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Items: 48

1.

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene epigenetically regulated.

Martínez-Calle N, Pascual M, Ordoñez R, San José-Enériz E, Kulis M, Miranda E, Guruceaga E, Segura V, Larráyoz MJ, Bellosillo B, Calasanz MJ, Besses C, Rifón J, Martín-Subero JI, Agirre X, Prosper F.

Haematologica. 2019 Jan 17. pii: haematol.2018.204917. doi: 10.3324/haematol.2018.204917. [Epub ahead of print]

2.

Proteogenomics in the context of the Human Proteome Project (HPP).

González-Gomariz J, Guruceaga E, López-Sánchez M, Segura V.

Expert Rev Proteomics. 2019 Jan 18:1-9. doi: 10.1080/14789450.2019.1571916. [Epub ahead of print]

PMID:
30654666
3.

Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network.

Román M, López I, Guruceaga E, Baraibar I, Ecay M, Collantes M, Nadal E, Vallejo A, Cadenas S, Miguel ME, Jang JH, Martin-Uriz PS, Castro-Labrador L, Vilas-Zornoza A, Lara-Astiaso D, Ponz-Sarvise M, Rolfo C, Santos ES, Raez LE, Taverna S, Behrens C, Weder W, Wistuba II, Vicent S, Gil-Bazo I.

Cancer Res. 2019 Feb 1;79(3):625-638. doi: 10.1158/0008-5472.CAN-18-1479. Epub 2018 Dec 18.

PMID:
30563891
4.

Sex-dependent gene expression after ochratoxin A insult in F344 rat kidney.

Vettorazzi A, Pastor L, Guruceaga E, López de Cerain A.

Food Chem Toxicol. 2019 Jan;123:337-348. doi: 10.1016/j.fct.2018.10.057. Epub 2018 Oct 25.

PMID:
30449730
5.

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets.

Cortazar AR, Torrano V, Martín-Martín N, Caro-Maldonado A, Camacho L, Hermanova I, Guruceaga E, Lorenzo-Martín LF, Caloto R, Gomis RR, Apaolaza I, Quesada V, Trka J, Gomez-Muñoz A, Vincent S, Bustelo XR, Planes FJ, Aransay AM, Carracedo A.

Cancer Res. 2018 Nov 1;78(21):6320-6328. doi: 10.1158/0008-5472.CAN-18-1669. Epub 2018 Sep 19.

PMID:
30232219
6.

Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection.

González-Morales A, Zabaleta A, Guruceaga E, Alonso MM, García-Moure M, Fernández-Irigoyen J, Santamaría E.

Oncotarget. 2018 Jul 24;9(57):31045-31065. doi: 10.18632/oncotarget.25774. eCollection 2018 Jul 24.

7.

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome.

Rodriguez-Madoz JR, San Jose-Eneriz E, Rabal O, Zapata-Linares N, Miranda E, Rodriguez S, Porciuncula A, Vilas-Zornoza A, Garate L, Segura V, Guruceaga E, Agirre X, Oyarzabal J, Prosper F.

PLoS One. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275. eCollection 2017.

8.

Enhanced Missing Proteins Detection in NCI60 Cell Lines Using an Integrative Search Engine Approach.

Guruceaga E, Garin-Muga A, Prieto G, Bejarano B, Marcilla M, Marín-Vicente C, Perez-Riverol Y, Casal JI, Vizcaíno JA, Corrales FJ, Segura V.

J Proteome Res. 2017 Dec 1;16(12):4374-4390. doi: 10.1021/acs.jproteome.7b00388. Epub 2017 Oct 11.

9.

Inducing heat shock protein 70 expression provides a robust antithrombotic effect with minimal bleeding risk.

Allende M, Molina E, Lecumberri R, Sanchez-Arias JA, Ugarte A, Guruceaga E, Oyarzabal J, Hermida J.

