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Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL, Thorburn A.

Dev Cell. 2019 Jul 30. pii: S1534-5807(19)30582-9. doi: 10.1016/j.devcel.2019.07.010. [Epub ahead of print]


A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies.

Mannheimer JD, Duval DL, Prasad A, Gustafson DL.

BMC Med Genomics. 2019 Jun 17;12(1):87. doi: 10.1186/s12920-019-0519-2.


Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing.

Das S, Idate R, Cronise KE, Gustafson DL, Duval DL.

Mol Cancer Ther. 2019 Aug;18(8):1460-1471. doi: 10.1158/1535-7163.MCT-18-1346. Epub 2019 Jun 7.


Assessment of compounded transdermal mirtazapine as an appetite stimulant in cats with chronic kidney disease.

Quimby JM, Benson KK, Summers SC, Saffire A, Herndon AK, Bai S, Gustafson DL.

J Feline Med Surg. 2019 Jun 4:1098612X19851303. doi: 10.1177/1098612X19851303. [Epub ahead of print]


Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer.

Cronise KE, Hernandez BG, Gustafson DL, Duval DL.

Mol Pharmacol. 2019 Jul;96(1):36-46. doi: 10.1124/mol.119.115808. Epub 2019 May 2.


Adoption and Use of Mobile Learning in Continuing Professional Development by Health and Human Services Professionals.

Curran V, Fleet L, Simmons K, Lannon H, Gustafson DL, Wang C, Garmsiri M, Wetsch L.

J Contin Educ Health Prof. 2019 Spring;39(2):76-85. doi: 10.1097/CEH.0000000000000243.


Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers.

Wittenburg LA, Weishaar K, Ramirez D, Gustafson DL.

Vet Comp Oncol. 2019 Jun;17(2):147-154. doi: 10.1111/vco.12455. Epub 2019 Feb 4.


Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics.

Ramirez DA, Collins KP, Aradi AE, Conger KA, Gustafson DL.

Drug Metab Dispos. 2019 Mar;47(3):257-268. doi: 10.1124/dmd.118.083766. Epub 2018 Dec 19.


The fecal microbiome and serum concentrations of indoxyl sulfate and p-cresol sulfate in cats with chronic kidney disease.

Summers SC, Quimby JM, Isaiah A, Suchodolski JS, Lunghofer PJ, Gustafson DL.

J Vet Intern Med. 2019 Mar;33(2):662-669. doi: 10.1111/jvim.15389. Epub 2018 Dec 18.


Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method.

Wittenburg LA, Ramirez D, Conger H, Gustafson DL.

Res Vet Sci. 2019 Feb;122:93-101. doi: 10.1016/j.rvsc.2018.11.009. Epub 2018 Nov 12.


In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease.

Fitzpatrick RL, Quimby JM, Benson KK, Ramirez D, Sieberg LG, Wittenburg LA, Gustafson DL.

J Vet Intern Med. 2018 Nov;32(6):1951-1957. doi: 10.1111/jvim.15237. Epub 2018 Oct 11.


A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer.

Diamond JR, Eckhardt SG, Pitts TM, van Bokhoven A, Aisner D, Gustafson DL, Capasso A, Sams S, Kabos P, Zolman K, Colvin T, Elias AD, Storniolo AM, Schneider BP, Gao D, Tentler JJ, Borges VF, Miller KD.

Breast Cancer Res. 2018 Aug 2;20(1):82. doi: 10.1186/s13058-018-1014-y.


Phase Ib Results of the Rational Combination of Selumetinib and Cyclosporin A in Advanced Solid Tumors with an Expansion Cohort in Metastatic Colorectal Cancer.

Krishnamurthy A, Dasari A, Noonan AM, Mehnert JM, Lockhart AC, Leong S, Capasso A, Stein MN, Sanoff HK, Lee JJ, Hansen A, Malhotra U, Rippke S, Gustafson DL, Pitts TM, Ellison K, Davis SL, Messersmith WA, Eckhardt SG, Lieu CH.

