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Items: 1 to 50 of 83

1.

Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease.

Jones K, Versteeg L, Damania A, Keegan B, Kendricks A, Pollet J, Cruz-Chan JV, Gusovsky F, Hotez PJ, Bottazzi ME.

Infect Immun. 2018 Mar 22;86(4). pii: e00876-17. doi: 10.1128/IAI.00876-17. Print 2018 Apr.

2.

The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge.

Younan P, Ramanathan P, Graber J, Gusovsky F, Bukreyev A.

MBio. 2017 Apr 25;8(2). pii: e00226-17. doi: 10.1128/mBio.00226-17.

3.

Lee Rubin: Our mentor and role model.

Bazenet C, Desmond H, Frank E, Doherty P, Eilers A, Gatchalian C, Glicksman M, Graczyk P, Gusovsky F, Ham J, Kaplan D, Klymkoswsky M, Kotkow K, Krolewski R, Lang P, O'Neil AL, McCarthy MJ, Meiri K, Miller F, Neumage MM, Ozek C, Philpott K, Piccinotti S, Price F, Raff M, Ratcliffe M, Relton J, Rhodes K, Schwob J, Smales C, Smith T, Spadoni C, Taylor J, Vekrellis K, Whitfield J.

Science. 2017 Feb 24;355(6327):806. doi: 10.1126/science.aam8703. No abstract available.

PMID:
28232547
4.

A simple fluorescence-based assay for quantification of the Toll-Like Receptor agonist E6020 in vaccine formulations.

Pollet J, Versteeg L, Rezende W, Strych U, Gusovsky F, Hotez PJ, Bottazzi ME.

Vaccine. 2017 Mar 7;35(10):1410-1416. doi: 10.1016/j.vaccine.2017.01.077. Epub 2017 Feb 9.

PMID:
28190745
5.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL.

Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7.

6.

Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.

7.

Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example.

Maru Y, Tomita T, Deguchi A, Ieguchi K, Takita M, Tsukahara F, Takemura K, Kitao A, Gusovsky F.

Endocr Metab Immune Disord Drug Targets. 2015;15(2):83-7. Review.

PMID:
26004773
8.

Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.

Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST.

Mol Pharmacol. 2014 Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16.

9.

The TLR4 antagonist Eritoran protects mice from lethal influenza infection.

Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN.

Nature. 2013 May 23;497(7450):498-502. doi: 10.1038/nature12118. Epub 2013 May 1.

10.

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.

Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W, AtaĆ­de MA, de Oliveira RB, Golenbock DT, Gazzinelli RT.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi: 10.1073/pnas.1015406108. Epub 2011 Feb 8.

11.
12.

Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II.

Shen Y, Du H, Kotake M, Matsushima T, Goto M, Shirota H, Gusovsky F, Li X, Jiang Y, Schiller S, Spyvee M, Davis H, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Wang Y.

Bioorg Med Chem Lett. 2010 May 15;20(10):3047-9. doi: 10.1016/j.bmcl.2010.03.119. Epub 2010 Apr 9.

PMID:
20427182
13.

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, Li W, Inoue Y, Ackermann K, Shirota H, Matsumoto I, Spyvee M, Schiller S, Sumida T, Gusovsky F, Lamphier M.

Br J Pharmacol. 2010 May;160(2):292-310. doi: 10.1111/j.1476-5381.2010.00647.x.

14.

Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.

Shen Y, Boivin R, Yoneda N, Du H, Schiller S, Matsushima T, Goto M, Shirota H, Gusovsky F, Lemelin C, Jiang Y, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Schnaderbeck M, Wang Y.

Bioorg Med Chem Lett. 2010 May 15;20(10):3155-7. doi: 10.1016/j.bmcl.2010.03.087. Epub 2010 Mar 30.

PMID:
20399648
15.

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead.

Du H, Matsushima T, Spyvee M, Goto M, Shirota H, Gusovsky F, Chiba K, Kotake M, Yoneda N, Eguchi Y, DiPietro L, Harmange JC, Gilbert S, Li XY, Davis H, Jiang Y, Zhang Z, Pelletier R, Wong N, Sakurai H, Yang H, Ito-Igarashi H, Kimura A, Kuboi Y, Mizui Y, Tanaka I, Ikemori-Kawada M, Kawakami Y, Inoue A, Kawai T, Kishi Y, Wang Y.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6196-9. doi: 10.1016/j.bmcl.2009.08.096. Epub 2009 Sep 3.

PMID:
19783437
16.
17.

Measurement of second messengers in signal transduction: cAMP and inositol phosphates.

Gusovsky F.

Curr Protoc Neurosci. 2001 May;Chapter 7:Unit7.12. doi: 10.1002/0471142301.ns0712s05.

PMID:
18428523
18.

Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist.

Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S, Przetak M, Chow J, Gusovsky F, Christ WJ, Rossignol DP.

J Pharmacol Exp Ther. 2003 Mar;304(3):1093-102.

19.

A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.

Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F.

J Pharmacol Exp Ther. 2002 Feb;300(2):655-61.

20.

Examination of chlorpromazine and other amphipathic drugs on the activity of lipopolysaccharide antagonists, E5564 and E5531.

Yang H, Daun JM, Rose JR, Christ WJ, Gusovsky F, Chow JC.

J Endotoxin Res. 2000;6(6):447-52.

PMID:
11521069
21.

A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.

Lien E, Chow JC, Hawkins LD, McGuinness PD, Miyake K, Espevik T, Gusovsky F, Golenbock DT.

