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Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach.

Faruqu FN, Wang JT, Xu L, McNickle L, Chong EM, Walters A, Gurney M, Clayton A, Smyth LA, Hider R, Sosabowski J, Al-Jamal KT.

Theranostics. 2019 Feb 28;9(6):1666-1682. doi: 10.7150/thno.27891. eCollection 2019.


Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D 3rd, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF.

J Med Chem. 2019 May 23;62(10):4884-4901. doi: 10.1021/acs.jmedchem.9b00193. Epub 2019 Apr 23.


The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy.

Seed RI, Taurozzi AJ, Wilcock DJ, Nappo G, Erb HHH, Read ML, Gurney M, Archer LK, Ito S, Rumsby MG, Petrie JL, Clayton A, Maitland NJ, Collins AT.

Sci Rep. 2019 Mar 26;9(1):5120. doi: 10.1038/s41598-019-41379-8.


Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells.

Figliuolo da Paz V, Jamwal DR, Gurney M, Midura-Kiela M, Harrison CA, Cox C, Wilson JM, Ghishan FK, Kiela PR.

Front Immunol. 2019 Feb 27;10:304. doi: 10.3389/fimmu.2019.00304. eCollection 2019.


Genetic Association of Phosphodiesterases With Human Cognitive Performance.

Gurney ME.

Front Mol Neurosci. 2019 Feb 8;12:22. doi: 10.3389/fnmol.2019.00022. eCollection 2019. Review.


Use of continuous glucose monitoring for sport in type 1 diabetes.

Abdulrahman A, Manhas J, Linane H, Gurney M, Fitzgerald C, O'Sullivan E.

BMJ Open Sport Exerc Med. 2018 Dec 17;4(1):e000432. doi: 10.1136/bmjsem-2018-000432. eCollection 2018.


Implementation and evaluation of a women's reproductive health pharmacy elective.

El-Ibiary SY, Azizoddin A, Petrossian L, Gurney MK.

Curr Pharm Teach Learn. 2018 Aug;10(8):1087-1096. doi: 10.1016/j.cptl.2018.05.007. Epub 2018 Jun 7.


Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice.

Zhang C, Xu Y, Chowdhary A, Fox D 3rd, Gurney ME, Zhang HT, Auerbach BD, Salvi RJ, Yang M, Li G, O'Donnell JM.

Neuropsychopharmacology. 2018 Oct;43(11):2299-2309. doi: 10.1038/s41386-018-0178-6. Epub 2018 Aug 14.


Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma.

Yeung V, Webber JP, Dunlop EA, Morgan H, Hutton J, Gurney M, Jones E, Falcon-Perez J, Tabi Z, Errington R, Clayton A.

Nanoscale. 2018 May 10;10(18):8547-8559. doi: 10.1039/c8nr02417k.


The Use of Facebook Advertising to Recruit Healthy Elderly People for a Clinical Trial: Baseline Metrics.

Cowie JM, Gurney ME.

JMIR Res Protoc. 2018 Jan 24;7(1):e20. doi: 10.2196/resprot.7918.


A retrospective study of feline trauma patients admitted to a referral centre.

Hernon T, Gurney M, Gibson S.

J Small Anim Pract. 2018 Apr;59(4):243-247. doi: 10.1111/jsap.12815. Epub 2018 Jan 17.


A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury.

Titus DJ, Wilson NM, Alcazar O, Calixte DA, Dietrich WD, Gurney ME, Atkins CM.

Neurobiol Learn Mem. 2018 Feb;148:38-49. doi: 10.1016/j.nlm.2017.12.008. Epub 2017 Dec 30.


Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D).

Gurney ME, Cogram P, Deacon RM, Rex C, Tranfaglia M.

Sci Rep. 2017 Nov 7;7(1):14653. doi: 10.1038/s41598-017-15028-x.


Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes.

Salimu J, Webber J, Gurney M, Al-Taei S, Clayton A, Tabi Z.

J Extracell Vesicles. 2017 Sep 3;6(1):1368823. doi: 10.1080/20013078.2017.1368823. eCollection 2017.


Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.

Wilson NM, Gurney ME, Dietrich WD, Atkins CM.

PLoS One. 2017 May 19;12(5):e0178013. doi: 10.1371/journal.pone.0178013. eCollection 2017.


The 2016 revised World Health Organization definition of 'myelodysplastic syndrome with isolated del(5q)'; prognostic implications of single versus double cytogenetic abnormalities.

Gurney M, Patnaik MM, Hanson CA, Litzow MR, Al-Kali A, Ketterling RP, Tefferi A, Gangat N.

Br J Haematol. 2017 Jul;178(1):57-60. doi: 10.1111/bjh.14636. Epub 2017 Apr 17.


Pathophysiology of Intestinal Na+/H+ exchange.