Thromb Haemost. 2017 Aug 30;117(9):1722-1729. doi: 10.1160/TH17-02-0108. Epub 2017 Jul 27.

PMID:
28837204
10.

Gene methylation parallelisms between peripheral blood cells and oral mucosa samples in relation to overweight.

San-Cristobal R, Navas-Carretero S, Milagro FI, Riezu-Boj JI, Guruceaga E, Celis-Morales C, Livingstone KM, Brennan L, Lovegrove JA, Daniel H, Saris WH, Traczyk I, Manios Y, Gibney ER, Gibney MJ, Mathers JC, Martinez JA.

J Physiol Biochem. 2016 Aug;73(3):465-474. doi: 10.1007/s13105-017-0560-6. Epub 2017 Mar 28. Erratum in: J Physiol Biochem. 2017 Oct 5;:.

PMID:
28353150
11.

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S.

Nat Commun. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294.

12.

EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth.

Perurena N, Zandueta C, Martínez-Canarias S, Moreno H, Vicent S, Almeida AS, Guruceaga E, Gomis RR, Santisteban M, Egeblad M, Hermida J, Lecanda F.

J Hematol Oncol. 2017 Jan 19;10(1):23. doi: 10.1186/s13045-017-0399-x.

13.

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

Llopiz D, Ruiz M, Infante S, Villanueva L, Silva L, Hervas-Stubbs S, Alignani D, Guruceaga E, Lasarte JJ, Sarobe P.

Oncotarget. 2017 Jan 10;8(2):2659-2671. doi: 10.18632/oncotarget.13736.

14.

Progress and pitfalls in finding the 'missing proteins' from the human proteome map.

Segura V, Garin-Muga A, Guruceaga E, Corrales FJ.

Expert Rev Proteomics. 2017 Jan;14(1):9-14. doi: 10.1080/14789450.2017.1265450. Epub 2016 Dec 2. Review.

PMID:
27885863
15.

Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells.

Acanda de la Rocha AM, López-Bertoni H, Guruceaga E, González-Huarriz M, Martínez-Vélez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MM.

PLoS One. 2016 Sep 26;11(9):e0163155. doi: 10.1371/journal.pone.0163155. eCollection 2016.

16.

Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.

Carnero E, Barriocanal M, Prior C, Pablo Unfried J, Segura V, Guruceaga E, Enguita M, Smerdou C, Gastaminza P, Fortes P.

EMBO Rep. 2016 Jul;17(7):1013-28. doi: 10.15252/embr.201541763. Epub 2016 Jun 9.

17.

MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia.

Pippa R, Dominguez A, Malumbres R, Endo A, Arriazu E, Marcotegui N, Guruceaga E, Odero MD.

Oncotarget. 2016 Jun 6;8(33):53989-54003. doi: 10.18632/oncotarget.9840. eCollection 2017 Aug 15.

18.

Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.

Allende M, Molina E, Guruceaga E, Tamayo I, González-Porras JR, Gonzalez-López TJ, Toledo E, Rabal O, Ugarte A, Roldán V, Rivera J, Oyarzabal J, Montes R, Hermida J.

Cardiovasc Res. 2016 Jun 1;110(3):309-18. doi: 10.1093/cvr/cvw049. Epub 2016 Mar 14.

PMID:
26976620
19.

Identification of new markers of recurrence in patients with unprovoked deep vein thrombosis by gene expression profiling: the retro study.

Montes R, Guruceaga E, González-Porras JR, Reverter JC, Marco P, Pina E, Páramo JA, Hermida J, Lecumberri R; Grupo de Trabajo de Patología Trombótica de la Sociedad Española de Trombosis y Hemostasia (SETH).

Eur J Haematol. 2016 Aug;97(2):128-36. doi: 10.1111/ejh.12692. Epub 2015 Nov 26.

PMID:
26505263
20.

Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance.

