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Elucidation of Spirodactylone, a Polycyclic Alkaloid from the Sponge Dactylia sp., and Nonenzymatic Generation from the Co-metabolite Denigrin B.

Kang U, Caldwell DR, Cartner LK, Wang D, Kim CK, Tian X, Bokesch HR, Henrich CJ, Woldemichael GM, Schnermann MJ, Gustafson KR.

Org Lett. 2019 May 31. doi: 10.1021/acs.orglett.9b01636. [Epub ahead of print]


Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol.

Kim HJ, Yim SH, Han F, Kang BY, Choi HJ, Jung DW, Williams DR, Gustafson KR, Kennelly EJ, Lee IS.

Molecules. 2019 Jan 22;24(3). pii: E394. doi: 10.3390/molecules24030394.


Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR.

J Nat Prod. 2019 Jan 25;82(1):154-162. doi: 10.1021/acs.jnatprod.8b00871. Epub 2019 Jan 2.


Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta.

Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR.

J Nat Prod. 2018 Dec 28;81(12):2750-2755. doi: 10.1021/acs.jnatprod.8b00761. Epub 2018 Nov 29.


Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling.

Valdeira ASC, Ritt DA, Morrison DK, McMahon JB, Gustafson KR, Salvador JAR.

Front Chem. 2018 Sep 28;6:434. doi: 10.3389/fchem.2018.00434. eCollection 2018.


Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

Mar Drugs. 2018 Jul 19;16(7). pii: E241. doi: 10.3390/md16070241.


Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling.

Yan P, Ritt DA, Zlotkowski K, Bokesch HR, Reinhold WC, Schneekloth JS Jr, Morrison DK, Gustafson KR.

J Nat Prod. 2018 Jul 27;81(7):1666-1672. doi: 10.1021/acs.jnatprod.8b00343. Epub 2018 Jul 6.


Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species.

Espindola LS, Dusi RG, Demarque DP, Braz-Filho R, Yan P, Bokesch HR, Gustafson KR, Beutler JA.

Molecules. 2018 Jun 20;23(6). pii: E1494. doi: 10.3390/molecules23061494.


Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery.

Tian XR, Tang HF, Tian XL, Hu JJ, Huang LL, Gustafson KR.

Future Med Chem. 2018 Jun 1;10(12):1497-1514. doi: 10.4155/fmc-2018-0012. Epub 2018 May 23. Review.


Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.

Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Saurí J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR.

Chem Sci. 2017 Nov 6;9(2):307-314. doi: 10.1039/c7sc01996c. eCollection 2018 Jan 14.


Enhanced measurement of residual chemical shift anisotropy for small molecule structure elucidation.

Liu Y, Cohen RD, Gustafson KR, Martin GE, Williamson RT.

Chem Commun (Camb). 2018 Apr 24;54(34):4254-4257. doi: 10.1039/c8cc00552d.


Structure Revision of Poecillastrin C and the Absolute Configuration of the β-Hydroxyaspartic Acid Residue.

Irie R, Takada K, Ise Y, Ohtsuka S, Okada S, Gustafson KR, Matsunaga S.

Org Lett. 2017 Oct 6;19(19):5395-5397. doi: 10.1021/acs.orglett.7b02835. Epub 2017 Sep 28.


Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.

Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS Jr.

Org Lett. 2017 Apr 7;19(7):1726-1729. doi: 10.1021/acs.orglett.7b00496. Epub 2017 Mar 27.


Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold.

Chan ST, Nani RR, Schauer EA, Martin GE, Williamson RT, Saurí J, Buevich AV, Schafer WA, Joyce LA, Goey AK, Figg WD, Ransom TT, Henrich CJ, McKee TC, Moser A, MacDonald SA, Khan S, McMahon JB, Schnermann MJ, Gustafson KR.

J Org Chem. 2016 Nov 18;81(22):10631-10640. Epub 2016 Nov 10.


Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.

