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Full focus on calcium.

Parys JB, Guse AH.

Sci Signal. 2019 Sep 17;12(599). pii: eaaz0961. doi: 10.1126/scisignal.aaz0961. Review.


Export Mechanisms and Energy Transduction in Type-III Secretion Machines.

Renault TT, Guse A, Erhardt M.

Curr Top Microbiol Immunol. 2019 Jun 20. doi: 10.1007/82_2019_166. [Epub ahead of print]


Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis.

Hambleton EA, Jones VAS, Maegele I, Kvaskoff D, Sachsenheimer T, Guse A.

Elife. 2019 Jun 4;8. pii: e43923. doi: 10.7554/eLife.43923.


P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23.


Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL.

J Org Chem. 2019 May 17;84(10):6143-6157. doi: 10.1021/acs.joc.9b00338. Epub 2019 May 7.


High-Resolution Calcium Imaging Method for Local Calcium Signaling.

Diercks BP, Werner R, Schetelig D, Wolf IMA, Guse AH.

Methods Mol Biol. 2019;1929:27-39. doi: 10.1007/978-1-4939-9030-6_3.


Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.


ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH.

Sci Signal. 2018 Dec 18;11(561). pii: eaat0358. doi: 10.1126/scisignal.aat0358.


NAD binding by human CD38 analyzed by Trp189 fluorescence.

Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1189-1196. doi: 10.1016/j.bbamcr.2018.11.011. Epub 2018 Nov 22.


Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays.

Ruthenbeck A, Marangoni E, Diercks BP, Krüger A, Froese A, Bork NI, Nikolaev VO, Guse AH, Meier C.

Molecules. 2018 Nov 13;23(11). pii: E2960. doi: 10.3390/molecules23112960.


Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL.

Sci Rep. 2018 Nov 13;8(1):16775. doi: 10.1038/s41598-018-34917-3.


TRPM2 activation: Paradigm shifted?

Fliegert R, Hölzer HT, Guse AH.

Cell Calcium. 2018 Dec;76:132-134. doi: 10.1016/j.ceca.2018.11.001. Epub 2018 Nov 3.


Microinjection to deliver protein, mRNA, and DNA into zygotes of the cnidarian endosymbiosis model Aiptasia sp.

Jones VAS, Bucher M, Hambleton EA, Guse A.

Sci Rep. 2018 Nov 6;8(1):16437. doi: 10.1038/s41598-018-34773-1.


Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)-dependent calcium signalling.

Guse AH, Diercks BP.

J Physiol. 2018 Jul;596(14):2735-2743. doi: 10.1113/JP275974. Epub 2018 Apr 26. Review.


[Medical education in motion].

Koch-Gromus U, Guse AH, van den Bussche H.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Feb;61(2):129-131. doi: 10.1007/s00103-018-2700-8. German. No abstract available.


[Model study programs in medicine : Innovations in medical education in Hamburg and Berlin].

Guse AH, Kuhlmey A.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Feb;61(2):132-140. doi: 10.1007/s00103-017-2678-7. Review. German.


Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.

Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F.

Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6.


A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum.

Fabiani FD, Renault TT, Peters B, Dietsche T, Gálvez EJC, Guse A, Freier K, Charpentier E, Strowig T, Franz-Wachtel M, Macek B, Wagner S, Hensel M, Erhardt M.

PLoS Biol. 2017 Aug 3;15(8):e2002267. doi: 10.1371/journal.pbio.2002267. eCollection 2017 Aug.


2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH.

Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26.


Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Fliegert R, Watt JM, Schöbel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A, Potter BVL, Guse AH.

Biochem J. 2017 Jun 16;474(13):2159-2175. doi: 10.1042/BCJ20170091.


Ca2+ Microdomains in T-Lymphocytes.

Wolf IMA, Guse AH.

Front Oncol. 2017 May 2;7:73. doi: 10.3389/fonc.2017.00073. eCollection 2017. Review.


Ultra-fast cell counters based on microtubular waveguides.

Bausch CS, Heyn C, Hansen W, Wolf IM, Diercks BP, Guse AH, Blick RH.

Sci Rep. 2017 Jan 30;7:41584. doi: 10.1038/srep41584.


Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations.

Diercks BP, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):977-986. doi: 10.1016/j.bbamcr.2016.11.026. Epub 2016 Nov 30.


Aiptasia sp. larvae as a model to reveal mechanisms of symbiont selection in cnidarians.

Wolfowicz I, Baumgarten S, Voss PA, Hambleton EA, Voolstra CR, Hatta M, Guse A.

Sci Rep. 2016 Sep 1;6:32366. doi: 10.1038/srep32366.


Exploring the value and role of integrated supportive science courses in the reformed medical curriculum iMED: a mixed methods study.

Eisenbarth S, Tilling T, Lueerss E, Meyer J, Sehner S, Guse AH, Guse Nee Kurré J.

BMC Med Educ. 2016 Apr 29;16:132. doi: 10.1186/s12909-016-0646-9.


Effects of Mentoring Speed Dating as an Innovative Matching Tool in Undergraduate Medical Education: A Mixed Methods Study.

Guse J, Schweigert E, Kulms G, Heinen I, Martens C, Guse AH.

PLoS One. 2016 Feb 9;11(2):e0147444. doi: 10.1371/journal.pone.0147444. eCollection 2016.