Zabaleta A, Riezu-Boj JI, Larrea E, Villanueva L, Lasarte JJ, Guruceaga E, Fisicaro P, Ezzikouri S, Missale G, Ferrari C, Benjelloun S, Prieto J, Sarobe P.

J Med Virol. 2016 May;88(5):843-51. doi: 10.1002/jmv.24399. Epub 2015 Oct 19.

PMID:
26447929
21.

Proteogenomics Dashboard for the Human Proteome Project.

Tabas-Madrid D, Alves-Cruzeiro J, Segura V, Guruceaga E, Vialas V, Prieto G, García C, Corrales FJ, Albar JP, Pascual-Montano A.

J Proteome Res. 2015 Sep 4;14(9):3738-49. doi: 10.1021/acs.jproteome.5b00466. Epub 2015 Jul 16.

PMID:
26144527
22.

Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex.

Erburu M, Cajaleon L, Guruceaga E, Venzala E, Muñoz-Cobo I, Beltrán E, Puerta E, Tordera RM.

Pharmacol Biochem Behav. 2015 Aug;135:227-36. doi: 10.1016/j.pbb.2015.06.001. Epub 2015 Jun 4.

PMID:
26051025
23.

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Agirre X, Castellano G, Pascual M, Heath S, Kulis M, Segura V, Bergmann A, Esteve A, Merkel A, Raineri E, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Russiñol N, Queirós AC, Beekman R, Rodríguez-Madoz JR, San José-Enériz E, Fang F, Gutiérrez NC, García-Verdugo JM, Robson MI, Schirmer EC, Guruceaga E, Martens JH, Gut M, Calasanz MJ, Flicek P, Siebert R, Campo E, Miguel JF, Melnick A, Stunnenberg HG, Gut IG, Prosper F, Martín-Subero JI.

Genome Res. 2015 Apr;25(4):478-87. doi: 10.1101/gr.180240.114. Epub 2015 Feb 2.

24.

Prediction of a missing protein expression map in the context of the human proteome project.

Guruceaga E, Sanchez del Pino MM, Corrales FJ, Segura V.

J Proteome Res. 2015 Mar 6;14(3):1350-60. doi: 10.1021/pr500850u. Epub 2015 Feb 5.

PMID:
25612097
25.

Type I Interferon Regulates the Expression of Long Non-Coding RNAs.

Carnero E, Barriocanal M, Segura V, Guruceaga E, Prior C, Börner K, Grimm D, Fortes P.

Front Immunol. 2014 Nov 6;5:548. doi: 10.3389/fimmu.2014.00548. eCollection 2014.

26.

Neuregulin-1β induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair.

Iglesias-García O, Baumgartner S, Macrí-Pellizzeri L, Rodriguez-Madoz JR, Abizanda G, Guruceaga E, Albiasu E, Corbacho D, Benavides-Vallve C, Soriano-Navarro M, González-Granero S, Gavira JJ, Krausgrill B, Rodriguez-Mañero M, García-Verdugo JM, Ortiz-de-Solorzano C, Halbach M, Hescheler J, Pelacho B, Prósper F.

Stem Cells Dev. 2015 Feb 15;24(4):484-96. doi: 10.1089/scd.2014.0211. Epub 2014 Nov 25.

27.

miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization.

Valencia K, Luis-Ravelo D, Bovy N, Antón I, Martínez-Canarias S, Zandueta C, Ormazábal C, Struman I, Tabruyn S, Rebmann V, De Las Rivas J, Guruceaga E, Bandrés E, Lecanda F.

Mol Oncol. 2014 May;8(3):689-703. doi: 10.1016/j.molonc.2014.01.012. Epub 2014 Feb 6.

28.

Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma.