Gurney MA, Laubitz D, Ghishan FK, Kiela PR.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):27-40. doi: 10.1016/j.jcmgh.2016.09.010.


28-Year-Old Woman With Malaise, Cough, Myalgia, and Dark Urine.

Gurney M, Cotter TG, Wittich CM.

Mayo Clin Proc. 2017 Jan;92(1):e1-e5. doi: 10.1016/j.mayocp.2016.03.027. No abstract available.


Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System.

Zhang C, Xu Y, Zhang HT, Gurney ME, O'Donnell JM.

Sci Rep. 2017 Jan 5;7:40115. doi: 10.1038/srep40115.


Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles.

Ratliff EP, Kotzebue RW, Molina B, Mauntz RE, Gonzalez A, Barekat A, El-Mecharrafie N, Garza S, Gurney MA, Achal M, Linton PJ, Harris GL, Finley KD.

PLoS One. 2016 Oct 6;11(10):e0164239. doi: 10.1371/journal.pone.0164239. eCollection 2016.


Gas and Bloating-Controlling Emissions: A Case-Based Review for the Primary Care Provider.

Cotter TG, Gurney M, Loftus CG.

Mayo Clin Proc. 2016 Aug;91(8):1105-13. doi: 10.1016/j.mayocp.2016.04.017. Review.


Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor.

Titus DJ, Wilson NM, Freund JE, Carballosa MM, Sikah KE, Furones C, Dietrich WD, Gurney ME, Atkins CM.

J Neurosci. 2016 Jul 6;36(27):7095-108. doi: 10.1523/JNEUROSCI.3212-15.2016.


Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array.

Welton JL, Brennan P, Gurney M, Webber JP, Spary LK, Carton DG, Falcón-Pérez JM, Walton SP, Mason MD, Tabi Z, Clayton A.

J Extracell Vesicles. 2016 Jun 29;5:31209. doi: 10.3402/jev.v5.31209. eCollection 2016.


Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10-formyltetrahydrofolate dehydrogenase.

Naz N, Jimenez AR, Sanjuan-Vilaplana A, Gurney M, Miyan J.

J Neurochem. 2016 Aug;138(4):610-23. doi: 10.1111/jnc.13686. Epub 2016 Jul 25.


Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery.

Emanueli C, Shearn AI, Laftah A, Fiorentino F, Reeves BC, Beltrami C, Mumford A, Clayton A, Gurney M, Shantikumar S, Angelini GD.

PLoS One. 2016 Apr 29;11(4):e0154274. doi: 10.1371/journal.pone.0154274. eCollection 2016.


Using an Er,Cr:YSGG laser to remove lithium disilicate restorations: A pilot study.

Gurney ML, Sharples SD, Phillips WB, Lee DJ.

J Prosthet Dent. 2016 Jan;115(1):90-4. doi: 10.1016/j.prosdent.2015.08.003. Epub 2015 Oct 14.


Accuracy of community-based blood pressure devices versus validated self-use devices.

Karr S, Gurney MK, Early NK.

J Am Pharm Assoc (2003). 2015 Jul-Aug;55(4):419-23. doi: 10.1331/JAPhA.2015.14146.


Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts.

Chowdhury R, Webber JP, Gurney M, Mason MD, Tabi Z, Clayton A.

Oncotarget. 2015 Jan 20;6(2):715-31.


This old heart: Cardiac aging and autophagy.

Linton PJ, Gurney M, Sengstock D, Mentzer RM Jr, Gottlieb RA.

J Mol Cell Cardiol. 2015 Jun;83:44-54. doi: 10.1016/j.yjmcc.2014.12.017. Epub 2014 Dec 24. Review.


Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease.

Gurney ME, D'Amato EC, Burgin AB.

Neurotherapeutics. 2015 Jan;12(1):49-56. doi: 10.1007/s13311-014-0309-7. Review.


Measuring cardiac autophagic flux in vitro and in vivo.

Gurney MA, Huang C, Ramil JM, Ravindran N, Andres AM, Sin J, Linton PJ, Gottlieb RA.

Methods Mol Biol. 2015;1219:187-97. doi: 10.1007/978-1-4939-1661-0_14.


Discovery of triazines as selective PDE4B versus PDE4D inhibitors.

Hagen TJ, Mo X, Burgin AB, Fox D 3rd, Zhang Z, Gurney ME.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):4031-4. doi: 10.1016/j.bmcl.2014.06.002. Epub 2014 Jun 12.


Analgesia for pelvic limb surgery. A review of peripheral nerve blocks and the extradural technique.

Gurney MA, Leece EA.

Vet Anaesth Analg. 2014 Sep;41(5):445-58. doi: 10.1111/vaa.12184. Epub 2014 Jun 25. Review.


Intra-articular mepivacaine reduces interventional analgesia requirements during arthroscopic surgery in dogs.

Dutton TA, Gurney MA, Bright SR.