Zhao M, Cheng S, Yuan W, Xi Y, Li X, Dong J, Huang K, Gustafson KR, Yan P.

Mar Drugs. 2016 Jun 3;14(6). pii: E111. doi: 10.3390/md14060111.


Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.

Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom TR, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

J Nat Prod. 2016 May 27;79(5):1267-75. doi: 10.1021/acs.jnatprod.5b00846. Epub 2016 May 3.


Structurally Diverse Metabolites from the Soft Coral Sinularia verruca Collected in the South China Sea.

Yuan W, Cheng S, Fu W, Zhao M, Li X, Cai Y, Dong J, Huang K, Gustafson KR, Yan P.

J Nat Prod. 2016 Apr 22;79(4):1124-31. doi: 10.1021/acs.jnatprod.6b00031. Epub 2016 Mar 24.


Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E.

Patridge EV, Darnell A, Kucera K, Phillips GM, Bokesch HR, Gustafson KR, Spakowicz DJ, Zhou L, Hungerford WM, Plummer M, Hoyer D, Narváez-Trujillo A, Phillips AJ, Strobel SA.

Nat Prod Commun. 2015 Oct;10(10):1649-54.


Stelliosphaerols A and B, Sesquiterpene-Polyol Conjugates from an Ecuadorian Fungal Endophyte.

Forcina GC, Castro A, Bokesch HR, Spakowicz DJ, Legaspi ME, Kucera K, Villota S, Narváez-Trujillo A, McMahon JB, Gustafson KR, Strobel SA.

J Nat Prod. 2015 Dec 24;78(12):3005-10. doi: 10.1021/acs.jnatprod.5b00749. Epub 2015 Dec 14.


Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.

Henrich CJ, Cartner LK, Wilson JA, Fuller RW, Rizzo AE, Reilly KM, McMahon JB, Gustafson KR.

J Nat Prod. 2015 Nov 25;78(11):2776-81. doi: 10.1021/acs.jnatprod.5b00753. Epub 2015 Oct 15.


Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.

Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, Gustafson KR.

Tetrahedron Lett. 2015 Jul 8;56(28):4215-4219.


Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.


Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

Henrich CJ, Brooks AD, Erickson KL, Thomas CL, Bokesch HR, Tewary P, Thompson CR, Pompei RJ, Gustafson KR, McMahon JB, Sayers TJ.

Cell Death Dis. 2015 Feb 26;6:e1666. doi: 10.1038/cddis.2015.38.


Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.

Sunassee SN, Ransom T, Henrich CJ, Beutler JA, Covell DG, McMahon JB, Gustafson KR.

J Nat Prod. 2014 Nov 26;77(11):2475-80. doi: 10.1021/np500556t. Epub 2014 Oct 22.


Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.

Grkovic T, Blees JS, Bayer MM, Colburn NH, Thomas CL, Henrich CJ, Peach ML, McMahon JB, Schmid T, Gustafson KR.

Mar Drugs. 2014 Aug 21;12(8):4593-601. doi: 10.3390/md12084593.


Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.

Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

Biochem Pharmacol. 2014 Apr 1;88(3):313-21. doi: 10.1016/j.bcp.2014.01.034. Epub 2014 Feb 7.


Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.

Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.

PLoS One. 2012;7(10):e46567. doi: 10.1371/journal.pone.0046567. Epub 2012 Oct 2.


Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.

McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, Van Wyk AW, Marcum SR, Gardella RS, Gustafson KR, Linehan WM, McMahon JB, Bottaro DP.

J Nat Prod. 2012 Sep 28;75(9):1632-6. Epub 2012 Aug 28.


Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.

Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR.

J Nat Prod. 2012 Aug 24;75(8):1490-4. doi: 10.1021/np3003518. Epub 2012 Jul 26.


A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor.

Sando L, Henriques ST, Foley F, Simonsen SM, Daly NL, Hall KN, Gustafson KR, Aguilar MI, Craik DJ.

