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Items: 19

1.

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris AE, Gopal K, Ussher JR, Sutendra G.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau8866. doi: 10.1126/scitranslmed.aau8866.

PMID:
30728290
2.

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaao4583. doi: 10.1126/scitranslmed.aao4583.

3.

A Paradigm Shift Is Needed in the Field of Pulmonary Arterial Hypertension for Its Entrance Into the Precision Medicine Era.

Gurtu V, Michelakis ED.

Circ Res. 2016 Dec 9;119(12):1276-1279. Review. No abstract available.

PMID:
27932471
4.

Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.

Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED.

Eur Urol. 2016 Apr;69(4):734-744. doi: 10.1016/j.eururo.2015.09.014. Epub 2016 Feb 18.

PMID:
26433571
5.

Cell-Based Gene Therapy in Pulmonary Arterial Hypertension: Journeys in Translational Medicine.

Gurtu V, Michelakis E.

Circ Res. 2015 Sep 11;117(7):596-8. doi: 10.1161/CIRCRESAHA.115.307247. No abstract available.

PMID:
26358109
6.

Emerging therapies and future directions in pulmonary arterial hypertension.

Gurtu V, Michelakis ED.

Can J Cardiol. 2015 Apr;31(4):489-501. doi: 10.1016/j.cjca.2015.01.028. Epub 2015 Jan 28. Review.

PMID:
25840098
7.

A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension.

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED.

Circ Res. 2015 Jan 2;116(1):56-69. doi: 10.1161/CIRCRESAHA.115.303910. Epub 2014 Oct 6.

PMID:
25287062
8.

Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED.

Cell Metab. 2014 Nov 4;20(5):827-839. doi: 10.1016/j.cmet.2014.08.011. Epub 2014 Oct 2.

9.

The relationship between peripheral arterial tonometry and classic measures of endothelial function.

Martin BJ, Gurtu V, Chan S, Anderson TJ.

Vasc Med. 2013 Feb;18(1):13-8. doi: 10.1177/1358863X12468194. Epub 2012 Dec 21.

PMID:
23263153
10.

A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

Nagendran J, Gurtu V, Fu DZ, Dyck JR, Haromy A, Ross DB, Rebeyka IM, Michelakis ED.

J Thorac Cardiovasc Surg. 2008 Jul;136(1):168-78, 178.e1-3. doi: 10.1016/j.jtcvs.2008.01.040. Epub 2008 May 23.

11.

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.

Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.

Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.

PMID:
17606845
12.

Caspase inhibition prevents staurosporine-induced apoptosis in CHO-K1 cells.

Zhang G, Yan G, Gurtu V, Spencer C, Kain SR.

Apoptosis. 1998;3(1):27-33.

PMID:
14646515
13.

Maternal effect for DNA mismatch repair in the mouse.

Gurtu VE, Verma S, Grossmann AH, Liskay RM, Skarnes WC, Baker SM.

Genetics. 2002 Jan;160(1):271-7.

14.

Microscopic imagery of mammalian cells expressing an enhanced green fluorescent protein gene.

Kain SR, Zhang G, Gurtu V, Kitts PA.

Methods Mol Biol. 1998;102:33-42. No abstract available.

PMID:
9680607
15.

Early detection of apoptosis using a fluorescent conjugate of annexin V.

Zhang G, Gurtu V, Kain SR, Yan G.

Biotechniques. 1997 Sep;23(3):525-31.

16.

Fluorometric and colorimetric detection of caspase activity associated with apoptosis.

Gurtu V, Kain SR, Zhang G.

Anal Biochem. 1997 Aug 15;251(1):98-102.

PMID:
9300088
17.

A cationic lipid for rapid and efficient delivery of plasmid DNA into mammalian cells.

Zhang G, Gurtu V, Smith TH, Nelson P, Kain SR.

Biochem Biophys Res Commun. 1997 Jul 9;236(1):126-9.

PMID:
9223438
18.

IRES bicistronic expression vectors for efficient creation of stable mammalian cell lines.

Gurtu V, Yan G, Zhang G.

Biochem Biophys Res Commun. 1996 Dec 4;229(1):295-8.

PMID:
8954121
19.

An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells.

Zhang G, Gurtu V, Kain SR.

Biochem Biophys Res Commun. 1996 Oct 23;227(3):707-11.

PMID:
8885998

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