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Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).

Baszczyňski O, Watt JM, Rozewitz MD, Fliegert R, Guse AH, Potter BVL.

RSC Adv. 2020;10(3):1776-1785. doi: 10.1039/C9RA09284F. Epub 2020 Jan 9.


The Hamburg integrated medical degree program iMED.

Rheingans A, Soulos A, Mohr S, Meyer J, Guse AH.

GMS J Med Educ. 2019 Oct 15;36(5):Doc52. doi: 10.3205/zma001260. eCollection 2019.


A structural overview of the ion channels of the TRPM family.

Huang Y, Fliegert R, Guse AH, Lü W, Du J.

Cell Calcium. 2020 Jan;85:102111. doi: 10.1016/j.ceca.2019.102111. Epub 2019 Nov 24. Review.


Full focus on calcium.

Parys JB, Guse AH.

Sci Signal. 2019 Sep 17;12(599). pii: eaaz0961. doi: 10.1126/scisignal.aaz0961. Review.


P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23.


Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL.

J Org Chem. 2019 May 17;84(10):6143-6157. doi: 10.1021/acs.joc.9b00338. Epub 2019 May 7.


High-Resolution Calcium Imaging Method for Local Calcium Signaling.

Diercks BP, Werner R, Schetelig D, Wolf IMA, Guse AH.

Methods Mol Biol. 2019;1929:27-39. doi: 10.1007/978-1-4939-9030-6_3.


Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.


ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH.

Sci Signal. 2018 Dec 18;11(561). pii: eaat0358. doi: 10.1126/scisignal.aat0358.


NAD binding by human CD38 analyzed by Trp189 fluorescence.

Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1189-1196. doi: 10.1016/j.bbamcr.2018.11.011. Epub 2018 Nov 22.


Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays.

Ruthenbeck A, Marangoni E, Diercks BP, Krüger A, Froese A, Bork NI, Nikolaev VO, Guse AH, Meier C.

Molecules. 2018 Nov 13;23(11). pii: E2960. doi: 10.3390/molecules23112960.


Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL.

Sci Rep. 2018 Nov 13;8(1):16775. doi: 10.1038/s41598-018-34917-3.


TRPM2 activation: Paradigm shifted?

Fliegert R, Hölzer HT, Guse AH.

Cell Calcium. 2018 Dec;76:132-134. doi: 10.1016/j.ceca.2018.11.001. Epub 2018 Nov 3.


Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)-dependent calcium signalling.

Guse AH, Diercks BP.

J Physiol. 2018 Jul;596(14):2735-2743. doi: 10.1113/JP275974. Epub 2018 Apr 26. Review.


[Medical education in motion].

Koch-Gromus U, Guse AH, van den Bussche H.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Feb;61(2):129-131. doi: 10.1007/s00103-018-2700-8. German. No abstract available.


[Model study programs in medicine : Innovations in medical education in Hamburg and Berlin].

Guse AH, Kuhlmey A.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Feb;61(2):132-140. doi: 10.1007/s00103-017-2678-7. Review. German.


2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH.

Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26.


Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Fliegert R, Watt JM, Schöbel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A, Potter BVL, Guse AH.

Biochem J. 2017 Jun 16;474(13):2159-2175. doi: 10.1042/BCJ20170091.


Ca2+ Microdomains in T-Lymphocytes.

Wolf IMA, Guse AH.

Front Oncol. 2017 May 2;7:73. doi: 10.3389/fonc.2017.00073. eCollection 2017. Review.


Ultra-fast cell counters based on microtubular waveguides.

Bausch CS, Heyn C, Hansen W, Wolf IM, Diercks BP, Guse AH, Blick RH.

Sci Rep. 2017 Jan 30;7:41584. doi: 10.1038/srep41584.


Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations.

Diercks BP, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):977-986. doi: 10.1016/j.bbamcr.2016.11.026. Epub 2016 Nov 30.


Exploring the value and role of integrated supportive science courses in the reformed medical curriculum iMED: a mixed methods study.

Eisenbarth S, Tilling T, Lueerss E, Meyer J, Sehner S, Guse AH, Guse Nee Kurré J.

BMC Med Educ. 2016 Apr 29;16:132. doi: 10.1186/s12909-016-0646-9.


Effects of Mentoring Speed Dating as an Innovative Matching Tool in Undergraduate Medical Education: A Mixed Methods Study.

Guse J, Schweigert E, Kulms G, Heinen I, Martens C, Guse AH.

PLoS One. 2016 Feb 9;11(2):e0147444. doi: 10.1371/journal.pone.0147444. eCollection 2016.


Ca(2+) microdomains, NAADP and type 1 ryanodine receptor in cell activation.

Guse AH, Wolf IM.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1379-84. doi: 10.1016/j.bbamcr.2016.01.014. Epub 2016 Jan 22. Review.


Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse AH.

Sci Signal. 2015 Oct 13;8(398):ra102. doi: 10.1126/scisignal.aab0863.


Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation.

Nebel M, Zhang B, Odoardi F, Flügel A, Potter BV, Guse AH.

Messenger (Los Angel). 2015 Jun;4(1):104-111.