Cancer Res. 2018 Sep 15;78(18):5398-5407. doi: 10.1158/0008-5472.CAN-18-0316. Epub 2018 Jul 24.


Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation.

Collins KP, Jackson KM, Gustafson DL.

J Pharmacol Exp Ther. 2018 Jun;365(3):447-459. doi: 10.1124/jpet.117.245639. Epub 2018 Feb 8.


Canine sarcomas as a surrogate for the human disease.

Gustafson DL, Duval DL, Regan DP, Thamm DH.

Pharmacol Ther. 2018 Aug;188:80-96. doi: 10.1016/j.pharmthera.2018.01.012. Epub 2018 Mar 9. Review.


Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.

Briggs JW, Ren L, Chakrabarti KR, Tsai YC, Weissman AM, Hansen RJ, Gustafson DL, Khan YA, Dinman JD, Khanna C.

PLoS One. 2017 Sep 19;12(9):e0185089. doi: 10.1371/journal.pone.0185089. eCollection 2017.


Preliminary pharmacokinetics of intravenous and subcutaneous dolasetron and pharmacodynamics of subcutaneous dolasetron in healthy cats.

Herndon AK, Quimby JM, Sieberg LG, Davis L, Caress AL, Ligas S, Hansen RJ, Wittenburg LA, Gustafson DL.

J Feline Med Surg. 2018 Aug;20(8):721-727. doi: 10.1177/1098612X17729310. Epub 2017 Sep 14.


A Review of Digital, Social, and Mobile Technologies in Health Professional Education.

Curran V, Matthews L, Fleet L, Simmons K, Gustafson DL, Wetsch L.

J Contin Educ Health Prof. 2017 Summer;37(3):195-206. doi: 10.1097/CEH.0000000000000168. Review.


Pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cats after oral, intravenous, and intraperitoneal administration of cyclophosphamide.

Stroda KA, Murphy JD, Hansen RJ, Brownlee L, Atencio EA, Gustafson DL, Lana SE.

Am J Vet Res. 2017 Jul;78(7):862-866. doi: 10.2460/ajvr.78.7.862.


Expression of Phosphorylated KIT in Canine Mast Cell Tumor.

Halsey CHC, Thamm DH, Weishaar KM, Burton JH, Charles JB, Gustafson DL, Avery AC, Ehrhart EJ.

Vet Pathol. 2017 May;54(3):387-394. doi: 10.1177/0300985816688943. Epub 2017 Jan 27.


Assessment of absorption of transdermal ondansetron in normal research cats.

Zajic LB, Herndon AK, Sieberg LG, Caress AL, Morgan PK, Hansen RJ, Wittenburg LA, Gustafson DL, Quimby JM.

J Feline Med Surg. 2017 Dec;19(12):1245-1248. doi: 10.1177/1098612X16688807. Epub 2017 Jan 23.


Docetaxel Accumulates in Lymphatic Circulation Following Subcutaneous Delivery Compared to Intravenous Delivery in Rats.

Worley DR, Hansen RJ, Wittenburg LA, Chubb LS, Gustafson DL.

Anticancer Res. 2016 Oct;36(10):5071-5078.


Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study.

Benson KK, Zajic LB, Morgan PK, Brown SR, Hansen RJ, Lunghofer PJ, Wittenburg LA, Gustafson DL, Quimby JM.

J Feline Med Surg. 2017 Oct;19(10):998-1006. doi: 10.1177/1098612X16667168. Epub 2016 Sep 1.


mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo.

Morrow JJ, Mendoza A, Koyen A, Lizardo MM, Ren L, Waybright TJ, Hansen RJ, Gustafson DL, Zhou M, Fan TM, Scacheri PC, Khanna C.

Clin Cancer Res. 2016 Dec 15;22(24):6129-6141. Epub 2016 Jun 24.


Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.

Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL.