Ca(2+) microdomains, NAADP and type 1 ryanodine receptor in cell activation.

Guse AH, Wolf IM.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1379-84. doi: 10.1016/j.bbamcr.2016.01.014. Epub 2016 Jan 22. Review.


Development and Symbiosis Establishment in the Cnidarian Endosymbiosis Model Aiptasia sp.

Bucher M, Wolfowicz I, Voss PA, Hambleton EA, Guse A.

Sci Rep. 2016 Jan 25;6:19867. doi: 10.1038/srep19867.


Induction of Gametogenesis in the Cnidarian Endosymbiosis Model Aiptasia sp.

Grawunder D, Hambleton EA, Bucher M, Wolfowicz I, Bechtoldt N, Guse A.

Sci Rep. 2015 Oct 26;5:15677. doi: 10.1038/srep15677.


Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse AH.

Sci Signal. 2015 Oct 13;8(398):ra102. doi: 10.1126/scisignal.aab0863.


The genome of Aiptasia, a sea anemone model for coral symbiosis.

Baumgarten S, Simakov O, Esherick LY, Liew YJ, Lehnert EM, Michell CT, Li Y, Hambleton EA, Guse A, Oates ME, Gough J, Weis VM, Aranda M, Pringle JR, Voolstra CR.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11893-8. doi: 10.1073/pnas.1513318112. Epub 2015 Aug 31.


Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation.

Nebel M, Zhang B, Odoardi F, Flügel A, Potter BV, Guse AH.

Messenger (Los Angel). 2015 Jun;4(1):104-111.


Calcium mobilizing second messengers derived from NAD.

Guse AH.

Biochim Biophys Acta. 2015 Sep;1854(9):1132-7. doi: 10.1016/j.bbapap.2014.12.015. Epub 2014 Dec 19. Review.


Speed mentoring: establishing successful mentoring relationships.

Kurré J, Schweigert E, Kulms G, Guse AH.

Med Educ. 2014 Nov;48(11):1131. doi: 10.1111/medu.12555. No abstract available.


NAD derived second messengers: Role in spontaneous diastolic Ca(2+) transients in murine cardiac myocytes.

Warszta D, Nebel M, Fliegert R, Guse AH.

DNA Repair (Amst). 2014 Nov;23:69-78. doi: 10.1016/j.dnarep.2014.05.007. Epub 2014 Jul 2.


Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose.

Tsuzuki T, Takano S, Sakaguchi N, Kudoh T, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Arisawa M, Potter BV, Shuto S.

Messenger (Los Angel). 2014 Jun-Dec;3(1-2):35-51. Epub 2014 Jun 1.


Similar specificities of symbiont uptake by adults and larvae in an anemone model system for coral biology.

Hambleton EA, Guse A, Pringle JR.

J Exp Biol. 2014 May 1;217(Pt 9):1613-9. doi: 10.1242/jeb.095679. Epub 2014 Feb 13.


Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.

Moreau C, Kirchberger T, Swarbrick JM, Bartlett SJ, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse AH, Potter BV.

J Med Chem. 2013 Dec 27;56(24):10079-102. doi: 10.1021/jm401497a. Epub 2013 Dec 13.


NAADP signaling revisited.

Guse AH, Ernst IM, Fliegert R.

Curr Top Med Chem. 2013;13(23):2978-90. Review.


A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties.

Schmeitz C, Hernandez-Vargas EA, Fliegert R, Guse AH, Meyer-Hermann M.

Front Immunol. 2013 Sep 18;4:277. doi: 10.3389/fimmu.2013.00277. eCollection 2013.


Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling.

Ernst IM, Fliegert R, Guse AH.

Front Immunol. 2013 Aug 29;4:259. doi: 10.3389/fimmu.2013.00259. eCollection 2013. Review.


N-terminal tagging of two-pore channels interferes with NAADP action.

Guse AH.

Biochem J. 2013 Jul 1;453(1):e1-2. doi: 10.1042/BJ20130676.


Measuring Ca2+ release evoked by cyclic adp-ribose.

Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):574-8. doi: 10.1101/pdb.prot073015.


Measuring CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) activity by reverse-phase HPLC.

Kirchberger T, Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):569-73. doi: 10.1101/pdb.prot073007.


Cycling assay for determining intracellular cyclic adp-ribose levels.

Bruzzone S, Guse AH.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):564-8. doi: 10.1101/pdb.prot072991.


Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger.

Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, Fukuda H, Arisawa M, Shuto S.

Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6633-7. doi: 10.1002/anie.201302098. Epub 2013 May 13. No abstract available.


CENP-A confers a reduction in height on octameric nucleosomes.

Miell MD, Fuller CJ, Guse A, Barysz HM, Downes A, Owen-Hughes T, Rappsilber J, Straight AF, Allshire RC.

Nat Struct Mol Biol. 2013 Jun;20(6):763-5. doi: 10.1038/nsmb.2574. Epub 2013 May 5.


Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH.

J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5.


A cell-free system for functional centromere and kinetochore assembly.

Guse A, Fuller CJ, Straight AF.

Nat Protoc. 2012 Oct;7(10):1847-69. doi: 10.1038/nprot.2012.112. Epub 2012 Sep 20.


Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.

Schmid F, Fliegert R, Westphal T, Bauche A, Guse AH.

J Biol Chem. 2012 Sep 21;287(39):32525-34. Epub 2012 Jul 31.

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