Calcium mobilizing second messengers derived from NAD.

Guse AH.

Biochim Biophys Acta. 2015 Sep;1854(9):1132-7. doi: 10.1016/j.bbapap.2014.12.015. Epub 2014 Dec 19. Review.


Speed mentoring: establishing successful mentoring relationships.

Kurré J, Schweigert E, Kulms G, Guse AH.

Med Educ. 2014 Nov;48(11):1131. doi: 10.1111/medu.12555. No abstract available.


NAD derived second messengers: Role in spontaneous diastolic Ca(2+) transients in murine cardiac myocytes.

Warszta D, Nebel M, Fliegert R, Guse AH.

DNA Repair (Amst). 2014 Nov;23:69-78. doi: 10.1016/j.dnarep.2014.05.007. Epub 2014 Jul 2.


Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose.

Tsuzuki T, Takano S, Sakaguchi N, Kudoh T, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Arisawa M, Potter BV, Shuto S.

Messenger (Los Angel). 2014 Jun-Dec;3(1-2):35-51. Epub 2014 Jun 1.


Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.

Moreau C, Kirchberger T, Swarbrick JM, Bartlett SJ, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse AH, Potter BV.

J Med Chem. 2013 Dec 27;56(24):10079-102. doi: 10.1021/jm401497a. Epub 2013 Dec 13.


NAADP signaling revisited.

Guse AH, Ernst IM, Fliegert R.

Curr Top Med Chem. 2013;13(23):2978-90. Review.


A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties.

Schmeitz C, Hernandez-Vargas EA, Fliegert R, Guse AH, Meyer-Hermann M.

Front Immunol. 2013 Sep 18;4:277. doi: 10.3389/fimmu.2013.00277. eCollection 2013.


Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling.

Ernst IM, Fliegert R, Guse AH.

Front Immunol. 2013 Aug 29;4:259. doi: 10.3389/fimmu.2013.00259. eCollection 2013. Review.


N-terminal tagging of two-pore channels interferes with NAADP action.

Guse AH.

Biochem J. 2013 Jul 1;453(1):e1-2. doi: 10.1042/BJ20130676.


Measuring Ca2+ release evoked by cyclic adp-ribose.

Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):574-8. doi: 10.1101/pdb.prot073015.


Measuring CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) activity by reverse-phase HPLC.

Kirchberger T, Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):569-73. doi: 10.1101/pdb.prot073007.


Cycling assay for determining intracellular cyclic adp-ribose levels.

Bruzzone S, Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):564-8. doi: 10.1101/pdb.prot072991.


Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger.

Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, Fukuda H, Arisawa M, Shuto S.

Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6633-7. doi: 10.1002/anie.201302098. Epub 2013 May 13. No abstract available.


Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH.

J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5.


Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.

Schmid F, Fliegert R, Westphal T, Bauche A, Guse AH.

J Biol Chem. 2012 Sep 21;287(39):32525-34. Epub 2012 Jul 31.


Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch-Nolte F.

PLoS One. 2012;7(7):e41269. doi: 10.1371/journal.pone.0041269. Epub 2012 Jul 27.


Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.

Walseth TF, Lin-Moshier Y, Weber K, Marchant JS, Slama JT, Guse AH.

Messenger (Los Angel). 2012 Jun 1;1(1):86-94.


Linking NAADP to ion channel activity: a unifying hypothesis.

Guse AH.

Sci Signal. 2012 Apr 24;5(221):pe18. doi: 10.1126/scisignal.2002890. Review.


Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.

Moreau C, Kirchberger T, Zhang B, Thomas MP, Weber K, Guse AH, Potter BV.

J Med Chem. 2012 Feb 23;55(4):1478-89. doi: 10.1021/jm201127y. Epub 2012 Feb 8.


CD38: a NAADP degrading enzyme.

Schmid F, Bruhn S, Weber K, Mittrücker HW, Guse AH.

FEBS Lett. 2011 Nov 16;585(22):3544-8. doi: 10.1016/j.febslet.2011.10.017. Epub 2011 Oct 19.


A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.

Qi N, Jung K, Wang M, Na LX, Yang ZJ, Zhang LR, Guse AH, Zhang LH.

Chem Commun (Camb). 2011 Sep 7;47(33):9462-4. doi: 10.1039/c1cc13062e. Epub 2011 Jul 22.


Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.

Moreau C, Ashamu GA, Bailey VC, Galione A, Guse AH, Potter BV.

Org Biomol Chem. 2011 Jan 7;9(1):278-90. doi: 10.1039/c0ob00396d. Epub 2010 Oct 25.


Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N(1)-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine-5',5''-cyclic pyrophosphate (8-CF(3)-cIDPRE) and its calcium release activity in T cells.

Dong M, Kirchberger T, Huang X, Yang ZJ, Zhang LR, Guse AH, Zhang LH.

Org Biomol Chem. 2010 Oct 21;8(20):4705-15. doi: 10.1039/c0ob00090f. Epub 2010 Aug 25.


Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.

Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A.

Brain. 2010 Jul;133(Pt 7):1930-43. doi: 10.1093/brain/awq135. Epub 2010 Jun 2.

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