Prior C, Perez-Gracia JL, Garcia-Donas J, Rodriguez-Antona C, Guruceaga E, Esteban E, Suarez C, Castellano D, del Alba AG, Lozano MD, Carles J, Climent MA, Arranz JA, Gallardo E, Puente J, Bellmunt J, Gurpide A, Lopez-Picazo JM, Hernandez AG, Mellado B, Martínez E, Moreno F, Font A, Calvo A.

PLoS One. 2014 Jan 24;9(1):e86263. doi: 10.1371/journal.pone.0086263. eCollection 2014.

29.

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool.

Manterola L, Guruceaga E, Gállego Pérez-Larraya J, González-Huarriz M, Jauregui P, Tejada S, Diez-Valle R, Segura V, Samprón N, Barrena C, Ruiz I, Agirre A, Ayuso A, Rodríguez J, González A, Xipell E, Matheu A, López de Munain A, Tuñón T, Zazpe I, García-Foncillas J, Paris S, Delattre JY, Alonso MM.

Neuro Oncol. 2014 Apr;16(4):520-7. doi: 10.1093/neuonc/not218. Epub 2014 Jan 16.

30.

Functional interpretation of microRNA-mRNA association in biological systems using R.

Guruceaga E, Segura V.

Comput Biol Med. 2014 Jan;44:124-31. doi: 10.1016/j.compbiomed.2013.11.001. Epub 2013 Nov 13.

PMID:
24377695
31.

A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer.

Luis-Ravelo D, Antón I, Zandueta C, Valencia K, Ormazábal C, Martínez-Canarias S, Guruceaga E, Perurena N, Vicent S, De Las Rivas J, Lecanda F.

Oncogene. 2014 Oct 23;33(43):5090-9. doi: 10.1038/onc.2013.440. Epub 2013 Oct 28.

PMID:
24166494
32.

Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells.

Aldaz B, Sagardoy A, Nogueira L, Guruceaga E, Grande L, Huse JT, Aznar MA, Díez-Valle R, Tejada-Solís S, Alonso MM, Fernandez-Luna JL, Martinez-Climent JA, Malumbres R.

PLoS One. 2013 Oct 14;8(10):e77098. doi: 10.1371/journal.pone.0077098. eCollection 2013.

33.

Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment.

Freire J, Ajona D, de Biurrun G, Agorreta J, Segura V, Guruceaga E, Bleau AM, Pio R, Blanco D, Montuenga LM.

Neoplasia. 2013 Aug;15(8):913-24.

34.

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.

Atorrasagasti C, Peixoto E, Aquino JB, Kippes N, Malvicini M, Alaniz L, Garcia M, Piccioni F, Fiore EJ, Bayo J, Bataller R, Guruceaga E, Corrales F, Podhajcer O, Mazzolini G.

PLoS One. 2013;8(2):e54962. doi: 10.1371/journal.pone.0054962. Epub 2013 Feb 11.

35.

Spanish human proteome project: dissection of chromosome 16.

Segura V, Medina-Aunon JA, Guruceaga E, Gharbi SI, González-Tejedo C, Sánchez del Pino MM, Canals F, Fuentes M, Casal JI, Martínez-Bartolomé S, Elortza F, Mato JM, Arizmendi JM, Abian J, Oliveira E, Gil C, Vivanco F, Blanco F, Albar JP, Corrales FJ.

J Proteome Res. 2013 Jan 4;12(1):112-22. doi: 10.1021/pr300898u. Epub 2012 Dec 12.

PMID:
23234512
36.

Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia.

García-Ortí L, Cristóbal I, Cirauqui C, Guruceaga E, Marcotegui N, Calasanz MJ, Castello-Cros R, Odero MD.

PLoS One. 2012;7(10):e47717. doi: 10.1371/journal.pone.0047717. Epub 2012 Oct 15.

37.

MicroRNA signatures of iPSCs and endoderm-derived tissues.

Porciuncula A, Zapata N, Guruceaga E, Agirre X, Barajas M, Prosper F.