J Pharmacol Exp Ther. 2016 Aug;358(2):282-93. doi: 10.1124/jpet.116.233908. Epub 2016 May 26.


Challenging 'girls only' publicly funded human papillomavirus vaccination programmes.

Law VG, Gustafson DL.

Nurs Inq. 2017 Jan;24(1). doi: 10.1111/nin.12140. Epub 2016 May 20.


The Flint Animal Cancer Center (FACC) Canine Tumour Cell Line Panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.

Fowles JS, Dailey DD, Gustafson DL, Thamm DH, Duval DL.

Vet Comp Oncol. 2017 Jun;15(2):481-492. doi: 10.1111/vco.12192. Epub 2016 May 19.


A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.

Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL.

Eur J Pharmacol. 2016 Aug 5;784:1-14. doi: 10.1016/j.ejphar.2016.05.006. Epub 2016 May 5.


Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer.

Zhou Q, Abraham AD, Li L, Babalmorad A, Bagby S, Arcaroli JJ, Hansen RJ, Valeriote FA, Gustafson DL, Schaack J, Messersmith WA, LaBarbera DV.

Oncogene. 2016 Sep 22;35(38):4990-9. doi: 10.1038/onc.2016.29. Epub 2016 Mar 7.


Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma.

Fowles JS, Brown KC, Hess AM, Duval DL, Gustafson DL.

BMC Bioinformatics. 2016 Feb 19;17:93. doi: 10.1186/s12859-016-0942-8.


Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

LeBlanc AK, Breen M, Choyke P, Dewhirst M, Fan TM, Gustafson DL, Helman LJ, Kastan MB, Knapp DW, Levin WJ, London C, Mason N, Mazcko C, Olson PN, Page R, Teicher BA, Thamm DH, Trent JM, Vail DM, Khanna C.

Sci Transl Med. 2016 Feb 3;8(324):324ps5. doi: 10.1126/scitranslmed.aaf0746. Review. No abstract available.


Does the public receive and adhere to boil water advisory recommendations? A cross-sectional study in Newfoundland and Labrador, Canada.

Jones-Bitton A, Gustafson DL, Butt K, Majowicz SE.

BMC Public Health. 2016 Jan 5;16:14. doi: 10.1186/s12889-015-2688-z.


Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs.

Larson JC, Allstadt SD, Fan TM, Khanna C, Lunghofer PJ, Hansen RJ, Gustafson DL, Legendre AM, Galyon GD, LeBlanc AK, Martin-Jimenez T.

Am J Vet Res. 2016 Jan;77(1):65-71. doi: 10.2460/ajvr.77.1.65.


Drug Selection in the Genomic Age: Application of the Coexpression Extrapolation Principle for Drug Repositioning in Cancer Therapy.

Gustafson DL, Fowles JS, Brown KC, Theodorescu D.

Assay Drug Dev Technol. 2015 Dec;13(10):623-7. doi: 10.1089/adt.2015.29012.dlgdrrr.


Limited sampling pharmacokinetics of subcutaneous ondansetron in healthy geriatric cats, cats with chronic kidney disease, and cats with liver disease.

Fitzpatrick RL, Wittenburg LA, Hansen RJ, Gustafson DL, Quimby JM.

J Vet Pharmacol Ther. 2016 Aug;39(4):350-5. doi: 10.1111/jvp.12286. Epub 2015 Dec 14.


Pharmacokinetics and bioavailability of orbifloxacin oral suspension in New Zealand White rabbits (Oryctolagus cuniculus).

Watson MK, Wittenburg LA, Bui CT, Jarosz KA, Gustafson DL, Johnston MS.

Am J Vet Res. 2015 Nov;76(11):946-51. doi: 10.2460/ajvr.76.11.946.


Comparison of the stability and pharmacokinetics in dogs of modified ciclosporin capsules stored at -20°C and room temperature.

Bachtel JC, Pendergraft JS, Rosychuk RA, Gustafson DL, Hansen RJ, Lunghofer PJ.