Chembiochem. 2011 Nov 4;12(16):2456-62. doi: 10.1002/cbic.201100450. Epub 2011 Sep 16.


Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.

Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4397-9. doi: 10.1016/j.bmcl.2011.06.044. Epub 2011 Jun 17.


Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.

Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.

J Nat Prod. 2011 May 27;74(5):1015-20. doi: 10.1021/np100918z. Epub 2011 May 3.


Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.

Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2113-5. doi: 10.1016/j.bmcl.2011.01.127. Epub 2011 Feb 23.


Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.

Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR.

J Nat Prod. 2011 Feb 25;74(2):262-6. doi: 10.1021/np100797y. Epub 2011 Jan 28.


Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.

Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3848-50. doi: 10.1016/j.bmcl.2010.05.057. Epub 2010 May 21.


Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.

Oku N, Takada K, Fuller RW, Wilson JA, Peach ML, Pannell LK, McMahon JB, Gustafson KR.

J Am Chem Soc. 2010 Aug 4;132(30):10278-85. doi: 10.1021/ja1016766.


Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter.

Takada K, Imamura N, Gustafson KR, Henrich CJ.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1330-3. doi: 10.1016/j.bmcl.2010.01.016. Epub 2010 Jan 11.


Botryllamides: natural product inhibitors of ABCG2.

Henrich CJ, Robey RW, Takada K, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, McMahon JB, Gustafson KR.

ACS Chem Biol. 2009 Aug 21;4(8):637-47. doi: 10.1021/cb900134c.


A selective small-molecule nuclear factor-kappaB inhibitor from a high-throughput cell-based assay for "activator protein-1 hits".

Kang MI, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, Colburn NH.

Mol Cancer Ther. 2009 Mar;8(3):571-81. doi: 10.1158/1535-7163.MCT-08-0811. Epub 2009 Mar 3.


Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.

Org Lett. 2009 Jan 1;11(1):57-60. doi: 10.1021/ol802339w.


Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds.

Mayer AM, Gustafson KR.

Eur J Cancer. 2008 Nov;44(16):2357-87. doi: 10.1016/j.ejca.2008.07.001. Epub 2008 Aug 11. Review.


Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

Smee DF, Bailey KW, Wong MH, O'Keefe BR, Gustafson KR, Mishin VP, Gubareva LV.

Antiviral Res. 2008 Dec;80(3):266-71. doi: 10.1016/j.antiviral.2008.06.003. Epub 2008 Jul 2.


Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.

J Nat Prod. 2008 Jan;71(1):47-52. Epub 2007 Dec 15.


Cyclotides as natural anti-HIV agents.

Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ.

Biopolymers. 2008;90(1):51-60.


An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB.

J Nat Prod. 2007 Oct;70(10):1647-9. Epub 2007 Oct 13.


Natural products active in aberrant c-Kit signaling.

Henrich CJ, Goncharova EI, Wilson JA, Gardella RS, Johnson TR, McMahon JB, Takada K, Bokesch HR, Gustafson KR.

Chem Biol Drug Des. 2007 May;69(5):321-30.


Structural assignment of poecillastrins B and C, macrolide lactams from the deep-water Caribbean sponge Poecillastra species.

Takada K, Choi BW, Rashid MA, Gamble WR, Cardellina JH 2nd, Van QN, Lloyd JR, McMahon JB, Gustafson KR.

J Nat Prod. 2007 Mar;70(3):428-31.


Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds.

Mayer AM, Gustafson KR.

Eur J Cancer. 2006 Sep;42(14):2241-70. Epub 2006 Aug 9. Review.


Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans.

Helle F, Wychowski C, Vu-Dac N, Gustafson KR, Voisset C, Dubuisson J.

J Biol Chem. 2006 Sep 1;281(35):25177-83. Epub 2006 Jun 29.


Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.

Oku N, Krishnamoorthy R, Benson AG, Ferguson RL, Lipton MA, Phillips LR, Gustafson KR, McMahon JB.

J Org Chem. 2005 Aug 19;70(17):6842-7.

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