Gene Expr Patterns. 2013 Jan-Feb;13(1-2):12-20. doi: 10.1016/j.gep.2012.08.002. Epub 2012 Sep 8.

PMID:
22982176
38.

Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer.

Valles I, Pajares MJ, Segura V, Guruceaga E, Gomez-Roman J, Blanco D, Tamura A, Montuenga LM, Pio R.

PLoS One. 2012;7(8):e42086. doi: 10.1371/journal.pone.0042086. Epub 2012 Aug 2.

39.

Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia.

Vázquez I, Maicas M, Marcotegui N, Conchillo A, Guruceaga E, Roman-Gomez J, Calasanz MJ, Agirre X, Prosper F, Odero MD.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):E167-8; author reply E169-70. doi: 10.1073/pnas.1011540107. Epub 2010 Oct 7. No abstract available.

40.

Molecular characterization of the Ggamma-globin-Tag transgenic mouse model of hormone refractory prostate cancer: comparison to human prostate cancer.

Calvo A, Perez-Stable C, Segura V, Catena R, Guruceaga E, Nguewa P, Blanco D, Parada L, Reiner T, Green JE.

Prostate. 2010 May 1;70(6):630-45. doi: 10.1002/pros.21097.

41.

Genome-wide proximal promoter analysis and interpretation.

Guruceaga E, Segura V, Corrales FJ, Rubio A.

Methods Mol Biol. 2010;593:157-74. doi: 10.1007/978-1-60327-194-3_8.

PMID:
19957149
42.

Adenovirus VA RNA-derived miRNAs target cellular genes involved in cell growth, gene expression and DNA repair.

Aparicio O, Carnero E, Abad X, Razquin N, Guruceaga E, Segura V, Fortes P.

Nucleic Acids Res. 2010 Jan;38(3):750-63. doi: 10.1093/nar/gkp1028. Epub 2009 Nov 19.

43.

FactorY, a bioinformatic resource for genome-wide promoter analysis.

Guruceaga E, Segura V, Corrales FJ, Rubio A.

Comput Biol Med. 2009 Apr;39(4):385-7. doi: 10.1016/j.compbiomed.2009.01.008. Epub 2009 Mar 9.

PMID:
19272592
44.

BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia.

José-Enériz ES, Román-Gómez J, Cordeu L, Ballestar E, Gárate L, Andreu EJ, Isidro I, Guruceaga E, Jiménez-Velasco A, Heiniger A, Torres A, Calasanz MJ, Esteller M, Gutiérrez NC, Rubio A, Pérez-Roger I, Agirre X, Prósper F.

Br J Haematol. 2008 Aug;142(4):571-82. doi: 10.1111/j.1365-2141.2008.07221.x. Epub 2008 Jun 5.

PMID:
18537972
45.

SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays.

Anton MA, Gorostiaga D, Guruceaga E, Segura V, Carmona-Saez P, Pascual-Montano A, Pio R, Montuenga LM, Rubio A.

Genome Biol. 2008;9(2):R46. doi: 10.1186/gb-2008-9-2-r46. Epub 2008 Feb 29.

46.

Identification of a gene-pathway associated with non-alcoholic steatohepatitis.

Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM.

J Hepatol. 2007 Apr;46(4):708-18. Epub 2006 Nov 30.

PMID:
17275126
47.

Correlation between gene expression and GO semantic similarity.

Sevilla JL, Segura V, Podhorski A, Guruceaga E, Mato JM, Martínez-Cruz LA, Corrales FJ, Rubio A.

IEEE/ACM Trans Comput Biol Bioinform. 2005 Oct-Dec;2(4):330-8.

PMID:
17044170
48.

GARBAN II: an integrative framework for extracting biological information from proteomic and genomic data.

Segura V, Podhorski A, Guruceaga E, Sevilla JL, Corrales FJ, Rubio A.

Proteomics. 2006 Apr;6 Suppl 1:S12-5. Review.

PMID:
16511812

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