Vet Dermatol. 2015 Aug;26(4):228-e50. doi: 10.1111/vde.12222.


Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere.

Pilon JL, Clausen DJ, Hansen RJ, Lunghofer PJ, Charles B, Rose BJ, Thamm DH, Gustafson DL, Bradner JE, Williams RM.

Cancer Chemother Pharmacol. 2015 Apr;75(4):671-82. doi: 10.1007/s00280-015-2675-1. Epub 2015 Jan 24.


Methodological and ethical issues in research using social media: a metamethod of Human Papillomavirus vaccine studies.

Gustafson DL, Woodworth CF.

BMC Med Res Methodol. 2014 Dec 2;14:127. doi: 10.1186/1471-2288-14-127.


Single- and multiple dose pharmacokinetics and multiple dose pharmacodynamics of oral ABT-116 (a TRPV1 antagonist) in dogs.

Niyom S, Mama KR, Gustafson DL, Rezende ML.

J Vet Pharmacol Ther. 2015 Aug;38(4):336-43. doi: 10.1111/jvp.12180. Epub 2014 Nov 5.


Pharmacokinetics and pharmacodynamics of propofol with or without 2% benzyl alcohol following a single induction dose administered intravenously in cats.

Griffenhagen GM, Rezende ML, Gustafson DL, Hansen RJ, Lunghofer PJ, Mama KR.

Vet Anaesth Analg. 2015 Sep;42(5):472-83. doi: 10.1111/vaa.12233. Epub 2014 Oct 20.


Pharmacokinetics of sustained-release analgesics in mice.

Kendall LV, Hansen RJ, Dorsey K, Kang S, Lunghofer PJ, Gustafson DL.

J Am Assoc Lab Anim Sci. 2014 Sep;53(5):478-84.


Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma.

Barnard RA, Wittenburg LA, Amaravadi RK, Gustafson DL, Thorburn A, Thamm DH.

Autophagy. 2014 Aug;10(8):1415-25. doi: 10.4161/auto.29165. Epub 2014 May 20.


Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia®) in canine mast cell tumor.

Halsey CH, Gustafson DL, Rose BJ, Wolf-Ringwall A, Burnett RC, Duval DL, Avery AC, Thamm DH.

BMC Vet Res. 2014 May 6;10:105. doi: 10.1186/1746-6148-10-105.


Ethics, "Vulnerability," and Feminist Participatory Action Research With a Disability Community.

Gustafson DL, Brunger F.

Qual Health Res. 2014 Jul;24(7):997-1005. Epub 2014 May 28.


Anonymous HIV testing: what does it mean in policy and practice? A case study in Newfoundland and Labrador, Canada.

Hancock A, Gustafson DL.

J Assoc Nurses AIDS Care. 2014 Sep-Oct;25(5):436-49. doi: 10.1016/j.jana.2014.01.007. Epub 2014 Apr 20.


STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.

Maycotte P, Gearheart CM, Barnard R, Aryal S, Mulcahy Levy JM, Fosmire SP, Hansen RJ, Morgan MJ, Porter CC, Gustafson DL, Thorburn A.

Cancer Res. 2014 May 1;74(9):2579-90. doi: 10.1158/0008-5472.CAN-13-3470. Epub 2014 Mar 3.


Autophagy and cancer therapy.

Thorburn A, Thamm DH, Gustafson DL.

Mol Pharmacol. 2014 Jun;85(6):830-8. doi: 10.1124/mol.114.091850. Epub 2014 Feb 26. Review.


Oral, subcutaneous, and intravenous pharmacokinetics of ondansetron in healthy cats.

Quimby JM, Lake RC, Hansen RJ, Lunghofer PJ, Gustafson DL.

J Vet Pharmacol Ther. 2014 Aug;37(4):348-53. doi: 10.1111/jvp.12094. Epub 2013 Dec 16.

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