J Small Anim Pract. 2014 Aug;55(8):405-8. doi: 10.1111/jsap.12232. Epub 2014 May 15.


The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice.

Butchbach ME, Singh J, Gurney ME, Burghes AH.

Exp Neurol. 2014 Jun;256:1-6. doi: 10.1016/j.expneurol.2014.03.005. Epub 2014 Mar 25.


Amantadine, an N-Methyl-D-Aspartate antagonist, for treatment of chronic neuropathic pain in a dog.

Madden M, Gurney M, Bright S.

Vet Anaesth Analg. 2014 Jul;41(4):440-1. doi: 10.1111/vaa.12141. Epub 2014 Mar 28. No abstract available.


Structural basis for the design of selective phosphodiesterase 4B inhibitors.

Fox D 3rd, Burgin AB, Gurney ME.

Cell Signal. 2014 Mar;26(3):657-63. doi: 10.1016/j.cellsig.2013.12.003. Epub 2013 Dec 19.


Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.

Tilly P, Charles AL, Ludwig S, Slimani F, Gross S, Meilhac O, Geny B, Stefansson K, Gurney ME, Fabre JE.

Cardiovasc Res. 2014 Mar 1;101(3):482-91. doi: 10.1093/cvr/cvt276. Epub 2013 Dec 9.


Compounding practices and beliefs of Arizona pharmacists.

Cauthon KA, Bowman BJ, Gurney MK.

Int J Pharm Compd. 2013 Mar-Apr;17(2):154-61.


Dectin-1 is required for resistance to coccidioidomycosis in mice.

Viriyakosol S, Jimenez Mdel P, Gurney MA, Ashbaugh ME, Fierer J.

MBio. 2013 Feb 5;4(1):e00597-12. doi: 10.1128/mBio.00597-12.


Report of the 2011-2012 AACP Professional Affairs Committee: addressing the teaching excellence of volunteer pharmacy preceptors.

Harris BJ, Butler M, Cardello E, Corelli R, Dahdal W, Gurney M, Harrell K, Murphy J, Pisano D, Sullivan M, Teeters J, Bradley-Baker L.

Am J Pharm Educ. 2012 Aug 10;76(6):S4. doi: 10.5688/ajpe766S4. No abstract available.


Pharmacological options for intra-operative and early postoperative analgesia: an update.

Gurney MA.

J Small Anim Pract. 2012 Jul;53(7):377-86. doi: 10.1111/j.1748-5827.2012.01243.x. Review.


Intra-articular morphine, bupivacaine or no treatment for postoperative analgesia following unilateral elbow joint arthroscopy.

Gurney MA, Rysnik M, Comerford EJ, Cripps PJ, Iff I.

J Small Anim Pract. 2012 Jul;53(7):387-92. doi: 10.1111/j.1748-5827.2012.01222.x. Epub 2012 Jun 19.


Peripheral nerve blocks of the pelvic limb in dogs: a retrospective clinical study.

Vettorato E, Bradbrook C, Gurney M, Aprea F, Clark L, Corletto F.

Vet Comp Orthop Traumatol. 2012;25(4):314-20. doi: 10.3415/VCOT-11-08-0111. Epub 2012 Apr 25.


Comparison of two methods for the management of intraoperative hypothermia in dogs.

Kibanda JO, Gurney M.

Vet Rec. 2012 Apr 14;170(15):392. doi: 10.1136/vr.100690. Epub 2012 Mar 28. No abstract available.


Prolonged neuromuscular blockade in a horse following concomitant use of vecuronium and atracurium.

Gurney M, Mosing M.

Vet Anaesth Analg. 2012 Jan;39(1):119-20. doi: 10.1111/j.1467-2995.2011.00683.x. Epub 2011 Nov 25. No abstract available.


Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus.

Burnside K, Lembo A, Harrell MI, Gurney M, Xue L, BinhTran NT, Connelly JE, Jewell KA, Schmidt BZ, de los Reyes M, Tao WA, Doran KS, Rajagopal L.

J Biol Chem. 2011 Dec 23;286(51):44197-210. doi: 10.1074/jbc.M111.313486. Epub 2011 Nov 11.


Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration.

Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS.

Nat Commun. 2011 Sep 6;2:462. doi: 10.1038/ncomms1474.


Small molecule allosteric modulators of phosphodiesterase 4.

Gurney ME, Burgin AB, Magnusson OT, Stewart LJ.

Handb Exp Pharmacol. 2011;(204):167-92. doi: 10.1007/978-3-642-17969-3_7. Review.


Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration.

Lembo A, Gurney MA, Burnside K, Banerjee A, de los Reyes M, Connelly JE, Lin WJ, Jewell KA, Vo A, Renken CW, Doran KS, Rajagopal L.

Mol Microbiol. 2010 Jul;77(2):431-43. doi: 10.1111/j.1365-2958.2010.07215.x. Epub 2010 May 19.

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