J Biol Chem. 2001 Jan 19;276(3):1873-80. Epub 2000 Oct 13.

23.

Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.

Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F.

J Biol Chem. 1999 Apr 16;274(16):10689-92.

24.

Enhancement of TNF-alpha synthesis by overexpression of G alpha z in a mast cell line.

Baumgartner RA, Hirasawa N, Ozawa K, Gusovsky F, Beaven MA.

J Immunol. 1996 Aug 15;157(4):1625-9.

PMID:
8759748
25.

Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers.

Daly JW, Lueders J, Padgett WL, Shin Y, Gusovsky F.

Biochem Pharmacol. 1995 Oct 12;50(8):1187-97.

PMID:
7488233
26.

Distinct mechanisms for Ca2+ entry induced by OKT3 and Ca2+ depletion in Jurkat T cells.

Sei Y, Takemura M, Gusovsky F, Skolnick P, Basile A.

Exp Cell Res. 1995 Jan;216(1):222-31.

PMID:
7813624
27.

Down-regulation of PKC alpha by lithium in vitro.

Bitran JA, Manji HK, Potter WZ, Gusovsky F.

Psychopharmacol Bull. 1995;31(2):449-52.

PMID:
7491404
28.

Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA.

Vanek M, Hawkins LD, Gusovsky F.

Mol Pharmacol. 1994 Nov;46(5):832-9.

PMID:
7969069
29.

Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C gamma.

Baumgartner RA, Ozawa K, Cunha-Melo JR, Yamada K, Gusovsky F, Beaven MA.

Mol Biol Cell. 1994 Apr;5(4):475-84.

30.

First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus.

Daly JW, Gusovsky F, Myers CW, Yotsu-Yamashita M, Yasumoto T.

Toxicon. 1994 Mar;32(3):279-85.

PMID:
8016850
31.

Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.

Chen GT, King M, Gusovsky F, Creveling CR, Daly JW, Chen BH, Nie JY, Kirk KL.

J Med Chem. 1993 Nov 26;36(24):3947-55.

PMID:
8254623
33.

Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.

Felder CC, MacArthur L, Ma AL, Gusovsky F, Kohn EC.

Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1706-10.

34.

Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel.

Gusovsky F, Padgett WL, Creveling CR, Daly JW.

Mol Pharmacol. 1992 Dec;42(6):1104-8.

PMID:
1336116
35.

Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor.

Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW.

Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-3.

36.

Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro.

Manji HK, Chen G, Bitran JA, Gusovsky F, Potter WZ.

Eur J Pharmacol. 1992 Nov 2;227(3):275-82.

PMID:
1361912
37.

Selective stimulation of Ca2+ flux in cells by maitotoxin.

Murata M, Gusovsky F, Yasumoto T, Daly JW.

Eur J Pharmacol. 1992 Sep 1;227(1):43-9.

PMID:
1330638
38.

Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor zeta chain.

Cenciarelli C, Hohman RJ, Atkinson TP, Gusovsky F, Weissman AM.

J Biol Chem. 1992 Jul 25;267(21):14527-30.

39.
40.

Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.

Soergel DG, Yasumoto T, Daly JW, Gusovsky F.

Mol Pharmacol. 1992 Mar;41(3):487-93.

PMID:
1312215
41.

Partial structures and binding studies of maitotoxin, the most potent marine toxin.

Murata M, Sasaki M, Yokoyama A, Iwashita T, Gusovsky F, Daly JW, Yasumoto T.

Bull Soc Pathol Exot. 1992;85(5 Pt 2):470-3.

PMID:
1340347
43.

Effects of mastoparan and related peptides on phosphoinositide breakdown in HL-60 cells and cell-free preparations.

Gusovsky F, Soergel DG, Daly JW.

Eur J Pharmacol. 1991 Apr 25;206(4):309-14.

PMID:
1655489
44.

Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.

Adejare A, Nie JY, Hebel D, Brackett LE, Choi O, Gusovsky F, Padgett WL, Daly JW, Creveling CR, Kirk KL.

J Med Chem. 1991 Mar;34(3):1063-8.

PMID:
1672155
45.

Chronic exposure of C6 glioma cells to desipramine desensitizes beta-adrenoceptors, but increases KL/KH ratio.

Manji HK, Chen GA, Bitran JA, Gusovsky F, Potter WZ.

Eur J Pharmacol. 1991 Feb 25;206(2):159-62.

PMID:
1648502
46.

Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation.

Gusovsky F, Gutkind JS.

Mol Pharmacol. 1991 Feb;39(2):124-9.

PMID:
1847491
47.

Effect of maitotoxin analogues on calcium influx and phosphoinositide breakdown in cultured cells.

Murata M, Gusovsky F, Sasaki M, Yokoyama A, Yasumoto T, Daly JW.

Toxicon. 1991;29(9):1085-96.

PMID:
1665603
48.

Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells: role of calcium uptake and phosphoinositide breakdown.

Soergel DG, Gusovsky F, Yasumoto T, Daly JW.

J Pharmacol Exp Ther. 1990 Dec;255(3):1360-5.

PMID:
2175805
49.
50.

Pumiliotoxin alkaloids: a new class of sodium channel agents.

Daly JW, Gusovsky F, McNeal ET, Secunda S, Bell M, Creveling CR, Nishizawa Y, Overman LE, Sharp MJ, Rossignol DP.

Biochem Pharmacol. 1990 Jul 15;40(2):315-26.

PMID:
2165404

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