, McCollum CW, Bondesson M, Kalasekar SM, Wlodarczyk BJ, Gustafsson JÅ, Cabrera RM, Finnell RH.

Reprod Toxicol. 2018 Oct;81:220-228. doi: 10.1016/j.reprotox.2018.07.080. Epub 2018 Aug 10.


ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function.

Bado I, Pham E, Soibam B, Nikolos F, Gustafsson JÅ, Thomas C.

Oncotarget. 2018 Apr 27;9(32):22509-22522. doi: 10.18632/oncotarget.25147. eCollection 2018 Apr 27.


ERα expression in T lymphocytes is dispensable for estrogenic effects in bone.

Gustafsson KL, Nilsson KH, Farman HH, Andersson A, Lionikaite V, Henning P, Wu J, Windahl SH, Islander U, Movérare-Skrtic S, Sjögren K, Carlsten H, Gustafsson JÅ, Ohlsson C, Lagerquist MK.

J Endocrinol. 2018 Aug;238(2):129-136. doi: 10.1530/JOE-18-0183. Epub 2018 May 30.


Estrogen receptor β controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage.

D'Errico F, Goverse G, Dai Y, Wu W, Stakenborg M, Labeeuw E, De Simone V, Verstockt B, Gomez-Pinilla PJ, Warner M, Di Leo A, Matteoli G, Gustafsson JA.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):5798-5803. doi: 10.1073/pnas.1720267115. Epub 2018 May 14.


Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress.

Xu S, Huang S, Luan Z, Chen T, Wei Y, Xing M, Li Y, Du C, Wang B, Zheng F, Wang N, Guan Y, Gustafsson JÅ, Zhang X.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5600-5605. doi: 10.1073/pnas.1803945115. Epub 2018 May 8.


Human Proislet Peptide Promotes Pancreatic Progenitor Cells to Ameliorate Diabetes Through FOXO1/Menin-Mediated Epigenetic Regulation.

Jiang Z, Shi D, Tu Y, Tian J, Zhang W, Xing B, Wang J, Liu S, Lou J, Gustafsson JÅ, Hua X, Ma X.

Diabetes. 2018 Jul;67(7):1345-1355. doi: 10.2337/db17-0885. Epub 2018 May 1.


Estrogen receptor subtypes dictate the proliferative nature of the mammary gland.

Dall GV, Hawthorne S, Seyed-Razavi Y, Vieusseux J, Wu W, Gustafsson JA, Byrne D, Murphy L, Risbridger GP, Britt KL.

J Endocrinol. 2018 Jun;237(3):323-336. doi: 10.1530/JOE-17-0582. Epub 2018 Apr 10.


Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.

Zhao L, Huang S, Mei S, Yang Z, Xu L, Zhou N, Yang Q, Shen Q, Wang W, Le X, Lau WB, Lau B, Wang X, Yi T, Zhao X, Wei Y, Warner M, Gustafsson JÅ, Zhou S.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681. doi: 10.1073/pnas.1803291115. Epub 2018 Mar 28.


The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling.

Faria M, Karami S, Granados-Principal S, Dey P, Verma A, Choi DS, Elemento O, Bawa-Khalfe T, Chang JC, Strom AM, Gustafsson JÅ.

Oncotarget. 2018 Jan 10;9(15):12201-12211. doi: 10.18632/oncotarget.24134. eCollection 2018 Feb 23.


Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells.

Villar-Pazos S, Martinez-Pinna J, Castellano-Muñoz M, Alonso-Magdalena P, Marroqui L, Quesada I, Gustafsson JA, Nadal A.

Sci Rep. 2018 Mar 6;8(1):4262. doi: 10.1038/s41598-018-21309-w.


Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse.

Cai Y, Tang X, Chen X, Li X, Wang Y, Bao X, Wang L, Sun D, Zhao J, Xing Y, Warner M, Xu H, Gustafsson JÅ, Fan X.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2725-E2733. doi: 10.1073/pnas.1800184115. Epub 2018 Mar 5.


Body weight homeostat that regulates fat mass independently of leptin in rats and mice.

Jansson JO, Palsdottir V, Hägg DA, Schéle E, Dickson SL, Anesten F, Bake T, Montelius M, Bellman J, Johansson ME, Cone RD, Drucker DJ, Wu J, Aleksic B, Törnqvist AE, Sjögren K, Gustafsson JÅ, Windahl SH, Ohlsson C.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):427-432. doi: 10.1073/pnas.1715687114. Epub 2017 Dec 26.


Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells.

Varshney MK, Inzunza J, Lupu D, Ganapathy V, Antonson P, Rüegg J, Nalvarte I, Gustafsson JÅ.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10428-E10437. doi: 10.1073/pnas.1714094114. Epub 2017 Nov 13.


ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.

Nikolos F, Thomas C, Bado I, Gustafsson JÅ.

Mol Cancer Res. 2018 Feb;16(2):233-242. doi: 10.1158/1541-7786.MCR-17-0201. Epub 2017 Nov 8.


Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α.

Bialesova L, Xu L, Gustafsson JÅ, Haldosen LA, Zhao C, Dahlman-Wright K.

Oncotarget. 2017 Sep 4;8(44):76622-76633. doi: 10.18632/oncotarget.20635. eCollection 2017 Sep 29.


Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells.

Villar-Pazos S, Martinez-Pinna J, Castellano-Muñoz M, Alonso-Magdalena P, Marroqui L, Quesada I, Gustafsson JA, Nadal A.

Sci Rep. 2017 Sep 18;7(1):11770. doi: 10.1038/s41598-017-11995-3. Erratum in: Sci Rep. 2018 Mar 6;8(1):4262.


Intratumor heterogeneity predicts metastasis of triple-negative breast cancer.

Yang F, Wang Y, Li Q, Cao L, Sun Z, Jin J, Fang H, Zhu A, Li Y, Zhang W, Wang Y, Xie H, Gustafsson JÅ, Wang S, Guan X.

Carcinogenesis. 2017 Sep 1;38(9):900-909. doi: 10.1093/carcin/bgx071.


Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis.

Bado I, Nikolos F, Rajapaksa G, Wu W, Castaneda J, Krishnamurthy S, Webb P, Gustafsson JÅ, Thomas C.

Breast Cancer Res. 2017 Jul 3;19(1):79. doi: 10.1186/s13058-017-0872-z.


Genomics of sex hormone receptor signaling in hepatic sexual dimorphism.

Zheng D, Wang X, Antonson P, Gustafsson JÅ, Li Z.

Mol Cell Endocrinol. 2018 Aug 15;471:33-41. doi: 10.1016/j.mce.2017.05.025. Epub 2017 May 26.


Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate.

Wu WF, Maneix L, Insunza J, Nalvarte I, Antonson P, Kere J, Yu NY, Tohonen V, Katayama S, Einarsdottir E, Krjutskov K, Dai YB, Huang B, Su W, Warner M, Gustafsson JÅ.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3816-E3822. doi: 10.1073/pnas.1702211114. Epub 2017 Apr 24.


Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.

Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson JÅ, Guan Y.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3181-3185. doi: 10.1073/pnas.1700172114. Epub 2017 Mar 7.


Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c.

Su W, Peng J, Li S, Dai YB, Wang CJ, Xu H, Gao M, Ruan XZ, Gustafsson JÅ, Guan YF, Zhang XY.

Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E357-E367. doi: 10.1152/ajpendo.00310.2016. Epub 2017 Mar 7.


High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha.

Ban Z, Maurischat P, Benz V, Brix S, Sonnenburg A, Schuler G, Klopfleisch R, Rothe M, Gustafsson JÅ, Foryst-Ludwig A, Kintscher U.

Sci Rep. 2017 Feb 24;7:43269. doi: 10.1038/srep43269.


Sex differences and effects of oestrogen in rat gastric mucosal defence.

Shore R, Björne H, Omoto Y, Siemiatkowska A, Gustafsson JÅ, Lindblad M, Holm L.

World J Gastroenterol. 2017 Jan 21;23(3):426-436. doi: 10.3748/wjg.v23.i3.426.


Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts.

Su W, Huang SZ, Gao M, Kong XM, Gustafsson JÅ, Xu SJ, Wang B, Zheng F, Chen LH, Wang NP, Guan YF, Zhang XY.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F619-F628. doi: 10.1152/ajprenal.00564.2016. Epub 2017 Jan 4.


Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.

Tu Z, Bayazit MB, Liu H, Zhang J, Busayavalasa K, Risal S, Shao J, Satyanarayana A, Coppola V, Tessarollo L, Singh M, Zheng C, Han C, Chen Z, Kaldis P, Gustafsson JÅ, Liu K.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):592-597. doi: 10.1073/pnas.1618465114. Epub 2016 Dec 28.


Estrogen Receptor β as a Pharmaceutical Target.

Warner M, Huang B, Gustafsson JA.

Trends Pharmacol Sci. 2017 Jan;38(1):92-99. doi: 10.1016/ Epub 2016 Dec 13. Review.


An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice.

Miao YF, Su W, Dai YB, Wu WF, Huang B, Barros RP, Nguyen H, Maneix L, Guan YF, Warner M, Gustafsson JÅ.

Sci Rep. 2016 Dec 6;6:38579. doi: 10.1038/srep38579.

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